LOCUS       NM_001387670           18136 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LIM domain containing preferred translocation partner
            in lipoma (LPP), transcript variant 23, mRNA.
ACCESSION   NM_001387670 XM_011512831
VERSION     NM_001387670.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18136)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18136)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 18136)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (bases 1 to 18136)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 18136)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (bases 1 to 18136)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (bases 1 to 18136)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (bases 1 to 18136)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (bases 1 to 18136)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (bases 1 to 18136)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022498.18, AC069226.19,
            AC063932.14, AC055711.18, AC009319.19 and KF510228.1.
            
            On Nov 20, 2020 this sequence version replaced XM_011512831.3.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130584.1, SRR14038193.783382.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC022498.18        60685-60780
            97-298              AC069226.19        127073-127274       c
            299-411             AC069226.19        48682-48794         c
            412-534             AC069226.19        8599-8721           c
            535-1218            AC063932.14        108433-109116       c
            1219-1345           AC063932.14        9884-10010          c
            1346-1515           AC055711.18        41842-42011
            1516-1694           AC055711.18        147929-148107
            1695-1815           AC055711.18        154372-154492
            1816-11556          AC009319.19        3236-12976
            11557-11937         KF510228.1         1-381
            11938-18136         AC009319.19        13359-19557
FEATURES             Location/Qualifiers
     source          1..18136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     gene            1..18136
                     /gene="LPP"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
     exon            1..96
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            97..298
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1944
                     /gene="LPP"
                     /note="isoform a is encoded by transcript variant 23; LIM
                     protein; lipoma preferred partner"
                     /codon_start=1
                     /product="lipoma-preferred partner isoform a"
                     /protein_id="NP_001374599.1"
                     /db_xref="CCDS:CCDS3291.1"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
                     /translation="MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKK
                     FAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQ
                     GNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTG
                     HKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSR
                     PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYI
                     PPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTP
                     PGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
