LOCUS       NM_001387669           18283 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LIM domain containing preferred translocation partner
            in lipoma (LPP), transcript variant 22, mRNA.
ACCESSION   NM_001387669
VERSION     NM_001387669.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18283)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18283)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 18283)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (bases 1 to 18283)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 18283)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (bases 1 to 18283)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (bases 1 to 18283)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (bases 1 to 18283)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (bases 1 to 18283)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (bases 1 to 18283)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022498.18, AC117507.5,
            AC069226.19, AC063932.14, AC055711.18, AC009319.19 and KF510228.1.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.2091396.1,
                                           SRR14372080.4608298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC022498.18        119240-119359
            121-243             AC117507.5         11500-11622
            244-445             AC069226.19        127073-127274       c
            446-558             AC069226.19        48682-48794         c
            559-681             AC069226.19        8599-8721           c
            682-1365            AC063932.14        108433-109116       c
            1366-1492           AC063932.14        9884-10010          c
            1493-1662           AC055711.18        41842-42011
            1663-1841           AC055711.18        147929-148107
            1842-1962           AC055711.18        154372-154492
            1963-11703          AC009319.19        3236-12976
            11704-12084         KF510228.1         1-381
            12085-18283         AC009319.19        13359-19557
FEATURES             Location/Qualifiers
     source          1..18283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     gene            1..18283
                     /gene="LPP"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
     exon            1..120
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            121..243
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            244..445
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..2091
                     /gene="LPP"
                     /note="isoform a is encoded by transcript variant 22; LIM
                     protein; lipoma preferred partner"
                     /codon_start=1
                     /product="lipoma-preferred partner isoform a"
                     /protein_id="NP_001374598.1"
                     /db_xref="CCDS:CCDS3291.1"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
                     /translation="MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKK
                     FAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQ
                     GNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTG
                     HKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSR
                     PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYI
                     PPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTP
                     PGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
                     LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNK
                     LRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRS
                     LDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHC
                     YRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            446..558
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            559..681
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1365
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1492
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1662
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1841
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1962
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..18283
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      18262..18267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPP"
                     /note="hexamer: AATAAA"
     polyA_site      18283
                     /gene="LPP"
                     /note="major polyA site"
ORIGIN      
        1 agttctgttc ccttcaggct tcgagaccac cgccttgctg tgtcccgtag tggactgagg
       61 gcctgcaaga gggagtgagg gctagtggag ggccagctgc ctgtgggggc tggacatcgt
      121 gtgggaactt tgaggctcag agacagagca gaagacagaa cctggtcttc tgattccctg
      181 tgttctgctt ttttcattgt tccactggac gctcatcaga gggaagatct ttttcctcaa
      241 ttgattccaa caatgtctca cccatcttgg ctgccaccca aaagcactgg tgagcccctc
      301 ggccatgtgc ctgcacggat ggagaccacc cattcctttg ggaaccccag catttcagtg
      361 tctacacaac agccacccaa aaagtttgcc ccggtagttg ctccaaaacc taagtacaac
      421 ccatacaaac aacctggagg tgagggtgat tttcttccac ccccacctcc acctctagat
      481 gattccagtg cccttccatc tatctctgga aactttcctc ctccaccacc tcttgatgaa
      541 gaggctttca aagtacaggg gaatcccgga ggcaagacac ttgaggagag gcgctccagc
      601 ctggacgctg agattgactc cttgaccagc atcttggctg accttgagtg cagctccccc
      661 tataagcctc ggcctccaca gagctccact ggttcaacag cctctcctcc agtttcgacc
      721 ccagtcacag gacacaagag aatggtcatc ccgaaccaac cccctctaac agcaaccaag
      781 aagtctacat tgaaaccaca gcctgcaccc caggctggac ccatccctgt ggctccaatc
      841 ggaacactca aaccccagcc tcagccagtc ccagcctcct acaccacggc ctccacttct
      901 tcaaggccta cctttaatgt gcaggtgaag tcagcccagc ccagccctca ttatatggct
      961 gccccttcat caggacaaat ttatggctca gggccccagg gctataacac tcagccagtt
     1021 cctgtctctg ggcagtgtcc acctccttca acacggggag gcatggatta tgcctacatt
     1081 ccaccaccag gacttcagcc ggagcctggg tatgggtatg cccccaacca gggacgctat
     1141 tatgaaggct actatgcagc agggccaggc tatgggggca gaaatgactc tgaccctacc
     1201 tatggtcaac aaggtcaccc aaatacctgg aaacgggaac cagggtacac tcctcctgga
     1261 gcagggaacc agaaccctcc tgggatgtat ccagtcactg gtcccaagaa gacctatatc
     1321 acagatcctg tttcagcccc ctgtgcgcca ccattgcagc caaagggtgg ccattcaggg
     1381 caactggggc cttcgtcagt tgccccttca ttccgcccag aggatgagct tgagcacctg
     1441 accaaaaaga tgctgtatga catggaaaat ccacctgctg acgaatactt tggccgctgt
     1501 gctcgctgtg gagaaaacgt agttggggaa ggtacaggat gcactgccat ggatcaggtc
     1561 ttccacgtgg attgttttac ctgcatcatc tgcaacaaca agctccgagg gcagccattc
     1621 tatgctgtgg aaaagaaagc atactgcgag ccctgctaca ttaatactct ggagcagtgc
     1681 aatgtgtgtt ccaagcccat catggagcgg attctccgag ccaccgggaa ggcctatcat
     1741 cctcactgtt tcacctgcgt gatgtgccac cgcagcctgg atgggatccc attcactgtg
     1801 gatgctggcg ggctcattca ctgcattgag gacttccaca agaaatttgc cccgcgatgt
