LOCUS       NM_001387664           18340 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LIM domain containing preferred translocation partner
            in lipoma (LPP), transcript variant 17, mRNA.
ACCESSION   NM_001387664
VERSION     NM_001387664.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18340)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18340)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 18340)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (bases 1 to 18340)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 18340)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (bases 1 to 18340)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (bases 1 to 18340)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (bases 1 to 18340)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (bases 1 to 18340)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (bases 1 to 18340)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022498.18, AC117507.5,
            AC069226.19, AC063932.14, AC055711.18, AC009319.19 and KF510228.1.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.713039.1,
                                           SRR14038193.1976050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267782, SAMN03465413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC022498.18        60426-60549
            125-243             AC022498.18        114728-114846
            244-300             AC117507.5         127758-127814
            301-502             AC069226.19        127073-127274       c
            503-615             AC069226.19        48682-48794         c
            616-738             AC069226.19        8599-8721           c
            739-1422            AC063932.14        108433-109116       c
            1423-1549           AC063932.14        9884-10010          c
            1550-1719           AC055711.18        41842-42011
            1720-1898           AC055711.18        147929-148107
            1899-2019           AC055711.18        154372-154492
            2020-11760          AC009319.19        3236-12976
            11761-12141         KF510228.1         1-381
            12142-18340         AC009319.19        13359-19557
FEATURES             Location/Qualifiers
     source          1..18340
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     gene            1..18340
                     /gene="LPP"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
     exon            1..124
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            125..243
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            244..300
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            301..502
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..2148
                     /gene="LPP"
                     /note="isoform a is encoded by transcript variant 17; LIM
                     protein; lipoma preferred partner"
                     /codon_start=1
                     /product="lipoma-preferred partner isoform a"
                     /protein_id="NP_001374593.1"
                     /db_xref="CCDS:CCDS3291.1"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
                     /translation="MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKK
                     FAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQ
                     GNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTG
                     HKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSR
                     PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYI
                     PPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTP
                     PGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
                     LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNK
                     LRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRS
                     LDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHC
                     YRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            503..615
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            616..738
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            739..1422
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1549
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1719
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1898
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2019
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..18340
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      18319..18324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPP"
                     /note="hexamer: AATAAA"
     polyA_site      18340
                     /gene="LPP"
                     /note="major polyA site"
ORIGIN      
        1 aaccagcagc cgctccagcc ctgccgaagt ttcacttttt gtctgtgggt tcgttcccgg
       61 gtcccgcgcg agctttcccg ggataagtag ctttagcgat cgggagacag ccgggcgctg
      121 caaggaattg aagagaatcc tgacaagtgg catgttggga aaggcctgaa ggaagccaga
      181 ccagcttgct ctcagagctc cttgggtccc ctgcggcccc caggtgatct tcagcaagac
      241 ctgcattgca gttggctgaa ccttgtgtca accatccatt ccaggagcca gctatctgag
      301 attccaacaa tgtctcaccc atcttggctg ccacccaaaa gcactggtga gcccctcggc
      361 catgtgcctg cacggatgga gaccacccat tcctttggga accccagcat ttcagtgtct
      421 acacaacagc cacccaaaaa gtttgccccg gtagttgctc caaaacctaa gtacaaccca
      481 tacaaacaac ctggaggtga gggtgatttt cttccacccc cacctccacc tctagatgat
      541 tccagtgccc ttccatctat ctctggaaac tttcctcctc caccacctct tgatgaagag
      601 gctttcaaag tacaggggaa tcccggaggc aagacacttg aggagaggcg ctccagcctg
      661 gacgctgaga ttgactcctt gaccagcatc ttggctgacc ttgagtgcag ctccccctat
      721 aagcctcggc ctccacagag ctccactggt tcaacagcct ctcctccagt ttcgacccca
      781 gtcacaggac acaagagaat ggtcatcccg aaccaacccc ctctaacagc aaccaagaag
      841 tctacattga aaccacagcc tgcaccccag gctggaccca tccctgtggc tccaatcgga
      901 acactcaaac cccagcctca gccagtccca gcctcctaca ccacggcctc cacttcttca
      961 aggcctacct ttaatgtgca ggtgaagtca gcccagccca gccctcatta tatggctgcc
     1021 ccttcatcag gacaaattta tggctcaggg ccccagggct ataacactca gccagttcct
     1081 gtctctgggc agtgtccacc tccttcaaca cggggaggca tggattatgc ctacattcca
     1141 ccaccaggac ttcagccgga gcctgggtat gggtatgccc ccaaccaggg acgctattat
     1201 gaaggctact atgcagcagg gccaggctat gggggcagaa atgactctga ccctacctat
     1261 ggtcaacaag gtcacccaaa tacctggaaa cgggaaccag ggtacactcc tcctggagca
     1321 gggaaccaga accctcctgg gatgtatcca gtcactggtc ccaagaagac ctatatcaca
     1381 gatcctgttt cagccccctg tgcgccacca ttgcagccaa agggtggcca ttcagggcaa
     1441 ctggggcctt cgtcagttgc cccttcattc cgcccagagg atgagcttga gcacctgacc
     1501 aaaaagatgc tgtatgacat ggaaaatcca cctgctgacg aatactttgg ccgctgtgct
     1561 cgctgtggag aaaacgtagt tggggaaggt acaggatgca ctgccatgga tcaggtcttc
     1621 cacgtggatt gttttacctg catcatctgc aacaacaagc tccgagggca gccattctat
     1681 gctgtggaaa agaaagcata ctgcgagccc tgctacatta atactctgga gcagtgcaat
