LOCUS       NM_001375462           18316 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LIM domain containing preferred translocation partner
            in lipoma (LPP), transcript variant 11, mRNA.
ACCESSION   NM_001375462
VERSION     NM_001375462.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18316)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18316)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 18316)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (bases 1 to 18316)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 18316)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (bases 1 to 18316)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (bases 1 to 18316)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (bases 1 to 18316)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (bases 1 to 18316)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (bases 1 to 18316)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022498.18, AC117507.5,
            AC069226.19, AC063932.14, AC055711.18, AC009319.19 and KF510228.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3237969.1,
                                           SRR14038196.721291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617246.5/ ENSP00000478901.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC022498.18        60685-60780
            97-219              AC117507.5         11500-11622
            220-276             AC117507.5         127758-127814
            277-478             AC069226.19        127073-127274       c
            479-591             AC069226.19        48682-48794         c
            592-714             AC069226.19        8599-8721           c
            715-1398            AC063932.14        108433-109116       c
            1399-1525           AC063932.14        9884-10010          c
            1526-1695           AC055711.18        41842-42011
            1696-1874           AC055711.18        147929-148107
            1875-1995           AC055711.18        154372-154492
            1996-11736          AC009319.19        3236-12976
            11737-12117         KF510228.1         1-381
            12118-18316         AC009319.19        13359-19557
FEATURES             Location/Qualifiers
     source          1..18316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     gene            1..18316
                     /gene="LPP"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
     exon            1..96
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            97..219
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            220..276
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            277..478
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            479..591
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            592..714
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1398
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1525
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1695
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1874
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1995
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..18316
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      18295..18300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPP"