     1861 tctgtgtgca aggagcctat tatgccagcc ccgggccagg aggagactgt ccgtattgtg
     1921 gctttggatc gagatttcca tgttcactgc taccgatgcg aggattgcgg tggtctcctg
     1981 tctgaaggag ataaccaagg ctgctacccc ttggatgggc acatcctctg caagacctgc
     2041 aactctgccc gcatcagggt gttgaccgcc aaggcgagca ctgaccttta gattcagtca
     2101 cctgttcagc cggcactgag aagaacgaac acaagaaaaa gataagaaat actagagtaa
     2161 aggccatcaa actacgcgat agtctctgtt cttcatctgc tattaacctt gccttagaaa
     2221 cacataaatt atgagatttt ttttaaaagt tgttaccaaa tacacatttc acattgaatc
     2281 atgtaggatc ttgatgggcc tttgttccca aggacttcca catttttgca cagattatgc
     2341 tccatcccat tcacttctgc attcctgtaa cttttaatcc ctatgtttgt ctcacttttc
     2401 atctggttga atggcttttc ttagtgtggt atttgctgtc acatagtttt tcctgggtga
     2461 gtctgccaac tcacaggtgc ttttaggctt gaaatctcca tcctatcatt tccgttttgc
     2521 ctgtgactgt aaagagtagc cattcttttc ccatgtattg aagaggatat tcttctcttg
     2581 ctttatacta ctcacgtcct tggggaggga aatgcacaat ttttttttgt taggctgtaa
     2641 agaatttaag ctgtaaatta cataagttag aacaagccca aatttaattt gcaaccatca
     2701 gaattcagaa tctatagtga ccagtgatca aggctaattg gaaaagagtt atcggcccat
     2761 agctaataag tagtgacaga caaccaagct tcaatatttt tctaaagaaa ttacaggtgg
     2821 gatatgctag aaaaggcatt ttggggttat gtttaaaaaa acattattgt cccacaatat
     2881 taccttaaga tttttctttt ccgcactacc tgaacattgt aatacagaca aacttgattt
     2941 cttctagaag ataacatttt caatactgtc ccacttctca tcttaaaaat attgtcatgt
     3001 ttattctaat atccaacaca actatcaaaa ttgccttttt ctctagagga tgaaggctgt
     3061 gaaaaaaccg ttcaaattct cttctttttc ttttttatta ccaggtccat tttgcctgac
     3121 aattgcaaat cagagcatac aaaataaaac tgtgcagttt tgtttggttt actttcaaaa
     3181 gagtagaaag cttgaaaaga ttctgaaacc acagtttcat tattctcata atccttctgc
     3241 aactgaaatt acatattgca ggagacattt tcatatcatc aatgtgacat ttacaccaca
     3301 ctttcaaaga caatcactga aacaaaaatt gtctttatga gctaaaaata tgcagaatct
     3361 ctgcctagaa tctttattca aacttttatt agccagtgaa acacttgctt gccaactgcc
     3421 aagccatact tattaagttc gaacatgttt cacttaagga gagacaccta gcttagtcat
     3481 ggcaagttgc cattttgtaa actaaggatt ttggactgag atttcttaaa tctttcttca
     3541 aatctcccac aagtatatac ttttaaatta tggagtattt taagtctaca aaaaggtata
     3601 aataataata taatgaattc ctatatacct aatacccagt ttaagacacc aaatataaca
     3661 agtataatta catcctccaa tgtaccgttt ccttattcca cagatatctt tttcattatt
     3721 gtgaagtgat gttcagattt ctagtttttt ttctagtttt taattttaac atcagaactg
     3781 aaataaaaaa ttatggatac gtgttttgaa ttgcaaacta ttcctcagga attccaatta
     3841 aatttatttt acttgaatag gaatgatcat aaaagtgatt ctttttttgt gactagaaat
     3901 tcttaagccg atggtcacta tagctcatcc ttaatgtatg gctcatttgc ttttgtcact
     3961 aaacggtttt gtgttagaac caccaaaatt atagctttta agagcttcct ttgaccactg
     4021 tctttttctt accctagttc tcttatcttt gatcgtatat ttctcataat gtgaaatatg
     4081 atgagattca cttaggggca gcatgttagt tttgggaggc aatgtcaact gtgtctctga
     4141 attcctgtct tccaaattga agccagacca tgctgatgac ctcaagtagc actgactatt
     4201 tgacaatagg gctgataatg taatcggctt gaattttgac ttagtaactt tttatgtaat
     4261 actttcggag aaattctctt taggacaaag cagagagtcc aatttattga gggatagatt
     4321 gtatctctta aagtggtcat attattatta attttgccaa aagaagaaga atttattgaa
     4381 tatttatact ataaaatgca gtaacattct acttgcttat tacatttaaa tccttgtgta
     4441 actgaatgtt tacatgtcaa gaggaaaagc tgtaagaaaa tgctgtcaca gacccatccc
     4501 tgtggcatcg tcagcagaat actgcttgct tacaatcttt attatgcatt cttataacat