     1741 gtgtgttcca agcccatcat ggagcggatt ctccgagcca ccgggaaggc ctatcatcct
     1801 cactgtttca cctgcgtgat gtgccaccgc agcctggatg ggatcccatt cactgtggat
     1861 gctggcgggc tcattcactg cattgaggac ttccacaaga aatttgcccc gcgatgttct
     1921 gtgtgcaagg agcctattat gccagccccg ggccaggagg agactgtccg tattgtggct
     1981 ttggatcgag atttccatgt tcactgctac cgatgcgagg attgcggtgg tctcctgtct
     2041 gaaggagata accaaggctg ctaccccttg gatgggcaca tcctctgcaa gacctgcaac
     2101 tctgcccgca tcagggtgtt gaccgccaag gcgagcactg acctttagat tcagtcacct
     2161 gttcagccgg cactgagaag aacgaacaca agaaaaagat aagaaatact agagtaaagg
     2221 ccatcaaact acgcgatagt ctctgttctt catctgctat taaccttgcc ttagaaacac
     2281 ataaattatg agattttttt taaaagttgt taccaaatac acatttcaca ttgaatcatg
     2341 taggatcttg atgggccttt gttcccaagg acttccacat ttttgcacag attatgctcc
     2401 atcccattca cttctgcatt cctgtaactt ttaatcccta tgtttgtctc acttttcatc
     2461 tggttgaatg gcttttctta gtgtggtatt tgctgtcaca tagtttttcc tgggtgagtc
     2521 tgccaactca caggtgcttt taggcttgaa atctccatcc tatcatttcc gttttgcctg
     2581 tgactgtaaa gagtagccat tcttttccca tgtattgaag aggatattct tctcttgctt
     2641 tatactactc acgtccttgg ggagggaaat gcacaatttt tttttgttag gctgtaaaga
     2701 atttaagctg taaattacat aagttagaac aagcccaaat ttaatttgca accatcagaa
     2761 ttcagaatct atagtgacca gtgatcaagg ctaattggaa aagagttatc ggcccatagc
     2821 taataagtag tgacagacaa ccaagcttca atatttttct aaagaaatta caggtgggat
     2881 atgctagaaa aggcattttg gggttatgtt taaaaaaaca ttattgtccc acaatattac
     2941 cttaagattt ttcttttccg cactacctga acattgtaat acagacaaac ttgatttctt
     3001 ctagaagata acattttcaa tactgtccca cttctcatct taaaaatatt gtcatgttta
     3061 ttctaatatc caacacaact atcaaaattg cctttttctc tagaggatga aggctgtgaa
     3121 aaaaccgttc aaattctctt ctttttcttt tttattacca ggtccatttt gcctgacaat
     3181 tgcaaatcag agcatacaaa ataaaactgt gcagttttgt ttggtttact ttcaaaagag
     3241 tagaaagctt gaaaagattc tgaaaccaca gtttcattat tctcataatc cttctgcaac
     3301 tgaaattaca tattgcagga gacattttca tatcatcaat gtgacattta caccacactt
     3361 tcaaagacaa tcactgaaac aaaaattgtc tttatgagct aaaaatatgc agaatctctg
     3421 cctagaatct ttattcaaac ttttattagc cagtgaaaca cttgcttgcc aactgccaag
     3481 ccatacttat taagttcgaa catgtttcac ttaaggagag acacctagct tagtcatggc
     3541 aagttgccat tttgtaaact aaggattttg gactgagatt tcttaaatct ttcttcaaat
     3601 ctcccacaag tatatacttt taaattatgg agtattttaa gtctacaaaa aggtataaat
     3661 aataatataa tgaattccta tatacctaat acccagttta agacaccaaa tataacaagt
     3721 ataattacat cctccaatgt accgtttcct tattccacag atatcttttt cattattgtg
     3781 aagtgatgtt cagatttcta gttttttttc tagtttttaa ttttaacatc agaactgaaa
     3841 taaaaaatta tggatacgtg ttttgaattg caaactattc ctcaggaatt ccaattaaat
     3901 ttattttact tgaataggaa tgatcataaa agtgattctt tttttgtgac tagaaattct
     3961 taagccgatg gtcactatag ctcatcctta atgtatggct catttgcttt tgtcactaaa
     4021 cggttttgtg ttagaaccac caaaattata gcttttaaga gcttcctttg accactgtct
     4081 ttttcttacc ctagttctct tatctttgat cgtatatttc tcataatgtg aaatatgatg
     4141 agattcactt aggggcagca tgttagtttt gggaggcaat gtcaactgtg tctctgaatt
     4201 cctgtcttcc aaattgaagc cagaccatgc tgatgacctc aagtagcact gactatttga
     4261 caatagggct gataatgtaa tcggcttgaa ttttgactta gtaacttttt atgtaatact
     4321 ttcggagaaa ttctctttag gacaaagcag agagtccaat ttattgaggg atagattgta
     4381 tctcttaaag tggtcatatt attattaatt ttgccaaaag aagaagaatt tattgaatat
     4441 ttatactata aaatgcagta acattctact tgcttattac atttaaatcc ttgtgtaact