                     LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNK
                     LRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRS
                     LDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHC
                     YRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            299..411
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            412..534
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            535..1218
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1345
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1515
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1694
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1815
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..18136
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      18115..18120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPP"
                     /note="hexamer: AATAAA"
     polyA_site      18136
                     /gene="LPP"
                     /note="major polyA site"
ORIGIN      
        1 acctcctcct ctgcctctgc ctccgcctcc agccgccgcc gccgccgccg ccgccgccac
       61 caccaccgcc gctgccccgg ctgcctcctc cctgagattc caacaatgtc tcacccatct
      121 tggctgccac ccaaaagcac tggtgagccc ctcggccatg tgcctgcacg gatggagacc
      181 acccattcct ttgggaaccc cagcatttca gtgtctacac aacagccacc caaaaagttt
      241 gccccggtag ttgctccaaa acctaagtac aacccataca aacaacctgg aggtgagggt
      301 gattttcttc cacccccacc tccacctcta gatgattcca gtgcccttcc atctatctct
      361 ggaaactttc ctcctccacc acctcttgat gaagaggctt tcaaagtaca ggggaatccc
      421 ggaggcaaga cacttgagga gaggcgctcc agcctggacg ctgagattga ctccttgacc
      481 agcatcttgg ctgaccttga gtgcagctcc ccctataagc ctcggcctcc acagagctcc
      541 actggttcaa cagcctctcc tccagtttcg accccagtca caggacacaa gagaatggtc
      601 atcccgaacc aaccccctct aacagcaacc aagaagtcta cattgaaacc acagcctgca
      661 ccccaggctg gacccatccc tgtggctcca atcggaacac tcaaacccca gcctcagcca
      721 gtcccagcct cctacaccac ggcctccact tcttcaaggc ctacctttaa tgtgcaggtg
      781 aagtcagccc agcccagccc tcattatatg gctgcccctt catcaggaca aatttatggc
      841 tcagggcccc agggctataa cactcagcca gttcctgtct ctgggcagtg tccacctcct
      901 tcaacacggg gaggcatgga ttatgcctac attccaccac caggacttca gccggagcct
      961 gggtatgggt atgcccccaa ccagggacgc tattatgaag gctactatgc agcagggcca
     1021 ggctatgggg gcagaaatga ctctgaccct acctatggtc aacaaggtca cccaaatacc
     1081 tggaaacggg aaccagggta cactcctcct ggagcaggga accagaaccc tcctgggatg
     1141 tatccagtca ctggtcccaa gaagacctat atcacagatc ctgtttcagc cccctgtgcg
     1201 ccaccattgc agccaaaggg tggccattca gggcaactgg ggccttcgtc agttgcccct
     1261 tcattccgcc cagaggatga gcttgagcac ctgaccaaaa agatgctgta tgacatggaa
     1321 aatccacctg ctgacgaata ctttggccgc tgtgctcgct gtggagaaaa cgtagttggg
     1381 gaaggtacag gatgcactgc catggatcag gtcttccacg tggattgttt tacctgcatc
     1441 atctgcaaca acaagctccg agggcagcca ttctatgctg tggaaaagaa agcatactgc
     1501 gagccctgct acattaatac tctggagcag tgcaatgtgt gttccaagcc catcatggag
     1561 cggattctcc gagccaccgg gaaggcctat catcctcact gtttcacctg cgtgatgtgc
     1621 caccgcagcc tggatgggat cccattcact gtggatgctg gcgggctcat tcactgcatt
     1681 gaggacttcc acaagaaatt tgccccgcga tgttctgtgt gcaaggagcc tattatgcca
     1741 gccccgggcc aggaggagac tgtccgtatt gtggctttgg atcgagattt ccatgttcac
     1801 tgctaccgat gcgaggattg cggtggtctc ctgtctgaag gagataacca aggctgctac
