LOCUS       NM_001387666           18435 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LIM domain containing preferred translocation partner
            in lipoma (LPP), transcript variant 19, mRNA.
ACCESSION   NM_001387666 XM_017006377
VERSION     NM_001387666.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18435)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18435)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 18435)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (bases 1 to 18435)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 18435)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (bases 1 to 18435)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (bases 1 to 18435)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (bases 1 to 18435)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (bases 1 to 18435)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (bases 1 to 18435)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022498.18, AC117507.5,
            AC069226.19, AC063932.14, AC055711.18, AC009319.19 and KF510228.1.
            
            On Nov 20, 2020 this sequence version replaced XM_017006377.1.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3976782.1,
                                           SRR14038192.4134974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932, SAMEA2154529
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC022498.18        60685-60780
            97-215              AC022498.18        114728-114846
            216-338             AC117507.5         11500-11622
            339-395             AC117507.5         127758-127814
            396-597             AC069226.19        127073-127274       c
            598-710             AC069226.19        48682-48794         c
            711-833             AC069226.19        8599-8721           c
            834-1517            AC063932.14        108433-109116       c
            1518-1644           AC063932.14        9884-10010          c
            1645-1814           AC055711.18        41842-42011
            1815-1993           AC055711.18        147929-148107
            1994-2114           AC055711.18        154372-154492
            2115-11855          AC009319.19        3236-12976
            11856-12236         KF510228.1         1-381
            12237-18435         AC009319.19        13359-19557
FEATURES             Location/Qualifiers
     source          1..18435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     gene            1..18435
                     /gene="LPP"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
     exon            1..96
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            97..215
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            216..338
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            339..395
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            396..597
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..2243
                     /gene="LPP"
                     /note="isoform a is encoded by transcript variant 19; LIM
                     protein; lipoma preferred partner"
                     /codon_start=1
                     /product="lipoma-preferred partner isoform a"
                     /protein_id="NP_001374595.1"
                     /db_xref="CCDS:CCDS3291.1"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
                     /translation="MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKK
                     FAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQ
                     GNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTG
                     HKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSR
                     PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYI
                     PPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTP
                     PGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
                     LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNK
                     LRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRS
                     LDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHC
                     YRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            598..710
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            711..833
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1517
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1644
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1814
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1993
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2114
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..18435
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      18414..18419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPP"
                     /note="hexamer: AATAAA"
     polyA_site      18435
                     /gene="LPP"
                     /note="major polyA site"
ORIGIN      
        1 acctcctcct ctgcctctgc ctccgcctcc agccgccgcc gccgccgccg ccgccgccac
       61 caccaccgcc gctgccccgg ctgcctcctc cctgaggaat tgaagagaat cctgacaagt
      121 ggcatgttgg gaaaggcctg aaggaagcca gaccagcttg ctctcagagc tccttgggtc
      181 ccctgcggcc cccaggtgat cttcagcaag acctggtggg aactttgagg ctcagagaca
      241 gagcagaaga cagaacctgg tcttctgatt ccctgtgttc tgcttttttc attgttccac
      301 tggacgctca tcagagggaa gatctttttc ctcaattgca ttgcagttgg ctgaaccttg
      361 tgtcaaccat ccattccagg agccagctat ctgagattcc aacaatgtct cacccatctt
      421 ggctgccacc caaaagcact ggtgagcccc tcggccatgt gcctgcacgg atggagacca
      481 cccattcctt tgggaacccc agcatttcag tgtctacaca acagccaccc aaaaagtttg
      541 ccccggtagt tgctccaaaa cctaagtaca acccatacaa acaacctgga ggtgagggtg
      601 attttcttcc acccccacct ccacctctag atgattccag tgcccttcca tctatctctg
      661 gaaactttcc tcctccacca cctcttgatg aagaggcttt caaagtacag gggaatcccg
      721 gaggcaagac acttgaggag aggcgctcca gcctggacgc tgagattgac tccttgacca
      781 gcatcttggc tgaccttgag tgcagctccc cctataagcc tcggcctcca cagagctcca
      841 ctggttcaac agcctctcct ccagtttcga ccccagtcac aggacacaag agaatggtca
      901 tcccgaacca accccctcta acagcaacca agaagtctac attgaaacca cagcctgcac
      961 cccaggctgg acccatccct gtggctccaa tcggaacact caaaccccag cctcagccag
     1021 tcccagcctc ctacaccacg gcctccactt cttcaaggcc tacctttaat gtgcaggtga
     1081 agtcagccca gcccagccct cattatatgg ctgccccttc atcaggacaa atttatggct
     1141 cagggcccca gggctataac actcagccag ttcctgtctc tgggcagtgt ccacctcctt
     1201 caacacgggg aggcatggat tatgcctaca ttccaccacc aggacttcag ccggagcctg
     1261 ggtatgggta tgcccccaac cagggacgct attatgaagg ctactatgca gcagggccag
     1321 gctatggggg cagaaatgac tctgacccta cctatggtca acaaggtcac ccaaatacct
     1381 ggaaacggga accagggtac actcctcctg gagcagggaa ccagaaccct cctgggatgt
     1441 atccagtcac tggtcccaag aagacctata tcacagatcc tgtttcagcc ccctgtgcgc
     1501 caccattgca gccaaagggt ggccattcag ggcaactggg gccttcgtca gttgcccctt
     1561 cattccgccc agaggatgag cttgagcacc tgaccaaaaa gatgctgtat gacatggaaa