     4501 gaatgtttac atgtcaagag gaaaagctgt aagaaaatgc tgtcacagac ccatccctgt
     4561 ggcatcgtca gcagaatact gcttgcttac aatctttatt atgcattctt ataacataac
     4621 ctcagagtat ctttaccaaa ggtttttaaa gtaaatctct ttttaagata gacttattct
     4681 tttataataa tgaatgtgca ctcatacata tgtagaaaca tttagattta gagttttttt
     4741 tttctttcac aaggtataat aaggaaagga tcctacaata ttttattcta gggtttctta
     4801 aatatatgat ttatattact gtcttttcta ttaatcattt gatttaaaca atgccaagtc
     4861 actctttttt agttgcatga aattttgcct gcaacagaga gaaaaagatt gtattacttt
     4921 aatgattata atcatactgt ctgctgatat aatatcataa ttgttgtggt ttaaatacat
     4981 aaatagtaga aaaatcagag tctataacag aaagtttgta aaaatatact gattttgaaa
     5041 agtatcagga atataaatat ttggtaattc tgtgtaacaa gagagacatg gaaaaggaaa
     5101 aaaatccact atatcatggg ctctgcagaa catatcaaaa taggatttct taaatttttc
     5161 aacccccaga ccatactgac tcaacatgga gtctcactgg ccaagaaaat tgcctttaaa
     5221 actcgaaaat aaggccaggt gtggtgactc acacttgtaa tcccagcaat ttgggaggct
     5281 gagacaggag gattgcctga ggccaggagt ttgacaccag cctgggcaac atagtgagac
     5341 cttgtctcta caaaaaataa aataaaataa aaaccaaatt agccagacat ggtggcatgc
     5401 gcttgtttaa aaaaacaaat aaataaataa tcgactcaaa aataagtcat gtgtcccagc
     5461 ataaggcatc aggttgttag atgctggcat ctctgcagct caaagatgtg ggttcttttt
     5521 cttgtcatta acacattgtt atttctgtag gagcaacttc tctgatcaaa attacttttc
     5581 tgggtatgtg ctgattaagg gggtggactt atcaacacta taattgttcc ctatgaaaga
     5641 ttccacagag atgtttatgg tgaggtttaa aggatatgaa actctacatt taaacaagta
     5701 ttttatattt gggtacagag gaagaaagag agggcttttt ccatggggct atagtagaga
     5761 gttagtggaa tatagacagg actctgaaaa cacaacttcc agccattttt ttagttagta
     5821 aaaatcctat taatgtgaac cagccaggaa taacagtgtt atttctattg gatatggttt
     5881 gggcttctct tgtcaaatct gtgtcggctg ccccctgatc cttccattat caagttttga
     5941 agggtgttgg ggaaattatg gcagctgcta gggagatcag ggaaacactg atgtaacctc
     6001 aaagcctctc accattcctc ttggcttgga aaggctttat tttttcatat acatttctag
     6061 aaatattgct attctacctt agtatttcac atttgtagtt caaacaagcg attgtccatc
     6121 tgttgcctag agctatagta catgtgtgtt atgaatgaaa tatgacagca tgttccatac
     6181 ccctgcttta gccatctgtg ggaaaccagc aaactgaaaa agacacctct gcaaaatgtg
     6241 cctcaagtcc atttcttggg atcgctcgtt tggtgcactc tcgtgggaga caatcagaga
     6301 acaacatata cttgtgcctt attttcaaag aatctattta cactactatg aatattccac
     6361 tgaagagtca atgatgtaaa tgataaccac caaatctcaa aaatatactc accaaaaagt
     6421 aaaaaagtaa aaaaaaaaaa aaaagaaaga aagaaaagaa agagagagaa gtcaactttt
     6481 catcttaata tattctagta gtatttattt tttccttgtc ttggaagtat ctcataggtc
     6541 tttaaatgag taaaacattt ttatgccaga aggtgatata atggatgtta gtgtttttta
     6601 tttgatttta cagtagtttt agtcagataa tgaggacaga gacttcaact tgattcttta
     6661 ccaccattca gcatattttt taattgtctt cattgtattt gcttaatagt ggtccagaca
     6721 agttcaaaac ttgttctcag tgaggcatta atatggtgca accatgaata tttcaggcca
     6781 agttattcac ttgacagata actagaatga aacttttctc atgaggctgt tgtttggtta
     6841 gcatagcctt atttcaaacc ttaaaaagtt acctgactga agctactatg acttggtaag
     6901 gattcttcct ctcttgcttt cttcctccct tcctttcttc ctcttccttc ctcctcttct
     6961 tattttcttt cctactttcc atcctaccta ttagtgttgc tgtacttgga ttttttgtaa
     7021 attaaatcaa tgcattatga ttttagggaa ttatgattat attcataagg ggaaggctac
     7081 cagaaaatat atgtggcatc cataaaatct tcttttatag gggcatattt tttaggttgt
     7141 atttattcgt aaagtgaaat gagataatag agtctttctg tttcatgtta atgaattttc
     7201 atcagggact gaggtcatag attcttggaa aattcatttg tgactgatct agttttctca