                     /note="hexamer: AATAAA"
     polyA_site      18316
                     /gene="LPP"
                     /note="major polyA site"
ORIGIN      
        1 acctcctcct ctgcctctgc ctccgcctcc agccgccgcc gccgccgccg ccgccgccac
       61 caccaccgcc gctgccccgg ctgcctcctc cctgaggtgg gaactttgag gctcagagac
      121 agagcagaag acagaacctg gtcttctgat tccctgtgtt ctgctttttt cattgttcca
      181 ctggacgctc atcagaggga agatcttttt cctcaattgc attgcagttg gctgaacctt
      241 gtgtcaacca tccattccag gagccagcta tctgagattc caacaatgtc tcacccatct
      301 tggctgccac ccaaaagcac tggtgagccc ctcggccatg tgcctgcacg gatggagacc
      361 acccattcct ttgggaaccc cagcatttca gtgtctacac aacagccacc caaaaagttt
      421 gccccggtag ttgctccaaa acctaagtac aacccataca aacaacctgg aggtgagggt
      481 gattttcttc cacccccacc tccacctcta gatgattcca gtgcccttcc atctatctct
      541 ggaaactttc ctcctccacc acctcttgat gaagaggctt tcaaagtaca ggggaatccc
      601 ggaggcaaga cacttgagga gaggcgctcc agcctggacg ctgagattga ctccttgacc
      661 agcatcttgg ctgaccttga gtgcagctcc ccctataagc ctcggcctcc acagagctcc
      721 actggttcaa cagcctctcc tccagtttcg accccagtca caggacacaa gagaatggtc
      781 atcccgaacc aaccccctct aacagcaacc aagaagtcta cattgaaacc acagcctgca
      841 ccccaggctg gacccatccc tgtggctcca atcggaacac tcaaacccca gcctcagcca
      901 gtcccagcct cctacaccac ggcctccact tcttcaaggc ctacctttaa tgtgcaggtg
      961 aagtcagccc agcccagccc tcattatatg gctgcccctt catcaggaca aatttatggc
     1021 tcagggcccc agggctataa cactcagcca gttcctgtct ctgggcagtg tccacctcct
     1081 tcaacacggg gaggcatgga ttatgcctac attccaccac caggacttca gccggagcct
     1141 gggtatgggt atgcccccaa ccagggacgc tattatgaag gctactatgc agcagggcca
     1201 ggctatgggg gcagaaatga ctctgaccct acctatggtc aacaaggtca cccaaatacc
     1261 tggaaacggg aaccagggta cactcctcct ggagcaggga accagaaccc tcctgggatg
     1321 tatccagtca ctggtcccaa gaagacctat atcacagatc ctgtttcagc cccctgtgcg
     1381 ccaccattgc agccaaaggg tggccattca gggcaactgg ggccttcgtc agttgcccct
     1441 tcattccgcc cagaggatga gcttgagcac ctgaccaaaa agatgctgta tgacatggaa
     1501 aatccacctg ctgacgaata ctttggccgc tgtgctcgct gtggagaaaa cgtagttggg
     1561 gaaggtacag gatgcactgc catggatcag gtcttccacg tggattgttt tacctgcatc
     1621 atctgcaaca acaagctccg agggcagcca ttctatgctg tggaaaagaa agcatactgc
     1681 gagccctgct acattaatac tctggagcag tgcaatgtgt gttccaagcc catcatggag
     1741 cggattctcc gagccaccgg gaaggcctat catcctcact gtttcacctg cgtgatgtgc
     1801 caccgcagcc tggatgggat cccattcact gtggatgctg gcgggctcat tcactgcatt
     1861 gaggacttcc acaagaaatt tgccccgcga tgttctgtgt gcaaggagcc tattatgcca
     1921 gccccgggcc aggaggagac tgtccgtatt gtggctttgg atcgagattt ccatgttcac
     1981 tgctaccgat gcgaggattg cggtggtctc ctgtctgaag gagataacca aggctgctac
     2041 cccttggatg ggcacatcct ctgcaagacc tgcaactctg cccgcatcag ggtgttgacc
     2101 gccaaggcga gcactgacct ttagattcag tcacctgttc agccggcact gagaagaacg
     2161 aacacaagaa aaagataaga aatactagag taaaggccat caaactacgc gatagtctct
     2221 gttcttcatc tgctattaac cttgccttag aaacacataa attatgagat tttttttaaa
     2281 agttgttacc aaatacacat ttcacattga atcatgtagg atcttgatgg gcctttgttc
     2341 ccaaggactt ccacattttt gcacagatta tgctccatcc cattcacttc tgcattcctg
     2401 taacttttaa tccctatgtt tgtctcactt ttcatctggt tgaatggctt ttcttagtgt
     2461 ggtatttgct gtcacatagt ttttcctggg tgagtctgcc aactcacagg tgcttttagg
