LOCUS       NM_000237               3565 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens lipoprotein lipase (LPL), mRNA.
ACCESSION   NM_000237
VERSION     NM_000237.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3565)
  AUTHORS   Li,Y., Cai,H., Lin,Y., Huang,Z., Zhou,A., Huang,T., Zeng,Y.E.,
            Ye,M., Guo,G. and Huang,Z.
  TITLE     Association of lipoprotein lipase (LPL) gene variants with
            hyperlipidemic acute pancreatitis in southeastern Chinese
            population
  JOURNAL   Arch Endocrinol Metab 68, e230195 (2024)
   PUBMED   38530959
  REMARK    GeneRIF: Association of lipoprotein lipase (LPL) gene variants with
            hyperlipidemic acute pancreatitis in southeastern Chinese
            population.
REFERENCE   2  (bases 1 to 3565)
  AUTHORS   Hsieh,P.C., Nfor,O.N., Lin,C.C., Hsiao,C.H. and Liaw,Y.P.
  TITLE     Metabolic syndrome risk in adult coffee drinkers with the rs301
            variant of the LPL gene
  JOURNAL   Nutr J 23 (1), 30 (2024)
   PUBMED   38429792
  REMARK    GeneRIF: Metabolic syndrome risk in adult coffee drinkers with the
            rs301 variant of the LPL gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3565)
  AUTHORS   Saiki,A., Takahashi,Y., Nakamura,S., Yamaoka,S., Abe,K., Tanaka,S.,
            Watanabe,Y., Yamaguchi,T., Nagayama,D., Ohira,M., Oshiro,T.,
            Tatsuno,I. and Shirai,K.
  TITLE     Relationship between Lipoprotein Lipase Derived from Subcutaneous
            Adipose Tissue and Cardio-Ankle Vascular Index in Japanese Patients
            with Severe Obesity
  JOURNAL   Obes Facts 17 (3), 255-263 (2024)
   PUBMED   38342095
  REMARK    GeneRIF: Relationship between Lipoprotein Lipase Derived from
            Subcutaneous Adipose Tissue and Cardio-Ankle Vascular Index in
            Japanese Patients with Severe Obesity.
REFERENCE   4  (bases 1 to 3565)
  AUTHORS   Hernandez-Baixauli,J., Chomiciute,G., Alcaide-Hidalgo,J.M.,
            Crescenti,A., Baselga-Escudero,L., Palacios-Jordan,H.,
            Foguet-Romero,E., Pedret,A., Valls,R.M., Sola,R., Mulero,M. and Del
            Bas,J.M.
  TITLE     Developing a model to predict the early risk of
            hypertriglyceridemia based on inhibiting lipoprotein lipase (LPL):
            a translational study
  JOURNAL   Sci Rep 13 (1), 22646 (2023)
   PUBMED   38114521
  REMARK    GeneRIF: Developing a model to predict the early risk of
            hypertriglyceridemia based on inhibiting lipoprotein lipase (LPL):
            a translational study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3565)
  AUTHORS   Shestopalov,A.V., Davydov,V.V., Tumanyan,G.T., Teplyakova,E.D.,
            Shkurat,T.P., Mashkina,E.V., Shkurat,M.A., Gaponov,A.M.,
            Sadova,A.A., Borisenko,O.V. and Roumiantsev,S.A.
  TITLE     The Association of Adipokines and Myokines in the Blood of Obese
            Children and Adolescents with Lipoprotein Lipase rs328 Gene
            Variants
  JOURNAL   J Obes 2023, 7392513 (2023)
   PUBMED   37901192
  REMARK    GeneRIF: The Association of Adipokines and Myokines in the Blood of
            Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene
            Variants.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3565)
  AUTHORS   Burnett,J.R., Hooper,A.J. and Hegele,R.A.
  TITLE     Familial Lipoprotein Lipase Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301485
REFERENCE   7  (bases 1 to 3565)
  AUTHORS   Chappell,D.A., Fry,G.L., Waknitz,M.A., Iverius,P.H., Williams,S.E.
            and Strickland,D.K.
  TITLE     The low density lipoprotein receptor-related protein/alpha
            2-macroglobulin receptor binds and mediates catabolism of bovine
            milk lipoprotein lipase
  JOURNAL   J Biol Chem 267 (36), 25764-25767 (1992)
   PUBMED   1281473
REFERENCE   8  (bases 1 to 3565)
  AUTHORS   Hata,A., Ridinger,D.N., Sutherland,S.D., Emi,M., Kwong,L.K.,
            Shuhua,J., Lubbers,A., Guy-Grand,B., Basdevant,A., Iverius,P.H. et
            al.
  TITLE     Missense mutations in exon 5 of the human lipoprotein lipase gene.
