LOCUS       NM_001387663           18193 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LIM domain containing preferred translocation partner
            in lipoma (LPP), transcript variant 16, mRNA.
ACCESSION   NM_001387663
VERSION     NM_001387663.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18193)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18193)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 18193)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (bases 1 to 18193)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 18193)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (bases 1 to 18193)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (bases 1 to 18193)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (bases 1 to 18193)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (bases 1 to 18193)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (bases 1 to 18193)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022498.18, AC117507.5,
            AC069226.19, AC063932.14, AC055711.18, AC009319.19 and KF510228.1.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3200258.1,
                                           SRR14372080.4402141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC022498.18        60685-60780
            97-153              AC117507.5         127758-127814
            154-355             AC069226.19        127073-127274       c
            356-468             AC069226.19        48682-48794         c
            469-591             AC069226.19        8599-8721           c
            592-1275            AC063932.14        108433-109116       c
            1276-1402           AC063932.14        9884-10010          c
            1403-1572           AC055711.18        41842-42011
            1573-1751           AC055711.18        147929-148107
            1752-1872           AC055711.18        154372-154492
            1873-11613          AC009319.19        3236-12976
            11614-11994         KF510228.1         1-381
            11995-18193         AC009319.19        13359-19557
FEATURES             Location/Qualifiers
     source          1..18193
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     gene            1..18193
                     /gene="LPP"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
     exon            1..96
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            97..153
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            154..355
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2001
                     /gene="LPP"
                     /note="isoform a is encoded by transcript variant 16; LIM
                     protein; lipoma preferred partner"
                     /codon_start=1
                     /product="lipoma-preferred partner isoform a"
                     /protein_id="NP_001374592.1"
                     /db_xref="CCDS:CCDS3291.1"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
                     /translation="MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKK
                     FAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQ
                     GNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTG
                     HKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSR
                     PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYI
                     PPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTP
                     PGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
                     LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNK
                     LRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRS
                     LDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHC
                     YRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            356..468
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            469..591
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            592..1275
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1402
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1572
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1751
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1872
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..18193
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      18172..18177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPP"
                     /note="hexamer: AATAAA"
     polyA_site      18193
                     /gene="LPP"
                     /note="major polyA site"
ORIGIN      
        1 acctcctcct ctgcctctgc ctccgcctcc agccgccgcc gccgccgccg ccgccgccac
       61 caccaccgcc gctgccccgg ctgcctcctc cctgagcatt gcagttggct gaaccttgtg
      121 tcaaccatcc attccaggag ccagctatct gagattccaa caatgtctca cccatcttgg
      181 ctgccaccca aaagcactgg tgagcccctc ggccatgtgc ctgcacggat ggagaccacc
      241 cattcctttg ggaaccccag catttcagtg tctacacaac agccacccaa aaagtttgcc
      301 ccggtagttg ctccaaaacc taagtacaac ccatacaaac aacctggagg tgagggtgat
      361 tttcttccac ccccacctcc acctctagat gattccagtg cccttccatc tatctctgga
      421 aactttcctc ctccaccacc tcttgatgaa gaggctttca aagtacaggg gaatcccgga
      481 ggcaagacac ttgaggagag gcgctccagc ctggacgctg agattgactc cttgaccagc
      541 atcttggctg accttgagtg cagctccccc tataagcctc ggcctccaca gagctccact
      601 ggttcaacag cctctcctcc agtttcgacc ccagtcacag gacacaagag aatggtcatc
      661 ccgaaccaac cccctctaac agcaaccaag aagtctacat tgaaaccaca gcctgcaccc
      721 caggctggac ccatccctgt ggctccaatc ggaacactca aaccccagcc tcagccagtc
      781 ccagcctcct acaccacggc ctccacttct tcaaggccta cctttaatgt gcaggtgaag
      841 tcagcccagc ccagccctca ttatatggct gccccttcat caggacaaat ttatggctca
      901 gggccccagg gctataacac tcagccagtt cctgtctctg ggcagtgtcc acctccttca
      961 acacggggag gcatggatta tgcctacatt ccaccaccag gacttcagcc ggagcctggg
     1021 tatgggtatg cccccaacca gggacgctat tatgaaggct actatgcagc agggccaggc
     1081 tatgggggca gaaatgactc tgaccctacc tatggtcaac aaggtcaccc aaatacctgg
     1141 aaacgggaac cagggtacac tcctcctgga gcagggaacc agaaccctcc tgggatgtat
     1201 ccagtcactg gtcccaagaa gacctatatc acagatcctg tttcagcccc ctgtgcgcca
     1261 ccattgcagc caaagggtgg ccattcaggg caactggggc cttcgtcagt tgccccttca
     1321 ttccgcccag aggatgagct tgagcacctg accaaaaaga tgctgtatga catggaaaat
     1381 ccacctgctg acgaatactt tggccgctgt gctcgctgtg gagaaaacgt agttggggaa
     1441 ggtacaggat gcactgccat ggatcaggtc ttccacgtgg attgttttac ctgcatcatc
     1501 tgcaacaaca agctccgagg gcagccattc tatgctgtgg aaaagaaagc atactgcgag
     1561 ccctgctaca ttaatactct ggagcagtgc aatgtgtgtt ccaagcccat catggagcgg
     1621 attctccgag ccaccgggaa ggcctatcat cctcactgtt tcacctgcgt gatgtgccac
     1681 cgcagcctgg atgggatccc attcactgtg gatgctggcg ggctcattca ctgcattgag
     1741 gacttccaca agaaatttgc cccgcgatgt tctgtgtgca aggagcctat tatgccagcc
