LOCUS       NM_001375463           18259 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LIM domain containing preferred translocation partner
            in lipoma (LPP), transcript variant 12, mRNA.
ACCESSION   NM_001375463
VERSION     NM_001375463.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18259)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18259)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 18259)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (bases 1 to 18259)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 18259)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (bases 1 to 18259)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (bases 1 to 18259)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (bases 1 to 18259)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (bases 1 to 18259)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (bases 1 to 18259)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022498.18, AC117507.5,
            AC069226.19, AC063932.14, AC055711.18, AC009319.19 and KF510228.1.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130584.1, SRR14038197.2255135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC022498.18        60685-60780
            97-219              AC117507.5         11500-11622
            220-421             AC069226.19        127073-127274       c
            422-534             AC069226.19        48682-48794         c
            535-657             AC069226.19        8599-8721           c
            658-1341            AC063932.14        108433-109116       c
            1342-1468           AC063932.14        9884-10010          c
            1469-1638           AC055711.18        41842-42011
            1639-1817           AC055711.18        147929-148107
            1818-1938           AC055711.18        154372-154492
            1939-11679          AC009319.19        3236-12976
            11680-12060         KF510228.1         1-381
            12061-18259         AC009319.19        13359-19557
FEATURES             Location/Qualifiers
     source          1..18259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     gene            1..18259
                     /gene="LPP"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
     exon            1..96
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            97..219
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            220..421
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2067
                     /gene="LPP"
                     /note="isoform a is encoded by transcript variant 12; LIM
                     protein; lipoma preferred partner"
                     /codon_start=1
                     /product="lipoma-preferred partner isoform a"
                     /protein_id="NP_001362392.1"
                     /db_xref="CCDS:CCDS3291.1"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
                     /translation="MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKK
                     FAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQ
                     GNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTG
                     HKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSR
                     PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYI
                     PPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTP
                     PGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