     1621 atccacctgc tgacgaatac tttggccgct gtgctcgctg tggagaaaac gtagttgggg
     1681 aaggtacagg atgcactgcc atggatcagg tcttccacgt ggattgtttt acctgcatca
     1741 tctgcaacaa caagctccga gggcagccat tctatgctgt ggaaaagaaa gcatactgcg
     1801 agccctgcta cattaatact ctggagcagt gcaatgtgtg ttccaagccc atcatggagc
     1861 ggattctccg agccaccggg aaggcctatc atcctcactg tttcacctgc gtgatgtgcc
     1921 accgcagcct ggatgggatc ccattcactg tggatgctgg cgggctcatt cactgcattg
     1981 aggacttcca caagaaattt gccccgcgat gttctgtgtg caaggagcct attatgccag
     2041 ccccgggcca ggaggagact gtccgtattg tggctttgga tcgagatttc catgttcact
     2101 gctaccgatg cgaggattgc ggtggtctcc tgtctgaagg agataaccaa ggctgctacc
     2161 ccttggatgg gcacatcctc tgcaagacct gcaactctgc ccgcatcagg gtgttgaccg
     2221 ccaaggcgag cactgacctt tagattcagt cacctgttca gccggcactg agaagaacga
     2281 acacaagaaa aagataagaa atactagagt aaaggccatc aaactacgcg atagtctctg
     2341 ttcttcatct gctattaacc ttgccttaga aacacataaa ttatgagatt ttttttaaaa
     2401 gttgttacca aatacacatt tcacattgaa tcatgtagga tcttgatggg cctttgttcc
     2461 caaggacttc cacatttttg cacagattat gctccatccc attcacttct gcattcctgt
     2521 aacttttaat ccctatgttt gtctcacttt tcatctggtt gaatggcttt tcttagtgtg
     2581 gtatttgctg tcacatagtt tttcctgggt gagtctgcca actcacaggt gcttttaggc
     2641 ttgaaatctc catcctatca tttccgtttt gcctgtgact gtaaagagta gccattcttt
     2701 tcccatgtat tgaagaggat attcttctct tgctttatac tactcacgtc cttggggagg
     2761 gaaatgcaca attttttttt gttaggctgt aaagaattta agctgtaaat tacataagtt
     2821 agaacaagcc caaatttaat ttgcaaccat cagaattcag aatctatagt gaccagtgat
     2881 caaggctaat tggaaaagag ttatcggccc atagctaata agtagtgaca gacaaccaag
     2941 cttcaatatt tttctaaaga aattacaggt gggatatgct agaaaaggca ttttggggtt
     3001 atgtttaaaa aaacattatt gtcccacaat attaccttaa gatttttctt ttccgcacta
     3061 cctgaacatt gtaatacaga caaacttgat ttcttctaga agataacatt ttcaatactg
     3121 tcccacttct catcttaaaa atattgtcat gtttattcta atatccaaca caactatcaa
     3181 aattgccttt ttctctagag gatgaaggct gtgaaaaaac cgttcaaatt ctcttctttt
     3241 tcttttttat taccaggtcc attttgcctg acaattgcaa atcagagcat acaaaataaa
     3301 actgtgcagt tttgtttggt ttactttcaa aagagtagaa agcttgaaaa gattctgaaa
     3361 ccacagtttc attattctca taatccttct gcaactgaaa ttacatattg caggagacat
     3421 tttcatatca tcaatgtgac atttacacca cactttcaaa gacaatcact gaaacaaaaa
     3481 ttgtctttat gagctaaaaa tatgcagaat ctctgcctag aatctttatt caaactttta
     3541 ttagccagtg aaacacttgc ttgccaactg ccaagccata cttattaagt tcgaacatgt
     3601 ttcacttaag gagagacacc tagcttagtc atggcaagtt gccattttgt aaactaagga
     3661 ttttggactg agatttctta aatctttctt caaatctccc acaagtatat acttttaaat
     3721 tatggagtat tttaagtcta caaaaaggta taaataataa tataatgaat tcctatatac
     3781 ctaataccca gtttaagaca ccaaatataa caagtataat tacatcctcc aatgtaccgt
     3841 ttccttattc cacagatatc tttttcatta ttgtgaagtg atgttcagat ttctagtttt
     3901 ttttctagtt tttaatttta acatcagaac tgaaataaaa aattatggat acgtgttttg
     3961 aattgcaaac tattcctcag gaattccaat taaatttatt ttacttgaat aggaatgatc
     4021 ataaaagtga ttcttttttt gtgactagaa attcttaagc cgatggtcac tatagctcat
     4081 ccttaatgta tggctcattt gcttttgtca ctaaacggtt ttgtgttaga accaccaaaa
     4141 ttatagcttt taagagcttc ctttgaccac tgtctttttc ttaccctagt tctcttatct
     4201 ttgatcgtat atttctcata atgtgaaata tgatgagatt cacttagggg cagcatgtta
     4261 gttttgggag gcaatgtcaa ctgtgtctct gaattcctgt cttccaaatt gaagccagac
     4321 catgctgatg acctcaagta gcactgacta tttgacaata gggctgataa tgtaatcggc
     4381 ttgaattttg acttagtaac tttttatgta atactttcgg agaaattctc tttaggacaa