     1861 cccttggatg ggcacatcct ctgcaagacc tgcaactctg cccgcatcag ggtgttgacc
     1921 gccaaggcga gcactgacct ttagattcag tcacctgttc agccggcact gagaagaacg
     1981 aacacaagaa aaagataaga aatactagag taaaggccat caaactacgc gatagtctct
     2041 gttcttcatc tgctattaac cttgccttag aaacacataa attatgagat tttttttaaa
     2101 agttgttacc aaatacacat ttcacattga atcatgtagg atcttgatgg gcctttgttc
     2161 ccaaggactt ccacattttt gcacagatta tgctccatcc cattcacttc tgcattcctg
     2221 taacttttaa tccctatgtt tgtctcactt ttcatctggt tgaatggctt ttcttagtgt
     2281 ggtatttgct gtcacatagt ttttcctggg tgagtctgcc aactcacagg tgcttttagg
     2341 cttgaaatct ccatcctatc atttccgttt tgcctgtgac tgtaaagagt agccattctt
     2401 ttcccatgta ttgaagagga tattcttctc ttgctttata ctactcacgt ccttggggag
     2461 ggaaatgcac aatttttttt tgttaggctg taaagaattt aagctgtaaa ttacataagt
     2521 tagaacaagc ccaaatttaa tttgcaacca tcagaattca gaatctatag tgaccagtga
     2581 tcaaggctaa ttggaaaaga gttatcggcc catagctaat aagtagtgac agacaaccaa
     2641 gcttcaatat ttttctaaag aaattacagg tgggatatgc tagaaaaggc attttggggt
     2701 tatgtttaaa aaaacattat tgtcccacaa tattacctta agatttttct tttccgcact
     2761 acctgaacat tgtaatacag acaaacttga tttcttctag aagataacat tttcaatact
     2821 gtcccacttc tcatcttaaa aatattgtca tgtttattct aatatccaac acaactatca
     2881 aaattgcctt tttctctaga ggatgaaggc tgtgaaaaaa ccgttcaaat tctcttcttt
     2941 ttctttttta ttaccaggtc cattttgcct gacaattgca aatcagagca tacaaaataa
     3001 aactgtgcag ttttgtttgg tttactttca aaagagtaga aagcttgaaa agattctgaa
     3061 accacagttt cattattctc ataatccttc tgcaactgaa attacatatt gcaggagaca
     3121 ttttcatatc atcaatgtga catttacacc acactttcaa agacaatcac tgaaacaaaa
     3181 attgtcttta tgagctaaaa atatgcagaa tctctgccta gaatctttat tcaaactttt
     3241 attagccagt gaaacacttg cttgccaact gccaagccat acttattaag ttcgaacatg
     3301 tttcacttaa ggagagacac ctagcttagt catggcaagt tgccattttg taaactaagg
     3361 attttggact gagatttctt aaatctttct tcaaatctcc cacaagtata tacttttaaa
     3421 ttatggagta ttttaagtct acaaaaaggt ataaataata atataatgaa ttcctatata
     3481 cctaataccc agtttaagac accaaatata acaagtataa ttacatcctc caatgtaccg
     3541 tttccttatt ccacagatat ctttttcatt attgtgaagt gatgttcaga tttctagttt
     3601 tttttctagt ttttaatttt aacatcagaa ctgaaataaa aaattatgga tacgtgtttt
     3661 gaattgcaaa ctattcctca ggaattccaa ttaaatttat tttacttgaa taggaatgat
     3721 cataaaagtg attctttttt tgtgactaga aattcttaag ccgatggtca ctatagctca
     3781 tccttaatgt atggctcatt tgcttttgtc actaaacggt tttgtgttag aaccaccaaa
     3841 attatagctt ttaagagctt cctttgacca ctgtcttttt cttaccctag ttctcttatc
     3901 tttgatcgta tatttctcat aatgtgaaat atgatgagat tcacttaggg gcagcatgtt
     3961 agttttggga ggcaatgtca actgtgtctc tgaattcctg tcttccaaat tgaagccaga
     4021 ccatgctgat gacctcaagt agcactgact atttgacaat agggctgata atgtaatcgg
     4081 cttgaatttt gacttagtaa ctttttatgt aatactttcg gagaaattct ctttaggaca
     4141 aagcagagag tccaatttat tgagggatag attgtatctc ttaaagtggt catattatta
     4201 ttaattttgc caaaagaaga agaatttatt gaatatttat actataaaat gcagtaacat
     4261 tctacttgct tattacattt aaatccttgt gtaactgaat gtttacatgt caagaggaaa
     4321 agctgtaaga aaatgctgtc acagacccat ccctgtggca tcgtcagcag aatactgctt
     4381 gcttacaatc tttattatgc attcttataa cataacctca gagtatcttt accaaaggtt
     4441 tttaaagtaa atctcttttt aagatagact tattctttta taataatgaa tgtgcactca
     4501 tacatatgta gaaacattta gatttagagt tttttttttc tttcacaagg tataataagg