     4561 aacctcagag tatctttacc aaaggttttt aaagtaaatc tctttttaag atagacttat
     4621 tcttttataa taatgaatgt gcactcatac atatgtagaa acatttagat ttagagtttt
     4681 ttttttcttt cacaaggtat aataaggaaa ggatcctaca atattttatt ctagggtttc
     4741 ttaaatatat gatttatatt actgtctttt ctattaatca tttgatttaa acaatgccaa
     4801 gtcactcttt tttagttgca tgaaattttg cctgcaacag agagaaaaag attgtattac
     4861 tttaatgatt ataatcatac tgtctgctga tataatatca taattgttgt ggtttaaata
     4921 cataaatagt agaaaaatca gagtctataa cagaaagttt gtaaaaatat actgattttg
     4981 aaaagtatca ggaatataaa tatttggtaa ttctgtgtaa caagagagac atggaaaagg
     5041 aaaaaaatcc actatatcat gggctctgca gaacatatca aaataggatt tcttaaattt
     5101 ttcaaccccc agaccatact gactcaacat ggagtctcac tggccaagaa aattgccttt
     5161 aaaactcgaa aataaggcca ggtgtggtga ctcacacttg taatcccagc aatttgggag
     5221 gctgagacag gaggattgcc tgaggccagg agtttgacac cagcctgggc aacatagtga
     5281 gaccttgtct ctacaaaaaa taaaataaaa taaaaaccaa attagccaga catggtggca
     5341 tgcgcttgtt taaaaaaaca aataaataaa taatcgactc aaaaataagt catgtgtccc
     5401 agcataaggc atcaggttgt tagatgctgg catctctgca gctcaaagat gtgggttctt
     5461 tttcttgtca ttaacacatt gttatttctg taggagcaac ttctctgatc aaaattactt
     5521 ttctgggtat gtgctgatta agggggtgga cttatcaaca ctataattgt tccctatgaa
     5581 agattccaca gagatgttta tggtgaggtt taaaggatat gaaactctac atttaaacaa
     5641 gtattttata tttgggtaca gaggaagaaa gagagggctt tttccatggg gctatagtag
     5701 agagttagtg gaatatagac aggactctga aaacacaact tccagccatt tttttagtta
     5761 gtaaaaatcc tattaatgtg aaccagccag gaataacagt gttatttcta ttggatatgg
     5821 tttgggcttc tcttgtcaaa tctgtgtcgg ctgccccctg atccttccat tatcaagttt
     5881 tgaagggtgt tggggaaatt atggcagctg ctagggagat cagggaaaca ctgatgtaac
     5941 ctcaaagcct ctcaccattc ctcttggctt ggaaaggctt tattttttca tatacatttc
     6001 tagaaatatt gctattctac cttagtattt cacatttgta gttcaaacaa gcgattgtcc
     6061 atctgttgcc tagagctata gtacatgtgt gttatgaatg aaatatgaca gcatgttcca
     6121 tacccctgct ttagccatct gtgggaaacc agcaaactga aaaagacacc tctgcaaaat
     6181 gtgcctcaag tccatttctt gggatcgctc gtttggtgca ctctcgtggg agacaatcag
     6241 agaacaacat atacttgtgc cttattttca aagaatctat ttacactact atgaatattc
     6301 cactgaagag tcaatgatgt aaatgataac caccaaatct caaaaatata ctcaccaaaa
     6361 agtaaaaaag taaaaaaaaa aaaaaaagaa agaaagaaaa gaaagagaga gaagtcaact
     6421 tttcatctta atatattcta gtagtattta ttttttcctt gtcttggaag tatctcatag
     6481 gtctttaaat gagtaaaaca tttttatgcc agaaggtgat ataatggatg ttagtgtttt
     6541 ttatttgatt ttacagtagt tttagtcaga taatgaggac agagacttca acttgattct
     6601 ttaccaccat tcagcatatt ttttaattgt cttcattgta tttgcttaat agtggtccag
     6661 acaagttcaa aacttgttct cagtgaggca ttaatatggt gcaaccatga atatttcagg
     6721 ccaagttatt cacttgacag ataactagaa tgaaactttt ctcatgaggc tgttgtttgg
     6781 ttagcatagc cttatttcaa accttaaaaa gttacctgac tgaagctact atgacttggt
     6841 aaggattctt cctctcttgc tttcttcctc ccttcctttc ttcctcttcc ttcctcctct
     6901 tcttattttc tttcctactt tccatcctac ctattagtgt tgctgtactt ggattttttg
     6961 taaattaaat caatgcatta tgattttagg gaattatgat tatattcata aggggaaggc
     7021 taccagaaaa tatatgtggc atccataaaa tcttctttta taggggcata ttttttaggt
     7081 tgtatttatt cgtaaagtga aatgagataa tagagtcttt ctgtttcatg ttaatgaatt
     7141 ttcatcaggg actgaggtca tagattcttg gaaaattcat ttgtgactga tctagttttc
     7201 tcagctgtat gcaaagtaat ctttcaaaga ctaggttaag attttttttt taagtctgaa
     7261 gcaatgtaac cccaaaaaat tataatttta atgatggcat tttattttat tccattgcag