     4441 agcagagagt ccaatttatt gagggataga ttgtatctct taaagtggtc atattattat
     4501 taattttgcc aaaagaagaa gaatttattg aatatttata ctataaaatg cagtaacatt
     4561 ctacttgctt attacattta aatccttgtg taactgaatg tttacatgtc aagaggaaaa
     4621 gctgtaagaa aatgctgtca cagacccatc cctgtggcat cgtcagcaga atactgcttg
     4681 cttacaatct ttattatgca ttcttataac ataacctcag agtatcttta ccaaaggttt
     4741 ttaaagtaaa tctcttttta agatagactt attcttttat aataatgaat gtgcactcat
     4801 acatatgtag aaacatttag atttagagtt ttttttttct ttcacaaggt ataataagga
     4861 aaggatccta caatatttta ttctagggtt tcttaaatat atgatttata ttactgtctt
     4921 ttctattaat catttgattt aaacaatgcc aagtcactct tttttagttg catgaaattt
     4981 tgcctgcaac agagagaaaa agattgtatt actttaatga ttataatcat actgtctgct
     5041 gatataatat cataattgtt gtggtttaaa tacataaata gtagaaaaat cagagtctat
     5101 aacagaaagt ttgtaaaaat atactgattt tgaaaagtat caggaatata aatatttggt
     5161 aattctgtgt aacaagagag acatggaaaa ggaaaaaaat ccactatatc atgggctctg
     5221 cagaacatat caaaatagga tttcttaaat ttttcaaccc ccagaccata ctgactcaac
     5281 atggagtctc actggccaag aaaattgcct ttaaaactcg aaaataaggc caggtgtggt
     5341 gactcacact tgtaatccca gcaatttggg aggctgagac aggaggattg cctgaggcca
     5401 ggagtttgac accagcctgg gcaacatagt gagaccttgt ctctacaaaa aataaaataa
     5461 aataaaaacc aaattagcca gacatggtgg catgcgcttg tttaaaaaaa caaataaata
     5521 aataatcgac tcaaaaataa gtcatgtgtc ccagcataag gcatcaggtt gttagatgct
     5581 ggcatctctg cagctcaaag atgtgggttc tttttcttgt cattaacaca ttgttatttc
     5641 tgtaggagca acttctctga tcaaaattac ttttctgggt atgtgctgat taagggggtg
     5701 gacttatcaa cactataatt gttccctatg aaagattcca cagagatgtt tatggtgagg
     5761 tttaaaggat atgaaactct acatttaaac aagtatttta tatttgggta cagaggaaga
     5821 aagagagggc tttttccatg gggctatagt agagagttag tggaatatag acaggactct
     5881 gaaaacacaa cttccagcca tttttttagt tagtaaaaat cctattaatg tgaaccagcc
     5941 aggaataaca gtgttatttc tattggatat ggtttgggct tctcttgtca aatctgtgtc
     6001 ggctgccccc tgatccttcc attatcaagt tttgaagggt gttggggaaa ttatggcagc
     6061 tgctagggag atcagggaaa cactgatgta acctcaaagc ctctcaccat tcctcttggc
     6121 ttggaaaggc tttatttttt catatacatt tctagaaata ttgctattct accttagtat
     6181 ttcacatttg tagttcaaac aagcgattgt ccatctgttg cctagagcta tagtacatgt
     6241 gtgttatgaa tgaaatatga cagcatgttc catacccctg ctttagccat ctgtgggaaa
     6301 ccagcaaact gaaaaagaca cctctgcaaa atgtgcctca agtccatttc ttgggatcgc
     6361 tcgtttggtg cactctcgtg ggagacaatc agagaacaac atatacttgt gccttatttt
     6421 caaagaatct atttacacta ctatgaatat tccactgaag agtcaatgat gtaaatgata
     6481 accaccaaat ctcaaaaata tactcaccaa aaagtaaaaa agtaaaaaaa aaaaaaaaag
     6541 aaagaaagaa aagaaagaga gagaagtcaa cttttcatct taatatattc tagtagtatt
     6601 tattttttcc ttgtcttgga agtatctcat aggtctttaa atgagtaaaa catttttatg
     6661 ccagaaggtg atataatgga tgttagtgtt ttttatttga ttttacagta gttttagtca
     6721 gataatgagg acagagactt caacttgatt ctttaccacc attcagcata ttttttaatt
     6781 gtcttcattg tatttgctta atagtggtcc agacaagttc aaaacttgtt ctcagtgagg
     6841 cattaatatg gtgcaaccat gaatatttca ggccaagtta ttcacttgac agataactag
     6901 aatgaaactt ttctcatgag gctgttgttt ggttagcata gccttatttc aaaccttaaa
     6961 aagttacctg actgaagcta ctatgacttg gtaaggattc ttcctctctt gctttcttcc
     7021 tcccttcctt tcttcctctt ccttcctcct cttcttattt tctttcctac tttccatcct
     7081 acctattagt gttgctgtac ttggattttt tgtaaattaa atcaatgcat tatgatttta
     7141 gggaattatg attatattca taaggggaag gctaccagaa aatatatgtg gcatccataa
     7201 aatcttcttt tataggggca tattttttag gttgtattta ttcgtaaagt gaaatgagat