                     LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNK
                     LRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRS
                     LDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHC
                     YRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            422..534
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            535..657
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            658..1341
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1468
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1638
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1817
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1938
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..18259
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      18238..18243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPP"
                     /note="hexamer: AATAAA"
     polyA_site      18259
                     /gene="LPP"
                     /note="major polyA site"
ORIGIN      
        1 acctcctcct ctgcctctgc ctccgcctcc agccgccgcc gccgccgccg ccgccgccac
       61 caccaccgcc gctgccccgg ctgcctcctc cctgaggtgg gaactttgag gctcagagac
      121 agagcagaag acagaacctg gtcttctgat tccctgtgtt ctgctttttt cattgttcca
      181 ctggacgctc atcagaggga agatcttttt cctcaattga ttccaacaat gtctcaccca
      241 tcttggctgc cacccaaaag cactggtgag cccctcggcc atgtgcctgc acggatggag
      301 accacccatt cctttgggaa ccccagcatt tcagtgtcta cacaacagcc acccaaaaag
      361 tttgccccgg tagttgctcc aaaacctaag tacaacccat acaaacaacc tggaggtgag
      421 ggtgattttc ttccaccccc acctccacct ctagatgatt ccagtgccct tccatctatc
      481 tctggaaact ttcctcctcc accacctctt gatgaagagg ctttcaaagt acaggggaat
      541 cccggaggca agacacttga ggagaggcgc tccagcctgg acgctgagat tgactccttg
      601 accagcatct tggctgacct tgagtgcagc tccccctata agcctcggcc tccacagagc
      661 tccactggtt caacagcctc tcctccagtt tcgaccccag tcacaggaca caagagaatg
      721 gtcatcccga accaaccccc tctaacagca accaagaagt ctacattgaa accacagcct
      781 gcaccccagg ctggacccat ccctgtggct ccaatcggaa cactcaaacc ccagcctcag
      841 ccagtcccag cctcctacac cacggcctcc acttcttcaa ggcctacctt taatgtgcag
      901 gtgaagtcag cccagcccag ccctcattat atggctgccc cttcatcagg acaaatttat
      961 ggctcagggc cccagggcta taacactcag ccagttcctg tctctgggca gtgtccacct
     1021 ccttcaacac ggggaggcat ggattatgcc tacattccac caccaggact tcagccggag
     1081 cctgggtatg ggtatgcccc caaccaggga cgctattatg aaggctacta tgcagcaggg
     1141 ccaggctatg ggggcagaaa tgactctgac cctacctatg gtcaacaagg tcacccaaat
     1201 acctggaaac gggaaccagg gtacactcct cctggagcag ggaaccagaa ccctcctggg
     1261 atgtatccag tcactggtcc caagaagacc tatatcacag atcctgtttc agccccctgt
     1321 gcgccaccat tgcagccaaa gggtggccat tcagggcaac tggggccttc gtcagttgcc
     1381 ccttcattcc gcccagagga tgagcttgag cacctgacca aaaagatgct gtatgacatg
     1441 gaaaatccac ctgctgacga atactttggc cgctgtgctc gctgtggaga aaacgtagtt
     1501 ggggaaggta caggatgcac tgccatggat caggtcttcc acgtggattg ttttacctgc
     1561 atcatctgca acaacaagct ccgagggcag ccattctatg ctgtggaaaa gaaagcatac
     1621 tgcgagccct gctacattaa tactctggag cagtgcaatg tgtgttccaa gcccatcatg
     1681 gagcggattc tccgagccac cgggaaggcc tatcatcctc actgtttcac ctgcgtgatg
     1741 tgccaccgca gcctggatgg gatcccattc actgtggatg ctggcgggct cattcactgc
     1801 attgaggact tccacaagaa atttgccccg cgatgttctg tgtgcaagga gcctattatg
