LOCUS       NM_001387675           17747 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LIM domain containing preferred translocation partner
            in lipoma (LPP), transcript variant 28, mRNA.
ACCESSION   NM_001387675
VERSION     NM_001387675.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 17747)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17747)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 17747)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (bases 1 to 17747)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 17747)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (bases 1 to 17747)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (bases 1 to 17747)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (bases 1 to 17747)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (bases 1 to 17747)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (bases 1 to 17747)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC063932.14, AC055711.18,
            AC009319.19 and KF510228.1.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.543113.1,
                                           SRR14038193.3366203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2158569
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC063932.14        133795-133939       c
            146-829             AC063932.14        108433-109116       c
            830-956             AC063932.14        9884-10010          c
            957-1126            AC055711.18        41842-42011
            1127-1305           AC055711.18        147929-148107
            1306-1426           AC055711.18        154372-154492
            1427-11167          AC009319.19        3236-12976
            11168-11548         KF510228.1         1-381
            11549-17747         AC009319.19        13359-19557
FEATURES             Location/Qualifiers
     source          1..17747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     gene            1..17747
                     /gene="LPP"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
     exon            1..145
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            146..829
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1555
                     /gene="LPP"
                     /note="isoform c is encoded by transcript variant 28; LIM
                     protein; lipoma preferred partner"
                     /codon_start=1
                     /product="lipoma-preferred partner isoform c"
                     /protein_id="NP_001374604.1"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
                     /translation="MVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVP
                     ASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPP
                     STRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHP
                     NTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPS
                     SVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHV
                     DCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHP
                     HCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRI
                     VALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            830..956
