LOCUS       NM_001375456           18502 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LIM domain containing preferred translocation partner
            in lipoma (LPP), transcript variant 5, mRNA.
ACCESSION   NM_001375456
VERSION     NM_001375456.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18502)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18502)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 18502)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (bases 1 to 18502)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 18502)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (bases 1 to 18502)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (bases 1 to 18502)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (bases 1 to 18502)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (bases 1 to 18502)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (bases 1 to 18502)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022498.18, AC069226.19,
            AC063932.14, AC055711.18, AC009319.19 and KF510228.1.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2544027.1,
                                           SRR14372080.640223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               AC022498.18        59549-59891
            344-462             AC022498.18        114728-114846
            463-664             AC069226.19        127073-127274       c
            665-777             AC069226.19        48682-48794         c
            778-900             AC069226.19        8599-8721           c
            901-1584            AC063932.14        108433-109116       c
            1585-1711           AC063932.14        9884-10010          c
            1712-1881           AC055711.18        41842-42011
            1882-2060           AC055711.18        147929-148107
            2061-2181           AC055711.18        154372-154492
            2182-11922          AC009319.19        3236-12976
            11923-12303         KF510228.1         1-381
            12304-18502         AC009319.19        13359-19557
FEATURES             Location/Qualifiers
     source          1..18502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     gene            1..18502
                     /gene="LPP"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
     exon            1..343
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            344..462
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            463..664
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..2310
                     /gene="LPP"
                     /note="isoform a is encoded by transcript variant 5; LIM
                     protein; lipoma preferred partner"
                     /codon_start=1
                     /product="lipoma-preferred partner isoform a"
                     /protein_id="NP_001362385.1"
                     /db_xref="CCDS:CCDS3291.1"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
                     /translation="MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKK
                     FAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQ
                     GNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTG
                     HKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSR
                     PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYI
                     PPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTP
                     PGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
                     LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNK
                     LRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRS
                     LDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHC
                     YRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            665..777
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            778..900
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1584
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1711
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1881
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2060
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2181
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..18502
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      18481..18486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPP"
                     /note="hexamer: AATAAA"
     polyA_site      18502
                     /gene="LPP"
                     /note="major polyA site"
ORIGIN      
        1 acaggacaga ggaagttgcc ctgaagcaac tgattgtcat tgatattcag ggctcgctgt
       61 caaccaggac cttccaggaa ctggctctgg gccaagagca gtagaaatca ctgggtggtc
      121 cgcacagctc gcgggcatct aacctgcttc aaggctcagg gctaaaaggg agccagggcc
      181 cttcctggag gcgggaaccc aagtgggagg cagagcgcct gggcccgctc ctcgatctgc
      241 tgagtgacga ccctgtacaa gtcatttctc ttccgagagc ttcagtttcc tcacgtgcca
      301 agcggacggg ttggaagttg gtctttgcca gctctgacac cttgaattga agagaatcct
      361 gacaagtggc atgttgggaa aggcctgaag gaagccagac cagcttgctc tcagagctcc
      421 ttgggtcccc tgcggccccc aggtgatctt cagcaagacc tgattccaac aatgtctcac
      481 ccatcttggc tgccacccaa aagcactggt gagcccctcg gccatgtgcc tgcacggatg
      541 gagaccaccc attcctttgg gaaccccagc atttcagtgt ctacacaaca gccacccaaa
      601 aagtttgccc cggtagttgc tccaaaacct aagtacaacc catacaaaca acctggaggt
      661 gagggtgatt ttcttccacc cccacctcca cctctagatg attccagtgc ccttccatct
      721 atctctggaa actttcctcc tccaccacct cttgatgaag aggctttcaa agtacagggg
      781 aatcccggag gcaagacact tgaggagagg cgctccagcc tggacgctga gattgactcc
      841 ttgaccagca tcttggctga ccttgagtgc agctccccct ataagcctcg gcctccacag
      901 agctccactg gttcaacagc ctctcctcca gtttcgaccc cagtcacagg acacaagaga
      961 atggtcatcc cgaaccaacc ccctctaaca gcaaccaaga agtctacatt gaaaccacag
     1021 cctgcacccc aggctggacc catccctgtg gctccaatcg gaacactcaa accccagcct
     1081 cagccagtcc cagcctccta caccacggcc tccacttctt caaggcctac ctttaatgtg
     1141 caggtgaagt cagcccagcc cagccctcat tatatggctg ccccttcatc aggacaaatt
     1201 tatggctcag ggccccaggg ctataacact cagccagttc ctgtctctgg gcagtgtcca
     1261 cctccttcaa cacggggagg catggattat gcctacattc caccaccagg acttcagccg
     1321 gagcctgggt atgggtatgc ccccaaccag ggacgctatt atgaaggcta ctatgcagca
     1381 gggccaggct atgggggcag aaatgactct gaccctacct atggtcaaca aggtcaccca
     1441 aatacctgga aacgggaacc agggtacact cctcctggag cagggaacca gaaccctcct
     1501 gggatgtatc cagtcactgg tcccaagaag acctatatca cagatcctgt ttcagccccc
     1561 tgtgcgccac cattgcagcc aaagggtggc cattcagggc aactggggcc ttcgtcagtt
     1621 gccccttcat tccgcccaga ggatgagctt gagcacctga ccaaaaagat gctgtatgac
     1681 atggaaaatc cacctgctga cgaatacttt ggccgctgtg ctcgctgtgg agaaaacgta
     1741 gttggggaag gtacaggatg cactgccatg gatcaggtct tccacgtgga ttgttttacc
     1801 tgcatcatct gcaacaacaa gctccgaggg cagccattct atgctgtgga aaagaaagca
     1861 tactgcgagc cctgctacat taatactctg gagcagtgca atgtgtgttc caagcccatc