     1801 ccgggccagg aggagactgt ccgtattgtg gctttggatc gagatttcca tgttcactgc
     1861 taccgatgcg aggattgcgg tggtctcctg tctgaaggag ataaccaagg ctgctacccc
     1921 ttggatgggc acatcctctg caagacctgc aactctgccc gcatcagggt gttgaccgcc
     1981 aaggcgagca ctgaccttta gattcagtca cctgttcagc cggcactgag aagaacgaac
     2041 acaagaaaaa gataagaaat actagagtaa aggccatcaa actacgcgat agtctctgtt
     2101 cttcatctgc tattaacctt gccttagaaa cacataaatt atgagatttt ttttaaaagt
     2161 tgttaccaaa tacacatttc acattgaatc atgtaggatc ttgatgggcc tttgttccca
     2221 aggacttcca catttttgca cagattatgc tccatcccat tcacttctgc attcctgtaa
     2281 cttttaatcc ctatgtttgt ctcacttttc atctggttga atggcttttc ttagtgtggt
     2341 atttgctgtc acatagtttt tcctgggtga gtctgccaac tcacaggtgc ttttaggctt
     2401 gaaatctcca tcctatcatt tccgttttgc ctgtgactgt aaagagtagc cattcttttc
     2461 ccatgtattg aagaggatat tcttctcttg ctttatacta ctcacgtcct tggggaggga
     2521 aatgcacaat ttttttttgt taggctgtaa agaatttaag ctgtaaatta cataagttag
     2581 aacaagccca aatttaattt gcaaccatca gaattcagaa tctatagtga ccagtgatca
     2641 aggctaattg gaaaagagtt atcggcccat agctaataag tagtgacaga caaccaagct
     2701 tcaatatttt tctaaagaaa ttacaggtgg gatatgctag aaaaggcatt ttggggttat
     2761 gtttaaaaaa acattattgt cccacaatat taccttaaga tttttctttt ccgcactacc
     2821 tgaacattgt aatacagaca aacttgattt cttctagaag ataacatttt caatactgtc
     2881 ccacttctca tcttaaaaat attgtcatgt ttattctaat atccaacaca actatcaaaa
     2941 ttgccttttt ctctagagga tgaaggctgt gaaaaaaccg ttcaaattct cttctttttc
     3001 ttttttatta ccaggtccat tttgcctgac aattgcaaat cagagcatac aaaataaaac
     3061 tgtgcagttt tgtttggttt actttcaaaa gagtagaaag cttgaaaaga ttctgaaacc
     3121 acagtttcat tattctcata atccttctgc aactgaaatt acatattgca ggagacattt
     3181 tcatatcatc aatgtgacat ttacaccaca ctttcaaaga caatcactga aacaaaaatt
     3241 gtctttatga gctaaaaata tgcagaatct ctgcctagaa tctttattca aacttttatt
     3301 agccagtgaa acacttgctt gccaactgcc aagccatact tattaagttc gaacatgttt
     3361 cacttaagga gagacaccta gcttagtcat ggcaagttgc cattttgtaa actaaggatt
     3421 ttggactgag atttcttaaa tctttcttca aatctcccac aagtatatac ttttaaatta
     3481 tggagtattt taagtctaca aaaaggtata aataataata taatgaattc ctatatacct
     3541 aatacccagt ttaagacacc aaatataaca agtataatta catcctccaa tgtaccgttt
     3601 ccttattcca cagatatctt tttcattatt gtgaagtgat gttcagattt ctagtttttt
     3661 ttctagtttt taattttaac atcagaactg aaataaaaaa ttatggatac gtgttttgaa
     3721 ttgcaaacta ttcctcagga attccaatta aatttatttt acttgaatag gaatgatcat
     3781 aaaagtgatt ctttttttgt gactagaaat tcttaagccg atggtcacta tagctcatcc
     3841 ttaatgtatg gctcatttgc ttttgtcact aaacggtttt gtgttagaac caccaaaatt
     3901 atagctttta agagcttcct ttgaccactg tctttttctt accctagttc tcttatcttt
     3961 gatcgtatat ttctcataat gtgaaatatg atgagattca cttaggggca gcatgttagt
     4021 tttgggaggc aatgtcaact gtgtctctga attcctgtct tccaaattga agccagacca
     4081 tgctgatgac ctcaagtagc actgactatt tgacaatagg gctgataatg taatcggctt
     4141 gaattttgac ttagtaactt tttatgtaat actttcggag aaattctctt taggacaaag
     4201 cagagagtcc aatttattga gggatagatt gtatctctta aagtggtcat attattatta
     4261 attttgccaa aagaagaaga atttattgaa tatttatact ataaaatgca gtaacattct
     4321 acttgcttat tacatttaaa tccttgtgta actgaatgtt tacatgtcaa gaggaaaagc
     4381 tgtaagaaaa tgctgtcaca gacccatccc tgtggcatcg tcagcagaat actgcttgct
     4441 tacaatcttt attatgcatt cttataacat aacctcagag tatctttacc aaaggttttt
     4501 aaagtaaatc tctttttaag atagacttat tcttttataa taatgaatgt gcactcatac