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1126
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1305
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1426
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..17747
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      17726..17731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPP"
                     /note="hexamer: AATAAA"
     polyA_site      17747
                     /gene="LPP"
                     /note="major polyA site"
ORIGIN      
        1 aatactgtca tttacacttg caggctgtta tgctttccag aaaacttttt ccgtaggttg
       61 cgaaagtgat taatctgctg ttaaaactga caaagaaggt tctctgataa gagaaagaat
      121 taaatgagga atttttcttt aaaaaagctc cactggttca acagcctctc ctccagtttc
      181 gaccccagtc acaggacaca agagaatggt catcccgaac caaccccctc taacagcaac
      241 caagaagtct acattgaaac cacagcctgc accccaggct ggacccatcc ctgtggctcc
      301 aatcggaaca ctcaaacccc agcctcagcc agtcccagcc tcctacacca cggcctccac
      361 ttcttcaagg cctaccttta atgtgcaggt gaagtcagcc cagcccagcc ctcattatat
      421 ggctgcccct tcatcaggac aaatttatgg ctcagggccc cagggctata acactcagcc
      481 agttcctgtc tctgggcagt gtccacctcc ttcaacacgg ggaggcatgg attatgccta
      541 cattccacca ccaggacttc agccggagcc tgggtatggg tatgccccca accagggacg
      601 ctattatgaa ggctactatg cagcagggcc aggctatggg ggcagaaatg actctgaccc
      661 tacctatggt caacaaggtc acccaaatac ctggaaacgg gaaccagggt acactcctcc
      721 tggagcaggg aaccagaacc ctcctgggat gtatccagtc actggtccca agaagaccta
      781 tatcacagat cctgtttcag ccccctgtgc gccaccattg cagccaaagg gtggccattc
      841 agggcaactg gggccttcgt cagttgcccc ttcattccgc ccagaggatg agcttgagca
      901 cctgaccaaa aagatgctgt atgacatgga aaatccacct gctgacgaat actttggccg
      961 ctgtgctcgc tgtggagaaa acgtagttgg ggaaggtaca ggatgcactg ccatggatca
     1021 ggtcttccac gtggattgtt ttacctgcat catctgcaac aacaagctcc gagggcagcc
     1081 attctatgct gtggaaaaga aagcatactg cgagccctgc tacattaata ctctggagca
     1141 gtgcaatgtg tgttccaagc ccatcatgga gcggattctc cgagccaccg ggaaggccta
     1201 tcatcctcac tgtttcacct gcgtgatgtg ccaccgcagc ctggatggga tcccattcac
     1261 tgtggatgct ggcgggctca ttcactgcat tgaggacttc cacaagaaat ttgccccgcg
     1321 atgttctgtg tgcaaggagc ctattatgcc agccccgggc caggaggaga ctgtccgtat
     1381 tgtggctttg gatcgagatt tccatgttca ctgctaccga tgcgaggatt gcggtggtct
     1441 cctgtctgaa ggagataacc aaggctgcta ccccttggat gggcacatcc tctgcaagac
     1501 ctgcaactct gcccgcatca gggtgttgac cgccaaggcg agcactgacc tttagattca
     1561 gtcacctgtt cagccggcac tgagaagaac gaacacaaga aaaagataag aaatactaga
     1621 gtaaaggcca tcaaactacg cgatagtctc tgttcttcat ctgctattaa ccttgcctta
     1681 gaaacacata aattatgaga ttttttttaa aagttgttac caaatacaca tttcacattg
     1741 aatcatgtag gatcttgatg ggcctttgtt cccaaggact tccacatttt tgcacagatt
     1801 atgctccatc ccattcactt ctgcattcct gtaactttta atccctatgt ttgtctcact
     1861 tttcatctgg ttgaatggct tttcttagtg tggtatttgc tgtcacatag tttttcctgg
     1921 gtgagtctgc caactcacag gtgcttttag gcttgaaatc tccatcctat catttccgtt
     1981 ttgcctgtga ctgtaaagag tagccattct tttcccatgt attgaagagg atattcttct
     2041 cttgctttat actactcacg tccttgggga gggaaatgca caattttttt ttgttaggct
     2101 gtaaagaatt taagctgtaa attacataag ttagaacaag cccaaattta atttgcaacc