     2521 cttgaaatct ccatcctatc atttccgttt tgcctgtgac tgtaaagagt agccattctt
     2581 ttcccatgta ttgaagagga tattcttctc ttgctttata ctactcacgt ccttggggag
     2641 ggaaatgcac aatttttttt tgttaggctg taaagaattt aagctgtaaa ttacataagt
     2701 tagaacaagc ccaaatttaa tttgcaacca tcagaattca gaatctatag tgaccagtga
     2761 tcaaggctaa ttggaaaaga gttatcggcc catagctaat aagtagtgac agacaaccaa
     2821 gcttcaatat ttttctaaag aaattacagg tgggatatgc tagaaaaggc attttggggt
     2881 tatgtttaaa aaaacattat tgtcccacaa tattacctta agatttttct tttccgcact
     2941 acctgaacat tgtaatacag acaaacttga tttcttctag aagataacat tttcaatact
     3001 gtcccacttc tcatcttaaa aatattgtca tgtttattct aatatccaac acaactatca
     3061 aaattgcctt tttctctaga ggatgaaggc tgtgaaaaaa ccgttcaaat tctcttcttt
     3121 ttctttttta ttaccaggtc cattttgcct gacaattgca aatcagagca tacaaaataa
     3181 aactgtgcag ttttgtttgg tttactttca aaagagtaga aagcttgaaa agattctgaa
     3241 accacagttt cattattctc ataatccttc tgcaactgaa attacatatt gcaggagaca
     3301 ttttcatatc atcaatgtga catttacacc acactttcaa agacaatcac tgaaacaaaa
     3361 attgtcttta tgagctaaaa atatgcagaa tctctgccta gaatctttat tcaaactttt
     3421 attagccagt gaaacacttg cttgccaact gccaagccat acttattaag ttcgaacatg
     3481 tttcacttaa ggagagacac ctagcttagt catggcaagt tgccattttg taaactaagg
     3541 attttggact gagatttctt aaatctttct tcaaatctcc cacaagtata tacttttaaa
     3601 ttatggagta ttttaagtct acaaaaaggt ataaataata atataatgaa ttcctatata
     3661 cctaataccc agtttaagac accaaatata acaagtataa ttacatcctc caatgtaccg
     3721 tttccttatt ccacagatat ctttttcatt attgtgaagt gatgttcaga tttctagttt
     3781 tttttctagt ttttaatttt aacatcagaa ctgaaataaa aaattatgga tacgtgtttt
     3841 gaattgcaaa ctattcctca ggaattccaa ttaaatttat tttacttgaa taggaatgat
     3901 cataaaagtg attctttttt tgtgactaga aattcttaag ccgatggtca ctatagctca
     3961 tccttaatgt atggctcatt tgcttttgtc actaaacggt tttgtgttag aaccaccaaa
     4021 attatagctt ttaagagctt cctttgacca ctgtcttttt cttaccctag ttctcttatc
     4081 tttgatcgta tatttctcat aatgtgaaat atgatgagat tcacttaggg gcagcatgtt
     4141 agttttggga ggcaatgtca actgtgtctc tgaattcctg tcttccaaat tgaagccaga
     4201 ccatgctgat gacctcaagt agcactgact atttgacaat agggctgata atgtaatcgg
     4261 cttgaatttt gacttagtaa ctttttatgt aatactttcg gagaaattct ctttaggaca
     4321 aagcagagag tccaatttat tgagggatag attgtatctc ttaaagtggt catattatta
     4381 ttaattttgc caaaagaaga agaatttatt gaatatttat actataaaat gcagtaacat
     4441 tctacttgct tattacattt aaatccttgt gtaactgaat gtttacatgt caagaggaaa
     4501 agctgtaaga aaatgctgtc acagacccat ccctgtggca tcgtcagcag aatactgctt
     4561 gcttacaatc tttattatgc attcttataa cataacctca gagtatcttt accaaaggtt
     4621 tttaaagtaa atctcttttt aagatagact tattctttta taataatgaa tgtgcactca
     4681 tacatatgta gaaacattta gatttagagt tttttttttc tttcacaagg tataataagg
     4741 aaaggatcct acaatatttt attctagggt ttcttaaata tatgatttat attactgtct
     4801 tttctattaa tcatttgatt taaacaatgc caagtcactc ttttttagtt gcatgaaatt
     4861 ttgcctgcaa cagagagaaa aagattgtat tactttaatg attataatca tactgtctgc
     4921 tgatataata tcataattgt tgtggtttaa atacataaat agtagaaaaa tcagagtcta
     4981 taacagaaag tttgtaaaaa tatactgatt ttgaaaagta tcaggaatat aaatatttgg
     5041 taattctgtg taacaagaga gacatggaaa aggaaaaaaa tccactatat catgggctct
     5101 gcagaacata tcaaaatagg atttcttaaa tttttcaacc cccagaccat actgactcaa