     1861 ccagccccgg gccaggagga gactgtccgt attgtggctt tggatcgaga tttccatgtt
     1921 cactgctacc gatgcgagga ttgcggtggt ctcctgtctg aaggagataa ccaaggctgc
     1981 taccccttgg atgggcacat cctctgcaag acctgcaact ctgcccgcat cagggtgttg
     2041 accgccaagg cgagcactga cctttagatt cagtcacctg ttcagccggc actgagaaga
     2101 acgaacacaa gaaaaagata agaaatacta gagtaaaggc catcaaacta cgcgatagtc
     2161 tctgttcttc atctgctatt aaccttgcct tagaaacaca taaattatga gatttttttt
     2221 aaaagttgtt accaaataca catttcacat tgaatcatgt aggatcttga tgggcctttg
     2281 ttcccaagga cttccacatt tttgcacaga ttatgctcca tcccattcac ttctgcattc
     2341 ctgtaacttt taatccctat gtttgtctca cttttcatct ggttgaatgg cttttcttag
     2401 tgtggtattt gctgtcacat agtttttcct gggtgagtct gccaactcac aggtgctttt
     2461 aggcttgaaa tctccatcct atcatttccg ttttgcctgt gactgtaaag agtagccatt
     2521 cttttcccat gtattgaaga ggatattctt ctcttgcttt atactactca cgtccttggg
     2581 gagggaaatg cacaattttt ttttgttagg ctgtaaagaa tttaagctgt aaattacata
     2641 agttagaaca agcccaaatt taatttgcaa ccatcagaat tcagaatcta tagtgaccag
     2701 tgatcaaggc taattggaaa agagttatcg gcccatagct aataagtagt gacagacaac
     2761 caagcttcaa tatttttcta aagaaattac aggtgggata tgctagaaaa ggcattttgg
     2821 ggttatgttt aaaaaaacat tattgtccca caatattacc ttaagatttt tcttttccgc
     2881 actacctgaa cattgtaata cagacaaact tgatttcttc tagaagataa cattttcaat
     2941 actgtcccac ttctcatctt aaaaatattg tcatgtttat tctaatatcc aacacaacta
     3001 tcaaaattgc ctttttctct agaggatgaa ggctgtgaaa aaaccgttca aattctcttc
     3061 tttttctttt ttattaccag gtccattttg cctgacaatt gcaaatcaga gcatacaaaa
     3121 taaaactgtg cagttttgtt tggtttactt tcaaaagagt agaaagcttg aaaagattct
     3181 gaaaccacag tttcattatt ctcataatcc ttctgcaact gaaattacat attgcaggag
     3241 acattttcat atcatcaatg tgacatttac accacacttt caaagacaat cactgaaaca
     3301 aaaattgtct ttatgagcta aaaatatgca gaatctctgc ctagaatctt tattcaaact
     3361 tttattagcc agtgaaacac ttgcttgcca actgccaagc catacttatt aagttcgaac
     3421 atgtttcact taaggagaga cacctagctt agtcatggca agttgccatt ttgtaaacta
     3481 aggattttgg actgagattt cttaaatctt tcttcaaatc tcccacaagt atatactttt
     3541 aaattatgga gtattttaag tctacaaaaa ggtataaata ataatataat gaattcctat
     3601 atacctaata cccagtttaa gacaccaaat ataacaagta taattacatc ctccaatgta
     3661 ccgtttcctt attccacaga tatctttttc attattgtga agtgatgttc agatttctag
     3721 ttttttttct agtttttaat tttaacatca gaactgaaat aaaaaattat ggatacgtgt
     3781 tttgaattgc aaactattcc tcaggaattc caattaaatt tattttactt gaataggaat
     3841 gatcataaaa gtgattcttt ttttgtgact agaaattctt aagccgatgg tcactatagc
     3901 tcatccttaa tgtatggctc atttgctttt gtcactaaac ggttttgtgt tagaaccacc
     3961 aaaattatag cttttaagag cttcctttga ccactgtctt tttcttaccc tagttctctt
     4021 atctttgatc gtatatttct cataatgtga aatatgatga gattcactta ggggcagcat
     4081 gttagttttg ggaggcaatg tcaactgtgt ctctgaattc ctgtcttcca aattgaagcc
     4141 agaccatgct gatgacctca agtagcactg actatttgac aatagggctg ataatgtaat
     4201 cggcttgaat tttgacttag taacttttta tgtaatactt tcggagaaat tctctttagg
     4261 acaaagcaga gagtccaatt tattgaggga tagattgtat ctcttaaagt ggtcatatta
     4321 ttattaattt tgccaaaaga agaagaattt attgaatatt tatactataa aatgcagtaa
     4381 cattctactt gcttattaca tttaaatcct tgtgtaactg aatgtttaca tgtcaagagg
     4441 aaaagctgta agaaaatgct gtcacagacc catccctgtg gcatcgtcag cagaatactg
     4501 cttgcttaca atctttatta tgcattctta taacataacc tcagagtatc tttaccaaag
     4561 gtttttaaag taaatctctt tttaagatag acttattctt ttataataat gaatgtgcac