     4561 atatgtagaa acatttagat ttagagtttt ttttttcttt cacaaggtat aataaggaaa
     4621 ggatcctaca atattttatt ctagggtttc ttaaatatat gatttatatt actgtctttt
     4681 ctattaatca tttgatttaa acaatgccaa gtcactcttt tttagttgca tgaaattttg
     4741 cctgcaacag agagaaaaag attgtattac tttaatgatt ataatcatac tgtctgctga
     4801 tataatatca taattgttgt ggtttaaata cataaatagt agaaaaatca gagtctataa
     4861 cagaaagttt gtaaaaatat actgattttg aaaagtatca ggaatataaa tatttggtaa
     4921 ttctgtgtaa caagagagac atggaaaagg aaaaaaatcc actatatcat gggctctgca
     4981 gaacatatca aaataggatt tcttaaattt ttcaaccccc agaccatact gactcaacat
     5041 ggagtctcac tggccaagaa aattgccttt aaaactcgaa aataaggcca ggtgtggtga
     5101 ctcacacttg taatcccagc aatttgggag gctgagacag gaggattgcc tgaggccagg
     5161 agtttgacac cagcctgggc aacatagtga gaccttgtct ctacaaaaaa taaaataaaa
     5221 taaaaaccaa attagccaga catggtggca tgcgcttgtt taaaaaaaca aataaataaa
     5281 taatcgactc aaaaataagt catgtgtccc agcataaggc atcaggttgt tagatgctgg
     5341 catctctgca gctcaaagat gtgggttctt tttcttgtca ttaacacatt gttatttctg
     5401 taggagcaac ttctctgatc aaaattactt ttctgggtat gtgctgatta agggggtgga
     5461 cttatcaaca ctataattgt tccctatgaa agattccaca gagatgttta tggtgaggtt
     5521 taaaggatat gaaactctac atttaaacaa gtattttata tttgggtaca gaggaagaaa
     5581 gagagggctt tttccatggg gctatagtag agagttagtg gaatatagac aggactctga
     5641 aaacacaact tccagccatt tttttagtta gtaaaaatcc tattaatgtg aaccagccag
     5701 gaataacagt gttatttcta ttggatatgg tttgggcttc tcttgtcaaa tctgtgtcgg
     5761 ctgccccctg atccttccat tatcaagttt tgaagggtgt tggggaaatt atggcagctg
     5821 ctagggagat cagggaaaca ctgatgtaac ctcaaagcct ctcaccattc ctcttggctt
     5881 ggaaaggctt tattttttca tatacatttc tagaaatatt gctattctac cttagtattt
     5941 cacatttgta gttcaaacaa gcgattgtcc atctgttgcc tagagctata gtacatgtgt
     6001 gttatgaatg aaatatgaca gcatgttcca tacccctgct ttagccatct gtgggaaacc
     6061 agcaaactga aaaagacacc tctgcaaaat gtgcctcaag tccatttctt gggatcgctc
     6121 gtttggtgca ctctcgtggg agacaatcag agaacaacat atacttgtgc cttattttca
     6181 aagaatctat ttacactact atgaatattc cactgaagag tcaatgatgt aaatgataac
     6241 caccaaatct caaaaatata ctcaccaaaa agtaaaaaag taaaaaaaaa aaaaaaagaa
     6301 agaaagaaaa gaaagagaga gaagtcaact tttcatctta atatattcta gtagtattta
     6361 ttttttcctt gtcttggaag tatctcatag gtctttaaat gagtaaaaca tttttatgcc
     6421 agaaggtgat ataatggatg ttagtgtttt ttatttgatt ttacagtagt tttagtcaga
     6481 taatgaggac agagacttca acttgattct ttaccaccat tcagcatatt ttttaattgt
     6541 cttcattgta tttgcttaat agtggtccag acaagttcaa aacttgttct cagtgaggca
     6601 ttaatatggt gcaaccatga atatttcagg ccaagttatt cacttgacag ataactagaa
     6661 tgaaactttt ctcatgaggc tgttgtttgg ttagcatagc cttatttcaa accttaaaaa
     6721 gttacctgac tgaagctact atgacttggt aaggattctt cctctcttgc tttcttcctc
     6781 ccttcctttc ttcctcttcc ttcctcctct tcttattttc tttcctactt tccatcctac
     6841 ctattagtgt tgctgtactt ggattttttg taaattaaat caatgcatta tgattttagg
     6901 gaattatgat tatattcata aggggaaggc taccagaaaa tatatgtggc atccataaaa
     6961 tcttctttta taggggcata ttttttaggt tgtatttatt cgtaaagtga aatgagataa
     7021 tagagtcttt ctgtttcatg ttaatgaatt ttcatcaggg actgaggtca tagattcttg
     7081 gaaaattcat ttgtgactga tctagttttc tcagctgtat gcaaagtaat ctttcaaaga
     7141 ctaggttaag attttttttt taagtctgaa gcaatgtaac cccaaaaaat tataatttta
     7201 atgatggcat tttattttat tccattgcag cttgataact ttccttatag caaaggaata