     4561 aaaggatcct acaatatttt attctagggt ttcttaaata tatgatttat attactgtct
     4621 tttctattaa tcatttgatt taaacaatgc caagtcactc ttttttagtt gcatgaaatt
     4681 ttgcctgcaa cagagagaaa aagattgtat tactttaatg attataatca tactgtctgc
     4741 tgatataata tcataattgt tgtggtttaa atacataaat agtagaaaaa tcagagtcta
     4801 taacagaaag tttgtaaaaa tatactgatt ttgaaaagta tcaggaatat aaatatttgg
     4861 taattctgtg taacaagaga gacatggaaa aggaaaaaaa tccactatat catgggctct
     4921 gcagaacata tcaaaatagg atttcttaaa tttttcaacc cccagaccat actgactcaa
     4981 catggagtct cactggccaa gaaaattgcc tttaaaactc gaaaataagg ccaggtgtgg
     5041 tgactcacac ttgtaatccc agcaatttgg gaggctgaga caggaggatt gcctgaggcc
     5101 aggagtttga caccagcctg ggcaacatag tgagaccttg tctctacaaa aaataaaata
     5161 aaataaaaac caaattagcc agacatggtg gcatgcgctt gtttaaaaaa acaaataaat
     5221 aaataatcga ctcaaaaata agtcatgtgt cccagcataa ggcatcaggt tgttagatgc
     5281 tggcatctct gcagctcaaa gatgtgggtt ctttttcttg tcattaacac attgttattt
     5341 ctgtaggagc aacttctctg atcaaaatta cttttctggg tatgtgctga ttaagggggt
     5401 ggacttatca acactataat tgttccctat gaaagattcc acagagatgt ttatggtgag
     5461 gtttaaagga tatgaaactc tacatttaaa caagtatttt atatttgggt acagaggaag
     5521 aaagagaggg ctttttccat ggggctatag tagagagtta gtggaatata gacaggactc
     5581 tgaaaacaca acttccagcc atttttttag ttagtaaaaa tcctattaat gtgaaccagc
     5641 caggaataac agtgttattt ctattggata tggtttgggc ttctcttgtc aaatctgtgt
     5701 cggctgcccc ctgatccttc cattatcaag ttttgaaggg tgttggggaa attatggcag
     5761 ctgctaggga gatcagggaa acactgatgt aacctcaaag cctctcacca ttcctcttgg
     5821 cttggaaagg ctttattttt tcatatacat ttctagaaat attgctattc taccttagta
     5881 tttcacattt gtagttcaaa caagcgattg tccatctgtt gcctagagct atagtacatg
     5941 tgtgttatga atgaaatatg acagcatgtt ccatacccct gctttagcca tctgtgggaa
     6001 accagcaaac tgaaaaagac acctctgcaa aatgtgcctc aagtccattt cttgggatcg
     6061 ctcgtttggt gcactctcgt gggagacaat cagagaacaa catatacttg tgccttattt
     6121 tcaaagaatc tatttacact actatgaata ttccactgaa gagtcaatga tgtaaatgat
     6181 aaccaccaaa tctcaaaaat atactcacca aaaagtaaaa aagtaaaaaa aaaaaaaaaa
     6241 gaaagaaaga aaagaaagag agagaagtca acttttcatc ttaatatatt ctagtagtat
     6301 ttattttttc cttgtcttgg aagtatctca taggtcttta aatgagtaaa acatttttat
     6361 gccagaaggt gatataatgg atgttagtgt tttttatttg attttacagt agttttagtc
     6421 agataatgag gacagagact tcaacttgat tctttaccac cattcagcat attttttaat
     6481 tgtcttcatt gtatttgctt aatagtggtc cagacaagtt caaaacttgt tctcagtgag
     6541 gcattaatat ggtgcaacca tgaatatttc aggccaagtt attcacttga cagataacta
     6601 gaatgaaact tttctcatga ggctgttgtt tggttagcat agccttattt caaaccttaa
     6661 aaagttacct gactgaagct actatgactt ggtaaggatt cttcctctct tgctttcttc
     6721 ctcccttcct ttcttcctct tccttcctcc tcttcttatt ttctttccta ctttccatcc
     6781 tacctattag tgttgctgta cttggatttt ttgtaaatta aatcaatgca ttatgatttt
     6841 agggaattat gattatattc ataaggggaa ggctaccaga aaatatatgt ggcatccata
     6901 aaatcttctt ttataggggc atatttttta ggttgtattt attcgtaaag tgaaatgaga
     6961 taatagagtc tttctgtttc atgttaatga attttcatca gggactgagg tcatagattc
     7021 ttggaaaatt catttgtgac tgatctagtt ttctcagctg tatgcaaagt aatctttcaa
     7081 agactaggtt aagatttttt ttttaagtct gaagcaatgt aaccccaaaa aattataatt
     7141 ttaatgatgg cattttattt tattccattg cagcttgata actttcctta tagcaaagga
     7201 ataactattg tattttcaga attttaacac agattaacac ttagcctgta agactaataa