     4621 tcatacatat gtagaaacat ttagatttag agtttttttt ttctttcaca aggtataata
     4681 aggaaaggat cctacaatat tttattctag ggtttcttaa atatatgatt tatattactg
     4741 tcttttctat taatcatttg atttaaacaa tgccaagtca ctctttttta gttgcatgaa
     4801 attttgcctg caacagagag aaaaagattg tattacttta atgattataa tcatactgtc
     4861 tgctgatata atatcataat tgttgtggtt taaatacata aatagtagaa aaatcagagt
     4921 ctataacaga aagtttgtaa aaatatactg attttgaaaa gtatcaggaa tataaatatt
     4981 tggtaattct gtgtaacaag agagacatgg aaaaggaaaa aaatccacta tatcatgggc
     5041 tctgcagaac atatcaaaat aggatttctt aaatttttca acccccagac catactgact
     5101 caacatggag tctcactggc caagaaaatt gcctttaaaa ctcgaaaata aggccaggtg
     5161 tggtgactca cacttgtaat cccagcaatt tgggaggctg agacaggagg attgcctgag
     5221 gccaggagtt tgacaccagc ctgggcaaca tagtgagacc ttgtctctac aaaaaataaa
     5281 ataaaataaa aaccaaatta gccagacatg gtggcatgcg cttgtttaaa aaaacaaata
     5341 aataaataat cgactcaaaa ataagtcatg tgtcccagca taaggcatca ggttgttaga
     5401 tgctggcatc tctgcagctc aaagatgtgg gttctttttc ttgtcattaa cacattgtta
     5461 tttctgtagg agcaacttct ctgatcaaaa ttacttttct gggtatgtgc tgattaaggg
     5521 ggtggactta tcaacactat aattgttccc tatgaaagat tccacagaga tgtttatggt
     5581 gaggtttaaa ggatatgaaa ctctacattt aaacaagtat tttatatttg ggtacagagg
     5641 aagaaagaga gggctttttc catggggcta tagtagagag ttagtggaat atagacagga
     5701 ctctgaaaac acaacttcca gccatttttt tagttagtaa aaatcctatt aatgtgaacc
     5761 agccaggaat aacagtgtta tttctattgg atatggtttg ggcttctctt gtcaaatctg
     5821 tgtcggctgc cccctgatcc ttccattatc aagttttgaa gggtgttggg gaaattatgg
     5881 cagctgctag ggagatcagg gaaacactga tgtaacctca aagcctctca ccattcctct
     5941 tggcttggaa aggctttatt ttttcatata catttctaga aatattgcta ttctacctta
     6001 gtatttcaca tttgtagttc aaacaagcga ttgtccatct gttgcctaga gctatagtac
     6061 atgtgtgtta tgaatgaaat atgacagcat gttccatacc cctgctttag ccatctgtgg
     6121 gaaaccagca aactgaaaaa gacacctctg caaaatgtgc ctcaagtcca tttcttggga
     6181 tcgctcgttt ggtgcactct cgtgggagac aatcagagaa caacatatac ttgtgcctta
     6241 ttttcaaaga atctatttac actactatga atattccact gaagagtcaa tgatgtaaat
     6301 gataaccacc aaatctcaaa aatatactca ccaaaaagta aaaaagtaaa aaaaaaaaaa
     6361 aaagaaagaa agaaaagaaa gagagagaag tcaacttttc atcttaatat attctagtag
     6421 tatttatttt ttccttgtct tggaagtatc tcataggtct ttaaatgagt aaaacatttt
     6481 tatgccagaa ggtgatataa tggatgttag tgttttttat ttgattttac agtagtttta
     6541 gtcagataat gaggacagag acttcaactt gattctttac caccattcag catatttttt
     6601 aattgtcttc attgtatttg cttaatagtg gtccagacaa gttcaaaact tgttctcagt
     6661 gaggcattaa tatggtgcaa ccatgaatat ttcaggccaa gttattcact tgacagataa
     6721 ctagaatgaa acttttctca tgaggctgtt gtttggttag catagcctta tttcaaacct
     6781 taaaaagtta cctgactgaa gctactatga cttggtaagg attcttcctc tcttgctttc
     6841 ttcctccctt cctttcttcc tcttccttcc tcctcttctt attttctttc ctactttcca
     6901 tcctacctat tagtgttgct gtacttggat tttttgtaaa ttaaatcaat gcattatgat
     6961 tttagggaat tatgattata ttcataaggg gaaggctacc agaaaatata tgtggcatcc
     7021 ataaaatctt cttttatagg ggcatatttt ttaggttgta tttattcgta aagtgaaatg
     7081 agataataga gtctttctgt ttcatgttaa tgaattttca tcagggactg aggtcataga
     7141 ttcttggaaa attcatttgt gactgatcta gttttctcag ctgtatgcaa agtaatcttt
     7201 caaagactag gttaagattt tttttttaag tctgaagcaa tgtaacccca aaaaattata
     7261 attttaatga tggcatttta ttttattcca ttgcagcttg ataactttcc ttatagcaaa