     7261 aatagagtct ttctgtttca tgttaatgaa ttttcatcag ggactgaggt catagattct
     7321 tggaaaattc atttgtgact gatctagttt tctcagctgt atgcaaagta atctttcaaa
     7381 gactaggtta agattttttt tttaagtctg aagcaatgta accccaaaaa attataattt
     7441 taatgatggc attttatttt attccattgc agcttgataa ctttccttat agcaaaggaa
     7501 taactattgt attttcagaa ttttaacaca gattaacact tagcctgtaa gactaataat
     7561 atattgtaat agttgatact aaaatatttt tcagcaggtt ggacagcacc agtttttctt
     7621 agatcacaga ctacaggcag aatttccctt caatccagaa aaaaggacac taatttcctt
     7681 ttctatttaa ttttcctggc ccttgtgcaa aaaattgtgg actctatctt agttacaaca
     7741 tgcatgtccc ttattttgtg gagagctgtg tgaaagatgc gttttttttc tttttttctt
     7801 tttttttttt ttgagacgga gtctggctct gtcacccagg ctggagtgca atggcacgat
     7861 ctcctctcac tgcaagctcc gcctcccagg ttcacgccat tctcctgtct cagcctcccg
     7921 agtagctggg actacaggcg cctgccacca cgcccggcta atttttttgt atttttagta
     7981 gagatggagt ttcacagtgt tagccaggat ggcctcgatc tcctgacctc gtgatccacc
     8041 cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc caccgtgccc cgcgtgtttt
     8101 tttctttagc tgattgacag gtccccttca aagttacaaa aaaaagtgct aatttttgct
     8161 gttaaattct ggttgttatt taattgacag aagtctcttg atgcacgaat aaatatctct
     8221 acatctagcc tttgttaaaa ataaaaatta atattctaca aacacctaca tatactagag
     8281 aggggtgaaa cactgcagct aattccttta taatactttc agatgattgc attaagcctt
     8341 tcatgttatg tggcattgtt aatttttcct agatacccat ccacttaagg gccagagaaa
     8401 tccttattca tttaactctg gtgggcattt atgtaacata cccaaataaa aacgttatta
     8461 aacagccaca atcgcattca gtcaacttgg cactgaatgt agcttctaaa atcagttctc
     8521 taccctacga atggaatgtt ctaccaagaa agagaagcat caccatgtca tcttgtgttc
     8581 tacaccacta tagagagtta cagttgcccc caaacacgaa tgctattccc aaataaaata
     8641 gaatcatgct ttgggaggcc aaggcgggcc gatcacgagg tcaggagatc gagaccatcc
     8701 tggctaacac ggtgaaaccc cgtctctact aaaaaaaaaa aaaaatacaa aaaattagcc
     8761 tggctcagtg gcgggcgcct gtagtcccag ctactcagga ggctgaggca ggagaatggc
     8821 gtgaacccgg gaagcggagc tttcagtgag ccgagatagc gccactgcag tccggcctgg
     8881 gcgaaagagc gagactccgt ctcaaaaaaa aaaaaaaaaa aataggatca tggccctttt
     8941 aaagatctga atcttctctg ttattttcct gatgaatcac catcccatat cttcttagtc
     9001 ctggccagta tgtagttgcg ctcacatacg tctattctag ctctgtagct ccacaaaaca
     9061 agtcttaagt ccaaatcttt gcctcttcat gtctgatatc accaactcat tcagcttttc
     9121 ttcacttatt gacatagtgt catgtcctat cactctctgc tgcttcttta aacagtggac
     9181 acaaacatat tttctaattt tcagtgtact cagtgaaact tggcagttca ccatgagtca
     9241 ggctaggttg aaaggctttc tttagggttg aaagtaaacg aaattggaat cacccaaaga
     9301 gaatttcccc aaaaaacctc agacccagaa gtgtaaaagc tacagaagga tagaactccc
     9361 atgtctacag acagttctgt tactttttgt tctgtactat tttggatgtt gccaaaatca
     9421 aattcatcct gaaaacagga agcaagctaa tgcatatgcc atccatgaga ttcccacttc
     9481 tgggtcagtt catattccat tcaacctttt ccttttatcc ttgtcttctt cagaataaga
     9541 catttttcct ccatattttc atattaaata ttaacacttt ataggttcta ctttaatata
     9601 tggacacttt acaggttata cataaatatt tgctggttga ttgatttcga gattcattca
     9661 ttctgtgctc aaatatttgt acctagagac gttacatgtt agaaaaagtg agcagcttct
     9721 ttctctaatc atttaggagt ccatattttt cttttctttt tgttctccca acatccttat
     9781 ctcttactca gctcttcaat ttataattac caaataatca ctgttagaga atcagcccct
     9841 aagtaacttt gattctggcc aactgtaata agatccaacc acttaaatct gtacttactc
     9901 aataggaagg aatgtgacat caggaagagt cattccagtg acattagtaa gactttatgg
     9961 agtacataaa atttgataag aaatcttgag ctgattcttt gacttgattt agaagttgag