     2161 atcagaattc agaatctata gtgaccagtg atcaaggcta attggaaaag agttatcggc
     2221 ccatagctaa taagtagtga cagacaacca agcttcaata tttttctaaa gaaattacag
     2281 gtgggatatg ctagaaaagg cattttgggg ttatgtttaa aaaaacatta ttgtcccaca
     2341 atattacctt aagatttttc ttttccgcac tacctgaaca ttgtaataca gacaaacttg
     2401 atttcttcta gaagataaca ttttcaatac tgtcccactt ctcatcttaa aaatattgtc
     2461 atgtttattc taatatccaa cacaactatc aaaattgcct ttttctctag aggatgaagg
     2521 ctgtgaaaaa accgttcaaa ttctcttctt tttctttttt attaccaggt ccattttgcc
     2581 tgacaattgc aaatcagagc atacaaaata aaactgtgca gttttgtttg gtttactttc
     2641 aaaagagtag aaagcttgaa aagattctga aaccacagtt tcattattct cataatcctt
     2701 ctgcaactga aattacatat tgcaggagac attttcatat catcaatgtg acatttacac
     2761 cacactttca aagacaatca ctgaaacaaa aattgtcttt atgagctaaa aatatgcaga
     2821 atctctgcct agaatcttta ttcaaacttt tattagccag tgaaacactt gcttgccaac
     2881 tgccaagcca tacttattaa gttcgaacat gtttcactta aggagagaca cctagcttag
     2941 tcatggcaag ttgccatttt gtaaactaag gattttggac tgagatttct taaatctttc
     3001 ttcaaatctc ccacaagtat atacttttaa attatggagt attttaagtc tacaaaaagg
     3061 tataaataat aatataatga attcctatat acctaatacc cagtttaaga caccaaatat
     3121 aacaagtata attacatcct ccaatgtacc gtttccttat tccacagata tctttttcat
     3181 tattgtgaag tgatgttcag atttctagtt ttttttctag tttttaattt taacatcaga
     3241 actgaaataa aaaattatgg atacgtgttt tgaattgcaa actattcctc aggaattcca
     3301 attaaattta ttttacttga ataggaatga tcataaaagt gattcttttt ttgtgactag
     3361 aaattcttaa gccgatggtc actatagctc atccttaatg tatggctcat ttgcttttgt
     3421 cactaaacgg ttttgtgtta gaaccaccaa aattatagct tttaagagct tcctttgacc
     3481 actgtctttt tcttacccta gttctcttat ctttgatcgt atatttctca taatgtgaaa
     3541 tatgatgaga ttcacttagg ggcagcatgt tagttttggg aggcaatgtc aactgtgtct
     3601 ctgaattcct gtcttccaaa ttgaagccag accatgctga tgacctcaag tagcactgac
     3661 tatttgacaa tagggctgat aatgtaatcg gcttgaattt tgacttagta actttttatg
     3721 taatactttc ggagaaattc tctttaggac aaagcagaga gtccaattta ttgagggata
     3781 gattgtatct cttaaagtgg tcatattatt attaattttg ccaaaagaag aagaatttat
     3841 tgaatattta tactataaaa tgcagtaaca ttctacttgc ttattacatt taaatccttg
     3901 tgtaactgaa tgtttacatg tcaagaggaa aagctgtaag aaaatgctgt cacagaccca
     3961 tccctgtggc atcgtcagca gaatactgct tgcttacaat ctttattatg cattcttata
     4021 acataacctc agagtatctt taccaaaggt ttttaaagta aatctctttt taagatagac
     4081 ttattctttt ataataatga atgtgcactc atacatatgt agaaacattt agatttagag
     4141 tttttttttt ctttcacaag gtataataag gaaaggatcc tacaatattt tattctaggg
     4201 tttcttaaat atatgattta tattactgtc ttttctatta atcatttgat ttaaacaatg
     4261 ccaagtcact cttttttagt tgcatgaaat tttgcctgca acagagagaa aaagattgta
     4321 ttactttaat gattataatc atactgtctg ctgatataat atcataattg ttgtggttta
     4381 aatacataaa tagtagaaaa atcagagtct ataacagaaa gtttgtaaaa atatactgat
     4441 tttgaaaagt atcaggaata taaatatttg gtaattctgt gtaacaagag agacatggaa
     4501 aaggaaaaaa atccactata tcatgggctc tgcagaacat atcaaaatag gatttcttaa
     4561 atttttcaac ccccagacca tactgactca acatggagtc tcactggcca agaaaattgc
     4621 ctttaaaact cgaaaataag gccaggtgtg gtgactcaca cttgtaatcc cagcaatttg
     4681 ggaggctgag acaggaggat tgcctgaggc caggagtttg acaccagcct gggcaacata
     4741 gtgagacctt gtctctacaa aaaataaaat aaaataaaaa ccaaattagc cagacatggt