     7261 gctgtatgca aagtaatctt tcaaagacta ggttaagatt ttttttttaa gtctgaagca
     7321 atgtaacccc aaaaaattat aattttaatg atggcatttt attttattcc attgcagctt
     7381 gataactttc cttatagcaa aggaataact attgtatttt cagaatttta acacagatta
     7441 acacttagcc tgtaagacta ataatatatt gtaatagttg atactaaaat atttttcagc
     7501 aggttggaca gcaccagttt ttcttagatc acagactaca ggcagaattt cccttcaatc
     7561 cagaaaaaag gacactaatt tccttttcta tttaattttc ctggcccttg tgcaaaaaat
     7621 tgtggactct atcttagtta caacatgcat gtcccttatt ttgtggagag ctgtgtgaaa
     7681 gatgcgtttt ttttcttttt ttcttttttt tttttttgag acggagtctg gctctgtcac
     7741 ccaggctgga gtgcaatggc acgatctcct ctcactgcaa gctccgcctc ccaggttcac
     7801 gccattctcc tgtctcagcc tcccgagtag ctgggactac aggcgcctgc caccacgccc
     7861 ggctaatttt tttgtatttt tagtagagat ggagtttcac agtgttagcc aggatggcct
     7921 cgatctcctg acctcgtgat ccacccgcct cggcctccca aagtgctggg attacaggcg
     7981 tgagccaccg tgccccgcgt gtttttttct ttagctgatt gacaggtccc cttcaaagtt
     8041 acaaaaaaaa gtgctaattt ttgctgttaa attctggttg ttatttaatt gacagaagtc
     8101 tcttgatgca cgaataaata tctctacatc tagcctttgt taaaaataaa aattaatatt
     8161 ctacaaacac ctacatatac tagagagggg tgaaacactg cagctaattc ctttataata
     8221 ctttcagatg attgcattaa gcctttcatg ttatgtggca ttgttaattt ttcctagata
     8281 cccatccact taagggccag agaaatcctt attcatttaa ctctggtggg catttatgta
     8341 acatacccaa ataaaaacgt tattaaacag ccacaatcgc attcagtcaa cttggcactg
     8401 aatgtagctt ctaaaatcag ttctctaccc tacgaatgga atgttctacc aagaaagaga
     8461 agcatcacca tgtcatcttg tgttctacac cactatagag agttacagtt gcccccaaac
     8521 acgaatgcta ttcccaaata aaatagaatc atgctttggg aggccaaggc gggccgatca
     8581 cgaggtcagg agatcgagac catcctggct aacacggtga aaccccgtct ctactaaaaa
     8641 aaaaaaaaaa tacaaaaaat tagcctggct cagtggcggg cgcctgtagt cccagctact
     8701 caggaggctg aggcaggaga atggcgtgaa cccgggaagc ggagctttca gtgagccgag
     8761 atagcgccac tgcagtccgg cctgggcgaa agagcgagac tccgtctcaa aaaaaaaaaa
     8821 aaaaaaatag gatcatggcc cttttaaaga tctgaatctt ctctgttatt ttcctgatga
     8881 atcaccatcc catatcttct tagtcctggc cagtatgtag ttgcgctcac atacgtctat
     8941 tctagctctg tagctccaca aaacaagtct taagtccaaa tctttgcctc ttcatgtctg
     9001 atatcaccaa ctcattcagc ttttcttcac ttattgacat agtgtcatgt cctatcactc
     9061 tctgctgctt ctttaaacag tggacacaaa catattttct aattttcagt gtactcagtg
     9121 aaacttggca gttcaccatg agtcaggcta ggttgaaagg ctttctttag ggttgaaagt
     9181 aaacgaaatt ggaatcaccc aaagagaatt tccccaaaaa acctcagacc cagaagtgta
     9241 aaagctacag aaggatagaa ctcccatgtc tacagacagt tctgttactt tttgttctgt
     9301 actattttgg atgttgccaa aatcaaattc atcctgaaaa caggaagcaa gctaatgcat
     9361 atgccatcca tgagattccc acttctgggt cagttcatat tccattcaac cttttccttt
     9421 tatccttgtc ttcttcagaa taagacattt ttcctccata ttttcatatt aaatattaac
     9481 actttatagg ttctacttta atatatggac actttacagg ttatacataa atatttgctg
     9541 gttgattgat ttcgagattc attcattctg tgctcaaata tttgtaccta gagacgttac
     9601 atgttagaaa aagtgagcag cttctttctc taatcattta ggagtccata tttttctttt
     9661 ctttttgttc tcccaacatc cttatctctt actcagctct tcaatttata attaccaaat
     9721 aatcactgtt agagaatcag cccctaagta actttgattc tggccaactg taataagatc
     9781 caaccactta aatctgtact tactcaatag gaaggaatgt gacatcagga agagtcattc
     9841 cagtgacatt agtaagactt tatggagtac ataaaatttg ataagaaatc ttgagctgat
     9901 tctttgactt gatttagaag ttgagaaaag agtatttaag gcacaacagg gaaacatggg
     9961 ctatactcag agaagaccct ctgcattggc caaaatatca tggattctgg aaattccttc