    10021 aaaagagtat ttaaggcaca acagggaaac atgggctata ctcagagaag accctctgca
    10081 ttggccaaaa tatcatggat tctggaaatt ccttcttaac agaaaaaaaa ggcttccaaa
    10141 taatcaggct gaatgggaag aaaaaggcat agaggaagcc tgaggaagta tttacttgct
    10201 tttcccatct ctttataatt ggaagagaag atgatctgcc aaaatataac ccagcatgca
    10261 cagtatggac aggaagcagc cctccatgaa ctttattatc acagaatatg agcattctta
    10321 ttgatccaca gctacatctt ctattcttgc agcaagggta catgtccttt gaccctccac
    10381 aaaagaacaa gcaggacatc tctattttcc tattgagtct gagtccatta ttagaaagga
    10441 cttcccagcc atcttttcta cttggtatta aaattccctt acagattcat tgctaagtgc
    10501 caattctttt tttttctttt gagacggagt cttgctctgt cgcccaggct ggagtgcagt
    10561 ggcgcaatct cggctcactg caagctccgc ttctcgggtt cacgccattc tcctgcctca
    10621 gcctcccgag tagctgggac tacagacgcc cgccaccgcg cccagctaat tttttttgta
    10681 cttttagtag agacggggtt tcaccgtggt ctcgatctcc tgacctcgtg atccgcccgc
    10741 ctcggcctcc caaagtgcca attctgactc tacttaaaca tcacctgtat cagggagctc
    10801 attattcctt gaggtcttac atttctttca gcacattttg ttccaagcta cacgacttta
    10861 aaacagagcc agcctttggg gcatatgttc tctttggtgc cacacaaaac ctgtagtaca
    10921 tgatacagtg ttgcttcccc cctccttttc cttccatata tatttgtttt gttttgggca
    10981 ttgcattact tttttgaatt tttaagaatc tctaaaatta gtctgaagga tgttctgagg
    11041 gccagacatt agaatttgtg agtttttttg ttgctggttg tactttccta tttagaagac
    11101 agaccgttct gacagttgtt gtgtagcttc atgccttccc cagtaactaa cccatgaaca
    11161 gtacacccct tttatctgac ttgttgataa tgaccttaaa aatgttagga aatgggccgg
    11221 gcgcggtggc tcgtgcctgt aatccagcac tttgggaggc cgaggcgagc ggatcatgag
    11281 gtcaagagat cgagaccatc ctggtcaaca tggtgaaacc ccgactctac taaaaaaaat
    11341 acaaaaatta gccgggcgtg ttggcgggcg cctgtagtcc caactacttg ggaggctgag
    11401 gcaggagaat cacctgaacc caggaggcag aggttgcagt gagcagagat tgcgccactg
    11461 cactccagcc tgggcgacag aacgagactc cgtctcaaaa aaaaaaaaaa aaaaaaaagg
    11521 ttgggaaata ttggtgtata atccccatgt ctaacaagga agaagtcaaa agcaaaagat
    11581 agtggtattg ccgaaaactc attatttcta gttagttcat ctgtggaaaa ggatatcgtt
    11641 cttgaggaga ggggttctat tatgctatag ttttctatgg aaatgtacaa atgctttcct
    11701 cattgctctg gatgactatt tagtttaaat aatatacctt tgtcatgggg aagaccatga
    11761 ttgtggcttc ttctacccca actttgaatg agagagcact gtaagcagaa actgccatca
    11821 gtctcctggg caggacctgg aggtaacttt ctgagctgta aaatagtaat tcctaagaga
    11881 gcttacaaac tgcttccaca cagaaaatag cgcagggagg acagttatta gtacccctat
    11941 tctagaagag aaagctgagg ctcaagccat taagtgactt gccaaaagct gtgacatagc
    12001 tgggaagtgg cagatttggg gatataacca ggtcttgcaa gtccagtgct gtctccaagt
    12061 agccacgctc acagctgaga acaccttaga ggacaatatc gacttcttac agactaccaa
    12121 gcccccagtc atccagggaa attcagagac caattgactg ccaggtggca aatccacatg
    12181 tgtactgcgg tctttagaga tcatttagag cttgcacaca tctgtgtctt cttgtgggaa
    12241 acctctaggt attctgtctg atcagcactg tgaggaagtt ggtgggaaaa ggccactgat
    12301 aagaacaaac aatgggcaga aggaagcaca ttgcaataaa tttccccaga gagagttcct
    12361 ttacattcca ttcaccaaaa acctctctgg aactgtcagg ttcagaatat caaccaagac
    12421 catatcattt agaattcatt ggcatgtaga ggtgactcga ttcctaaaag aagcctctct
    12481 cccatgaacc acgatgtacg ttccacagag gcagaaaccg ccgtaggtta gcaatgcatt
    12541 ttagtctttc tctccattca catttactga gagcacacca cgtgcatgtt gctgcaacag
    12601 gcatttccga tagagccgat ccatgagcta acaatgtctg aaaacaaatg ttatggaact
    12661 gttggcattt ctgagatttg gcctttgcca tttgatagac tttgcttccc aggatgctgt
    12721 cattttgtga ttttttataa ttacaaggaa tttggtacca tgttgttttc aaaaaacctc
    12781 ctagaaagtc tccatgtatg ctctagaagt tgctctacgt aacagttcag caagcaagtg