     4801 ggcatgcgct tgtttaaaaa aacaaataaa taaataatcg actcaaaaat aagtcatgtg
     4861 tcccagcata aggcatcagg ttgttagatg ctggcatctc tgcagctcaa agatgtgggt
     4921 tctttttctt gtcattaaca cattgttatt tctgtaggag caacttctct gatcaaaatt
     4981 acttttctgg gtatgtgctg attaaggggg tggacttatc aacactataa ttgttcccta
     5041 tgaaagattc cacagagatg tttatggtga ggtttaaagg atatgaaact ctacatttaa
     5101 acaagtattt tatatttggg tacagaggaa gaaagagagg gctttttcca tggggctata
     5161 gtagagagtt agtggaatat agacaggact ctgaaaacac aacttccagc cattttttta
     5221 gttagtaaaa atcctattaa tgtgaaccag ccaggaataa cagtgttatt tctattggat
     5281 atggtttggg cttctcttgt caaatctgtg tcggctgccc cctgatcctt ccattatcaa
     5341 gttttgaagg gtgttgggga aattatggca gctgctaggg agatcaggga aacactgatg
     5401 taacctcaaa gcctctcacc attcctcttg gcttggaaag gctttatttt ttcatataca
     5461 tttctagaaa tattgctatt ctaccttagt atttcacatt tgtagttcaa acaagcgatt
     5521 gtccatctgt tgcctagagc tatagtacat gtgtgttatg aatgaaatat gacagcatgt
     5581 tccatacccc tgctttagcc atctgtggga aaccagcaaa ctgaaaaaga cacctctgca
     5641 aaatgtgcct caagtccatt tcttgggatc gctcgtttgg tgcactctcg tgggagacaa
     5701 tcagagaaca acatatactt gtgccttatt ttcaaagaat ctatttacac tactatgaat
     5761 attccactga agagtcaatg atgtaaatga taaccaccaa atctcaaaaa tatactcacc
     5821 aaaaagtaaa aaagtaaaaa aaaaaaaaaa agaaagaaag aaaagaaaga gagagaagtc
     5881 aacttttcat cttaatatat tctagtagta tttatttttt ccttgtcttg gaagtatctc
     5941 ataggtcttt aaatgagtaa aacattttta tgccagaagg tgatataatg gatgttagtg
     6001 ttttttattt gattttacag tagttttagt cagataatga ggacagagac ttcaacttga
     6061 ttctttacca ccattcagca tattttttaa ttgtcttcat tgtatttgct taatagtggt
     6121 ccagacaagt tcaaaacttg ttctcagtga ggcattaata tggtgcaacc atgaatattt
     6181 caggccaagt tattcacttg acagataact agaatgaaac ttttctcatg aggctgttgt
     6241 ttggttagca tagccttatt tcaaacctta aaaagttacc tgactgaagc tactatgact
     6301 tggtaaggat tcttcctctc ttgctttctt cctcccttcc tttcttcctc ttccttcctc
     6361 ctcttcttat tttctttcct actttccatc ctacctatta gtgttgctgt acttggattt
     6421 tttgtaaatt aaatcaatgc attatgattt tagggaatta tgattatatt cataagggga
     6481 aggctaccag aaaatatatg tggcatccat aaaatcttct tttatagggg catatttttt
     6541 aggttgtatt tattcgtaaa gtgaaatgag ataatagagt ctttctgttt catgttaatg
     6601 aattttcatc agggactgag gtcatagatt cttggaaaat tcatttgtga ctgatctagt
     6661 tttctcagct gtatgcaaag taatctttca aagactaggt taagattttt tttttaagtc
     6721 tgaagcaatg taaccccaaa aaattataat tttaatgatg gcattttatt ttattccatt
     6781 gcagcttgat aactttcctt atagcaaagg aataactatt gtattttcag aattttaaca
     6841 cagattaaca cttagcctgt aagactaata atatattgta atagttgata ctaaaatatt
     6901 tttcagcagg ttggacagca ccagtttttc ttagatcaca gactacaggc agaatttccc
     6961 ttcaatccag aaaaaaggac actaatttcc ttttctattt aattttcctg gcccttgtgc
     7021 aaaaaattgt ggactctatc ttagttacaa catgcatgtc ccttattttg tggagagctg
     7081 tgtgaaagat gcgttttttt tctttttttc tttttttttt ttttgagacg gagtctggct
     7141 ctgtcaccca ggctggagtg caatggcacg atctcctctc actgcaagct ccgcctccca
     7201 ggttcacgcc attctcctgt ctcagcctcc cgagtagctg ggactacagg cgcctgccac
     7261 cacgcccggc taattttttt gtatttttag tagagatgga gtttcacagt gttagccagg
     7321 atggcctcga tctcctgacc tcgtgatcca cccgcctcgg cctcccaaag tgctgggatt