     7261 tatattgtaa tagttgatac taaaatattt ttcagcaggt tggacagcac cagtttttct
     7321 tagatcacag actacaggca gaatttccct tcaatccaga aaaaaggaca ctaatttcct
     7381 tttctattta attttcctgg cccttgtgca aaaaattgtg gactctatct tagttacaac
     7441 atgcatgtcc cttattttgt ggagagctgt gtgaaagatg cgtttttttt ctttttttct
     7501 tttttttttt tttgagacgg agtctggctc tgtcacccag gctggagtgc aatggcacga
     7561 tctcctctca ctgcaagctc cgcctcccag gttcacgcca ttctcctgtc tcagcctccc
     7621 gagtagctgg gactacaggc gcctgccacc acgcccggct aatttttttg tatttttagt
     7681 agagatggag tttcacagtg ttagccagga tggcctcgat ctcctgacct cgtgatccac
     7741 ccgcctcggc ctcccaaagt gctgggatta caggcgtgag ccaccgtgcc ccgcgtgttt
     7801 ttttctttag ctgattgaca ggtccccttc aaagttacaa aaaaaagtgc taatttttgc
     7861 tgttaaattc tggttgttat ttaattgaca gaagtctctt gatgcacgaa taaatatctc
     7921 tacatctagc ctttgttaaa aataaaaatt aatattctac aaacacctac atatactaga
     7981 gaggggtgaa acactgcagc taattccttt ataatacttt cagatgattg cattaagcct
     8041 ttcatgttat gtggcattgt taatttttcc tagataccca tccacttaag ggccagagaa
     8101 atccttattc atttaactct ggtgggcatt tatgtaacat acccaaataa aaacgttatt
     8161 aaacagccac aatcgcattc agtcaacttg gcactgaatg tagcttctaa aatcagttct
     8221 ctaccctacg aatggaatgt tctaccaaga aagagaagca tcaccatgtc atcttgtgtt
     8281 ctacaccact atagagagtt acagttgccc ccaaacacga atgctattcc caaataaaat
     8341 agaatcatgc tttgggaggc caaggcgggc cgatcacgag gtcaggagat cgagaccatc
     8401 ctggctaaca cggtgaaacc ccgtctctac taaaaaaaaa aaaaaataca aaaaattagc
     8461 ctggctcagt ggcgggcgcc tgtagtccca gctactcagg aggctgaggc aggagaatgg
     8521 cgtgaacccg ggaagcggag ctttcagtga gccgagatag cgccactgca gtccggcctg
     8581 ggcgaaagag cgagactccg tctcaaaaaa aaaaaaaaaa aaataggatc atggcccttt
     8641 taaagatctg aatcttctct gttattttcc tgatgaatca ccatcccata tcttcttagt
     8701 cctggccagt atgtagttgc gctcacatac gtctattcta gctctgtagc tccacaaaac
     8761 aagtcttaag tccaaatctt tgcctcttca tgtctgatat caccaactca ttcagctttt
     8821 cttcacttat tgacatagtg tcatgtccta tcactctctg ctgcttcttt aaacagtgga
     8881 cacaaacata ttttctaatt ttcagtgtac tcagtgaaac ttggcagttc accatgagtc
     8941 aggctaggtt gaaaggcttt ctttagggtt gaaagtaaac gaaattggaa tcacccaaag
     9001 agaatttccc caaaaaacct cagacccaga agtgtaaaag ctacagaagg atagaactcc
     9061 catgtctaca gacagttctg ttactttttg ttctgtacta ttttggatgt tgccaaaatc
     9121 aaattcatcc tgaaaacagg aagcaagcta atgcatatgc catccatgag attcccactt
     9181 ctgggtcagt tcatattcca ttcaaccttt tccttttatc cttgtcttct tcagaataag
     9241 acatttttcc tccatatttt catattaaat attaacactt tataggttct actttaatat
     9301 atggacactt tacaggttat acataaatat ttgctggttg attgatttcg agattcattc
     9361 attctgtgct caaatatttg tacctagaga cgttacatgt tagaaaaagt gagcagcttc
     9421 tttctctaat catttaggag tccatatttt tcttttcttt ttgttctccc aacatcctta
     9481 tctcttactc agctcttcaa tttataatta ccaaataatc actgttagag aatcagcccc
     9541 taagtaactt tgattctggc caactgtaat aagatccaac cacttaaatc tgtacttact
     9601 caataggaag gaatgtgaca tcaggaagag tcattccagt gacattagta agactttatg
     9661 gagtacataa aatttgataa gaaatcttga gctgattctt tgacttgatt tagaagttga
     9721 gaaaagagta tttaaggcac aacagggaaa catgggctat actcagagaa gaccctctgc
     9781 attggccaaa atatcatgga ttctggaaat tccttcttaa cagaaaaaaa aggcttccaa
     9841 ataatcaggc tgaatgggaa gaaaaaggca tagaggaagc ctgaggaagt atttacttgc
     9901 ttttcccatc tctttataat tggaagagaa gatgatctgc caaaatataa cccagcatgc
     9961 acagtatgga caggaagcag ccctccatga actttattat cacagaatat gagcattctt