     1921 atggagcgga ttctccgagc caccgggaag gcctatcatc ctcactgttt cacctgcgtg
     1981 atgtgccacc gcagcctgga tgggatccca ttcactgtgg atgctggcgg gctcattcac
     2041 tgcattgagg acttccacaa gaaatttgcc ccgcgatgtt ctgtgtgcaa ggagcctatt
     2101 atgccagccc cgggccagga ggagactgtc cgtattgtgg ctttggatcg agatttccat
     2161 gttcactgct accgatgcga ggattgcggt ggtctcctgt ctgaaggaga taaccaaggc
     2221 tgctacccct tggatgggca catcctctgc aagacctgca actctgcccg catcagggtg
     2281 ttgaccgcca aggcgagcac tgacctttag attcagtcac ctgttcagcc ggcactgaga
     2341 agaacgaaca caagaaaaag ataagaaata ctagagtaaa ggccatcaaa ctacgcgata
     2401 gtctctgttc ttcatctgct attaaccttg ccttagaaac acataaatta tgagattttt
     2461 tttaaaagtt gttaccaaat acacatttca cattgaatca tgtaggatct tgatgggcct
     2521 ttgttcccaa ggacttccac atttttgcac agattatgct ccatcccatt cacttctgca
     2581 ttcctgtaac ttttaatccc tatgtttgtc tcacttttca tctggttgaa tggcttttct
     2641 tagtgtggta tttgctgtca catagttttt cctgggtgag tctgccaact cacaggtgct
     2701 tttaggcttg aaatctccat cctatcattt ccgttttgcc tgtgactgta aagagtagcc
     2761 attcttttcc catgtattga agaggatatt cttctcttgc tttatactac tcacgtcctt
     2821 ggggagggaa atgcacaatt tttttttgtt aggctgtaaa gaatttaagc tgtaaattac
     2881 ataagttaga acaagcccaa atttaatttg caaccatcag aattcagaat ctatagtgac
     2941 cagtgatcaa ggctaattgg aaaagagtta tcggcccata gctaataagt agtgacagac
     3001 aaccaagctt caatattttt ctaaagaaat tacaggtggg atatgctaga aaaggcattt
     3061 tggggttatg tttaaaaaaa cattattgtc ccacaatatt accttaagat ttttcttttc
     3121 cgcactacct gaacattgta atacagacaa acttgatttc ttctagaaga taacattttc
     3181 aatactgtcc cacttctcat cttaaaaata ttgtcatgtt tattctaata tccaacacaa
     3241 ctatcaaaat tgcctttttc tctagaggat gaaggctgtg aaaaaaccgt tcaaattctc
     3301 ttctttttct tttttattac caggtccatt ttgcctgaca attgcaaatc agagcataca
     3361 aaataaaact gtgcagtttt gtttggttta ctttcaaaag agtagaaagc ttgaaaagat
     3421 tctgaaacca cagtttcatt attctcataa tccttctgca actgaaatta catattgcag
     3481 gagacatttt catatcatca atgtgacatt tacaccacac tttcaaagac aatcactgaa
     3541 acaaaaattg tctttatgag ctaaaaatat gcagaatctc tgcctagaat ctttattcaa
     3601 acttttatta gccagtgaaa cacttgcttg ccaactgcca agccatactt attaagttcg
     3661 aacatgtttc acttaaggag agacacctag cttagtcatg gcaagttgcc attttgtaaa
     3721 ctaaggattt tggactgaga tttcttaaat ctttcttcaa atctcccaca agtatatact
     3781 tttaaattat ggagtatttt aagtctacaa aaaggtataa ataataatat aatgaattcc
     3841 tatataccta atacccagtt taagacacca aatataacaa gtataattac atcctccaat
     3901 gtaccgtttc cttattccac agatatcttt ttcattattg tgaagtgatg ttcagatttc
     3961 tagttttttt tctagttttt aattttaaca tcagaactga aataaaaaat tatggatacg
     4021 tgttttgaat tgcaaactat tcctcaggaa ttccaattaa atttatttta cttgaatagg
     4081 aatgatcata aaagtgattc tttttttgtg actagaaatt cttaagccga tggtcactat
     4141 agctcatcct taatgtatgg ctcatttgct tttgtcacta aacggttttg tgttagaacc
     4201 accaaaatta tagcttttaa gagcttcctt tgaccactgt ctttttctta ccctagttct
     4261 cttatctttg atcgtatatt tctcataatg tgaaatatga tgagattcac ttaggggcag
     4321 catgttagtt ttgggaggca atgtcaactg tgtctctgaa ttcctgtctt ccaaattgaa
     4381 gccagaccat gctgatgacc tcaagtagca ctgactattt gacaataggg ctgataatgt
     4441 aatcggcttg aattttgact tagtaacttt ttatgtaata ctttcggaga aattctcttt
     4501 aggacaaagc agagagtcca atttattgag ggatagattg tatctcttaa agtggtcata
     4561 ttattattaa ttttgccaaa agaagaagaa tttattgaat atttatacta taaaatgcag
     4621 taacattcta cttgcttatt acatttaaat ccttgtgtaa ctgaatgttt acatgtcaag