     7381 acaggcgtga gccaccgtgc cccgcgtgtt tttttcttta gctgattgac aggtcccctt
     7441 caaagttaca aaaaaaagtg ctaatttttg ctgttaaatt ctggttgtta tttaattgac
     7501 agaagtctct tgatgcacga ataaatatct ctacatctag cctttgttaa aaataaaaat
     7561 taatattcta caaacaccta catatactag agaggggtga aacactgcag ctaattcctt
     7621 tataatactt tcagatgatt gcattaagcc tttcatgtta tgtggcattg ttaatttttc
     7681 ctagataccc atccacttaa gggccagaga aatccttatt catttaactc tggtgggcat
     7741 ttatgtaaca tacccaaata aaaacgttat taaacagcca caatcgcatt cagtcaactt
     7801 ggcactgaat gtagcttcta aaatcagttc tctaccctac gaatggaatg ttctaccaag
     7861 aaagagaagc atcaccatgt catcttgtgt tctacaccac tatagagagt tacagttgcc
     7921 cccaaacacg aatgctattc ccaaataaaa tagaatcatg ctttgggagg ccaaggcggg
     7981 ccgatcacga ggtcaggaga tcgagaccat cctggctaac acggtgaaac cccgtctcta
     8041 ctaaaaaaaa aaaaaaatac aaaaaattag cctggctcag tggcgggcgc ctgtagtccc
     8101 agctactcag gaggctgagg caggagaatg gcgtgaaccc gggaagcgga gctttcagtg
     8161 agccgagata gcgccactgc agtccggcct gggcgaaaga gcgagactcc gtctcaaaaa
     8221 aaaaaaaaaa aaaataggat catggccctt ttaaagatct gaatcttctc tgttattttc
     8281 ctgatgaatc accatcccat atcttcttag tcctggccag tatgtagttg cgctcacata
     8341 cgtctattct agctctgtag ctccacaaaa caagtcttaa gtccaaatct ttgcctcttc
     8401 atgtctgata tcaccaactc attcagcttt tcttcactta ttgacatagt gtcatgtcct
     8461 atcactctct gctgcttctt taaacagtgg acacaaacat attttctaat tttcagtgta
     8521 ctcagtgaaa cttggcagtt caccatgagt caggctaggt tgaaaggctt tctttagggt
     8581 tgaaagtaaa cgaaattgga atcacccaaa gagaatttcc ccaaaaaacc tcagacccag
     8641 aagtgtaaaa gctacagaag gatagaactc ccatgtctac agacagttct gttacttttt
     8701 gttctgtact attttggatg ttgccaaaat caaattcatc ctgaaaacag gaagcaagct
     8761 aatgcatatg ccatccatga gattcccact tctgggtcag ttcatattcc attcaacctt
     8821 ttccttttat ccttgtcttc ttcagaataa gacatttttc ctccatattt tcatattaaa
     8881 tattaacact ttataggttc tactttaata tatggacact ttacaggtta tacataaata
     8941 tttgctggtt gattgatttc gagattcatt cattctgtgc tcaaatattt gtacctagag
     9001 acgttacatg ttagaaaaag tgagcagctt ctttctctaa tcatttagga gtccatattt
     9061 ttcttttctt tttgttctcc caacatcctt atctcttact cagctcttca atttataatt
     9121 accaaataat cactgttaga gaatcagccc ctaagtaact ttgattctgg ccaactgtaa
     9181 taagatccaa ccacttaaat ctgtacttac tcaataggaa ggaatgtgac atcaggaaga
     9241 gtcattccag tgacattagt aagactttat ggagtacata aaatttgata agaaatcttg
     9301 agctgattct ttgacttgat ttagaagttg agaaaagagt atttaaggca caacagggaa
     9361 acatgggcta tactcagaga agaccctctg cattggccaa aatatcatgg attctggaaa
     9421 ttccttctta acagaaaaaa aaggcttcca aataatcagg ctgaatggga agaaaaaggc
     9481 atagaggaag cctgaggaag tatttacttg cttttcccat ctctttataa ttggaagaga
     9541 agatgatctg ccaaaatata acccagcatg cacagtatgg acaggaagca gccctccatg
     9601 aactttatta tcacagaata tgagcattct tattgatcca cagctacatc ttctattctt
     9661 gcagcaaggg tacatgtcct ttgaccctcc acaaaagaac aagcaggaca tctctatttt
     9721 cctattgagt ctgagtccat tattagaaag gacttcccag ccatcttttc tacttggtat
     9781 taaaattccc ttacagattc attgctaagt gccaattctt tttttttctt ttgagacgga
     9841 gtcttgctct gtcgcccagg ctggagtgca gtggcgcaat ctcggctcac tgcaagctcc
     9901 gcttctcggg ttcacgccat tctcctgcct cagcctcccg agtagctggg actacagacg