            Inactivation correlates with loss of dimerization
  JOURNAL   J Biol Chem 267 (28), 20132-20139 (1992)
   PUBMED   1400331
REFERENCE   9  (bases 1 to 3565)
  AUTHORS   Emmerich,J., Beg,O.U., Peterson,J., Previato,L., Brunzell,J.D.,
            Brewer,H.B. Jr. and Santamarina-Fojo,S.
  TITLE     Human lipoprotein lipase. Analysis of the catalytic triad by
            site-directed mutagenesis of Ser-132, Asp-156, and His-241
  JOURNAL   J Biol Chem 267 (6), 4161-4165 (1992)
   PUBMED   1371284
REFERENCE   10 (bases 1 to 3565)
  AUTHORS   Kinnunen,P.K. and Ehnolm,C.
  TITLE     Effect of serum and C-apoproteins from very low density
            lipoproteins on human postheparin plasma hepatic lipase
  JOURNAL   FEBS Lett 65 (3), 354-357 (1976)
   PUBMED   182536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK092286.1, M15856.1 and
            AC100802.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 22, 2018 this sequence version replaced NM_000237.2.
            
            Summary: LPL encodes lipoprotein lipase, which is expressed in
            heart, muscle, and adipose tissue. LPL functions as a homodimer,
            and has the dual functions of triglyceride hydrolase and
            ligand/bridging factor for receptor-mediated lipoprotein uptake.
            Severe mutations that cause LPL deficiency result in type I
            hyperlipoproteinemia, while less extreme mutations in LPL are
            linked to many disorders of lipoprotein metabolism. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M15856.1, AK290290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650287.1/ ENSP00000497642.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK092286.1         1-14
            15-2439             M15856.1           1-2425
            2440-3565           AC100802.2         45004-46129
FEATURES             Location/Qualifiers
     source          1..3565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..3565
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /note="lipoprotein lipase"
                     /db_xref="GeneID:4023"
                     /db_xref="HGNC:HGNC:6677"
                     /db_xref="MIM:609708"
     exon            1..276
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1616
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /EC_number="3.1.1.34"
                     /EC_number="3.1.1.32"
                     /note="phospholipase A1"
                     /codon_start=1
                     /product="lipoprotein lipase precursor"
                     /protein_id="NP_000228.1"
                     /db_xref="CCDS:CCDS6012.1"
                     /db_xref="GeneID:4023"
                     /db_xref="HGNC:HGNC:6677"
                     /db_xref="MIM:609708"
                     /translation="MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALR
                     TPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKR
                     EPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSL
                     GAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPG
                     RSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFI
                     DSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRS
                     QMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFL
                     IYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKV
                     SHLQKGKAPAVFVKCHDKSLNKKSG"
     exon            277..437
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /inference="alignment:Splign:2.1.0"
     exon            438..617
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /inference="alignment:Splign:2.1.0"
     exon            618..729
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /inference="alignment:Splign:2.1.0"
     exon            730..963
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1206
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1327
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1510
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1615
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..3565
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3537..3542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /note="hexamer: AATAAA"
     polyA_site      3565
                     /gene="LPL"
                     /gene_synonym="HDLCQ11; LIPD"
                     /note="major polyA site"
ORIGIN      