    10021 ttaacagaaa aaaaaggctt ccaaataatc aggctgaatg ggaagaaaaa ggcatagagg
    10081 aagcctgagg aagtatttac ttgcttttcc catctcttta taattggaag agaagatgat
    10141 ctgccaaaat ataacccagc atgcacagta tggacaggaa gcagccctcc atgaacttta
    10201 ttatcacaga atatgagcat tcttattgat ccacagctac atcttctatt cttgcagcaa
    10261 gggtacatgt cctttgaccc tccacaaaag aacaagcagg acatctctat tttcctattg
    10321 agtctgagtc cattattaga aaggacttcc cagccatctt ttctacttgg tattaaaatt
    10381 cccttacaga ttcattgcta agtgccaatt cttttttttt cttttgagac ggagtcttgc
    10441 tctgtcgccc aggctggagt gcagtggcgc aatctcggct cactgcaagc tccgcttctc
    10501 gggttcacgc cattctcctg cctcagcctc ccgagtagct gggactacag acgcccgcca
    10561 ccgcgcccag ctaatttttt ttgtactttt agtagagacg gggtttcacc gtggtctcga
    10621 tctcctgacc tcgtgatccg cccgcctcgg cctcccaaag tgccaattct gactctactt
    10681 aaacatcacc tgtatcaggg agctcattat tccttgaggt cttacatttc tttcagcaca
    10741 ttttgttcca agctacacga ctttaaaaca gagccagcct ttggggcata tgttctcttt
    10801 ggtgccacac aaaacctgta gtacatgata cagtgttgct tcccccctcc ttttccttcc
    10861 atatatattt gttttgtttt gggcattgca ttactttttt gaatttttaa gaatctctaa
    10921 aattagtctg aaggatgttc tgagggccag acattagaat ttgtgagttt ttttgttgct
    10981 ggttgtactt tcctatttag aagacagacc gttctgacag ttgttgtgta gcttcatgcc
    11041 ttccccagta actaacccat gaacagtaca ccccttttat ctgacttgtt gataatgacc
    11101 ttaaaaatgt taggaaatgg gccgggcgcg gtggctcgtg cctgtaatcc agcactttgg
    11161 gaggccgagg cgagcggatc atgaggtcaa gagatcgaga ccatcctggt caacatggtg
    11221 aaaccccgac tctactaaaa aaaatacaaa aattagccgg gcgtgttggc gggcgcctgt
    11281 agtcccaact acttgggagg ctgaggcagg agaatcacct gaacccagga ggcagaggtt
    11341 gcagtgagca gagattgcgc cactgcactc cagcctgggc gacagaacga gactccgtct
    11401 caaaaaaaaa aaaaaaaaaa aaaggttggg aaatattggt gtataatccc catgtctaac
    11461 aaggaagaag tcaaaagcaa aagatagtgg tattgccgaa aactcattat ttctagttag
    11521 ttcatctgtg gaaaaggata tcgttcttga ggagaggggt tctattatgc tatagttttc
    11581 tatggaaatg tacaaatgct ttcctcattg ctctggatga ctatttagtt taaataatat
    11641 acctttgtca tggggaagac catgattgtg gcttcttcta ccccaacttt gaatgagaga
    11701 gcactgtaag cagaaactgc catcagtctc ctgggcagga cctggaggta actttctgag
    11761 ctgtaaaata gtaattccta agagagctta caaactgctt ccacacagaa aatagcgcag
    11821 ggaggacagt tattagtacc cctattctag aagagaaagc tgaggctcaa gccattaagt
    11881 gacttgccaa aagctgtgac atagctggga agtggcagat ttggggatat aaccaggtct
    11941 tgcaagtcca gtgctgtctc caagtagcca cgctcacagc tgagaacacc ttagaggaca
    12001 atatcgactt cttacagact accaagcccc cagtcatcca gggaaattca gagaccaatt
    12061 gactgccagg tggcaaatcc acatgtgtac tgcggtcttt agagatcatt tagagcttgc
    12121 acacatctgt gtcttcttgt gggaaacctc taggtattct gtctgatcag cactgtgagg
    12181 aagttggtgg gaaaaggcca ctgataagaa caaacaatgg gcagaaggaa gcacattgca
    12241 ataaatttcc ccagagagag ttcctttaca ttccattcac caaaaacctc tctggaactg
    12301 tcaggttcag aatatcaacc aagaccatat catttagaat tcattggcat gtagaggtga
    12361 ctcgattcct aaaagaagcc tctctcccat gaaccacgat gtacgttcca cagaggcaga
    12421 aaccgccgta ggttagcaat gcattttagt ctttctctcc attcacattt actgagagca
    12481 caccacgtgc atgttgctgc aacaggcatt tccgatagag ccgatccatg agctaacaat
    12541 gtctgaaaac aaatgttatg gaactgttgg catttctgag atttggcctt tgccatttga
    12601 tagactttgc ttcccaggat gctgtcattt tgtgattttt tataattaca aggaatttgg
    12661 taccatgttg ttttcaaaaa acctcctaga aagtctccat gtatgctcta gaagttgctc
    12721 tacgtaacag ttcagcaagc aagtgttcct tctcttgagc tgcgtccctc aggaagctgt