     4681 aggaaaagct gtaagaaaat gctgtcacag acccatccct gtggcatcgt cagcagaata
     4741 ctgcttgctt acaatcttta ttatgcattc ttataacata acctcagagt atctttacca
     4801 aaggttttta aagtaaatct ctttttaaga tagacttatt cttttataat aatgaatgtg
     4861 cactcataca tatgtagaaa catttagatt tagagttttt tttttctttc acaaggtata
     4921 ataaggaaag gatcctacaa tattttattc tagggtttct taaatatatg atttatatta
     4981 ctgtcttttc tattaatcat ttgatttaaa caatgccaag tcactctttt ttagttgcat
     5041 gaaattttgc ctgcaacaga gagaaaaaga ttgtattact ttaatgatta taatcatact
     5101 gtctgctgat ataatatcat aattgttgtg gtttaaatac ataaatagta gaaaaatcag
     5161 agtctataac agaaagtttg taaaaatata ctgattttga aaagtatcag gaatataaat
     5221 atttggtaat tctgtgtaac aagagagaca tggaaaagga aaaaaatcca ctatatcatg
     5281 ggctctgcag aacatatcaa aataggattt cttaaatttt tcaaccccca gaccatactg
     5341 actcaacatg gagtctcact ggccaagaaa attgccttta aaactcgaaa ataaggccag
     5401 gtgtggtgac tcacacttgt aatcccagca atttgggagg ctgagacagg aggattgcct
     5461 gaggccagga gtttgacacc agcctgggca acatagtgag accttgtctc tacaaaaaat
     5521 aaaataaaat aaaaaccaaa ttagccagac atggtggcat gcgcttgttt aaaaaaacaa
     5581 ataaataaat aatcgactca aaaataagtc atgtgtccca gcataaggca tcaggttgtt
     5641 agatgctggc atctctgcag ctcaaagatg tgggttcttt ttcttgtcat taacacattg
     5701 ttatttctgt aggagcaact tctctgatca aaattacttt tctgggtatg tgctgattaa
     5761 gggggtggac ttatcaacac tataattgtt ccctatgaaa gattccacag agatgtttat
     5821 ggtgaggttt aaaggatatg aaactctaca tttaaacaag tattttatat ttgggtacag
     5881 aggaagaaag agagggcttt ttccatgggg ctatagtaga gagttagtgg aatatagaca
     5941 ggactctgaa aacacaactt ccagccattt ttttagttag taaaaatcct attaatgtga
     6001 accagccagg aataacagtg ttatttctat tggatatggt ttgggcttct cttgtcaaat
     6061 ctgtgtcggc tgccccctga tccttccatt atcaagtttt gaagggtgtt ggggaaatta
     6121 tggcagctgc tagggagatc agggaaacac tgatgtaacc tcaaagcctc tcaccattcc
     6181 tcttggcttg gaaaggcttt attttttcat atacatttct agaaatattg ctattctacc
     6241 ttagtatttc acatttgtag ttcaaacaag cgattgtcca tctgttgcct agagctatag
     6301 tacatgtgtg ttatgaatga aatatgacag catgttccat acccctgctt tagccatctg
     6361 tgggaaacca gcaaactgaa aaagacacct ctgcaaaatg tgcctcaagt ccatttcttg
     6421 ggatcgctcg tttggtgcac tctcgtggga gacaatcaga gaacaacata tacttgtgcc
     6481 ttattttcaa agaatctatt tacactacta tgaatattcc actgaagagt caatgatgta
     6541 aatgataacc accaaatctc aaaaatatac tcaccaaaaa gtaaaaaagt aaaaaaaaaa
     6601 aaaaaagaaa gaaagaaaag aaagagagag aagtcaactt ttcatcttaa tatattctag
     6661 tagtatttat tttttccttg tcttggaagt atctcatagg tctttaaatg agtaaaacat
     6721 ttttatgcca gaaggtgata taatggatgt tagtgttttt tatttgattt tacagtagtt
     6781 ttagtcagat aatgaggaca gagacttcaa cttgattctt taccaccatt cagcatattt
     6841 tttaattgtc ttcattgtat ttgcttaata gtggtccaga caagttcaaa acttgttctc
     6901 agtgaggcat taatatggtg caaccatgaa tatttcaggc caagttattc acttgacaga
     6961 taactagaat gaaacttttc tcatgaggct gttgtttggt tagcatagcc ttatttcaaa
     7021 ccttaaaaag ttacctgact gaagctacta tgacttggta aggattcttc ctctcttgct
     7081 ttcttcctcc cttcctttct tcctcttcct tcctcctctt cttattttct ttcctacttt
     7141 ccatcctacc tattagtgtt gctgtacttg gattttttgt aaattaaatc aatgcattat
     7201 gattttaggg aattatgatt atattcataa ggggaaggct accagaaaat atatgtggca
     7261 tccataaaat cttcttttat aggggcatat tttttaggtt gtatttattc gtaaagtgaa
     7321 atgagataat agagtctttc tgtttcatgt taatgaattt tcatcaggga ctgaggtcat
     7381 agattcttgg aaaattcatt tgtgactgat ctagttttct cagctgtatg caaagtaatc