     7261 actattgtat tttcagaatt ttaacacaga ttaacactta gcctgtaaga ctaataatat
     7321 attgtaatag ttgatactaa aatatttttc agcaggttgg acagcaccag tttttcttag
     7381 atcacagact acaggcagaa tttcccttca atccagaaaa aaggacacta atttcctttt
     7441 ctatttaatt ttcctggccc ttgtgcaaaa aattgtggac tctatcttag ttacaacatg
     7501 catgtccctt attttgtgga gagctgtgtg aaagatgcgt tttttttctt tttttctttt
     7561 tttttttttt gagacggagt ctggctctgt cacccaggct ggagtgcaat ggcacgatct
     7621 cctctcactg caagctccgc ctcccaggtt cacgccattc tcctgtctca gcctcccgag
     7681 tagctgggac tacaggcgcc tgccaccacg cccggctaat ttttttgtat ttttagtaga
     7741 gatggagttt cacagtgtta gccaggatgg cctcgatctc ctgacctcgt gatccacccg
     7801 cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgtgccccg cgtgtttttt
     7861 tctttagctg attgacaggt ccccttcaaa gttacaaaaa aaagtgctaa tttttgctgt
     7921 taaattctgg ttgttattta attgacagaa gtctcttgat gcacgaataa atatctctac
     7981 atctagcctt tgttaaaaat aaaaattaat attctacaaa cacctacata tactagagag
     8041 gggtgaaaca ctgcagctaa ttcctttata atactttcag atgattgcat taagcctttc
     8101 atgttatgtg gcattgttaa tttttcctag atacccatcc acttaagggc cagagaaatc
     8161 cttattcatt taactctggt gggcatttat gtaacatacc caaataaaaa cgttattaaa
     8221 cagccacaat cgcattcagt caacttggca ctgaatgtag cttctaaaat cagttctcta
     8281 ccctacgaat ggaatgttct accaagaaag agaagcatca ccatgtcatc ttgtgttcta
     8341 caccactata gagagttaca gttgccccca aacacgaatg ctattcccaa ataaaataga
     8401 atcatgcttt gggaggccaa ggcgggccga tcacgaggtc aggagatcga gaccatcctg
     8461 gctaacacgg tgaaaccccg tctctactaa aaaaaaaaaa aaatacaaaa aattagcctg
     8521 gctcagtggc gggcgcctgt agtcccagct actcaggagg ctgaggcagg agaatggcgt
     8581 gaacccggga agcggagctt tcagtgagcc gagatagcgc cactgcagtc cggcctgggc
     8641 gaaagagcga gactccgtct caaaaaaaaa aaaaaaaaaa taggatcatg gcccttttaa
     8701 agatctgaat cttctctgtt attttcctga tgaatcacca tcccatatct tcttagtcct
     8761 ggccagtatg tagttgcgct cacatacgtc tattctagct ctgtagctcc acaaaacaag
     8821 tcttaagtcc aaatctttgc ctcttcatgt ctgatatcac caactcattc agcttttctt
     8881 cacttattga catagtgtca tgtcctatca ctctctgctg cttctttaaa cagtggacac
     8941 aaacatattt tctaattttc agtgtactca gtgaaacttg gcagttcacc atgagtcagg
     9001 ctaggttgaa aggctttctt tagggttgaa agtaaacgaa attggaatca cccaaagaga
     9061 atttccccaa aaaacctcag acccagaagt gtaaaagcta cagaaggata gaactcccat
     9121 gtctacagac agttctgtta ctttttgttc tgtactattt tggatgttgc caaaatcaaa
     9181 ttcatcctga aaacaggaag caagctaatg catatgccat ccatgagatt cccacttctg
     9241 ggtcagttca tattccattc aaccttttcc ttttatcctt gtcttcttca gaataagaca
     9301 tttttcctcc atattttcat attaaatatt aacactttat aggttctact ttaatatatg
     9361 gacactttac aggttataca taaatatttg ctggttgatt gatttcgaga ttcattcatt
     9421 ctgtgctcaa atatttgtac ctagagacgt tacatgttag aaaaagtgag cagcttcttt
     9481 ctctaatcat ttaggagtcc atatttttct tttctttttg ttctcccaac atccttatct
     9541 cttactcagc tcttcaattt ataattacca aataatcact gttagagaat cagcccctaa
     9601 gtaactttga ttctggccaa ctgtaataag atccaaccac ttaaatctgt acttactcaa
     9661 taggaaggaa tgtgacatca ggaagagtca ttccagtgac attagtaaga ctttatggag
     9721 tacataaaat ttgataagaa atcttgagct gattctttga cttgatttag aagttgagaa
     9781 aagagtattt aaggcacaac agggaaacat gggctatact cagagaagac cctctgcatt
     9841 ggccaaaata tcatggattc tggaaattcc ttcttaacag aaaaaaaagg cttccaaata
     9901 atcaggctga atgggaagaa aaaggcatag aggaagcctg aggaagtatt tacttgcttt
     9961 tcccatctct ttataattgg aagagaagat gatctgccaa aatataaccc agcatgcaca