    12781 acctttaggg tgtgctttcc actttttatt tcctctcatt tcactccttt cattgtttgc
    12841 tatatcctaa aatatgtgaa gtgagagaaa aaatatcatt tcttctcatt aaatctcctg
    12901 cattaaatct aagaatcctt taaaataatc acacctgata agtgttttat gcatttccct
    12961 ccctggagtg ttatcatcca tcaagccagt atcatcatcc acctgcttat tccttgggac
    13021 taatgagagc caagttaaat agcaaatgac ttctcacccc ttcctagtcc tcatgcctga
    13081 ggaataaggg cgacattaat gggagcggga gagtggtggc tttggttgag atgcacgttc
    13141 acagactaga aaagtgcctc acctccatgg tgtatatgtg ccaccttttc ttaatccagt
    13201 ctatcattgt tggacatttg ggttggttcc aagtctttgc tattgtgaat agtgccgcaa
    13261 taaacataag tgtgcatgtg tctttatagc agcatgattt ataatccttt gggtatatac
    13321 ccagtaatgg gatggctggg tcaaatggta tttctagttc tagatccctg aggaatctcc
    13381 acactgactt ccacaatggt tgaactagtt cacagtccca ccaacagtgt aaaagtgttc
    13441 ttatttctcc acatcctctc cagcacctgt tgtttcctga ctttttaatg attgccattc
    13501 taactggtgt gagatggtat ctcatagtgg ttttgatttg catttctctg atggccagtg
    13561 atggtgagca ttttttcatg tgtttcttgg ctgcataaat gtcttctttt gagaagtgtc
    13621 tgttcaatac tatgcagcca taaaaaatga tgagttcatg tcctttgtag ggacatggat
    13681 gaaattggaa atcatcattc tcagtaaact atctcaagga caaaaaacca aacaccacat
    13741 gttctcactc acaggtggga attgaacaat gagaacacat ggacacagga aggggaacat
    13801 cacactctgg ggactgttgt ggggtggagg gaggagggag ggatagcatt aggagatata
    13861 cctaatgcta aatgacgagt taatgggtgc agcacaccag catggcacat gtatacatat
    13921 gtaactaacc tgcacattgt gcacatgtac cctaaaactt aaagtataat aataatgaaa
    13981 taaaattaaa aaaaaaaaag aaaagtgcct cacctccctg tgaggcttga tgaatattgt
    14041 ggccagtgag tggaaaatga ttcttgtcga atagacagag tattcccacc ccaggaatgg
    14101 attaatagaa gacacaattt gagcacttct cagaattatc tagtatgcct gagtagagac
    14161 tcacatgggt ggaatctgtg ttgtctcatc agagggaata aaaagacaat gaggtggtaa
    14221 atgtgaaaaa agcagccttt tagaaaaaca ttattttcaa atacctttat aaatcatcta
    14281 atttatcttc acataatata aagaaaaaac taataaaaat tttcgtattt cactttacat
    14341 aatatgttct cccatattta gggatcatac aattgtattg tcttcaaaac acacacacac
    14401 acacatacac acacacacac acacacacac acaccccttc caagaaagct gatccttcag
    14461 aaaataaatc ttatttttaa gcacttgggt tttcaggcca gaaaattaat aaatcctaaa
    14521 cctgacccat ttttgtaaca gctaaaaagg agaagaaaaa gctagttaaa ttttgtgtgg
    14581 atccatttat ctcttaaaat atgccaaagc aatttgaggt gggggtggaa acaggtattt
    14641 atctctcatg cgtgattctc tctttatatt tctatctgtt gggaaaaggg taaagaacta
    14701 ttcttggtca ttattgatgt attgtgttgc cactttgtat ggtgcctgct gtgctttatc
    14761 ccgaggcata gcagtaatcg ttactatctt gactctttcc ttcatcacaa gagagtaaat
    14821 atgaagtctg aatgtcgttc ctcaccccca aattgtttaa ctctgcttcc aaactagttt
    14881 aagaaatgca aaatgggaag agctagcttt tcttagatac atttcttcct tttttattct
    14941 ttcttgggag acgttaagta taaaagggaa aaagtcagtt ccttcttctc tctctttctc
    15001 tttgggtgac agcaatgctc acttagtaat tataaactgg aaataggaga gtagcttgag
    15061 caggttatga tatatctgcc caatgtgttt cattccttca aacataaact ttgagagtaa
    15121 aagagatttt tataatttaa atgccaacga caggaatggc ctcatgtttt aactttcaaa
    15181 taataaatgg ggagttggta tttgggcaga gtttgcattt tactaatcct atatactttg
    15241 agcttagttt ttagaattgt gtcaaataca tcaacatatc aggattatag tgccaaaaat
    15301 agttaaagtg ccttggtcct ccctctgtag gcagcaaatt gaaactaaca tgggaccatg
    15361 ccatccttct agcataatgg agaagtctga actgaggagt atctttgatg aaagacattt
    15421 aggaccctag aaactaaatc ttgtcaccaa gactttatag taaagtagta gcaaaattat
    15481 ttttaaaaga ctttcttcct tttactaccc atttcctctc ttgggaaagc tgatgagcaa
    15541 attatccaag actcatttct ttattaggca aagtcagaat atttcccctc tgaaaatctg