     5161 catggagtct cactggccaa gaaaattgcc tttaaaactc gaaaataagg ccaggtgtgg
     5221 tgactcacac ttgtaatccc agcaatttgg gaggctgaga caggaggatt gcctgaggcc
     5281 aggagtttga caccagcctg ggcaacatag tgagaccttg tctctacaaa aaataaaata
     5341 aaataaaaac caaattagcc agacatggtg gcatgcgctt gtttaaaaaa acaaataaat
     5401 aaataatcga ctcaaaaata agtcatgtgt cccagcataa ggcatcaggt tgttagatgc
     5461 tggcatctct gcagctcaaa gatgtgggtt ctttttcttg tcattaacac attgttattt
     5521 ctgtaggagc aacttctctg atcaaaatta cttttctggg tatgtgctga ttaagggggt
     5581 ggacttatca acactataat tgttccctat gaaagattcc acagagatgt ttatggtgag
     5641 gtttaaagga tatgaaactc tacatttaaa caagtatttt atatttgggt acagaggaag
     5701 aaagagaggg ctttttccat ggggctatag tagagagtta gtggaatata gacaggactc
     5761 tgaaaacaca acttccagcc atttttttag ttagtaaaaa tcctattaat gtgaaccagc
     5821 caggaataac agtgttattt ctattggata tggtttgggc ttctcttgtc aaatctgtgt
     5881 cggctgcccc ctgatccttc cattatcaag ttttgaaggg tgttggggaa attatggcag
     5941 ctgctaggga gatcagggaa acactgatgt aacctcaaag cctctcacca ttcctcttgg
     6001 cttggaaagg ctttattttt tcatatacat ttctagaaat attgctattc taccttagta
     6061 tttcacattt gtagttcaaa caagcgattg tccatctgtt gcctagagct atagtacatg
     6121 tgtgttatga atgaaatatg acagcatgtt ccatacccct gctttagcca tctgtgggaa
     6181 accagcaaac tgaaaaagac acctctgcaa aatgtgcctc aagtccattt cttgggatcg
     6241 ctcgtttggt gcactctcgt gggagacaat cagagaacaa catatacttg tgccttattt
     6301 tcaaagaatc tatttacact actatgaata ttccactgaa gagtcaatga tgtaaatgat
     6361 aaccaccaaa tctcaaaaat atactcacca aaaagtaaaa aagtaaaaaa aaaaaaaaaa
     6421 gaaagaaaga aaagaaagag agagaagtca acttttcatc ttaatatatt ctagtagtat
     6481 ttattttttc cttgtcttgg aagtatctca taggtcttta aatgagtaaa acatttttat
     6541 gccagaaggt gatataatgg atgttagtgt tttttatttg attttacagt agttttagtc
     6601 agataatgag gacagagact tcaacttgat tctttaccac cattcagcat attttttaat
     6661 tgtcttcatt gtatttgctt aatagtggtc cagacaagtt caaaacttgt tctcagtgag
     6721 gcattaatat ggtgcaacca tgaatatttc aggccaagtt attcacttga cagataacta
     6781 gaatgaaact tttctcatga ggctgttgtt tggttagcat agccttattt caaaccttaa
     6841 aaagttacct gactgaagct actatgactt ggtaaggatt cttcctctct tgctttcttc
     6901 ctcccttcct ttcttcctct tccttcctcc tcttcttatt ttctttccta ctttccatcc
     6961 tacctattag tgttgctgta cttggatttt ttgtaaatta aatcaatgca ttatgatttt
     7021 agggaattat gattatattc ataaggggaa ggctaccaga aaatatatgt ggcatccata
     7081 aaatcttctt ttataggggc atatttttta ggttgtattt attcgtaaag tgaaatgaga
     7141 taatagagtc tttctgtttc atgttaatga attttcatca gggactgagg tcatagattc
     7201 ttggaaaatt catttgtgac tgatctagtt ttctcagctg tatgcaaagt aatctttcaa
     7261 agactaggtt aagatttttt ttttaagtct gaagcaatgt aaccccaaaa aattataatt
     7321 ttaatgatgg cattttattt tattccattg cagcttgata actttcctta tagcaaagga
     7381 ataactattg tattttcaga attttaacac agattaacac ttagcctgta agactaataa
     7441 tatattgtaa tagttgatac taaaatattt ttcagcaggt tggacagcac cagtttttct
     7501 tagatcacag actacaggca gaatttccct tcaatccaga aaaaaggaca ctaatttcct
     7561 tttctattta attttcctgg cccttgtgca aaaaattgtg gactctatct tagttacaac
     7621 atgcatgtcc cttattttgt ggagagctgt gtgaaagatg cgtttttttt ctttttttct
     7681 tttttttttt tttgagacgg agtctggctc tgtcacccag gctggagtgc aatggcacga
     7741 tctcctctca ctgcaagctc cgcctcccag gttcacgcca ttctcctgtc tcagcctccc