    10021 gtatggacag gaagcagccc tccatgaact ttattatcac agaatatgag cattcttatt
    10081 gatccacagc tacatcttct attcttgcag caagggtaca tgtcctttga ccctccacaa
    10141 aagaacaagc aggacatctc tattttccta ttgagtctga gtccattatt agaaaggact
    10201 tcccagccat cttttctact tggtattaaa attcccttac agattcattg ctaagtgcca
    10261 attctttttt tttcttttga gacggagtct tgctctgtcg cccaggctgg agtgcagtgg
    10321 cgcaatctcg gctcactgca agctccgctt ctcgggttca cgccattctc ctgcctcagc
    10381 ctcccgagta gctgggacta cagacgcccg ccaccgcgcc cagctaattt tttttgtact
    10441 tttagtagag acggggtttc accgtggtct cgatctcctg acctcgtgat ccgcccgcct
    10501 cggcctccca aagtgccaat tctgactcta cttaaacatc acctgtatca gggagctcat
    10561 tattccttga ggtcttacat ttctttcagc acattttgtt ccaagctaca cgactttaaa
    10621 acagagccag cctttggggc atatgttctc tttggtgcca cacaaaacct gtagtacatg
    10681 atacagtgtt gcttcccccc tccttttcct tccatatata tttgttttgt tttgggcatt
    10741 gcattacttt tttgaatttt taagaatctc taaaattagt ctgaaggatg ttctgagggc
    10801 cagacattag aatttgtgag tttttttgtt gctggttgta ctttcctatt tagaagacag
    10861 accgttctga cagttgttgt gtagcttcat gccttcccca gtaactaacc catgaacagt
    10921 acaccccttt tatctgactt gttgataatg accttaaaaa tgttaggaaa tgggccgggc
    10981 gcggtggctc gtgcctgtaa tccagcactt tgggaggccg aggcgagcgg atcatgaggt
    11041 caagagatcg agaccatcct ggtcaacatg gtgaaacccc gactctacta aaaaaaatac
    11101 aaaaattagc cgggcgtgtt ggcgggcgcc tgtagtccca actacttggg aggctgaggc
    11161 aggagaatca cctgaaccca ggaggcagag gttgcagtga gcagagattg cgccactgca
    11221 ctccagcctg ggcgacagaa cgagactccg tctcaaaaaa aaaaaaaaaa aaaaaaggtt
    11281 gggaaatatt ggtgtataat ccccatgtct aacaaggaag aagtcaaaag caaaagatag
    11341 tggtattgcc gaaaactcat tatttctagt tagttcatct gtggaaaagg atatcgttct
    11401 tgaggagagg ggttctatta tgctatagtt ttctatggaa atgtacaaat gctttcctca
    11461 ttgctctgga tgactattta gtttaaataa tatacctttg tcatggggaa gaccatgatt
    11521 gtggcttctt ctaccccaac tttgaatgag agagcactgt aagcagaaac tgccatcagt
    11581 ctcctgggca ggacctggag gtaactttct gagctgtaaa atagtaattc ctaagagagc
    11641 ttacaaactg cttccacaca gaaaatagcg cagggaggac agttattagt acccctattc
    11701 tagaagagaa agctgaggct caagccatta agtgacttgc caaaagctgt gacatagctg
    11761 ggaagtggca gatttgggga tataaccagg tcttgcaagt ccagtgctgt ctccaagtag
    11821 ccacgctcac agctgagaac accttagagg acaatatcga cttcttacag actaccaagc
    11881 ccccagtcat ccagggaaat tcagagacca attgactgcc aggtggcaaa tccacatgtg
    11941 tactgcggtc tttagagatc atttagagct tgcacacatc tgtgtcttct tgtgggaaac
    12001 ctctaggtat tctgtctgat cagcactgtg aggaagttgg tgggaaaagg ccactgataa
    12061 gaacaaacaa tgggcagaag gaagcacatt gcaataaatt tccccagaga gagttccttt
    12121 acattccatt caccaaaaac ctctctggaa ctgtcaggtt cagaatatca accaagacca
    12181 tatcatttag aattcattgg catgtagagg tgactcgatt cctaaaagaa gcctctctcc
    12241 catgaaccac gatgtacgtt ccacagaggc agaaaccgcc gtaggttagc aatgcatttt
    12301 agtctttctc tccattcaca tttactgaga gcacaccacg tgcatgttgc tgcaacaggc
    12361 atttccgata gagccgatcc atgagctaac aatgtctgaa aacaaatgtt atggaactgt
    12421 tggcatttct gagatttggc ctttgccatt tgatagactt tgcttcccag gatgctgtca
    12481 ttttgtgatt ttttataatt acaaggaatt tggtaccatg ttgttttcaa aaaacctcct
    12541 agaaagtctc catgtatgct ctagaagttg ctctacgtaa cagttcagca agcaagtgtt
    12601 ccttctcttg agctgcgtcc ctcaggaagc tgtaccttta gggtgtgctt tccacttttt
    12661 atttcctctc atttcactcc tttcattgtt tgctatatcc taaaatatgt gaagtgagag