     7321 cttgataact ttccttatag caaaggaata actattgtat tttcagaatt ttaacacaga
     7381 ttaacactta gcctgtaaga ctaataatat attgtaatag ttgatactaa aatatttttc
     7441 agcaggttgg acagcaccag tttttcttag atcacagact acaggcagaa tttcccttca
     7501 atccagaaaa aaggacacta atttcctttt ctatttaatt ttcctggccc ttgtgcaaaa
     7561 aattgtggac tctatcttag ttacaacatg catgtccctt attttgtgga gagctgtgtg
     7621 aaagatgcgt tttttttctt tttttctttt tttttttttt gagacggagt ctggctctgt
     7681 cacccaggct ggagtgcaat ggcacgatct cctctcactg caagctccgc ctcccaggtt
     7741 cacgccattc tcctgtctca gcctcccgag tagctgggac tacaggcgcc tgccaccacg
     7801 cccggctaat ttttttgtat ttttagtaga gatggagttt cacagtgtta gccaggatgg
     7861 cctcgatctc ctgacctcgt gatccacccg cctcggcctc ccaaagtgct gggattacag
     7921 gcgtgagcca ccgtgccccg cgtgtttttt tctttagctg attgacaggt ccccttcaaa
     7981 gttacaaaaa aaagtgctaa tttttgctgt taaattctgg ttgttattta attgacagaa
     8041 gtctcttgat gcacgaataa atatctctac atctagcctt tgttaaaaat aaaaattaat
     8101 attctacaaa cacctacata tactagagag gggtgaaaca ctgcagctaa ttcctttata
     8161 atactttcag atgattgcat taagcctttc atgttatgtg gcattgttaa tttttcctag
     8221 atacccatcc acttaagggc cagagaaatc cttattcatt taactctggt gggcatttat
     8281 gtaacatacc caaataaaaa cgttattaaa cagccacaat cgcattcagt caacttggca
     8341 ctgaatgtag cttctaaaat cagttctcta ccctacgaat ggaatgttct accaagaaag
     8401 agaagcatca ccatgtcatc ttgtgttcta caccactata gagagttaca gttgccccca
     8461 aacacgaatg ctattcccaa ataaaataga atcatgcttt gggaggccaa ggcgggccga
     8521 tcacgaggtc aggagatcga gaccatcctg gctaacacgg tgaaaccccg tctctactaa
     8581 aaaaaaaaaa aaatacaaaa aattagcctg gctcagtggc gggcgcctgt agtcccagct
     8641 actcaggagg ctgaggcagg agaatggcgt gaacccggga agcggagctt tcagtgagcc
     8701 gagatagcgc cactgcagtc cggcctgggc gaaagagcga gactccgtct caaaaaaaaa
     8761 aaaaaaaaaa taggatcatg gcccttttaa agatctgaat cttctctgtt attttcctga
     8821 tgaatcacca tcccatatct tcttagtcct ggccagtatg tagttgcgct cacatacgtc
     8881 tattctagct ctgtagctcc acaaaacaag tcttaagtcc aaatctttgc ctcttcatgt
     8941 ctgatatcac caactcattc agcttttctt cacttattga catagtgtca tgtcctatca
     9001 ctctctgctg cttctttaaa cagtggacac aaacatattt tctaattttc agtgtactca
     9061 gtgaaacttg gcagttcacc atgagtcagg ctaggttgaa aggctttctt tagggttgaa
     9121 agtaaacgaa attggaatca cccaaagaga atttccccaa aaaacctcag acccagaagt
     9181 gtaaaagcta cagaaggata gaactcccat gtctacagac agttctgtta ctttttgttc
     9241 tgtactattt tggatgttgc caaaatcaaa ttcatcctga aaacaggaag caagctaatg
     9301 catatgccat ccatgagatt cccacttctg ggtcagttca tattccattc aaccttttcc
     9361 ttttatcctt gtcttcttca gaataagaca tttttcctcc atattttcat attaaatatt
     9421 aacactttat aggttctact ttaatatatg gacactttac aggttataca taaatatttg
     9481 ctggttgatt gatttcgaga ttcattcatt ctgtgctcaa atatttgtac ctagagacgt
     9541 tacatgttag aaaaagtgag cagcttcttt ctctaatcat ttaggagtcc atatttttct
     9601 tttctttttg ttctcccaac atccttatct cttactcagc tcttcaattt ataattacca
     9661 aataatcact gttagagaat cagcccctaa gtaactttga ttctggccaa ctgtaataag
     9721 atccaaccac ttaaatctgt acttactcaa taggaaggaa tgtgacatca ggaagagtca
     9781 ttccagtgac attagtaaga ctttatggag tacataaaat ttgataagaa atcttgagct
     9841 gattctttga cttgatttag aagttgagaa aagagtattt aaggcacaac agggaaacat
     9901 gggctatact cagagaagac cctctgcatt ggccaaaata tcatggattc tggaaattcc
     9961 ttcttaacag aaaaaaaagg cttccaaata atcaggctga atgggaagaa aaaggcatag
    10021 aggaagcctg aggaagtatt tacttgcttt tcccatctct ttataattgg aagagaagat