        1 gtcagactcg attccccctc ttcctcctcc tcaagggaaa gctgcccact tctagctgcc
       61 ctgccatccc ctttaaaggg cgacttgctc agcgccaaac cgcggctcca gccctctcca
      121 gcctccggct cagccggctc atcagtcggt ccgcgccttg cagctcctcc agagggacgc
      181 gccccgagat ggagagcaaa gccctgctcg tgctgactct ggccgtgtgg ctccagagtc
      241 tgaccgcctc ccgcggaggg gtggccgccg ccgaccaaag aagagatttt atcgacatcg
      301 aaagtaaatt tgccctaagg acccctgaag acacagctga ggacacttgc cacctcattc
      361 ccggagtagc agagtccgtg gctacctgtc atttcaatca cagcagcaaa accttcatgg
      421 tgatccatgg ctggacggta acaggaatgt atgagagttg ggtgccaaaa cttgtggccg
      481 ccctgtacaa gagagaacca gactccaatg tcattgtggt ggactggctg tcacgggctc
      541 aggagcatta cccagtgtcc gcgggctaca ccaaactggt gggacaggat gtggcccggt
      601 ttatcaactg gatggaggag gagtttaact accctctgga caatgtccat ctcttgggat
      661 acagccttgg agcccatgct gctggcattg caggaagtct gaccaataag aaagtcaaca
      721 gaattactgg cctcgatcca gctggaccta actttgagta tgcagaagcc ccgagtcgtc
      781 tttctcctga tgatgcagat tttgtagacg tcttacacac attcaccaga gggtcccctg
      841 gtcgaagcat tggaatccag aaaccagttg ggcatgttga catttacccg aatggaggta
      901 cttttcagcc aggatgtaac attggagaag ctatccgcgt gattgcagag agaggacttg
      961 gagatgtgga ccagctagtg aagtgctccc acgagcgctc cattcatctc ttcatcgact
     1021 ctctgttgaa tgaagaaaat ccaagtaagg cctacaggtg cagttccaag gaagcctttg
     1081 agaaagggct ctgcttgagt tgtagaaaga accgctgcaa caatctgggc tatgagatca
     1141 ataaagtcag agccaaaaga agcagcaaaa tgtacctgaa gactcgttct cagatgccct
     1201 acaaagtctt ccattaccaa gtaaagattc atttttctgg gactgagagt gaaacccata
     1261 ccaatcaggc ctttgagatt tctctgtatg gcaccgtggc cgagagtgag aacatcccat
     1321 tcactctgcc tgaagtttcc acaaataaga cctactcctt cctaatttac acagaggtag
     1381 atattggaga actactcatg ttgaagctca aatggaagag tgattcatac tttagctggt
     1441 cagactggtg gagcagtccc ggcttcgcca ttcagaagat cagagtaaaa gcaggagaga
     1501 ctcagaaaaa ggtgatcttc tgttctaggg agaaagtgtc tcatttgcag aaaggaaagg
     1561 cacctgcggt atttgtgaaa tgccatgaca agtctctgaa taagaagtca ggctgaaact
     1621 gggcgaatct acagaacaaa gaacggcatg tgaattctgt gaagaatgaa gtggaggaag
     1681 taacttttac aaaacatacc cagtgtttgg ggtgtttcaa aagtggattt tcctgaatat
     1741 taatcccagc cctacccttg ttagttattt taggagacag tctcaagcac taaaaagtgg
     1801 ctaattcaat ttatggggta tagtggccaa atagcacatc ctccaacgtt aaaagacagt
     1861 ggatcatgaa aagtgctgtt ttgtcctttg agaaagaaat aattgtttga gcgcagagta
     1921 aaataaggct ccttcatgtg gcgtattggg ccatagccta taattggtta gaacctccta
     1981 ttttaattgg aattctggat ctttcggact gaggccttct caaactttac tctaagtctc
     2041 caagaataca gaaaatgctt ttccgcggca cgaatcagac tcatctacac agcagtatga
     2101 atgatgtttt agaatgattc cctcttgcta ttggaatgtg gtccagacgt caaccaggaa
     2161 catgtaactt ggagagggac gaagaaaggg tctgataaac acagaggttt taaacagtcc
     2221 ctaccattgg cctgcatcat gacaaagtta caaattcaag gagatataaa atctagatca
     2281 attaattctt aataggcttt atcgtttatt gcttaatccc tctctccccc ttcttttttg
     2341 tctcaagatt atattataat aatgttctct gggtaggtgt tgaaaatgag cctgtaatcc
     2401 tcagctgaca cataatttga atggtgcaga aaaaaaaaaa gaaaccgtaa ttttattatt
     2461 agattctcca aatgattttc atcaatttaa aatcattcaa tatctgacag ttactcttca
     2521 gttttaggct taccttggtc atgcttcagt tgtacttcca gtgcgtctct tttgttcctg
     2581 gctttgacat gaaaagatag gtttgagttc aaattttgca ttgtgtgagc ttctacagat
     2641 tttagacaag gaccgttttt actaagtaaa agggtggaga ggttcctggg gtggattcct
     2701 aagcagtgct tgtaaaccat cgcgtgcaat gagccagatg gagtaccatg agggttgcta
     2761 tttgttgttt ttaacaacta atcaagagtg agtgaacaac tatttataaa ctagatctcc
     2821 tatttttcag aatgctcttc tacgtataaa tatgaaatga taaagatgtc aaatatctca
     2881 gaggctatag ctgggaaccc gactgtgaaa gtatgtgata tctgaacaca tactagaaag
     2941 ctctgcatgt gtgttgtcct tcagcataat tcggaaggga aaacagtcga tcaagggatg
     3001 tattggaaca tgtcggagta gaaattgttc ctgatgtgcc agaacttcga ccctttctct
     3061 gagagagatg atcgtgccta taaatagtag gaccaatgtt gtgattaaca tcatcaggct
     3121 tggaatgaat tctctctaaa aataaaatga tgtatgattt gttgttggca tcccctttat
     3181 taattcatta aatttctgga tttgggttgt gacccagggt gcattaactt aaaagattca
     3241 ctaaagcagc acatagcact gggaactctg gctccgaaaa actttgttat atatatcaag
     3301 gatgttctgg ctttacattt tatttattag ctgtaaatac atgtgtggat gtgtaaatgg
     3361 agcttgtaca tattggaaag gtcattgtgg ctatctgcat ttataaatgt gtggtgctaa
     3421 ctgtatgtgt ctttatcagt gatggtctca cagagccaac tcactcttat gaaatgggct
     3481 ttaacaaaac aagaaagaaa cgtacttaac tgtgtgaaga aatggaatca gcttttaata
     3541 aaattgacaa cattttatta ccaca
//