    12841 ttccttctct tgagctgcgt ccctcaggaa gctgtacctt tagggtgtgc tttccacttt
    12901 ttatttcctc tcatttcact cctttcattg tttgctatat cctaaaatat gtgaagtgag
    12961 agaaaaaata tcatttcttc tcattaaatc tcctgcatta aatctaagaa tcctttaaaa
    13021 taatcacacc tgataagtgt tttatgcatt tccctccctg gagtgttatc atccatcaag
    13081 ccagtatcat catccacctg cttattcctt gggactaatg agagccaagt taaatagcaa
    13141 atgacttctc accccttcct agtcctcatg cctgaggaat aagggcgaca ttaatgggag
    13201 cgggagagtg gtggctttgg ttgagatgca cgttcacaga ctagaaaagt gcctcacctc
    13261 catggtgtat atgtgccacc ttttcttaat ccagtctatc attgttggac atttgggttg
    13321 gttccaagtc tttgctattg tgaatagtgc cgcaataaac ataagtgtgc atgtgtcttt
    13381 atagcagcat gatttataat cctttgggta tatacccagt aatgggatgg ctgggtcaaa
    13441 tggtatttct agttctagat ccctgaggaa tctccacact gacttccaca atggttgaac
    13501 tagttcacag tcccaccaac agtgtaaaag tgttcttatt tctccacatc ctctccagca
    13561 cctgttgttt cctgactttt taatgattgc cattctaact ggtgtgagat ggtatctcat
    13621 agtggttttg atttgcattt ctctgatggc cagtgatggt gagcattttt tcatgtgttt
    13681 cttggctgca taaatgtctt cttttgagaa gtgtctgttc aatactatgc agccataaaa
    13741 aatgatgagt tcatgtcctt tgtagggaca tggatgaaat tggaaatcat cattctcagt
    13801 aaactatctc aaggacaaaa aaccaaacac cacatgttct cactcacagg tgggaattga
    13861 acaatgagaa cacatggaca caggaagggg aacatcacac tctggggact gttgtggggt
    13921 ggagggagga gggagggata gcattaggag atatacctaa tgctaaatga cgagttaatg
    13981 ggtgcagcac accagcatgg cacatgtata catatgtaac taacctgcac attgtgcaca
    14041 tgtaccctaa aacttaaagt ataataataa tgaaataaaa ttaaaaaaaa aaaagaaaag
    14101 tgcctcacct ccctgtgagg cttgatgaat attgtggcca gtgagtggaa aatgattctt
    14161 gtcgaataga cagagtattc ccaccccagg aatggattaa tagaagacac aatttgagca
    14221 cttctcagaa ttatctagta tgcctgagta gagactcaca tgggtggaat ctgtgttgtc
    14281 tcatcagagg gaataaaaag acaatgaggt ggtaaatgtg aaaaaagcag ccttttagaa
    14341 aaacattatt ttcaaatacc tttataaatc atctaattta tcttcacata atataaagaa
    14401 aaaactaata aaaattttcg tatttcactt tacataatat gttctcccat atttagggat
    14461 catacaattg tattgtcttc aaaacacaca cacacacaca tacacacaca cacacacaca
    14521 cacacacacc ccttccaaga aagctgatcc ttcagaaaat aaatcttatt tttaagcact
    14581 tgggttttca ggccagaaaa ttaataaatc ctaaacctga cccatttttg taacagctaa
    14641 aaaggagaag aaaaagctag ttaaattttg tgtggatcca tttatctctt aaaatatgcc
    14701 aaagcaattt gaggtggggg tggaaacagg tatttatctc tcatgcgtga ttctctcttt
    14761 atatttctat ctgttgggaa aagggtaaag aactattctt ggtcattatt gatgtattgt
    14821 gttgccactt tgtatggtgc ctgctgtgct ttatcccgag gcatagcagt aatcgttact
    14881 atcttgactc tttccttcat cacaagagag taaatatgaa gtctgaatgt cgttcctcac
    14941 ccccaaattg tttaactctg cttccaaact agtttaagaa atgcaaaatg ggaagagcta
    15001 gcttttctta gatacatttc ttcctttttt attctttctt gggagacgtt aagtataaaa
    15061 gggaaaaagt cagttccttc ttctctctct ttctctttgg gtgacagcaa tgctcactta
    15121 gtaattataa actggaaata ggagagtagc ttgagcaggt tatgatatat ctgcccaatg
    15181 tgtttcattc cttcaaacat aaactttgag agtaaaagag atttttataa tttaaatgcc
    15241 aacgacagga atggcctcat gttttaactt tcaaataata aatggggagt tggtatttgg
    15301 gcagagtttg cattttacta atcctatata ctttgagctt agtttttaga attgtgtcaa
    15361 atacatcaac atatcaggat tatagtgcca aaaatagtta aagtgccttg gtcctccctc
    15421 tgtaggcagc aaattgaaac taacatggga ccatgccatc cttctagcat aatggagaag
    15481 tctgaactga ggagtatctt tgatgaaaga catttaggac cctagaaact aaatcttgtc
    15541 accaagactt tatagtaaag tagtagcaaa attattttta aaagactttc ttccttttac
    15601 tacccatttc ctctcttggg aaagctgatg agcaaattat ccaagactca tttctttatt