    12721 aaaaaatatc atttcttctc attaaatctc ctgcattaaa tctaagaatc ctttaaaata
    12781 atcacacctg ataagtgttt tatgcatttc cctccctgga gtgttatcat ccatcaagcc
    12841 agtatcatca tccacctgct tattccttgg gactaatgag agccaagtta aatagcaaat
    12901 gacttctcac cccttcctag tcctcatgcc tgaggaataa gggcgacatt aatgggagcg
    12961 ggagagtggt ggctttggtt gagatgcacg ttcacagact agaaaagtgc ctcacctcca
    13021 tggtgtatat gtgccacctt ttcttaatcc agtctatcat tgttggacat ttgggttggt
    13081 tccaagtctt tgctattgtg aatagtgccg caataaacat aagtgtgcat gtgtctttat
    13141 agcagcatga tttataatcc tttgggtata tacccagtaa tgggatggct gggtcaaatg
    13201 gtatttctag ttctagatcc ctgaggaatc tccacactga cttccacaat ggttgaacta
    13261 gttcacagtc ccaccaacag tgtaaaagtg ttcttatttc tccacatcct ctccagcacc
    13321 tgttgtttcc tgacttttta atgattgcca ttctaactgg tgtgagatgg tatctcatag
    13381 tggttttgat ttgcatttct ctgatggcca gtgatggtga gcattttttc atgtgtttct
    13441 tggctgcata aatgtcttct tttgagaagt gtctgttcaa tactatgcag ccataaaaaa
    13501 tgatgagttc atgtcctttg tagggacatg gatgaaattg gaaatcatca ttctcagtaa
    13561 actatctcaa ggacaaaaaa ccaaacacca catgttctca ctcacaggtg ggaattgaac
    13621 aatgagaaca catggacaca ggaaggggaa catcacactc tggggactgt tgtggggtgg
    13681 agggaggagg gagggatagc attaggagat atacctaatg ctaaatgacg agttaatggg
    13741 tgcagcacac cagcatggca catgtataca tatgtaacta acctgcacat tgtgcacatg
    13801 taccctaaaa cttaaagtat aataataatg aaataaaatt aaaaaaaaaa aagaaaagtg
    13861 cctcacctcc ctgtgaggct tgatgaatat tgtggccagt gagtggaaaa tgattcttgt
    13921 cgaatagaca gagtattccc accccaggaa tggattaata gaagacacaa tttgagcact
    13981 tctcagaatt atctagtatg cctgagtaga gactcacatg ggtggaatct gtgttgtctc
    14041 atcagaggga ataaaaagac aatgaggtgg taaatgtgaa aaaagcagcc ttttagaaaa
    14101 acattatttt caaatacctt tataaatcat ctaatttatc ttcacataat ataaagaaaa
    14161 aactaataaa aattttcgta tttcacttta cataatatgt tctcccatat ttagggatca
    14221 tacaattgta ttgtcttcaa aacacacaca cacacacata cacacacaca cacacacaca
    14281 cacacacccc ttccaagaaa gctgatcctt cagaaaataa atcttatttt taagcacttg
    14341 ggttttcagg ccagaaaatt aataaatcct aaacctgacc catttttgta acagctaaaa
    14401 aggagaagaa aaagctagtt aaattttgtg tggatccatt tatctcttaa aatatgccaa
    14461 agcaatttga ggtgggggtg gaaacaggta tttatctctc atgcgtgatt ctctctttat
    14521 atttctatct gttgggaaaa gggtaaagaa ctattcttgg tcattattga tgtattgtgt
    14581 tgccactttg tatggtgcct gctgtgcttt atcccgaggc atagcagtaa tcgttactat
    14641 cttgactctt tccttcatca caagagagta aatatgaagt ctgaatgtcg ttcctcaccc
    14701 ccaaattgtt taactctgct tccaaactag tttaagaaat gcaaaatggg aagagctagc
    14761 ttttcttaga tacatttctt ccttttttat tctttcttgg gagacgttaa gtataaaagg
    14821 gaaaaagtca gttccttctt ctctctcttt ctctttgggt gacagcaatg ctcacttagt
    14881 aattataaac tggaaatagg agagtagctt gagcaggtta tgatatatct gcccaatgtg
    14941 tttcattcct tcaaacataa actttgagag taaaagagat ttttataatt taaatgccaa
    15001 cgacaggaat ggcctcatgt tttaactttc aaataataaa tggggagttg gtatttgggc
    15061 agagtttgca ttttactaat cctatatact ttgagcttag tttttagaat tgtgtcaaat
    15121 acatcaacat atcaggatta tagtgccaaa aatagttaaa gtgccttggt cctccctctg
    15181 taggcagcaa attgaaacta acatgggacc atgccatcct tctagcataa tggagaagtc
    15241 tgaactgagg agtatctttg atgaaagaca tttaggaccc tagaaactaa atcttgtcac
    15301 caagacttta tagtaaagta gtagcaaaat tatttttaaa agactttctt ccttttacta
    15361 cccatttcct ctcttgggaa agctgatgag caaattatcc aagactcatt tctttattag
    15421 gcaaagtcag aatatttccc ctctgaaaat ctgaattatg ccctcattct ttttcaagaa