    10021 attgatccac agctacatct tctattcttg cagcaagggt acatgtcctt tgaccctcca
    10081 caaaagaaca agcaggacat ctctattttc ctattgagtc tgagtccatt attagaaagg
    10141 acttcccagc catcttttct acttggtatt aaaattccct tacagattca ttgctaagtg
    10201 ccaattcttt ttttttcttt tgagacggag tcttgctctg tcgcccaggc tggagtgcag
    10261 tggcgcaatc tcggctcact gcaagctccg cttctcgggt tcacgccatt ctcctgcctc
    10321 agcctcccga gtagctggga ctacagacgc ccgccaccgc gcccagctaa ttttttttgt
    10381 acttttagta gagacggggt ttcaccgtgg tctcgatctc ctgacctcgt gatccgcccg
    10441 cctcggcctc ccaaagtgcc aattctgact ctacttaaac atcacctgta tcagggagct
    10501 cattattcct tgaggtctta catttctttc agcacatttt gttccaagct acacgacttt
    10561 aaaacagagc cagcctttgg ggcatatgtt ctctttggtg ccacacaaaa cctgtagtac
    10621 atgatacagt gttgcttccc ccctcctttt ccttccatat atatttgttt tgttttgggc
    10681 attgcattac ttttttgaat ttttaagaat ctctaaaatt agtctgaagg atgttctgag
    10741 ggccagacat tagaatttgt gagttttttt gttgctggtt gtactttcct atttagaaga
    10801 cagaccgttc tgacagttgt tgtgtagctt catgccttcc ccagtaacta acccatgaac
    10861 agtacacccc ttttatctga cttgttgata atgaccttaa aaatgttagg aaatgggccg
    10921 ggcgcggtgg ctcgtgcctg taatccagca ctttgggagg ccgaggcgag cggatcatga
    10981 ggtcaagaga tcgagaccat cctggtcaac atggtgaaac cccgactcta ctaaaaaaaa
    11041 tacaaaaatt agccgggcgt gttggcgggc gcctgtagtc ccaactactt gggaggctga
    11101 ggcaggagaa tcacctgaac ccaggaggca gaggttgcag tgagcagaga ttgcgccact
    11161 gcactccagc ctgggcgaca gaacgagact ccgtctcaaa aaaaaaaaaa aaaaaaaaag
    11221 gttgggaaat attggtgtat aatccccatg tctaacaagg aagaagtcaa aagcaaaaga
    11281 tagtggtatt gccgaaaact cattatttct agttagttca tctgtggaaa aggatatcgt
    11341 tcttgaggag aggggttcta ttatgctata gttttctatg gaaatgtaca aatgctttcc
    11401 tcattgctct ggatgactat ttagtttaaa taatatacct ttgtcatggg gaagaccatg
    11461 attgtggctt cttctacccc aactttgaat gagagagcac tgtaagcaga aactgccatc
    11521 agtctcctgg gcaggacctg gaggtaactt tctgagctgt aaaatagtaa ttcctaagag
    11581 agcttacaaa ctgcttccac acagaaaata gcgcagggag gacagttatt agtaccccta
    11641 ttctagaaga gaaagctgag gctcaagcca ttaagtgact tgccaaaagc tgtgacatag
    11701 ctgggaagtg gcagatttgg ggatataacc aggtcttgca agtccagtgc tgtctccaag
    11761 tagccacgct cacagctgag aacaccttag aggacaatat cgacttctta cagactacca
    11821 agcccccagt catccaggga aattcagaga ccaattgact gccaggtggc aaatccacat
    11881 gtgtactgcg gtctttagag atcatttaga gcttgcacac atctgtgtct tcttgtggga
    11941 aacctctagg tattctgtct gatcagcact gtgaggaagt tggtgggaaa aggccactga
    12001 taagaacaaa caatgggcag aaggaagcac attgcaataa atttccccag agagagttcc
    12061 tttacattcc attcaccaaa aacctctctg gaactgtcag gttcagaata tcaaccaaga
    12121 ccatatcatt tagaattcat tggcatgtag aggtgactcg attcctaaaa gaagcctctc
    12181 tcccatgaac cacgatgtac gttccacaga ggcagaaacc gccgtaggtt agcaatgcat
    12241 tttagtcttt ctctccattc acatttactg agagcacacc acgtgcatgt tgctgcaaca
    12301 ggcatttccg atagagccga tccatgagct aacaatgtct gaaaacaaat gttatggaac
    12361 tgttggcatt tctgagattt ggcctttgcc atttgataga ctttgcttcc caggatgctg
    12421 tcattttgtg attttttata attacaagga atttggtacc atgttgtttt caaaaaacct
    12481 cctagaaagt ctccatgtat gctctagaag ttgctctacg taacagttca gcaagcaagt
    12541 gttccttctc ttgagctgcg tccctcagga agctgtacct ttagggtgtg ctttccactt
    12601 tttatttcct ctcatttcac tcctttcatt gtttgctata tcctaaaata tgtgaagtga
    12661 gagaaaaaat atcatttctt ctcattaaat ctcctgcatt aaatctaaga atcctttaaa