     7801 gagtagctgg gactacaggc gcctgccacc acgcccggct aatttttttg tatttttagt
     7861 agagatggag tttcacagtg ttagccagga tggcctcgat ctcctgacct cgtgatccac
     7921 ccgcctcggc ctcccaaagt gctgggatta caggcgtgag ccaccgtgcc ccgcgtgttt
     7981 ttttctttag ctgattgaca ggtccccttc aaagttacaa aaaaaagtgc taatttttgc
     8041 tgttaaattc tggttgttat ttaattgaca gaagtctctt gatgcacgaa taaatatctc
     8101 tacatctagc ctttgttaaa aataaaaatt aatattctac aaacacctac atatactaga
     8161 gaggggtgaa acactgcagc taattccttt ataatacttt cagatgattg cattaagcct
     8221 ttcatgttat gtggcattgt taatttttcc tagataccca tccacttaag ggccagagaa
     8281 atccttattc atttaactct ggtgggcatt tatgtaacat acccaaataa aaacgttatt
     8341 aaacagccac aatcgcattc agtcaacttg gcactgaatg tagcttctaa aatcagttct
     8401 ctaccctacg aatggaatgt tctaccaaga aagagaagca tcaccatgtc atcttgtgtt
     8461 ctacaccact atagagagtt acagttgccc ccaaacacga atgctattcc caaataaaat
     8521 agaatcatgc tttgggaggc caaggcgggc cgatcacgag gtcaggagat cgagaccatc
     8581 ctggctaaca cggtgaaacc ccgtctctac taaaaaaaaa aaaaaataca aaaaattagc
     8641 ctggctcagt ggcgggcgcc tgtagtccca gctactcagg aggctgaggc aggagaatgg
     8701 cgtgaacccg ggaagcggag ctttcagtga gccgagatag cgccactgca gtccggcctg
     8761 ggcgaaagag cgagactccg tctcaaaaaa aaaaaaaaaa aaataggatc atggcccttt
     8821 taaagatctg aatcttctct gttattttcc tgatgaatca ccatcccata tcttcttagt
     8881 cctggccagt atgtagttgc gctcacatac gtctattcta gctctgtagc tccacaaaac
     8941 aagtcttaag tccaaatctt tgcctcttca tgtctgatat caccaactca ttcagctttt
     9001 cttcacttat tgacatagtg tcatgtccta tcactctctg ctgcttcttt aaacagtgga
     9061 cacaaacata ttttctaatt ttcagtgtac tcagtgaaac ttggcagttc accatgagtc
     9121 aggctaggtt gaaaggcttt ctttagggtt gaaagtaaac gaaattggaa tcacccaaag
     9181 agaatttccc caaaaaacct cagacccaga agtgtaaaag ctacagaagg atagaactcc
     9241 catgtctaca gacagttctg ttactttttg ttctgtacta ttttggatgt tgccaaaatc
     9301 aaattcatcc tgaaaacagg aagcaagcta atgcatatgc catccatgag attcccactt
     9361 ctgggtcagt tcatattcca ttcaaccttt tccttttatc cttgtcttct tcagaataag
     9421 acatttttcc tccatatttt catattaaat attaacactt tataggttct actttaatat
     9481 atggacactt tacaggttat acataaatat ttgctggttg attgatttcg agattcattc
     9541 attctgtgct caaatatttg tacctagaga cgttacatgt tagaaaaagt gagcagcttc
     9601 tttctctaat catttaggag tccatatttt tcttttcttt ttgttctccc aacatcctta
     9661 tctcttactc agctcttcaa tttataatta ccaaataatc actgttagag aatcagcccc
     9721 taagtaactt tgattctggc caactgtaat aagatccaac cacttaaatc tgtacttact
     9781 caataggaag gaatgtgaca tcaggaagag tcattccagt gacattagta agactttatg
     9841 gagtacataa aatttgataa gaaatcttga gctgattctt tgacttgatt tagaagttga
     9901 gaaaagagta tttaaggcac aacagggaaa catgggctat actcagagaa gaccctctgc
     9961 attggccaaa atatcatgga ttctggaaat tccttcttaa cagaaaaaaa aggcttccaa
    10021 ataatcaggc tgaatgggaa gaaaaaggca tagaggaagc ctgaggaagt atttacttgc
    10081 ttttcccatc tctttataat tggaagagaa gatgatctgc caaaatataa cccagcatgc
    10141 acagtatgga caggaagcag ccctccatga actttattat cacagaatat gagcattctt
    10201 attgatccac agctacatct tctattcttg cagcaagggt acatgtcctt tgaccctcca
    10261 caaaagaaca agcaggacat ctctattttc ctattgagtc tgagtccatt attagaaagg
    10321 acttcccagc catcttttct acttggtatt aaaattccct tacagattca ttgctaagtg
    10381 ccaattcttt ttttttcttt tgagacggag tcttgctctg tcgcccaggc tggagtgcag