    10081 gatctgccaa aatataaccc agcatgcaca gtatggacag gaagcagccc tccatgaact
    10141 ttattatcac agaatatgag cattcttatt gatccacagc tacatcttct attcttgcag
    10201 caagggtaca tgtcctttga ccctccacaa aagaacaagc aggacatctc tattttccta
    10261 ttgagtctga gtccattatt agaaaggact tcccagccat cttttctact tggtattaaa
    10321 attcccttac agattcattg ctaagtgcca attctttttt tttcttttga gacggagtct
    10381 tgctctgtcg cccaggctgg agtgcagtgg cgcaatctcg gctcactgca agctccgctt
    10441 ctcgggttca cgccattctc ctgcctcagc ctcccgagta gctgggacta cagacgcccg
    10501 ccaccgcgcc cagctaattt tttttgtact tttagtagag acggggtttc accgtggtct
    10561 cgatctcctg acctcgtgat ccgcccgcct cggcctccca aagtgccaat tctgactcta
    10621 cttaaacatc acctgtatca gggagctcat tattccttga ggtcttacat ttctttcagc
    10681 acattttgtt ccaagctaca cgactttaaa acagagccag cctttggggc atatgttctc
    10741 tttggtgcca cacaaaacct gtagtacatg atacagtgtt gcttcccccc tccttttcct
    10801 tccatatata tttgttttgt tttgggcatt gcattacttt tttgaatttt taagaatctc
    10861 taaaattagt ctgaaggatg ttctgagggc cagacattag aatttgtgag tttttttgtt
    10921 gctggttgta ctttcctatt tagaagacag accgttctga cagttgttgt gtagcttcat
    10981 gccttcccca gtaactaacc catgaacagt acaccccttt tatctgactt gttgataatg
    11041 accttaaaaa tgttaggaaa tgggccgggc gcggtggctc gtgcctgtaa tccagcactt
    11101 tgggaggccg aggcgagcgg atcatgaggt caagagatcg agaccatcct ggtcaacatg
    11161 gtgaaacccc gactctacta aaaaaaatac aaaaattagc cgggcgtgtt ggcgggcgcc
    11221 tgtagtccca actacttggg aggctgaggc aggagaatca cctgaaccca ggaggcagag
    11281 gttgcagtga gcagagattg cgccactgca ctccagcctg ggcgacagaa cgagactccg
    11341 tctcaaaaaa aaaaaaaaaa aaaaaaggtt gggaaatatt ggtgtataat ccccatgtct
    11401 aacaaggaag aagtcaaaag caaaagatag tggtattgcc gaaaactcat tatttctagt
    11461 tagttcatct gtggaaaagg atatcgttct tgaggagagg ggttctatta tgctatagtt
    11521 ttctatggaa atgtacaaat gctttcctca ttgctctgga tgactattta gtttaaataa
    11581 tatacctttg tcatggggaa gaccatgatt gtggcttctt ctaccccaac tttgaatgag
    11641 agagcactgt aagcagaaac tgccatcagt ctcctgggca ggacctggag gtaactttct
    11701 gagctgtaaa atagtaattc ctaagagagc ttacaaactg cttccacaca gaaaatagcg
    11761 cagggaggac agttattagt acccctattc tagaagagaa agctgaggct caagccatta
    11821 agtgacttgc caaaagctgt gacatagctg ggaagtggca gatttgggga tataaccagg
    11881 tcttgcaagt ccagtgctgt ctccaagtag ccacgctcac agctgagaac accttagagg
    11941 acaatatcga cttcttacag actaccaagc ccccagtcat ccagggaaat tcagagacca
    12001 attgactgcc aggtggcaaa tccacatgtg tactgcggtc tttagagatc atttagagct
    12061 tgcacacatc tgtgtcttct tgtgggaaac ctctaggtat tctgtctgat cagcactgtg
    12121 aggaagttgg tgggaaaagg ccactgataa gaacaaacaa tgggcagaag gaagcacatt
    12181 gcaataaatt tccccagaga gagttccttt acattccatt caccaaaaac ctctctggaa
    12241 ctgtcaggtt cagaatatca accaagacca tatcatttag aattcattgg catgtagagg
    12301 tgactcgatt cctaaaagaa gcctctctcc catgaaccac gatgtacgtt ccacagaggc
    12361 agaaaccgcc gtaggttagc aatgcatttt agtctttctc tccattcaca tttactgaga
    12421 gcacaccacg tgcatgttgc tgcaacaggc atttccgata gagccgatcc atgagctaac
    12481 aatgtctgaa aacaaatgtt atggaactgt tggcatttct gagatttggc ctttgccatt
    12541 tgatagactt tgcttcccag gatgctgtca ttttgtgatt ttttataatt acaaggaatt
    12601 tggtaccatg ttgttttcaa aaaacctcct agaaagtctc catgtatgct ctagaagttg
    12661 ctctacgtaa cagttcagca agcaagtgtt ccttctcttg agctgcgtcc ctcaggaagc
    12721 tgtaccttta gggtgtgctt tccacttttt atttcctctc atttcactcc tttcattgtt