     7441 tttcaaagac taggttaaga tttttttttt aagtctgaag caatgtaacc ccaaaaaatt
     7501 ataattttaa tgatggcatt ttattttatt ccattgcagc ttgataactt tccttatagc
     7561 aaaggaataa ctattgtatt ttcagaattt taacacagat taacacttag cctgtaagac
     7621 taataatata ttgtaatagt tgatactaaa atatttttca gcaggttgga cagcaccagt
     7681 ttttcttaga tcacagacta caggcagaat ttcccttcaa tccagaaaaa aggacactaa
     7741 tttccttttc tatttaattt tcctggccct tgtgcaaaaa attgtggact ctatcttagt
     7801 tacaacatgc atgtccctta ttttgtggag agctgtgtga aagatgcgtt ttttttcttt
     7861 ttttcttttt tttttttttg agacggagtc tggctctgtc acccaggctg gagtgcaatg
     7921 gcacgatctc ctctcactgc aagctccgcc tcccaggttc acgccattct cctgtctcag
     7981 cctcccgagt agctgggact acaggcgcct gccaccacgc ccggctaatt tttttgtatt
     8041 tttagtagag atggagtttc acagtgttag ccaggatggc ctcgatctcc tgacctcgtg
     8101 atccacccgc ctcggcctcc caaagtgctg ggattacagg cgtgagccac cgtgccccgc
     8161 gtgttttttt ctttagctga ttgacaggtc cccttcaaag ttacaaaaaa aagtgctaat
     8221 ttttgctgtt aaattctggt tgttatttaa ttgacagaag tctcttgatg cacgaataaa
     8281 tatctctaca tctagccttt gttaaaaata aaaattaata ttctacaaac acctacatat
     8341 actagagagg ggtgaaacac tgcagctaat tcctttataa tactttcaga tgattgcatt
     8401 aagcctttca tgttatgtgg cattgttaat ttttcctaga tacccatcca cttaagggcc
     8461 agagaaatcc ttattcattt aactctggtg ggcatttatg taacataccc aaataaaaac
     8521 gttattaaac agccacaatc gcattcagtc aacttggcac tgaatgtagc ttctaaaatc
     8581 agttctctac cctacgaatg gaatgttcta ccaagaaaga gaagcatcac catgtcatct
     8641 tgtgttctac accactatag agagttacag ttgcccccaa acacgaatgc tattcccaaa
     8701 taaaatagaa tcatgctttg ggaggccaag gcgggccgat cacgaggtca ggagatcgag
     8761 accatcctgg ctaacacggt gaaaccccgt ctctactaaa aaaaaaaaaa aatacaaaaa
     8821 attagcctgg ctcagtggcg ggcgcctgta gtcccagcta ctcaggaggc tgaggcagga
     8881 gaatggcgtg aacccgggaa gcggagcttt cagtgagccg agatagcgcc actgcagtcc
     8941 ggcctgggcg aaagagcgag actccgtctc aaaaaaaaaa aaaaaaaaat aggatcatgg
     9001 cccttttaaa gatctgaatc ttctctgtta ttttcctgat gaatcaccat cccatatctt
     9061 cttagtcctg gccagtatgt agttgcgctc acatacgtct attctagctc tgtagctcca
     9121 caaaacaagt cttaagtcca aatctttgcc tcttcatgtc tgatatcacc aactcattca
     9181 gcttttcttc acttattgac atagtgtcat gtcctatcac tctctgctgc ttctttaaac
     9241 agtggacaca aacatatttt ctaattttca gtgtactcag tgaaacttgg cagttcacca
     9301 tgagtcaggc taggttgaaa ggctttcttt agggttgaaa gtaaacgaaa ttggaatcac
     9361 ccaaagagaa tttccccaaa aaacctcaga cccagaagtg taaaagctac agaaggatag
     9421 aactcccatg tctacagaca gttctgttac tttttgttct gtactatttt ggatgttgcc
     9481 aaaatcaaat tcatcctgaa aacaggaagc aagctaatgc atatgccatc catgagattc
     9541 ccacttctgg gtcagttcat attccattca accttttcct tttatccttg tcttcttcag
     9601 aataagacat ttttcctcca tattttcata ttaaatatta acactttata ggttctactt
     9661 taatatatgg acactttaca ggttatacat aaatatttgc tggttgattg atttcgagat
     9721 tcattcattc tgtgctcaaa tatttgtacc tagagacgtt acatgttaga aaaagtgagc
     9781 agcttctttc tctaatcatt taggagtcca tatttttctt ttctttttgt tctcccaaca
     9841 tccttatctc ttactcagct cttcaattta taattaccaa ataatcactg ttagagaatc
     9901 agcccctaag taactttgat tctggccaac tgtaataaga tccaaccact taaatctgta
     9961 cttactcaat aggaaggaat gtgacatcag gaagagtcat tccagtgaca ttagtaagac
    10021 tttatggagt acataaaatt tgataagaaa tcttgagctg attctttgac ttgatttaga
    10081 agttgagaaa agagtattta aggcacaaca gggaaacatg ggctatactc agagaagacc
    10141 ctctgcattg gccaaaatat catggattct ggaaattcct tcttaacaga aaaaaaaggc