     7321 ggaataacta ttgtattttc agaattttaa cacagattaa cacttagcct gtaagactaa
     7381 taatatattg taatagttga tactaaaata tttttcagca ggttggacag caccagtttt
     7441 tcttagatca cagactacag gcagaatttc ccttcaatcc agaaaaaagg acactaattt
     7501 ccttttctat ttaattttcc tggcccttgt gcaaaaaatt gtggactcta tcttagttac
     7561 aacatgcatg tcccttattt tgtggagagc tgtgtgaaag atgcgttttt tttctttttt
     7621 tctttttttt ttttttgaga cggagtctgg ctctgtcacc caggctggag tgcaatggca
     7681 cgatctcctc tcactgcaag ctccgcctcc caggttcacg ccattctcct gtctcagcct
     7741 cccgagtagc tgggactaca ggcgcctgcc accacgcccg gctaattttt ttgtattttt
     7801 agtagagatg gagtttcaca gtgttagcca ggatggcctc gatctcctga cctcgtgatc
     7861 cacccgcctc ggcctcccaa agtgctggga ttacaggcgt gagccaccgt gccccgcgtg
     7921 tttttttctt tagctgattg acaggtcccc ttcaaagtta caaaaaaaag tgctaatttt
     7981 tgctgttaaa ttctggttgt tatttaattg acagaagtct cttgatgcac gaataaatat
     8041 ctctacatct agcctttgtt aaaaataaaa attaatattc tacaaacacc tacatatact
     8101 agagaggggt gaaacactgc agctaattcc tttataatac tttcagatga ttgcattaag
     8161 cctttcatgt tatgtggcat tgttaatttt tcctagatac ccatccactt aagggccaga
     8221 gaaatcctta ttcatttaac tctggtgggc atttatgtaa catacccaaa taaaaacgtt
     8281 attaaacagc cacaatcgca ttcagtcaac ttggcactga atgtagcttc taaaatcagt
     8341 tctctaccct acgaatggaa tgttctacca agaaagagaa gcatcaccat gtcatcttgt
     8401 gttctacacc actatagaga gttacagttg cccccaaaca cgaatgctat tcccaaataa
     8461 aatagaatca tgctttggga ggccaaggcg ggccgatcac gaggtcagga gatcgagacc
     8521 atcctggcta acacggtgaa accccgtctc tactaaaaaa aaaaaaaaat acaaaaaatt
     8581 agcctggctc agtggcgggc gcctgtagtc ccagctactc aggaggctga ggcaggagaa
     8641 tggcgtgaac ccgggaagcg gagctttcag tgagccgaga tagcgccact gcagtccggc
     8701 ctgggcgaaa gagcgagact ccgtctcaaa aaaaaaaaaa aaaaaatagg atcatggccc
     8761 ttttaaagat ctgaatcttc tctgttattt tcctgatgaa tcaccatccc atatcttctt
     8821 agtcctggcc agtatgtagt tgcgctcaca tacgtctatt ctagctctgt agctccacaa
     8881 aacaagtctt aagtccaaat ctttgcctct tcatgtctga tatcaccaac tcattcagct
     8941 tttcttcact tattgacata gtgtcatgtc ctatcactct ctgctgcttc tttaaacagt
     9001 ggacacaaac atattttcta attttcagtg tactcagtga aacttggcag ttcaccatga
     9061 gtcaggctag gttgaaaggc tttctttagg gttgaaagta aacgaaattg gaatcaccca
     9121 aagagaattt ccccaaaaaa cctcagaccc agaagtgtaa aagctacaga aggatagaac
     9181 tcccatgtct acagacagtt ctgttacttt ttgttctgta ctattttgga tgttgccaaa
     9241 atcaaattca tcctgaaaac aggaagcaag ctaatgcata tgccatccat gagattccca
     9301 cttctgggtc agttcatatt ccattcaacc ttttcctttt atccttgtct tcttcagaat
     9361 aagacatttt tcctccatat tttcatatta aatattaaca ctttataggt tctactttaa
     9421 tatatggaca ctttacaggt tatacataaa tatttgctgg ttgattgatt tcgagattca
     9481 ttcattctgt gctcaaatat ttgtacctag agacgttaca tgttagaaaa agtgagcagc
     9541 ttctttctct aatcatttag gagtccatat ttttcttttc tttttgttct cccaacatcc
     9601 ttatctctta ctcagctctt caatttataa ttaccaaata atcactgtta gagaatcagc
     9661 ccctaagtaa ctttgattct ggccaactgt aataagatcc aaccacttaa atctgtactt
     9721 actcaatagg aaggaatgtg acatcaggaa gagtcattcc agtgacatta gtaagacttt
     9781 atggagtaca taaaatttga taagaaatct tgagctgatt ctttgacttg atttagaagt
     9841 tgagaaaaga gtatttaagg cacaacaggg aaacatgggc tatactcaga gaagaccctc
     9901 tgcattggcc aaaatatcat ggattctgga aattccttct taacagaaaa aaaaggcttc
     9961 caaataatca ggctgaatgg gaagaaaaag gcatagagga agcctgagga agtatttact
    10021 tgcttttccc atctctttat aattggaaga gaagatgatc tgccaaaata taacccagca