    12781 tgctatatcc taaaatatgt gaagtgagag aaaaaatatc atttcttctc attaaatctc
    12841 ctgcattaaa tctaagaatc ctttaaaata atcacacctg ataagtgttt tatgcatttc
    12901 cctccctgga gtgttatcat ccatcaagcc agtatcatca tccacctgct tattccttgg
    12961 gactaatgag agccaagtta aatagcaaat gacttctcac cccttcctag tcctcatgcc
    13021 tgaggaataa gggcgacatt aatgggagcg ggagagtggt ggctttggtt gagatgcacg
    13081 ttcacagact agaaaagtgc ctcacctcca tggtgtatat gtgccacctt ttcttaatcc
    13141 agtctatcat tgttggacat ttgggttggt tccaagtctt tgctattgtg aatagtgccg
    13201 caataaacat aagtgtgcat gtgtctttat agcagcatga tttataatcc tttgggtata
    13261 tacccagtaa tgggatggct gggtcaaatg gtatttctag ttctagatcc ctgaggaatc
    13321 tccacactga cttccacaat ggttgaacta gttcacagtc ccaccaacag tgtaaaagtg
    13381 ttcttatttc tccacatcct ctccagcacc tgttgtttcc tgacttttta atgattgcca
    13441 ttctaactgg tgtgagatgg tatctcatag tggttttgat ttgcatttct ctgatggcca
    13501 gtgatggtga gcattttttc atgtgtttct tggctgcata aatgtcttct tttgagaagt
    13561 gtctgttcaa tactatgcag ccataaaaaa tgatgagttc atgtcctttg tagggacatg
    13621 gatgaaattg gaaatcatca ttctcagtaa actatctcaa ggacaaaaaa ccaaacacca
    13681 catgttctca ctcacaggtg ggaattgaac aatgagaaca catggacaca ggaaggggaa
    13741 catcacactc tggggactgt tgtggggtgg agggaggagg gagggatagc attaggagat
    13801 atacctaatg ctaaatgacg agttaatggg tgcagcacac cagcatggca catgtataca
    13861 tatgtaacta acctgcacat tgtgcacatg taccctaaaa cttaaagtat aataataatg
    13921 aaataaaatt aaaaaaaaaa aagaaaagtg cctcacctcc ctgtgaggct tgatgaatat
    13981 tgtggccagt gagtggaaaa tgattcttgt cgaatagaca gagtattccc accccaggaa
    14041 tggattaata gaagacacaa tttgagcact tctcagaatt atctagtatg cctgagtaga
    14101 gactcacatg ggtggaatct gtgttgtctc atcagaggga ataaaaagac aatgaggtgg
    14161 taaatgtgaa aaaagcagcc ttttagaaaa acattatttt caaatacctt tataaatcat
    14221 ctaatttatc ttcacataat ataaagaaaa aactaataaa aattttcgta tttcacttta
    14281 cataatatgt tctcccatat ttagggatca tacaattgta ttgtcttcaa aacacacaca
    14341 cacacacata cacacacaca cacacacaca cacacacccc ttccaagaaa gctgatcctt
    14401 cagaaaataa atcttatttt taagcacttg ggttttcagg ccagaaaatt aataaatcct
    14461 aaacctgacc catttttgta acagctaaaa aggagaagaa aaagctagtt aaattttgtg
    14521 tggatccatt tatctcttaa aatatgccaa agcaatttga ggtgggggtg gaaacaggta
    14581 tttatctctc atgcgtgatt ctctctttat atttctatct gttgggaaaa gggtaaagaa
    14641 ctattcttgg tcattattga tgtattgtgt tgccactttg tatggtgcct gctgtgcttt
    14701 atcccgaggc atagcagtaa tcgttactat cttgactctt tccttcatca caagagagta
    14761 aatatgaagt ctgaatgtcg ttcctcaccc ccaaattgtt taactctgct tccaaactag
    14821 tttaagaaat gcaaaatggg aagagctagc ttttcttaga tacatttctt ccttttttat
    14881 tctttcttgg gagacgttaa gtataaaagg gaaaaagtca gttccttctt ctctctcttt
    14941 ctctttgggt gacagcaatg ctcacttagt aattataaac tggaaatagg agagtagctt
    15001 gagcaggtta tgatatatct gcccaatgtg tttcattcct tcaaacataa actttgagag
    15061 taaaagagat ttttataatt taaatgccaa cgacaggaat ggcctcatgt tttaactttc
    15121 aaataataaa tggggagttg gtatttgggc agagtttgca ttttactaat cctatatact
    15181 ttgagcttag tttttagaat tgtgtcaaat acatcaacat atcaggatta tagtgccaaa
    15241 aatagttaaa gtgccttggt cctccctctg taggcagcaa attgaaacta acatgggacc
    15301 atgccatcct tctagcataa tggagaagtc tgaactgagg agtatctttg atgaaagaca
    15361 tttaggaccc tagaaactaa atcttgtcac caagacttta tagtaaagta gtagcaaaat
    15421 tatttttaaa agactttctt ccttttacta cccatttcct ctcttgggaa agctgatgag
    15481 caaattatcc aagactcatt tctttattag gcaaagtcag aatatttccc ctctgaaaat