    10441 tggcgcaatc tcggctcact gcaagctccg cttctcgggt tcacgccatt ctcctgcctc
    10501 agcctcccga gtagctggga ctacagacgc ccgccaccgc gcccagctaa ttttttttgt
    10561 acttttagta gagacggggt ttcaccgtgg tctcgatctc ctgacctcgt gatccgcccg
    10621 cctcggcctc ccaaagtgcc aattctgact ctacttaaac atcacctgta tcagggagct
    10681 cattattcct tgaggtctta catttctttc agcacatttt gttccaagct acacgacttt
    10741 aaaacagagc cagcctttgg ggcatatgtt ctctttggtg ccacacaaaa cctgtagtac
    10801 atgatacagt gttgcttccc ccctcctttt ccttccatat atatttgttt tgttttgggc
    10861 attgcattac ttttttgaat ttttaagaat ctctaaaatt agtctgaagg atgttctgag
    10921 ggccagacat tagaatttgt gagttttttt gttgctggtt gtactttcct atttagaaga
    10981 cagaccgttc tgacagttgt tgtgtagctt catgccttcc ccagtaacta acccatgaac
    11041 agtacacccc ttttatctga cttgttgata atgaccttaa aaatgttagg aaatgggccg
    11101 ggcgcggtgg ctcgtgcctg taatccagca ctttgggagg ccgaggcgag cggatcatga
    11161 ggtcaagaga tcgagaccat cctggtcaac atggtgaaac cccgactcta ctaaaaaaaa
    11221 tacaaaaatt agccgggcgt gttggcgggc gcctgtagtc ccaactactt gggaggctga
    11281 ggcaggagaa tcacctgaac ccaggaggca gaggttgcag tgagcagaga ttgcgccact
    11341 gcactccagc ctgggcgaca gaacgagact ccgtctcaaa aaaaaaaaaa aaaaaaaaag
    11401 gttgggaaat attggtgtat aatccccatg tctaacaagg aagaagtcaa aagcaaaaga
    11461 tagtggtatt gccgaaaact cattatttct agttagttca tctgtggaaa aggatatcgt
    11521 tcttgaggag aggggttcta ttatgctata gttttctatg gaaatgtaca aatgctttcc
    11581 tcattgctct ggatgactat ttagtttaaa taatatacct ttgtcatggg gaagaccatg
    11641 attgtggctt cttctacccc aactttgaat gagagagcac tgtaagcaga aactgccatc
    11701 agtctcctgg gcaggacctg gaggtaactt tctgagctgt aaaatagtaa ttcctaagag
    11761 agcttacaaa ctgcttccac acagaaaata gcgcagggag gacagttatt agtaccccta
    11821 ttctagaaga gaaagctgag gctcaagcca ttaagtgact tgccaaaagc tgtgacatag
    11881 ctgggaagtg gcagatttgg ggatataacc aggtcttgca agtccagtgc tgtctccaag
    11941 tagccacgct cacagctgag aacaccttag aggacaatat cgacttctta cagactacca
    12001 agcccccagt catccaggga aattcagaga ccaattgact gccaggtggc aaatccacat
    12061 gtgtactgcg gtctttagag atcatttaga gcttgcacac atctgtgtct tcttgtggga
    12121 aacctctagg tattctgtct gatcagcact gtgaggaagt tggtgggaaa aggccactga
    12181 taagaacaaa caatgggcag aaggaagcac attgcaataa atttccccag agagagttcc
    12241 tttacattcc attcaccaaa aacctctctg gaactgtcag gttcagaata tcaaccaaga
    12301 ccatatcatt tagaattcat tggcatgtag aggtgactcg attcctaaaa gaagcctctc
    12361 tcccatgaac cacgatgtac gttccacaga ggcagaaacc gccgtaggtt agcaatgcat
    12421 tttagtcttt ctctccattc acatttactg agagcacacc acgtgcatgt tgctgcaaca
    12481 ggcatttccg atagagccga tccatgagct aacaatgtct gaaaacaaat gttatggaac
    12541 tgttggcatt tctgagattt ggcctttgcc atttgataga ctttgcttcc caggatgctg
    12601 tcattttgtg attttttata attacaagga atttggtacc atgttgtttt caaaaaacct
    12661 cctagaaagt ctccatgtat gctctagaag ttgctctacg taacagttca gcaagcaagt
    12721 gttccttctc ttgagctgcg tccctcagga agctgtacct ttagggtgtg ctttccactt
    12781 tttatttcct ctcatttcac tcctttcatt gtttgctata tcctaaaata tgtgaagtga
    12841 gagaaaaaat atcatttctt ctcattaaat ctcctgcatt aaatctaaga atcctttaaa
    12901 ataatcacac ctgataagtg ttttatgcat ttccctccct ggagtgttat catccatcaa
    12961 gccagtatca tcatccacct gcttattcct tgggactaat gagagccaag ttaaatagca
    13021 aatgacttct caccccttcc tagtcctcat gcctgaggaa taagggcgac attaatggga
