LOCUS       NP_001362391             612 aa            linear   PRI 19-AUG-2024
DEFINITION  lipoma-preferred partner isoform a [Homo sapiens].
ACCESSION   NP_001362391
VERSION     NP_001362391.1
DBSOURCE    REFSEQ: accession NM_001375462.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 612)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 612)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (residues 1 to 612)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (residues 1 to 612)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 612)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (residues 1 to 612)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (residues 1 to 612)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (residues 1 to 612)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (residues 1 to 612)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (residues 1 to 612)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022498.18, AC117507.5,
            AC069226.19, AC063932.14, AC055711.18, AC009319.19 and KF510228.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3237969.1,
                                           SRR14038196.721291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617246.5/ ENSP00000478901.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..612
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     Protein         1..612
                     /product="lipoma-preferred partner isoform a"
                     /note="LIM protein; lipoma preferred partner"
                     /calculated_mol_wt=65616
     Region          1..118
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q93052.1)"
     Region          <19..388
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            108
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q8BFW7; propagated from
                     UniProtKB/Swiss-Prot (Q93052.1)"
     Site            116
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5XI07; propagated from
                     UniProtKB/Swiss-Prot (Q93052.1)"
     Region          132..219
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q93052.1)"
     Site            151
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5XI07; propagated from
                     UniProtKB/Swiss-Prot (Q93052.1)"
     Site            244
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q8BFW7; propagated from
                     UniProtKB/Swiss-Prot (Q93052.1)"
     Site            301
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q8BFW7; propagated from
                     UniProtKB/Swiss-Prot (Q93052.1)"
     Region          307..387
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q93052.1)"
     Site            333
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q93052.1)"
     Site            371..372
                     /site_type="other"
                     /note="Breakpoint for translocation to form HMGA2-LPP;
                     propagated from UniProtKB/Swiss-Prot (Q93052.1)"
     Site            375
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q93052.1)"
     Region          416..469
                     /region_name="LIM1_TRIP6"
                     /note="The first LIM domain of Thyroid
                     receptor-interacting protein 6 (TRIP6); cd09350"
                     /db_xref="CDD:188736"
     Site            order(416,419,438,441,444,447,465,468)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188736"
     Site            470..471
                     /site_type="other"
                     /note="Breakpoint for translocation to form HMGA2-LPP and
                     KMT2A/MLL1-LPP; propagated from UniProtKB/Swiss-Prot
                     (Q93052.1)"
     Region          476..528
                     /region_name="LIM2_TRIP6"
                     /note="The second LIM domain of Thyroid
                     receptor-interacting protein 6 (TRIP6); cd09356"
                     /db_xref="CDD:188742"
     Site            order(476,479,496,499,502,505,524,527)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188742"
     Region          536..601
                     /region_name="LIM3_TRIP6"
                     /note="The third LIM domain of Thyroid
                     receptor-interacting protein 6 (TRIP6); cd09436"
                     /db_xref="CDD:188820"
     Site            order(536,539,563,566,569,572,593,596)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188820"
     CDS             1..612
                     /gene="LPP"
                     /coded_by="NM_001375462.1:286..2124"
                     /note="isoform a is encoded by transcript variant 11"
                     /db_xref="CCDS:CCDS3291.1"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
ORIGIN      
        1 mshpswlppk stgeplghvp armetthsfg npsisvstqq ppkkfapvva pkpkynpykq
       61 pggegdflpp pppplddssa lpsisgnfpp pppldeeafk vqgnpggktl eerrssldae
      121 idsltsilad lecsspykpr ppqsstgsta sppvstpvtg hkrmvipnqp pltatkkstl
      181 kpqpapqagp ipvapigtlk pqpqpvpasy ttastssrpt fnvqvksaqp sphymaapss
      241 gqiygsgpqg yntqpvpvsg qcpppstrgg mdyayipppg lqpepgygya pnqgryyegy
      301 yaagpgyggr ndsdptygqq ghpntwkrep gytppgagnq nppgmypvtg pkktyitdpv
      361 sapcapplqp kgghsgqlgp ssvapsfrpe delehltkkm lydmenppad eyfgrcarcg
      421 envvgegtgc tamdqvfhvd cftciicnnk lrgqpfyave kkaycepcyi ntleqcnvcs
      481 kpimerilra tgkayhphcf tcvmchrsld gipftvdagg lihciedfhk kfaprcsvck
      541 epimpapgqe etvrivaldr dfhvhcyrce dcggllsegd nqgcypldgh ilcktcnsar
      601 irvltakast dl
//