    10081 tgcacagtat ggacaggaag cagccctcca tgaactttat tatcacagaa tatgagcatt
    10141 cttattgatc cacagctaca tcttctattc ttgcagcaag ggtacatgtc ctttgaccct
    10201 ccacaaaaga acaagcagga catctctatt ttcctattga gtctgagtcc attattagaa
    10261 aggacttccc agccatcttt tctacttggt attaaaattc ccttacagat tcattgctaa
    10321 gtgccaattc tttttttttc ttttgagacg gagtcttgct ctgtcgccca ggctggagtg
    10381 cagtggcgca atctcggctc actgcaagct ccgcttctcg ggttcacgcc attctcctgc
    10441 ctcagcctcc cgagtagctg ggactacaga cgcccgccac cgcgcccagc taattttttt
    10501 tgtactttta gtagagacgg ggtttcaccg tggtctcgat ctcctgacct cgtgatccgc
    10561 ccgcctcggc ctcccaaagt gccaattctg actctactta aacatcacct gtatcaggga
    10621 gctcattatt ccttgaggtc ttacatttct ttcagcacat tttgttccaa gctacacgac
    10681 tttaaaacag agccagcctt tggggcatat gttctctttg gtgccacaca aaacctgtag
    10741 tacatgatac agtgttgctt cccccctcct tttccttcca tatatatttg ttttgttttg
    10801 ggcattgcat tacttttttg aatttttaag aatctctaaa attagtctga aggatgttct
    10861 gagggccaga cattagaatt tgtgagtttt tttgttgctg gttgtacttt cctatttaga
    10921 agacagaccg ttctgacagt tgttgtgtag cttcatgcct tccccagtaa ctaacccatg
    10981 aacagtacac cccttttatc tgacttgttg ataatgacct taaaaatgtt aggaaatggg
    11041 ccgggcgcgg tggctcgtgc ctgtaatcca gcactttggg aggccgaggc gagcggatca
    11101 tgaggtcaag agatcgagac catcctggtc aacatggtga aaccccgact ctactaaaaa
    11161 aaatacaaaa attagccggg cgtgttggcg ggcgcctgta gtcccaacta cttgggaggc
    11221 tgaggcagga gaatcacctg aacccaggag gcagaggttg cagtgagcag agattgcgcc
    11281 actgcactcc agcctgggcg acagaacgag actccgtctc aaaaaaaaaa aaaaaaaaaa
    11341 aaggttggga aatattggtg tataatcccc atgtctaaca aggaagaagt caaaagcaaa
    11401 agatagtggt attgccgaaa actcattatt tctagttagt tcatctgtgg aaaaggatat
    11461 cgttcttgag gagaggggtt ctattatgct atagttttct atggaaatgt acaaatgctt
    11521 tcctcattgc tctggatgac tatttagttt aaataatata cctttgtcat ggggaagacc
    11581 atgattgtgg cttcttctac cccaactttg aatgagagag cactgtaagc agaaactgcc
    11641 atcagtctcc tgggcaggac ctggaggtaa ctttctgagc tgtaaaatag taattcctaa
    11701 gagagcttac aaactgcttc cacacagaaa atagcgcagg gaggacagtt attagtaccc
    11761 ctattctaga agagaaagct gaggctcaag ccattaagtg acttgccaaa agctgtgaca
    11821 tagctgggaa gtggcagatt tggggatata accaggtctt gcaagtccag tgctgtctcc
    11881 aagtagccac gctcacagct gagaacacct tagaggacaa tatcgacttc ttacagacta
    11941 ccaagccccc agtcatccag ggaaattcag agaccaattg actgccaggt ggcaaatcca
    12001 catgtgtact gcggtcttta gagatcattt agagcttgca cacatctgtg tcttcttgtg
    12061 ggaaacctct aggtattctg tctgatcagc actgtgagga agttggtggg aaaaggccac
    12121 tgataagaac aaacaatggg cagaaggaag cacattgcaa taaatttccc cagagagagt
    12181 tcctttacat tccattcacc aaaaacctct ctggaactgt caggttcaga atatcaacca
    12241 agaccatatc atttagaatt cattggcatg tagaggtgac tcgattccta aaagaagcct
    12301 ctctcccatg aaccacgatg tacgttccac agaggcagaa accgccgtag gttagcaatg
    12361 cattttagtc tttctctcca ttcacattta ctgagagcac accacgtgca tgttgctgca
    12421 acaggcattt ccgatagagc cgatccatga gctaacaatg tctgaaaaca aatgttatgg
    12481 aactgttggc atttctgaga tttggccttt gccatttgat agactttgct tcccaggatg
    12541 ctgtcatttt gtgatttttt ataattacaa ggaatttggt accatgttgt tttcaaaaaa
    12601 cctcctagaa agtctccatg tatgctctag aagttgctct acgtaacagt tcagcaagca
    12661 agtgttcctt ctcttgagct gcgtccctca ggaagctgta cctttagggt gtgctttcca
    12721 ctttttattt cctctcattt cactcctttc attgtttgct atatcctaaa atatgtgaag