    13081 gcgggagagt ggtggctttg gttgagatgc acgttcacag actagaaaag tgcctcacct
    13141 ccatggtgta tatgtgccac cttttcttaa tccagtctat cattgttgga catttgggtt
    13201 ggttccaagt ctttgctatt gtgaatagtg ccgcaataaa cataagtgtg catgtgtctt
    13261 tatagcagca tgatttataa tcctttgggt atatacccag taatgggatg gctgggtcaa
    13321 atggtatttc tagttctaga tccctgagga atctccacac tgacttccac aatggttgaa
    13381 ctagttcaca gtcccaccaa cagtgtaaaa gtgttcttat ttctccacat cctctccagc
    13441 acctgttgtt tcctgacttt ttaatgattg ccattctaac tggtgtgaga tggtatctca
    13501 tagtggtttt gatttgcatt tctctgatgg ccagtgatgg tgagcatttt ttcatgtgtt
    13561 tcttggctgc ataaatgtct tcttttgaga agtgtctgtt caatactatg cagccataaa
    13621 aaatgatgag ttcatgtcct ttgtagggac atggatgaaa ttggaaatca tcattctcag
    13681 taaactatct caaggacaaa aaaccaaaca ccacatgttc tcactcacag gtgggaattg
    13741 aacaatgaga acacatggac acaggaaggg gaacatcaca ctctggggac tgttgtgggg
    13801 tggagggagg agggagggat agcattagga gatataccta atgctaaatg acgagttaat
    13861 gggtgcagca caccagcatg gcacatgtat acatatgtaa ctaacctgca cattgtgcac
    13921 atgtacccta aaacttaaag tataataata atgaaataaa attaaaaaaa aaaaagaaaa
    13981 gtgcctcacc tccctgtgag gcttgatgaa tattgtggcc agtgagtgga aaatgattct
    14041 tgtcgaatag acagagtatt cccaccccag gaatggatta atagaagaca caatttgagc
    14101 acttctcaga attatctagt atgcctgagt agagactcac atgggtggaa tctgtgttgt
    14161 ctcatcagag ggaataaaaa gacaatgagg tggtaaatgt gaaaaaagca gccttttaga
    14221 aaaacattat tttcaaatac ctttataaat catctaattt atcttcacat aatataaaga
    14281 aaaaactaat aaaaattttc gtatttcact ttacataata tgttctccca tatttaggga
    14341 tcatacaatt gtattgtctt caaaacacac acacacacac atacacacac acacacacac
    14401 acacacacac cccttccaag aaagctgatc cttcagaaaa taaatcttat ttttaagcac
    14461 ttgggttttc aggccagaaa attaataaat cctaaacctg acccattttt gtaacagcta
    14521 aaaaggagaa gaaaaagcta gttaaatttt gtgtggatcc atttatctct taaaatatgc
    14581 caaagcaatt tgaggtgggg gtggaaacag gtatttatct ctcatgcgtg attctctctt
    14641 tatatttcta tctgttggga aaagggtaaa gaactattct tggtcattat tgatgtattg
    14701 tgttgccact ttgtatggtg cctgctgtgc tttatcccga ggcatagcag taatcgttac
    14761 tatcttgact ctttccttca tcacaagaga gtaaatatga agtctgaatg tcgttcctca
    14821 cccccaaatt gtttaactct gcttccaaac tagtttaaga aatgcaaaat gggaagagct
    14881 agcttttctt agatacattt cttccttttt tattctttct tgggagacgt taagtataaa
    14941 agggaaaaag tcagttcctt cttctctctc tttctctttg ggtgacagca atgctcactt
    15001 agtaattata aactggaaat aggagagtag cttgagcagg ttatgatata tctgcccaat
    15061 gtgtttcatt ccttcaaaca taaactttga gagtaaaaga gatttttata atttaaatgc
    15121 caacgacagg aatggcctca tgttttaact ttcaaataat aaatggggag ttggtatttg
    15181 ggcagagttt gcattttact aatcctatat actttgagct tagtttttag aattgtgtca
    15241 aatacatcaa catatcagga ttatagtgcc aaaaatagtt aaagtgcctt ggtcctccct
    15301 ctgtaggcag caaattgaaa ctaacatggg accatgccat ccttctagca taatggagaa
    15361 gtctgaactg aggagtatct ttgatgaaag acatttagga ccctagaaac taaatcttgt
    15421 caccaagact ttatagtaaa gtagtagcaa aattattttt aaaagacttt cttcctttta
    15481 ctacccattt cctctcttgg gaaagctgat gagcaaatta tccaagactc atttctttat
    15541 taggcaaagt cagaatattt cccctctgaa aatctgaatt atgccctcat tctttttcaa
    15601 gaaatatctc aaagagcaaa tagaattaaa catgacactt gattgtctga ttatttggca