     9961 cccgccaccg cgcccagcta attttttttg tacttttagt agagacgggg tttcaccgtg
    10021 gtctcgatct cctgacctcg tgatccgccc gcctcggcct cccaaagtgc caattctgac
    10081 tctacttaaa catcacctgt atcagggagc tcattattcc ttgaggtctt acatttcttt
    10141 cagcacattt tgttccaagc tacacgactt taaaacagag ccagcctttg gggcatatgt
    10201 tctctttggt gccacacaaa acctgtagta catgatacag tgttgcttcc cccctccttt
    10261 tccttccata tatatttgtt ttgttttggg cattgcatta cttttttgaa tttttaagaa
    10321 tctctaaaat tagtctgaag gatgttctga gggccagaca ttagaatttg tgagtttttt
    10381 tgttgctggt tgtactttcc tatttagaag acagaccgtt ctgacagttg ttgtgtagct
    10441 tcatgccttc cccagtaact aacccatgaa cagtacaccc cttttatctg acttgttgat
    10501 aatgacctta aaaatgttag gaaatgggcc gggcgcggtg gctcgtgcct gtaatccagc
    10561 actttgggag gccgaggcga gcggatcatg aggtcaagag atcgagacca tcctggtcaa
    10621 catggtgaaa ccccgactct actaaaaaaa atacaaaaat tagccgggcg tgttggcggg
    10681 cgcctgtagt cccaactact tgggaggctg aggcaggaga atcacctgaa cccaggaggc
    10741 agaggttgca gtgagcagag attgcgccac tgcactccag cctgggcgac agaacgagac
    10801 tccgtctcaa aaaaaaaaaa aaaaaaaaaa ggttgggaaa tattggtgta taatccccat
    10861 gtctaacaag gaagaagtca aaagcaaaag atagtggtat tgccgaaaac tcattatttc
    10921 tagttagttc atctgtggaa aaggatatcg ttcttgagga gaggggttct attatgctat
    10981 agttttctat ggaaatgtac aaatgctttc ctcattgctc tggatgacta tttagtttaa
    11041 ataatatacc tttgtcatgg ggaagaccat gattgtggct tcttctaccc caactttgaa
    11101 tgagagagca ctgtaagcag aaactgccat cagtctcctg ggcaggacct ggaggtaact
    11161 ttctgagctg taaaatagta attcctaaga gagcttacaa actgcttcca cacagaaaat
    11221 agcgcaggga ggacagttat tagtacccct attctagaag agaaagctga ggctcaagcc
    11281 attaagtgac ttgccaaaag ctgtgacata gctgggaagt ggcagatttg gggatataac
    11341 caggtcttgc aagtccagtg ctgtctccaa gtagccacgc tcacagctga gaacacctta
    11401 gaggacaata tcgacttctt acagactacc aagcccccag tcatccaggg aaattcagag
    11461 accaattgac tgccaggtgg caaatccaca tgtgtactgc ggtctttaga gatcatttag
    11521 agcttgcaca catctgtgtc ttcttgtggg aaacctctag gtattctgtc tgatcagcac
    11581 tgtgaggaag ttggtgggaa aaggccactg ataagaacaa acaatgggca gaaggaagca
    11641 cattgcaata aatttcccca gagagagttc ctttacattc cattcaccaa aaacctctct
    11701 ggaactgtca ggttcagaat atcaaccaag accatatcat ttagaattca ttggcatgta
    11761 gaggtgactc gattcctaaa agaagcctct ctcccatgaa ccacgatgta cgttccacag
    11821 aggcagaaac cgccgtaggt tagcaatgca ttttagtctt tctctccatt cacatttact
    11881 gagagcacac cacgtgcatg ttgctgcaac aggcatttcc gatagagccg atccatgagc
    11941 taacaatgtc tgaaaacaaa tgttatggaa ctgttggcat ttctgagatt tggcctttgc
    12001 catttgatag actttgcttc ccaggatgct gtcattttgt gattttttat aattacaagg
    12061 aatttggtac catgttgttt tcaaaaaacc tcctagaaag tctccatgta tgctctagaa
    12121 gttgctctac gtaacagttc agcaagcaag tgttccttct cttgagctgc gtccctcagg
    12181 aagctgtacc tttagggtgt gctttccact ttttatttcc tctcatttca ctcctttcat
    12241 tgtttgctat atcctaaaat atgtgaagtg agagaaaaaa tatcatttct tctcattaaa
    12301 tctcctgcat taaatctaag aatcctttaa aataatcaca cctgataagt gttttatgca
    12361 tttccctccc tggagtgtta tcatccatca agccagtatc atcatccacc tgcttattcc
    12421 ttgggactaa tgagagccaa gttaaatagc aaatgacttc tcaccccttc ctagtcctca
    12481 tgcctgagga ataagggcga cattaatggg agcgggagag tggtggcttt ggttgagatg