    12781 tgagagaaaa aatatcattt cttctcatta aatctcctgc attaaatcta agaatccttt
    12841 aaaataatca cacctgataa gtgttttatg catttccctc cctggagtgt tatcatccat
    12901 caagccagta tcatcatcca cctgcttatt ccttgggact aatgagagcc aagttaaata
    12961 gcaaatgact tctcacccct tcctagtcct catgcctgag gaataagggc gacattaatg
    13021 ggagcgggag agtggtggct ttggttgaga tgcacgttca cagactagaa aagtgcctca
    13081 cctccatggt gtatatgtgc caccttttct taatccagtc tatcattgtt ggacatttgg
    13141 gttggttcca agtctttgct attgtgaata gtgccgcaat aaacataagt gtgcatgtgt
    13201 ctttatagca gcatgattta taatcctttg ggtatatacc cagtaatggg atggctgggt
    13261 caaatggtat ttctagttct agatccctga ggaatctcca cactgacttc cacaatggtt
    13321 gaactagttc acagtcccac caacagtgta aaagtgttct tatttctcca catcctctcc
    13381 agcacctgtt gtttcctgac tttttaatga ttgccattct aactggtgtg agatggtatc
    13441 tcatagtggt tttgatttgc atttctctga tggccagtga tggtgagcat tttttcatgt
    13501 gtttcttggc tgcataaatg tcttcttttg agaagtgtct gttcaatact atgcagccat
    13561 aaaaaatgat gagttcatgt cctttgtagg gacatggatg aaattggaaa tcatcattct
    13621 cagtaaacta tctcaaggac aaaaaaccaa acaccacatg ttctcactca caggtgggaa
    13681 ttgaacaatg agaacacatg gacacaggaa ggggaacatc acactctggg gactgttgtg
    13741 gggtggaggg aggagggagg gatagcatta ggagatatac ctaatgctaa atgacgagtt
    13801 aatgggtgca gcacaccagc atggcacatg tatacatatg taactaacct gcacattgtg
    13861 cacatgtacc ctaaaactta aagtataata ataatgaaat aaaattaaaa aaaaaaaaga
    13921 aaagtgcctc acctccctgt gaggcttgat gaatattgtg gccagtgagt ggaaaatgat
    13981 tcttgtcgaa tagacagagt attcccaccc caggaatgga ttaatagaag acacaatttg
    14041 agcacttctc agaattatct agtatgcctg agtagagact cacatgggtg gaatctgtgt
    14101 tgtctcatca gagggaataa aaagacaatg aggtggtaaa tgtgaaaaaa gcagcctttt
    14161 agaaaaacat tattttcaaa tacctttata aatcatctaa tttatcttca cataatataa
    14221 agaaaaaact aataaaaatt ttcgtatttc actttacata atatgttctc ccatatttag
    14281 ggatcataca attgtattgt cttcaaaaca cacacacaca cacatacaca cacacacaca
    14341 cacacacaca caccccttcc aagaaagctg atccttcaga aaataaatct tatttttaag
    14401 cacttgggtt ttcaggccag aaaattaata aatcctaaac ctgacccatt tttgtaacag
    14461 ctaaaaagga gaagaaaaag ctagttaaat tttgtgtgga tccatttatc tcttaaaata
    14521 tgccaaagca atttgaggtg ggggtggaaa caggtattta tctctcatgc gtgattctct
    14581 ctttatattt ctatctgttg ggaaaagggt aaagaactat tcttggtcat tattgatgta
    14641 ttgtgttgcc actttgtatg gtgcctgctg tgctttatcc cgaggcatag cagtaatcgt
    14701 tactatcttg actctttcct tcatcacaag agagtaaata tgaagtctga atgtcgttcc
    14761 tcacccccaa attgtttaac tctgcttcca aactagttta agaaatgcaa aatgggaaga
    14821 gctagctttt cttagataca tttcttcctt ttttattctt tcttgggaga cgttaagtat
    14881 aaaagggaaa aagtcagttc cttcttctct ctctttctct ttgggtgaca gcaatgctca
    14941 cttagtaatt ataaactgga aataggagag tagcttgagc aggttatgat atatctgccc
    15001 aatgtgtttc attccttcaa acataaactt tgagagtaaa agagattttt ataatttaaa
    15061 tgccaacgac aggaatggcc tcatgtttta actttcaaat aataaatggg gagttggtat
    15121 ttgggcagag tttgcatttt actaatccta tatactttga gcttagtttt tagaattgtg
    15181 tcaaatacat caacatatca ggattatagt gccaaaaata gttaaagtgc cttggtcctc
    15241 cctctgtagg cagcaaattg aaactaacat gggaccatgc catccttcta gcataatgga
    15301 gaagtctgaa ctgaggagta tctttgatga aagacattta ggaccctaga aactaaatct
    15361 tgtcaccaag actttatagt aaagtagtag caaaattatt tttaaaagac tttcttcctt
    15421 ttactaccca tttcctctct tgggaaagct gatgagcaaa ttatccaaga ctcatttctt
    15481 tattaggcaa agtcagaata tttcccctct gaaaatctga attatgccct cattcttttt