    15601 aattatgccc tcattctttt tcaagaaata tctcaaagag caaatagaat taaacatgac
    15661 acttgattgt ctgattattt ggcatgtata aaattatcat gtggcttaat gtgccttaag
    15721 tgaaaattta aacttagacc tgaaaccttt acagttggat gtagcgttga gcttttgcat
    15781 gttttctgta taataaacca cttttgtttt gtttgttttg tcttttaacc tacaccttta
    15841 tcattactct aacagattta gggcttctct ttctctacag ctaagtaagg gaatatgtgc
    15901 aattatgaga catacaaaaa aggaaaggga aaggactttc taagtagcaa atctgtgcca
    15961 tgaagtagat gtggcgtgaa gatacagagc ctgaggatag taattttccc tgagccacgc
    16021 acacaggctt ttatttcatg ccttttctct ttctgtgccg tcacctttga gaaaaacgat
    16081 tgcaccttct ccaagtctgc ctttttaaca gctacagtta agttggcaag acttccccag
    16141 ctctgaatat agccatttgc cgactccggc ctctttgcga gactgactca aatctgtgat
    16201 cttctgttca gcatacacat cagcaaagtg agaagatgag cactaaatat aggctctatt
    16261 aactttactt ttagatttac tgccttcaaa aagtgcctat tctgagcaac ataaacgtta
    16321 ttccttacat atgtatgtac acacggtacc cagagtcgta ctgtgcagcc ttcaaaaaca
    16381 taccatcaga aagagtaggt gctgagataa ggaaactttg ccaaatgaaa gaaagtcact
    16441 cacttccaat atcccctctc aagcggctac cgtgaaacgg gctgcaaaca cattccctga
    16501 gcatcccttg ctgatacagc ttctttatat ttatatccta ctggatggta gcatattgct
    16561 aaggtttcct gtactctgct tcaagggaat gtaagcttta tggcattgaa acatttaggg
    16621 aaaaaaaaga tgtttaagag aattaataga gccgtagtct gtattaggat gtgtgtcata
    16681 tgtgtgttct ataaactaag catcggtggg tttagagtgt taaagtgtca gcacattcct
    16741 tctccttttg tctctcaggc taacatgaga gaaaatagaa aagtcttggc tgtggggatt
    16801 ggaagctcag ggggccaaat gtccttgcca gatccttaga gcattacttt gactcctaaa
    16861 aatagtagtg tatgttattt gatggctttt gtttccatag ttccatcact gacaaaactg
    16921 tcaatactgt tgatggagca gcagcatagc ctagagtgat gcattcttac ccagaggtgg
    16981 caataggaga gggtccatgt aaataggacg aggtagacag tgcatgattg taggagaagg
    17041 gttgaaggga ggacatgatt ccaaaaaaga tcgttctcaa tgtgtcgtct gactcaacca
    17101 gctggcagat tacacttgcc aagtcgttcc ctttccttct aagtcagttg gctccatatt
    17161 cacttgaata tgcctctgtt tgggcaaagc aagatacctc cacttaacct ttatccaagg
    17221 aagctcttgg tgtcctcttg gtcataaagt tgtctcctac ctaacccagt tttaccaaat
    17281 ggaagtaaaa ggggacaaac tatggaagat ggactccatg ccattgcagt cagccaccat
    17341 tctcttttcc atataaggag ccccattaca taagctacgg gtgaggttgg aacagctatg
    17401 tttcataatt tcaagagtgt gaccaccctg ctctagtcat catcattgga tgaatccagt
    17461 tgactctttg gcaaaagggt gatacttttc actaaaaatg cctactcttc ctgttgatgt
    17521 tccttttctg tttttacctt gtccaatttc cacactagtc atttttttta ttttttagag
    17581 gatcagattt tagcgctgga aaatgagttc aaaaatttca gtgtaatgtc ataaggatgt
    17641 tgggatacag agattttttt tttccttgga aacaaatgga ctgggaagaa acacagcatg
    17701 gctttgctct gagtttcaat ctgatgatta tgaccatgga agatagtctt atgtaaaggt
    17761 taaatggtgt ttacaagtgg atagataagg cggagatggt gagaagccgg gttttctcta
    17821 tgctaaatgt gtctactaag agcagcactt cctactagct aagcacaatc atagccccac
    17881 cgtgatgagc tgctagtctg aataacattc cctgacttag ggaaaggcac acaaaaacat
    17941 ataaagaata tgtctatttt catatgtgtg atactgacag agccatggta ttcctaaaat
    18001 ataggtttct cttttttctt gtattcttag caaattgcat ttattcacta cattacaaac
    18061 catcactgat gtatccaaaa tagcacacat agttcagtat gaaaataaga gaataaaatc
    18121 tgttataagc aagtgattta ggtattttct tttgtgttta tgcattatct gactatatta
    18181 aaacctgttt ttctatttac cttctatcag ttttctctac caattatgtt ttttcaatgc
    18241 tctataagaa tgaatatgga aattatattt cttttttctg taaaagagtt gcaactactt
    18301 tattatattt agaaatccaa taaacttctt attacattta
//