    15661 tgtataaaat tatcatgtgg cttaatgtgc cttaagtgaa aatttaaact tagacctgaa
    15721 acctttacag ttggatgtag cgttgagctt ttgcatgttt tctgtataat aaaccacttt
    15781 tgttttgttt gttttgtctt ttaacctaca cctttatcat tactctaaca gatttagggc
    15841 ttctctttct ctacagctaa gtaagggaat atgtgcaatt atgagacata caaaaaagga
    15901 aagggaaagg actttctaag tagcaaatct gtgccatgaa gtagatgtgg cgtgaagata
    15961 cagagcctga ggatagtaat tttccctgag ccacgcacac aggcttttat ttcatgcctt
    16021 ttctctttct gtgccgtcac ctttgagaaa aacgattgca ccttctccaa gtctgccttt
    16081 ttaacagcta cagttaagtt ggcaagactt ccccagctct gaatatagcc atttgccgac
    16141 tccggcctct ttgcgagact gactcaaatc tgtgatcttc tgttcagcat acacatcagc
    16201 aaagtgagaa gatgagcact aaatataggc tctattaact ttacttttag atttactgcc
    16261 ttcaaaaagt gcctattctg agcaacataa acgttattcc ttacatatgt atgtacacac
    16321 ggtacccaga gtcgtactgt gcagccttca aaaacatacc atcagaaaga gtaggtgctg
    16381 agataaggaa actttgccaa atgaaagaaa gtcactcact tccaatatcc cctctcaagc
    16441 ggctaccgtg aaacgggctg caaacacatt ccctgagcat cccttgctga tacagcttct
    16501 ttatatttat atcctactgg atggtagcat attgctaagg tttcctgtac tctgcttcaa
    16561 gggaatgtaa gctttatggc attgaaacat ttagggaaaa aaaagatgtt taagagaatt
    16621 aatagagccg tagtctgtat taggatgtgt gtcatatgtg tgttctataa actaagcatc
    16681 ggtgggttta gagtgttaaa gtgtcagcac attccttctc cttttgtctc tcaggctaac
    16741 atgagagaaa atagaaaagt cttggctgtg gggattggaa gctcaggggg ccaaatgtcc
    16801 ttgccagatc cttagagcat tactttgact cctaaaaata gtagtgtatg ttatttgatg
    16861 gcttttgttt ccatagttcc atcactgaca aaactgtcaa tactgttgat ggagcagcag
    16921 catagcctag agtgatgcat tcttacccag aggtggcaat aggagagggt ccatgtaaat
    16981 aggacgaggt agacagtgca tgattgtagg agaagggttg aagggaggac atgattccaa
    17041 aaaagatcgt tctcaatgtg tcgtctgact caaccagctg gcagattaca cttgccaagt
    17101 cgttcccttt ccttctaagt cagttggctc catattcact tgaatatgcc tctgtttggg
    17161 caaagcaaga tacctccact taacctttat ccaaggaagc tcttggtgtc ctcttggtca
    17221 taaagttgtc tcctacctaa cccagtttta ccaaatggaa gtaaaagggg acaaactatg
    17281 gaagatggac tccatgccat tgcagtcagc caccattctc ttttccatat aaggagcccc
    17341 attacataag ctacgggtga ggttggaaca gctatgtttc ataatttcaa gagtgtgacc
    17401 accctgctct agtcatcatc attggatgaa tccagttgac tctttggcaa aagggtgata
    17461 cttttcacta aaaatgccta ctcttcctgt tgatgttcct tttctgtttt taccttgtcc
    17521 aatttccaca ctagtcattt tttttatttt ttagaggatc agattttagc gctggaaaat
    17581 gagttcaaaa atttcagtgt aatgtcataa ggatgttggg atacagagat tttttttttc
    17641 cttggaaaca aatggactgg gaagaaacac agcatggctt tgctctgagt ttcaatctga
    17701 tgattatgac catggaagat agtcttatgt aaaggttaaa tggtgtttac aagtggatag
    17761 ataaggcgga gatggtgaga agccgggttt tctctatgct aaatgtgtct actaagagca
    17821 gcacttccta ctagctaagc acaatcatag ccccaccgtg atgagctgct agtctgaata
    17881 acattccctg acttagggaa aggcacacaa aaacatataa agaatatgtc tattttcata
    17941 tgtgtgatac tgacagagcc atggtattcc taaaatatag gtttctcttt tttcttgtat
    18001 tcttagcaaa ttgcatttat tcactacatt acaaaccatc actgatgtat ccaaaatagc
    18061 acacatagtt cagtatgaaa ataagagaat aaaatctgtt ataagcaagt gatttaggta
    18121 ttttcttttg tgtttatgca ttatctgact atattaaaac ctgtttttct atttaccttc
    18181 tatcagtttt ctctaccaat tatgtttttt caatgctcta taagaatgaa tatggaaatt
    18241 atatttcttt tttctgtaaa agagttgcaa ctactttatt atatttagaa atccaataaa
    18301 cttcttatta cattta
//