    15541 caagaaatat ctcaaagagc aaatagaatt aaacatgaca cttgattgtc tgattatttg
    15601 gcatgtataa aattatcatg tggcttaatg tgccttaagt gaaaatttaa acttagacct
    15661 gaaaccttta cagttggatg tagcgttgag cttttgcatg ttttctgtat aataaaccac
    15721 ttttgttttg tttgttttgt cttttaacct acacctttat cattactcta acagatttag
    15781 ggcttctctt tctctacagc taagtaaggg aatatgtgca attatgagac atacaaaaaa
    15841 ggaaagggaa aggactttct aagtagcaaa tctgtgccat gaagtagatg tggcgtgaag
    15901 atacagagcc tgaggatagt aattttccct gagccacgca cacaggcttt tatttcatgc
    15961 cttttctctt tctgtgccgt cacctttgag aaaaacgatt gcaccttctc caagtctgcc
    16021 tttttaacag ctacagttaa gttggcaaga cttccccagc tctgaatata gccatttgcc
    16081 gactccggcc tctttgcgag actgactcaa atctgtgatc ttctgttcag catacacatc
    16141 agcaaagtga gaagatgagc actaaatata ggctctatta actttacttt tagatttact
    16201 gccttcaaaa agtgcctatt ctgagcaaca taaacgttat tccttacata tgtatgtaca
    16261 cacggtaccc agagtcgtac tgtgcagcct tcaaaaacat accatcagaa agagtaggtg
    16321 ctgagataag gaaactttgc caaatgaaag aaagtcactc acttccaata tcccctctca
    16381 agcggctacc gtgaaacggg ctgcaaacac attccctgag catcccttgc tgatacagct
    16441 tctttatatt tatatcctac tggatggtag catattgcta aggtttcctg tactctgctt
    16501 caagggaatg taagctttat ggcattgaaa catttaggga aaaaaaagat gtttaagaga
    16561 attaatagag ccgtagtctg tattaggatg tgtgtcatat gtgtgttcta taaactaagc
    16621 atcggtgggt ttagagtgtt aaagtgtcag cacattcctt ctccttttgt ctctcaggct
    16681 aacatgagag aaaatagaaa agtcttggct gtggggattg gaagctcagg gggccaaatg
    16741 tccttgccag atccttagag cattactttg actcctaaaa atagtagtgt atgttatttg
    16801 atggcttttg tttccatagt tccatcactg acaaaactgt caatactgtt gatggagcag
    16861 cagcatagcc tagagtgatg cattcttacc cagaggtggc aataggagag ggtccatgta
    16921 aataggacga ggtagacagt gcatgattgt aggagaaggg ttgaagggag gacatgattc
    16981 caaaaaagat cgttctcaat gtgtcgtctg actcaaccag ctggcagatt acacttgcca
    17041 agtcgttccc tttccttcta agtcagttgg ctccatattc acttgaatat gcctctgttt
    17101 gggcaaagca agatacctcc acttaacctt tatccaagga agctcttggt gtcctcttgg
    17161 tcataaagtt gtctcctacc taacccagtt ttaccaaatg gaagtaaaag gggacaaact
    17221 atggaagatg gactccatgc cattgcagtc agccaccatt ctcttttcca tataaggagc
    17281 cccattacat aagctacggg tgaggttgga acagctatgt ttcataattt caagagtgtg
    17341 accaccctgc tctagtcatc atcattggat gaatccagtt gactctttgg caaaagggtg
    17401 atacttttca ctaaaaatgc ctactcttcc tgttgatgtt ccttttctgt ttttaccttg
    17461 tccaatttcc acactagtca ttttttttat tttttagagg atcagatttt agcgctggaa
    17521 aatgagttca aaaatttcag tgtaatgtca taaggatgtt gggatacaga gatttttttt
    17581 ttccttggaa acaaatggac tgggaagaaa cacagcatgg ctttgctctg agtttcaatc
    17641 tgatgattat gaccatggaa gatagtctta tgtaaaggtt aaatggtgtt tacaagtgga
    17701 tagataaggc ggagatggtg agaagccggg ttttctctat gctaaatgtg tctactaaga
    17761 gcagcacttc ctactagcta agcacaatca tagccccacc gtgatgagct gctagtctga
    17821 ataacattcc ctgacttagg gaaaggcaca caaaaacata taaagaatat gtctattttc
    17881 atatgtgtga tactgacaga gccatggtat tcctaaaata taggtttctc ttttttcttg
    17941 tattcttagc aaattgcatt tattcactac attacaaacc atcactgatg tatccaaaat
    18001 agcacacata gttcagtatg aaaataagag aataaaatct gttataagca agtgatttag
    18061 gtattttctt ttgtgtttat gcattatctg actatattaa aacctgtttt tctatttacc
    18121 ttctatcagt tttctctacc aattatgttt tttcaatgct ctataagaat gaatatggaa
    18181 attatatttc ttttttctgt aaaagagttg caactacttt attatattta gaaatccaat
    18241 aaacttctta ttacattta
//