    15541 ctgaattatg ccctcattct ttttcaagaa atatctcaaa gagcaaatag aattaaacat
    15601 gacacttgat tgtctgatta tttggcatgt ataaaattat catgtggctt aatgtgcctt
    15661 aagtgaaaat ttaaacttag acctgaaacc tttacagttg gatgtagcgt tgagcttttg
    15721 catgttttct gtataataaa ccacttttgt tttgtttgtt ttgtctttta acctacacct
    15781 ttatcattac tctaacagat ttagggcttc tctttctcta cagctaagta agggaatatg
    15841 tgcaattatg agacatacaa aaaaggaaag ggaaaggact ttctaagtag caaatctgtg
    15901 ccatgaagta gatgtggcgt gaagatacag agcctgagga tagtaatttt ccctgagcca
    15961 cgcacacagg cttttatttc atgccttttc tctttctgtg ccgtcacctt tgagaaaaac
    16021 gattgcacct tctccaagtc tgccttttta acagctacag ttaagttggc aagacttccc
    16081 cagctctgaa tatagccatt tgccgactcc ggcctctttg cgagactgac tcaaatctgt
    16141 gatcttctgt tcagcataca catcagcaaa gtgagaagat gagcactaaa tataggctct
    16201 attaacttta cttttagatt tactgccttc aaaaagtgcc tattctgagc aacataaacg
    16261 ttattcctta catatgtatg tacacacggt acccagagtc gtactgtgca gccttcaaaa
    16321 acataccatc agaaagagta ggtgctgaga taaggaaact ttgccaaatg aaagaaagtc
    16381 actcacttcc aatatcccct ctcaagcggc taccgtgaaa cgggctgcaa acacattccc
    16441 tgagcatccc ttgctgatac agcttcttta tatttatatc ctactggatg gtagcatatt
    16501 gctaaggttt cctgtactct gcttcaaggg aatgtaagct ttatggcatt gaaacattta
    16561 gggaaaaaaa agatgtttaa gagaattaat agagccgtag tctgtattag gatgtgtgtc
    16621 atatgtgtgt tctataaact aagcatcggt gggtttagag tgttaaagtg tcagcacatt
    16681 ccttctcctt ttgtctctca ggctaacatg agagaaaata gaaaagtctt ggctgtgggg
    16741 attggaagct cagggggcca aatgtccttg ccagatcctt agagcattac tttgactcct
    16801 aaaaatagta gtgtatgtta tttgatggct tttgtttcca tagttccatc actgacaaaa
    16861 ctgtcaatac tgttgatgga gcagcagcat agcctagagt gatgcattct tacccagagg
    16921 tggcaatagg agagggtcca tgtaaatagg acgaggtaga cagtgcatga ttgtaggaga
    16981 agggttgaag ggaggacatg attccaaaaa agatcgttct caatgtgtcg tctgactcaa
    17041 ccagctggca gattacactt gccaagtcgt tccctttcct tctaagtcag ttggctccat
    17101 attcacttga atatgcctct gtttgggcaa agcaagatac ctccacttaa cctttatcca
    17161 aggaagctct tggtgtcctc ttggtcataa agttgtctcc tacctaaccc agttttacca
    17221 aatggaagta aaaggggaca aactatggaa gatggactcc atgccattgc agtcagccac
    17281 cattctcttt tccatataag gagccccatt acataagcta cgggtgaggt tggaacagct
    17341 atgtttcata atttcaagag tgtgaccacc ctgctctagt catcatcatt ggatgaatcc
    17401 agttgactct ttggcaaaag ggtgatactt ttcactaaaa atgcctactc ttcctgttga
    17461 tgttcctttt ctgtttttac cttgtccaat ttccacacta gtcatttttt ttatttttta
    17521 gaggatcaga ttttagcgct ggaaaatgag ttcaaaaatt tcagtgtaat gtcataagga
    17581 tgttgggata cagagatttt ttttttcctt ggaaacaaat ggactgggaa gaaacacagc
    17641 atggctttgc tctgagtttc aatctgatga ttatgaccat ggaagatagt cttatgtaaa
    17701 ggttaaatgg tgtttacaag tggatagata aggcggagat ggtgagaagc cgggttttct
    17761 ctatgctaaa tgtgtctact aagagcagca cttcctacta gctaagcaca atcatagccc
    17821 caccgtgatg agctgctagt ctgaataaca ttccctgact tagggaaagg cacacaaaaa
    17881 catataaaga atatgtctat tttcatatgt gtgatactga cagagccatg gtattcctaa
    17941 aatataggtt tctctttttt cttgtattct tagcaaattg catttattca ctacattaca
    18001 aaccatcact gatgtatcca aaatagcaca catagttcag tatgaaaata agagaataaa
    18061 atctgttata agcaagtgat ttaggtattt tcttttgtgt ttatgcatta tctgactata
    18121 ttaaaacctg tttttctatt taccttctat cagttttctc taccaattat gttttttcaa
    18181 tgctctataa gaatgaatat ggaaattata tttctttttt ctgtaaaaga gttgcaacta
    18241 ctttattata tttagaaatc caataaactt cttattacat tta
//