    15661 aggcaaagtc agaatatttc ccctctgaaa atctgaatta tgccctcatt ctttttcaag
    15721 aaatatctca aagagcaaat agaattaaac atgacacttg attgtctgat tatttggcat
    15781 gtataaaatt atcatgtggc ttaatgtgcc ttaagtgaaa atttaaactt agacctgaaa
    15841 cctttacagt tggatgtagc gttgagcttt tgcatgtttt ctgtataata aaccactttt
    15901 gttttgtttg ttttgtcttt taacctacac ctttatcatt actctaacag atttagggct
    15961 tctctttctc tacagctaag taagggaata tgtgcaatta tgagacatac aaaaaaggaa
    16021 agggaaagga ctttctaagt agcaaatctg tgccatgaag tagatgtggc gtgaagatac
    16081 agagcctgag gatagtaatt ttccctgagc cacgcacaca ggcttttatt tcatgccttt
    16141 tctctttctg tgccgtcacc tttgagaaaa acgattgcac cttctccaag tctgcctttt
    16201 taacagctac agttaagttg gcaagacttc cccagctctg aatatagcca tttgccgact
    16261 ccggcctctt tgcgagactg actcaaatct gtgatcttct gttcagcata cacatcagca
    16321 aagtgagaag atgagcacta aatataggct ctattaactt tacttttaga tttactgcct
    16381 tcaaaaagtg cctattctga gcaacataaa cgttattcct tacatatgta tgtacacacg
    16441 gtacccagag tcgtactgtg cagccttcaa aaacatacca tcagaaagag taggtgctga
    16501 gataaggaaa ctttgccaaa tgaaagaaag tcactcactt ccaatatccc ctctcaagcg
    16561 gctaccgtga aacgggctgc aaacacattc cctgagcatc ccttgctgat acagcttctt
    16621 tatatttata tcctactgga tggtagcata ttgctaaggt ttcctgtact ctgcttcaag
    16681 ggaatgtaag ctttatggca ttgaaacatt tagggaaaaa aaagatgttt aagagaatta
    16741 atagagccgt agtctgtatt aggatgtgtg tcatatgtgt gttctataaa ctaagcatcg
    16801 gtgggtttag agtgttaaag tgtcagcaca ttccttctcc ttttgtctct caggctaaca
    16861 tgagagaaaa tagaaaagtc ttggctgtgg ggattggaag ctcagggggc caaatgtcct
    16921 tgccagatcc ttagagcatt actttgactc ctaaaaatag tagtgtatgt tatttgatgg
    16981 cttttgtttc catagttcca tcactgacaa aactgtcaat actgttgatg gagcagcagc
    17041 atagcctaga gtgatgcatt cttacccaga ggtggcaata ggagagggtc catgtaaata
    17101 ggacgaggta gacagtgcat gattgtagga gaagggttga agggaggaca tgattccaaa
    17161 aaagatcgtt ctcaatgtgt cgtctgactc aaccagctgg cagattacac ttgccaagtc
    17221 gttccctttc cttctaagtc agttggctcc atattcactt gaatatgcct ctgtttgggc
    17281 aaagcaagat acctccactt aacctttatc caaggaagct cttggtgtcc tcttggtcat
    17341 aaagttgtct cctacctaac ccagttttac caaatggaag taaaagggga caaactatgg
    17401 aagatggact ccatgccatt gcagtcagcc accattctct tttccatata aggagcccca
    17461 ttacataagc tacgggtgag gttggaacag ctatgtttca taatttcaag agtgtgacca
    17521 ccctgctcta gtcatcatca ttggatgaat ccagttgact ctttggcaaa agggtgatac
    17581 ttttcactaa aaatgcctac tcttcctgtt gatgttcctt ttctgttttt accttgtcca
    17641 atttccacac tagtcatttt ttttattttt tagaggatca gattttagcg ctggaaaatg
    17701 agttcaaaaa tttcagtgta atgtcataag gatgttggga tacagagatt ttttttttcc
    17761 ttggaaacaa atggactggg aagaaacaca gcatggcttt gctctgagtt tcaatctgat
    17821 gattatgacc atggaagata gtcttatgta aaggttaaat ggtgtttaca agtggataga
    17881 taaggcggag atggtgagaa gccgggtttt ctctatgcta aatgtgtcta ctaagagcag
    17941 cacttcctac tagctaagca caatcatagc cccaccgtga tgagctgcta gtctgaataa
    18001 cattccctga cttagggaaa ggcacacaaa aacatataaa gaatatgtct attttcatat
    18061 gtgtgatact gacagagcca tggtattcct aaaatatagg tttctctttt ttcttgtatt
    18121 cttagcaaat tgcatttatt cactacatta caaaccatca ctgatgtatc caaaatagca
    18181 cacatagttc agtatgaaaa taagagaata aaatctgtta taagcaagtg atttaggtat
    18241 tttcttttgt gtttatgcat tatctgacta tattaaaacc tgtttttcta tttaccttct
    18301 atcagttttc tctaccaatt atgttttttc aatgctctat aagaatgaat atggaaatta
    18361 tatttctttt ttctgtaaaa gagttgcaac tactttatta tatttagaaa tccaataaac
    18421 ttcttattac attta
//