    12541 cacgttcaca gactagaaaa gtgcctcacc tccatggtgt atatgtgcca ccttttctta
    12601 atccagtcta tcattgttgg acatttgggt tggttccaag tctttgctat tgtgaatagt
    12661 gccgcaataa acataagtgt gcatgtgtct ttatagcagc atgatttata atcctttggg
    12721 tatataccca gtaatgggat ggctgggtca aatggtattt ctagttctag atccctgagg
    12781 aatctccaca ctgacttcca caatggttga actagttcac agtcccacca acagtgtaaa
    12841 agtgttctta tttctccaca tcctctccag cacctgttgt ttcctgactt tttaatgatt
    12901 gccattctaa ctggtgtgag atggtatctc atagtggttt tgatttgcat ttctctgatg
    12961 gccagtgatg gtgagcattt tttcatgtgt ttcttggctg cataaatgtc ttcttttgag
    13021 aagtgtctgt tcaatactat gcagccataa aaaatgatga gttcatgtcc tttgtaggga
    13081 catggatgaa attggaaatc atcattctca gtaaactatc tcaaggacaa aaaaccaaac
    13141 accacatgtt ctcactcaca ggtgggaatt gaacaatgag aacacatgga cacaggaagg
    13201 ggaacatcac actctgggga ctgttgtggg gtggagggag gagggaggga tagcattagg
    13261 agatatacct aatgctaaat gacgagttaa tgggtgcagc acaccagcat ggcacatgta
    13321 tacatatgta actaacctgc acattgtgca catgtaccct aaaacttaaa gtataataat
    13381 aatgaaataa aattaaaaaa aaaaaagaaa agtgcctcac ctccctgtga ggcttgatga
    13441 atattgtggc cagtgagtgg aaaatgattc ttgtcgaata gacagagtat tcccacccca
    13501 ggaatggatt aatagaagac acaatttgag cacttctcag aattatctag tatgcctgag
    13561 tagagactca catgggtgga atctgtgttg tctcatcaga gggaataaaa agacaatgag
    13621 gtggtaaatg tgaaaaaagc agccttttag aaaaacatta ttttcaaata cctttataaa
    13681 tcatctaatt tatcttcaca taatataaag aaaaaactaa taaaaatttt cgtatttcac
    13741 tttacataat atgttctccc atatttaggg atcatacaat tgtattgtct tcaaaacaca
    13801 cacacacaca catacacaca cacacacaca cacacacaca ccccttccaa gaaagctgat
    13861 ccttcagaaa ataaatctta tttttaagca cttgggtttt caggccagaa aattaataaa
    13921 tcctaaacct gacccatttt tgtaacagct aaaaaggaga agaaaaagct agttaaattt
    13981 tgtgtggatc catttatctc ttaaaatatg ccaaagcaat ttgaggtggg ggtggaaaca
    14041 ggtatttatc tctcatgcgt gattctctct ttatatttct atctgttggg aaaagggtaa
    14101 agaactattc ttggtcatta ttgatgtatt gtgttgccac tttgtatggt gcctgctgtg
    14161 ctttatcccg aggcatagca gtaatcgtta ctatcttgac tctttccttc atcacaagag
    14221 agtaaatatg aagtctgaat gtcgttcctc acccccaaat tgtttaactc tgcttccaaa
    14281 ctagtttaag aaatgcaaaa tgggaagagc tagcttttct tagatacatt tcttcctttt
    14341 ttattctttc ttgggagacg ttaagtataa aagggaaaaa gtcagttcct tcttctctct
    14401 ctttctcttt gggtgacagc aatgctcact tagtaattat aaactggaaa taggagagta
    14461 gcttgagcag gttatgatat atctgcccaa tgtgtttcat tccttcaaac ataaactttg
    14521 agagtaaaag agatttttat aatttaaatg ccaacgacag gaatggcctc atgttttaac
    14581 tttcaaataa taaatgggga gttggtattt gggcagagtt tgcattttac taatcctata
    14641 tactttgagc ttagttttta gaattgtgtc aaatacatca acatatcagg attatagtgc
    14701 caaaaatagt taaagtgcct tggtcctccc tctgtaggca gcaaattgaa actaacatgg
    14761 gaccatgcca tccttctagc ataatggaga agtctgaact gaggagtatc tttgatgaaa
    14821 gacatttagg accctagaaa ctaaatcttg tcaccaagac tttatagtaa agtagtagca
    14881 aaattatttt taaaagactt tcttcctttt actacccatt tcctctcttg ggaaagctga
    14941 tgagcaaatt atccaagact catttcttta ttaggcaaag tcagaatatt tcccctctga
    15001 aaatctgaat tatgccctca ttctttttca agaaatatct caaagagcaa atagaattaa
    15061 acatgacact tgattgtctg attatttggc atgtataaaa ttatcatgtg gcttaatgtg
    15121 ccttaagtga aaatttaaac ttagacctga aacctttaca gttggatgta gcgttgagct