    12721 ataatcacac ctgataagtg ttttatgcat ttccctccct ggagtgttat catccatcaa
    12781 gccagtatca tcatccacct gcttattcct tgggactaat gagagccaag ttaaatagca
    12841 aatgacttct caccccttcc tagtcctcat gcctgaggaa taagggcgac attaatggga
    12901 gcgggagagt ggtggctttg gttgagatgc acgttcacag actagaaaag tgcctcacct
    12961 ccatggtgta tatgtgccac cttttcttaa tccagtctat cattgttgga catttgggtt
    13021 ggttccaagt ctttgctatt gtgaatagtg ccgcaataaa cataagtgtg catgtgtctt
    13081 tatagcagca tgatttataa tcctttgggt atatacccag taatgggatg gctgggtcaa
    13141 atggtatttc tagttctaga tccctgagga atctccacac tgacttccac aatggttgaa
    13201 ctagttcaca gtcccaccaa cagtgtaaaa gtgttcttat ttctccacat cctctccagc
    13261 acctgttgtt tcctgacttt ttaatgattg ccattctaac tggtgtgaga tggtatctca
    13321 tagtggtttt gatttgcatt tctctgatgg ccagtgatgg tgagcatttt ttcatgtgtt
    13381 tcttggctgc ataaatgtct tcttttgaga agtgtctgtt caatactatg cagccataaa
    13441 aaatgatgag ttcatgtcct ttgtagggac atggatgaaa ttggaaatca tcattctcag
    13501 taaactatct caaggacaaa aaaccaaaca ccacatgttc tcactcacag gtgggaattg
    13561 aacaatgaga acacatggac acaggaaggg gaacatcaca ctctggggac tgttgtgggg
    13621 tggagggagg agggagggat agcattagga gatataccta atgctaaatg acgagttaat
    13681 gggtgcagca caccagcatg gcacatgtat acatatgtaa ctaacctgca cattgtgcac
    13741 atgtacccta aaacttaaag tataataata atgaaataaa attaaaaaaa aaaaagaaaa
    13801 gtgcctcacc tccctgtgag gcttgatgaa tattgtggcc agtgagtgga aaatgattct
    13861 tgtcgaatag acagagtatt cccaccccag gaatggatta atagaagaca caatttgagc
    13921 acttctcaga attatctagt atgcctgagt agagactcac atgggtggaa tctgtgttgt
    13981 ctcatcagag ggaataaaaa gacaatgagg tggtaaatgt gaaaaaagca gccttttaga
    14041 aaaacattat tttcaaatac ctttataaat catctaattt atcttcacat aatataaaga
    14101 aaaaactaat aaaaattttc gtatttcact ttacataata tgttctccca tatttaggga
    14161 tcatacaatt gtattgtctt caaaacacac acacacacac atacacacac acacacacac
    14221 acacacacac cccttccaag aaagctgatc cttcagaaaa taaatcttat ttttaagcac
    14281 ttgggttttc aggccagaaa attaataaat cctaaacctg acccattttt gtaacagcta
    14341 aaaaggagaa gaaaaagcta gttaaatttt gtgtggatcc atttatctct taaaatatgc
    14401 caaagcaatt tgaggtgggg gtggaaacag gtatttatct ctcatgcgtg attctctctt
    14461 tatatttcta tctgttggga aaagggtaaa gaactattct tggtcattat tgatgtattg
    14521 tgttgccact ttgtatggtg cctgctgtgc tttatcccga ggcatagcag taatcgttac
    14581 tatcttgact ctttccttca tcacaagaga gtaaatatga agtctgaatg tcgttcctca
    14641 cccccaaatt gtttaactct gcttccaaac tagtttaaga aatgcaaaat gggaagagct
    14701 agcttttctt agatacattt cttccttttt tattctttct tgggagacgt taagtataaa
    14761 agggaaaaag tcagttcctt cttctctctc tttctctttg ggtgacagca atgctcactt
    14821 agtaattata aactggaaat aggagagtag cttgagcagg ttatgatata tctgcccaat
    14881 gtgtttcatt ccttcaaaca taaactttga gagtaaaaga gatttttata atttaaatgc
    14941 caacgacagg aatggcctca tgttttaact ttcaaataat aaatggggag ttggtatttg
    15001 ggcagagttt gcattttact aatcctatat actttgagct tagtttttag aattgtgtca
    15061 aatacatcaa catatcagga ttatagtgcc aaaaatagtt aaagtgcctt ggtcctccct
    15121 ctgtaggcag caaattgaaa ctaacatggg accatgccat ccttctagca taatggagaa
    15181 gtctgaactg aggagtatct ttgatgaaag acatttagga ccctagaaac taaatcttgt
    15241 caccaagact ttatagtaaa gtagtagcaa aattattttt aaaagacttt cttcctttta
    15301 ctacccattt cctctcttgg gaaagctgat gagcaaatta tccaagactc atttctttat
    15361 taggcaaagt cagaatattt cccctctgaa aatctgaatt atgccctcat tctttttcaa