    10201 ttccaaataa tcaggctgaa tgggaagaaa aaggcataga ggaagcctga ggaagtattt
    10261 acttgctttt cccatctctt tataattgga agagaagatg atctgccaaa atataaccca
    10321 gcatgcacag tatggacagg aagcagccct ccatgaactt tattatcaca gaatatgagc
    10381 attcttattg atccacagct acatcttcta ttcttgcagc aagggtacat gtcctttgac
    10441 cctccacaaa agaacaagca ggacatctct attttcctat tgagtctgag tccattatta
    10501 gaaaggactt cccagccatc ttttctactt ggtattaaaa ttcccttaca gattcattgc
    10561 taagtgccaa ttcttttttt ttcttttgag acggagtctt gctctgtcgc ccaggctgga
    10621 gtgcagtggc gcaatctcgg ctcactgcaa gctccgcttc tcgggttcac gccattctcc
    10681 tgcctcagcc tcccgagtag ctgggactac agacgcccgc caccgcgccc agctaatttt
    10741 ttttgtactt ttagtagaga cggggtttca ccgtggtctc gatctcctga cctcgtgatc
    10801 cgcccgcctc ggcctcccaa agtgccaatt ctgactctac ttaaacatca cctgtatcag
    10861 ggagctcatt attccttgag gtcttacatt tctttcagca cattttgttc caagctacac
    10921 gactttaaaa cagagccagc ctttggggca tatgttctct ttggtgccac acaaaacctg
    10981 tagtacatga tacagtgttg cttcccccct ccttttcctt ccatatatat ttgttttgtt
    11041 ttgggcattg cattactttt ttgaattttt aagaatctct aaaattagtc tgaaggatgt
    11101 tctgagggcc agacattaga atttgtgagt ttttttgttg ctggttgtac tttcctattt
    11161 agaagacaga ccgttctgac agttgttgtg tagcttcatg ccttccccag taactaaccc
    11221 atgaacagta cacccctttt atctgacttg ttgataatga ccttaaaaat gttaggaaat
    11281 gggccgggcg cggtggctcg tgcctgtaat ccagcacttt gggaggccga ggcgagcgga
    11341 tcatgaggtc aagagatcga gaccatcctg gtcaacatgg tgaaaccccg actctactaa
    11401 aaaaaataca aaaattagcc gggcgtgttg gcgggcgcct gtagtcccaa ctacttggga
    11461 ggctgaggca ggagaatcac ctgaacccag gaggcagagg ttgcagtgag cagagattgc
    11521 gccactgcac tccagcctgg gcgacagaac gagactccgt ctcaaaaaaa aaaaaaaaaa
    11581 aaaaaggttg ggaaatattg gtgtataatc cccatgtcta acaaggaaga agtcaaaagc
    11641 aaaagatagt ggtattgccg aaaactcatt atttctagtt agttcatctg tggaaaagga
    11701 tatcgttctt gaggagaggg gttctattat gctatagttt tctatggaaa tgtacaaatg
    11761 ctttcctcat tgctctggat gactatttag tttaaataat atacctttgt catggggaag
    11821 accatgattg tggcttcttc taccccaact ttgaatgaga gagcactgta agcagaaact
    11881 gccatcagtc tcctgggcag gacctggagg taactttctg agctgtaaaa tagtaattcc
    11941 taagagagct tacaaactgc ttccacacag aaaatagcgc agggaggaca gttattagta
    12001 cccctattct agaagagaaa gctgaggctc aagccattaa gtgacttgcc aaaagctgtg
    12061 acatagctgg gaagtggcag atttggggat ataaccaggt cttgcaagtc cagtgctgtc
    12121 tccaagtagc cacgctcaca gctgagaaca ccttagagga caatatcgac ttcttacaga
    12181 ctaccaagcc cccagtcatc cagggaaatt cagagaccaa ttgactgcca ggtggcaaat
    12241 ccacatgtgt actgcggtct ttagagatca tttagagctt gcacacatct gtgtcttctt
    12301 gtgggaaacc tctaggtatt ctgtctgatc agcactgtga ggaagttggt gggaaaaggc
    12361 cactgataag aacaaacaat gggcagaagg aagcacattg caataaattt ccccagagag
    12421 agttccttta cattccattc accaaaaacc tctctggaac tgtcaggttc agaatatcaa
    12481 ccaagaccat atcatttaga attcattggc atgtagaggt gactcgattc ctaaaagaag
    12541 cctctctccc atgaaccacg atgtacgttc cacagaggca gaaaccgccg taggttagca
    12601 atgcatttta gtctttctct ccattcacat ttactgagag cacaccacgt gcatgttgct
    12661 gcaacaggca tttccgatag agccgatcca tgagctaaca atgtctgaaa acaaatgtta
    12721 tggaactgtt ggcatttctg agatttggcc tttgccattt gatagacttt gcttcccagg
    12781 atgctgtcat tttgtgattt tttataatta caaggaattt ggtaccatgt tgttttcaaa
    12841 aaacctccta gaaagtctcc atgtatgctc tagaagttgc tctacgtaac agttcagcaa
    12901 gcaagtgttc cttctcttga gctgcgtccc tcaggaagct gtacctttag ggtgtgcttt