    15181 tttgcatgtt ttctgtataa taaaccactt ttgttttgtt tgttttgtct tttaacctac
    15241 acctttatca ttactctaac agatttaggg cttctctttc tctacagcta agtaagggaa
    15301 tatgtgcaat tatgagacat acaaaaaagg aaagggaaag gactttctaa gtagcaaatc
    15361 tgtgccatga agtagatgtg gcgtgaagat acagagcctg aggatagtaa ttttccctga
    15421 gccacgcaca caggctttta tttcatgcct tttctctttc tgtgccgtca cctttgagaa
    15481 aaacgattgc accttctcca agtctgcctt tttaacagct acagttaagt tggcaagact
    15541 tccccagctc tgaatatagc catttgccga ctccggcctc tttgcgagac tgactcaaat
    15601 ctgtgatctt ctgttcagca tacacatcag caaagtgaga agatgagcac taaatatagg
    15661 ctctattaac tttactttta gatttactgc cttcaaaaag tgcctattct gagcaacata
    15721 aacgttattc cttacatatg tatgtacaca cggtacccag agtcgtactg tgcagccttc
    15781 aaaaacatac catcagaaag agtaggtgct gagataagga aactttgcca aatgaaagaa
    15841 agtcactcac ttccaatatc ccctctcaag cggctaccgt gaaacgggct gcaaacacat
    15901 tccctgagca tcccttgctg atacagcttc tttatattta tatcctactg gatggtagca
    15961 tattgctaag gtttcctgta ctctgcttca agggaatgta agctttatgg cattgaaaca
    16021 tttagggaaa aaaaagatgt ttaagagaat taatagagcc gtagtctgta ttaggatgtg
    16081 tgtcatatgt gtgttctata aactaagcat cggtgggttt agagtgttaa agtgtcagca
    16141 cattccttct ccttttgtct ctcaggctaa catgagagaa aatagaaaag tcttggctgt
    16201 ggggattgga agctcagggg gccaaatgtc cttgccagat ccttagagca ttactttgac
    16261 tcctaaaaat agtagtgtat gttatttgat ggcttttgtt tccatagttc catcactgac
    16321 aaaactgtca atactgttga tggagcagca gcatagccta gagtgatgca ttcttaccca
    16381 gaggtggcaa taggagaggg tccatgtaaa taggacgagg tagacagtgc atgattgtag
    16441 gagaagggtt gaagggagga catgattcca aaaaagatcg ttctcaatgt gtcgtctgac
    16501 tcaaccagct ggcagattac acttgccaag tcgttccctt tccttctaag tcagttggct
    16561 ccatattcac ttgaatatgc ctctgtttgg gcaaagcaag atacctccac ttaaccttta
    16621 tccaaggaag ctcttggtgt cctcttggtc ataaagttgt ctcctaccta acccagtttt
    16681 accaaatgga agtaaaaggg gacaaactat ggaagatgga ctccatgcca ttgcagtcag
    16741 ccaccattct cttttccata taaggagccc cattacataa gctacgggtg aggttggaac
    16801 agctatgttt cataatttca agagtgtgac caccctgctc tagtcatcat cattggatga
    16861 atccagttga ctctttggca aaagggtgat acttttcact aaaaatgcct actcttcctg
    16921 ttgatgttcc ttttctgttt ttaccttgtc caatttccac actagtcatt ttttttattt
    16981 tttagaggat cagattttag cgctggaaaa tgagttcaaa aatttcagtg taatgtcata
    17041 aggatgttgg gatacagaga tttttttttt ccttggaaac aaatggactg ggaagaaaca
    17101 cagcatggct ttgctctgag tttcaatctg atgattatga ccatggaaga tagtcttatg
    17161 taaaggttaa atggtgttta caagtggata gataaggcgg agatggtgag aagccgggtt
    17221 ttctctatgc taaatgtgtc tactaagagc agcacttcct actagctaag cacaatcata
    17281 gccccaccgt gatgagctgc tagtctgaat aacattccct gacttaggga aaggcacaca
    17341 aaaacatata aagaatatgt ctattttcat atgtgtgata ctgacagagc catggtattc
    17401 ctaaaatata ggtttctctt ttttcttgta ttcttagcaa attgcattta ttcactacat
    17461 tacaaaccat cactgatgta tccaaaatag cacacatagt tcagtatgaa aataagagaa
    17521 taaaatctgt tataagcaag tgatttaggt attttctttt gtgtttatgc attatctgac
    17581 tatattaaaa cctgtttttc tatttacctt ctatcagttt tctctaccaa ttatgttttt
    17641 tcaatgctct ataagaatga atatggaaat tatatttctt ttttctgtaa aagagttgca
    17701 actactttat tatatttaga aatccaataa acttcttatt acattta
//