    15481 atatctcaaa gagcaaatag aattaaacat gacacttgat tgtctgatta tttggcatgt
    15541 ataaaattat catgtggctt aatgtgcctt aagtgaaaat ttaaacttag acctgaaacc
    15601 tttacagttg gatgtagcgt tgagcttttg catgttttct gtataataaa ccacttttgt
    15661 tttgtttgtt ttgtctttta acctacacct ttatcattac tctaacagat ttagggcttc
    15721 tctttctcta cagctaagta agggaatatg tgcaattatg agacatacaa aaaaggaaag
    15781 ggaaaggact ttctaagtag caaatctgtg ccatgaagta gatgtggcgt gaagatacag
    15841 agcctgagga tagtaatttt ccctgagcca cgcacacagg cttttatttc atgccttttc
    15901 tctttctgtg ccgtcacctt tgagaaaaac gattgcacct tctccaagtc tgccttttta
    15961 acagctacag ttaagttggc aagacttccc cagctctgaa tatagccatt tgccgactcc
    16021 ggcctctttg cgagactgac tcaaatctgt gatcttctgt tcagcataca catcagcaaa
    16081 gtgagaagat gagcactaaa tataggctct attaacttta cttttagatt tactgccttc
    16141 aaaaagtgcc tattctgagc aacataaacg ttattcctta catatgtatg tacacacggt
    16201 acccagagtc gtactgtgca gccttcaaaa acataccatc agaaagagta ggtgctgaga
    16261 taaggaaact ttgccaaatg aaagaaagtc actcacttcc aatatcccct ctcaagcggc
    16321 taccgtgaaa cgggctgcaa acacattccc tgagcatccc ttgctgatac agcttcttta
    16381 tatttatatc ctactggatg gtagcatatt gctaaggttt cctgtactct gcttcaaggg
    16441 aatgtaagct ttatggcatt gaaacattta gggaaaaaaa agatgtttaa gagaattaat
    16501 agagccgtag tctgtattag gatgtgtgtc atatgtgtgt tctataaact aagcatcggt
    16561 gggtttagag tgttaaagtg tcagcacatt ccttctcctt ttgtctctca ggctaacatg
    16621 agagaaaata gaaaagtctt ggctgtgggg attggaagct cagggggcca aatgtccttg
    16681 ccagatcctt agagcattac tttgactcct aaaaatagta gtgtatgtta tttgatggct
    16741 tttgtttcca tagttccatc actgacaaaa ctgtcaatac tgttgatgga gcagcagcat
    16801 agcctagagt gatgcattct tacccagagg tggcaatagg agagggtcca tgtaaatagg
    16861 acgaggtaga cagtgcatga ttgtaggaga agggttgaag ggaggacatg attccaaaaa
    16921 agatcgttct caatgtgtcg tctgactcaa ccagctggca gattacactt gccaagtcgt
    16981 tccctttcct tctaagtcag ttggctccat attcacttga atatgcctct gtttgggcaa
    17041 agcaagatac ctccacttaa cctttatcca aggaagctct tggtgtcctc ttggtcataa
    17101 agttgtctcc tacctaaccc agttttacca aatggaagta aaaggggaca aactatggaa
    17161 gatggactcc atgccattgc agtcagccac cattctcttt tccatataag gagccccatt
    17221 acataagcta cgggtgaggt tggaacagct atgtttcata atttcaagag tgtgaccacc
    17281 ctgctctagt catcatcatt ggatgaatcc agttgactct ttggcaaaag ggtgatactt
    17341 ttcactaaaa atgcctactc ttcctgttga tgttcctttt ctgtttttac cttgtccaat
    17401 ttccacacta gtcatttttt ttatttttta gaggatcaga ttttagcgct ggaaaatgag
    17461 ttcaaaaatt tcagtgtaat gtcataagga tgttgggata cagagatttt ttttttcctt
    17521 ggaaacaaat ggactgggaa gaaacacagc atggctttgc tctgagtttc aatctgatga
    17581 ttatgaccat ggaagatagt cttatgtaaa ggttaaatgg tgtttacaag tggatagata
    17641 aggcggagat ggtgagaagc cgggttttct ctatgctaaa tgtgtctact aagagcagca
    17701 cttcctacta gctaagcaca atcatagccc caccgtgatg agctgctagt ctgaataaca
    17761 ttccctgact tagggaaagg cacacaaaaa catataaaga atatgtctat tttcatatgt
    17821 gtgatactga cagagccatg gtattcctaa aatataggtt tctctttttt cttgtattct
    17881 tagcaaattg catttattca ctacattaca aaccatcact gatgtatcca aaatagcaca
    17941 catagttcag tatgaaaata agagaataaa atctgttata agcaagtgat ttaggtattt
    18001 tcttttgtgt ttatgcatta tctgactata ttaaaacctg tttttctatt taccttctat
    18061 cagttttctc taccaattat gttttttcaa tgctctataa gaatgaatat ggaaattata
    18121 tttctttttt ctgtaaaaga gttgcaacta ctttattata tttagaaatc caataaactt
    18181 cttattacat tta
//