    12961 ccacttttta tttcctctca tttcactcct ttcattgttt gctatatcct aaaatatgtg
    13021 aagtgagaga aaaaatatca tttcttctca ttaaatctcc tgcattaaat ctaagaatcc
    13081 tttaaaataa tcacacctga taagtgtttt atgcatttcc ctccctggag tgttatcatc
    13141 catcaagcca gtatcatcat ccacctgctt attccttggg actaatgaga gccaagttaa
    13201 atagcaaatg acttctcacc ccttcctagt cctcatgcct gaggaataag ggcgacatta
    13261 atgggagcgg gagagtggtg gctttggttg agatgcacgt tcacagacta gaaaagtgcc
    13321 tcacctccat ggtgtatatg tgccaccttt tcttaatcca gtctatcatt gttggacatt
    13381 tgggttggtt ccaagtcttt gctattgtga atagtgccgc aataaacata agtgtgcatg
    13441 tgtctttata gcagcatgat ttataatcct ttgggtatat acccagtaat gggatggctg
    13501 ggtcaaatgg tatttctagt tctagatccc tgaggaatct ccacactgac ttccacaatg
    13561 gttgaactag ttcacagtcc caccaacagt gtaaaagtgt tcttatttct ccacatcctc
    13621 tccagcacct gttgtttcct gactttttaa tgattgccat tctaactggt gtgagatggt
    13681 atctcatagt ggttttgatt tgcatttctc tgatggccag tgatggtgag cattttttca
    13741 tgtgtttctt ggctgcataa atgtcttctt ttgagaagtg tctgttcaat actatgcagc
    13801 cataaaaaat gatgagttca tgtcctttgt agggacatgg atgaaattgg aaatcatcat
    13861 tctcagtaaa ctatctcaag gacaaaaaac caaacaccac atgttctcac tcacaggtgg
    13921 gaattgaaca atgagaacac atggacacag gaaggggaac atcacactct ggggactgtt
    13981 gtggggtgga gggaggaggg agggatagca ttaggagata tacctaatgc taaatgacga
    14041 gttaatgggt gcagcacacc agcatggcac atgtatacat atgtaactaa cctgcacatt
    14101 gtgcacatgt accctaaaac ttaaagtata ataataatga aataaaatta aaaaaaaaaa
    14161 agaaaagtgc ctcacctccc tgtgaggctt gatgaatatt gtggccagtg agtggaaaat
    14221 gattcttgtc gaatagacag agtattccca ccccaggaat ggattaatag aagacacaat
    14281 ttgagcactt ctcagaatta tctagtatgc ctgagtagag actcacatgg gtggaatctg
    14341 tgttgtctca tcagagggaa taaaaagaca atgaggtggt aaatgtgaaa aaagcagcct
    14401 tttagaaaaa cattattttc aaataccttt ataaatcatc taatttatct tcacataata
    14461 taaagaaaaa actaataaaa attttcgtat ttcactttac ataatatgtt ctcccatatt
    14521 tagggatcat acaattgtat tgtcttcaaa acacacacac acacacatac acacacacac
    14581 acacacacac acacacccct tccaagaaag ctgatccttc agaaaataaa tcttattttt
    14641 aagcacttgg gttttcaggc cagaaaatta ataaatccta aacctgaccc atttttgtaa
    14701 cagctaaaaa ggagaagaaa aagctagtta aattttgtgt ggatccattt atctcttaaa
    14761 atatgccaaa gcaatttgag gtgggggtgg aaacaggtat ttatctctca tgcgtgattc
    14821 tctctttata tttctatctg ttgggaaaag ggtaaagaac tattcttggt cattattgat
    14881 gtattgtgtt gccactttgt atggtgcctg ctgtgcttta tcccgaggca tagcagtaat
    14941 cgttactatc ttgactcttt ccttcatcac aagagagtaa atatgaagtc tgaatgtcgt
    15001 tcctcacccc caaattgttt aactctgctt ccaaactagt ttaagaaatg caaaatggga
    15061 agagctagct tttcttagat acatttcttc cttttttatt ctttcttggg agacgttaag
    15121 tataaaaggg aaaaagtcag ttccttcttc tctctctttc tctttgggtg acagcaatgc
    15181 tcacttagta attataaact ggaaatagga gagtagcttg agcaggttat gatatatctg
    15241 cccaatgtgt ttcattcctt caaacataaa ctttgagagt aaaagagatt tttataattt
    15301 aaatgccaac gacaggaatg gcctcatgtt ttaactttca aataataaat ggggagttgg
    15361 tatttgggca gagtttgcat tttactaatc ctatatactt tgagcttagt ttttagaatt
    15421 gtgtcaaata catcaacata tcaggattat agtgccaaaa atagttaaag tgccttggtc
    15481 ctccctctgt aggcagcaaa ttgaaactaa catgggacca tgccatcctt ctagcataat
    15541 ggagaagtct gaactgagga gtatctttga tgaaagacat ttaggaccct agaaactaaa
    15601 tcttgtcacc aagactttat agtaaagtag tagcaaaatt atttttaaaa gactttcttc
    15661 cttttactac ccatttcctc tcttgggaaa gctgatgagc aaattatcca agactcattt