    15421 gaaatatctc aaagagcaaa tagaattaaa catgacactt gattgtctga ttatttggca
    15481 tgtataaaat tatcatgtgg cttaatgtgc cttaagtgaa aatttaaact tagacctgaa
    15541 acctttacag ttggatgtag cgttgagctt ttgcatgttt tctgtataat aaaccacttt
    15601 tgttttgttt gttttgtctt ttaacctaca cctttatcat tactctaaca gatttagggc
    15661 ttctctttct ctacagctaa gtaagggaat atgtgcaatt atgagacata caaaaaagga
    15721 aagggaaagg actttctaag tagcaaatct gtgccatgaa gtagatgtgg cgtgaagata
    15781 cagagcctga ggatagtaat tttccctgag ccacgcacac aggcttttat ttcatgcctt
    15841 ttctctttct gtgccgtcac ctttgagaaa aacgattgca ccttctccaa gtctgccttt
    15901 ttaacagcta cagttaagtt ggcaagactt ccccagctct gaatatagcc atttgccgac
    15961 tccggcctct ttgcgagact gactcaaatc tgtgatcttc tgttcagcat acacatcagc
    16021 aaagtgagaa gatgagcact aaatataggc tctattaact ttacttttag atttactgcc
    16081 ttcaaaaagt gcctattctg agcaacataa acgttattcc ttacatatgt atgtacacac
    16141 ggtacccaga gtcgtactgt gcagccttca aaaacatacc atcagaaaga gtaggtgctg
    16201 agataaggaa actttgccaa atgaaagaaa gtcactcact tccaatatcc cctctcaagc
    16261 ggctaccgtg aaacgggctg caaacacatt ccctgagcat cccttgctga tacagcttct
    16321 ttatatttat atcctactgg atggtagcat attgctaagg tttcctgtac tctgcttcaa
    16381 gggaatgtaa gctttatggc attgaaacat ttagggaaaa aaaagatgtt taagagaatt
    16441 aatagagccg tagtctgtat taggatgtgt gtcatatgtg tgttctataa actaagcatc
    16501 ggtgggttta gagtgttaaa gtgtcagcac attccttctc cttttgtctc tcaggctaac
    16561 atgagagaaa atagaaaagt cttggctgtg gggattggaa gctcaggggg ccaaatgtcc
    16621 ttgccagatc cttagagcat tactttgact cctaaaaata gtagtgtatg ttatttgatg
    16681 gcttttgttt ccatagttcc atcactgaca aaactgtcaa tactgttgat ggagcagcag
    16741 catagcctag agtgatgcat tcttacccag aggtggcaat aggagagggt ccatgtaaat
    16801 aggacgaggt agacagtgca tgattgtagg agaagggttg aagggaggac atgattccaa
    16861 aaaagatcgt tctcaatgtg tcgtctgact caaccagctg gcagattaca cttgccaagt
    16921 cgttcccttt ccttctaagt cagttggctc catattcact tgaatatgcc tctgtttggg
    16981 caaagcaaga tacctccact taacctttat ccaaggaagc tcttggtgtc ctcttggtca
    17041 taaagttgtc tcctacctaa cccagtttta ccaaatggaa gtaaaagggg acaaactatg
    17101 gaagatggac tccatgccat tgcagtcagc caccattctc ttttccatat aaggagcccc
    17161 attacataag ctacgggtga ggttggaaca gctatgtttc ataatttcaa gagtgtgacc
    17221 accctgctct agtcatcatc attggatgaa tccagttgac tctttggcaa aagggtgata
    17281 cttttcacta aaaatgccta ctcttcctgt tgatgttcct tttctgtttt taccttgtcc
    17341 aatttccaca ctagtcattt tttttatttt ttagaggatc agattttagc gctggaaaat
    17401 gagttcaaaa atttcagtgt aatgtcataa ggatgttggg atacagagat tttttttttc
    17461 cttggaaaca aatggactgg gaagaaacac agcatggctt tgctctgagt ttcaatctga
    17521 tgattatgac catggaagat agtcttatgt aaaggttaaa tggtgtttac aagtggatag
    17581 ataaggcgga gatggtgaga agccgggttt tctctatgct aaatgtgtct actaagagca
    17641 gcacttccta ctagctaagc acaatcatag ccccaccgtg atgagctgct agtctgaata
    17701 acattccctg acttagggaa aggcacacaa aaacatataa agaatatgtc tattttcata
    17761 tgtgtgatac tgacagagcc atggtattcc taaaatatag gtttctcttt tttcttgtat
    17821 tcttagcaaa ttgcatttat tcactacatt acaaaccatc actgatgtat ccaaaatagc
    17881 acacatagtt cagtatgaaa ataagagaat aaaatctgtt ataagcaagt gatttaggta
    17941 ttttcttttg tgtttatgca ttatctgact atattaaaac ctgtttttct atttaccttc
    18001 tatcagtttt ctctaccaat tatgtttttt caatgctcta taagaatgaa tatggaaatt
    18061 atatttcttt tttctgtaaa agagttgcaa ctactttatt atatttagaa atccaataaa
    18121 cttcttatta cattta
//