    15721 ctttattagg caaagtcaga atatttcccc tctgaaaatc tgaattatgc cctcattctt
    15781 tttcaagaaa tatctcaaag agcaaataga attaaacatg acacttgatt gtctgattat
    15841 ttggcatgta taaaattatc atgtggctta atgtgcctta agtgaaaatt taaacttaga
    15901 cctgaaacct ttacagttgg atgtagcgtt gagcttttgc atgttttctg tataataaac
    15961 cacttttgtt ttgtttgttt tgtcttttaa cctacacctt tatcattact ctaacagatt
    16021 tagggcttct ctttctctac agctaagtaa gggaatatgt gcaattatga gacatacaaa
    16081 aaaggaaagg gaaaggactt tctaagtagc aaatctgtgc catgaagtag atgtggcgtg
    16141 aagatacaga gcctgaggat agtaattttc cctgagccac gcacacaggc ttttatttca
    16201 tgccttttct ctttctgtgc cgtcaccttt gagaaaaacg attgcacctt ctccaagtct
    16261 gcctttttaa cagctacagt taagttggca agacttcccc agctctgaat atagccattt
    16321 gccgactccg gcctctttgc gagactgact caaatctgtg atcttctgtt cagcatacac
    16381 atcagcaaag tgagaagatg agcactaaat ataggctcta ttaactttac ttttagattt
    16441 actgccttca aaaagtgcct attctgagca acataaacgt tattccttac atatgtatgt
    16501 acacacggta cccagagtcg tactgtgcag ccttcaaaaa cataccatca gaaagagtag
    16561 gtgctgagat aaggaaactt tgccaaatga aagaaagtca ctcacttcca atatcccctc
    16621 tcaagcggct accgtgaaac gggctgcaaa cacattccct gagcatccct tgctgataca
    16681 gcttctttat atttatatcc tactggatgg tagcatattg ctaaggtttc ctgtactctg
    16741 cttcaaggga atgtaagctt tatggcattg aaacatttag ggaaaaaaaa gatgtttaag
    16801 agaattaata gagccgtagt ctgtattagg atgtgtgtca tatgtgtgtt ctataaacta
    16861 agcatcggtg ggtttagagt gttaaagtgt cagcacattc cttctccttt tgtctctcag
    16921 gctaacatga gagaaaatag aaaagtcttg gctgtgggga ttggaagctc agggggccaa
    16981 atgtccttgc cagatcctta gagcattact ttgactccta aaaatagtag tgtatgttat
    17041 ttgatggctt ttgtttccat agttccatca ctgacaaaac tgtcaatact gttgatggag
    17101 cagcagcata gcctagagtg atgcattctt acccagaggt ggcaatagga gagggtccat
    17161 gtaaatagga cgaggtagac agtgcatgat tgtaggagaa gggttgaagg gaggacatga
    17221 ttccaaaaaa gatcgttctc aatgtgtcgt ctgactcaac cagctggcag attacacttg
    17281 ccaagtcgtt ccctttcctt ctaagtcagt tggctccata ttcacttgaa tatgcctctg
    17341 tttgggcaaa gcaagatacc tccacttaac ctttatccaa ggaagctctt ggtgtcctct
    17401 tggtcataaa gttgtctcct acctaaccca gttttaccaa atggaagtaa aaggggacaa
    17461 actatggaag atggactcca tgccattgca gtcagccacc attctctttt ccatataagg
    17521 agccccatta cataagctac gggtgaggtt ggaacagcta tgtttcataa tttcaagagt
    17581 gtgaccaccc tgctctagtc atcatcattg gatgaatcca gttgactctt tggcaaaagg
    17641 gtgatacttt tcactaaaaa tgcctactct tcctgttgat gttccttttc tgtttttacc
    17701 ttgtccaatt tccacactag tcattttttt tattttttag aggatcagat tttagcgctg
    17761 gaaaatgagt tcaaaaattt cagtgtaatg tcataaggat gttgggatac agagattttt
    17821 tttttccttg gaaacaaatg gactgggaag aaacacagca tggctttgct ctgagtttca
    17881 atctgatgat tatgaccatg gaagatagtc ttatgtaaag gttaaatggt gtttacaagt
    17941 ggatagataa ggcggagatg gtgagaagcc gggttttctc tatgctaaat gtgtctacta
    18001 agagcagcac ttcctactag ctaagcacaa tcatagcccc accgtgatga gctgctagtc
    18061 tgaataacat tccctgactt agggaaaggc acacaaaaac atataaagaa tatgtctatt
    18121 ttcatatgtg tgatactgac agagccatgg tattcctaaa atataggttt ctcttttttc
    18181 ttgtattctt agcaaattgc atttattcac tacattacaa accatcactg atgtatccaa
    18241 aatagcacac atagttcagt atgaaaataa gagaataaaa tctgttataa gcaagtgatt
    18301 taggtatttt cttttgtgtt tatgcattat ctgactatat taaaacctgt ttttctattt
    18361 accttctatc agttttctct accaattatg ttttttcaat gctctataag aatgaatatg
    18421 gaaattatat ttcttttttc tgtaaaagag ttgcaactac tttattatat ttagaaatcc
    18481 aataaacttc ttattacatt ta
//
