LOCUS       NM_022896               4462 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens lipin 3 (LPIN3), transcript variant 3, mRNA.
ACCESSION   NM_022896 XM_372866
VERSION     NM_022896.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4462)
  AUTHORS   Wang,F., Liu,Y., Dong,Y., Zhao,M., Huang,H., Jin,J., Fan,L. and
            Xiang,R.
  TITLE     Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and
            obesity by disrupting the expression and nucleocytoplasmic
            localization of Lipin1
  JOURNAL   Front Med 18 (1), 180-191 (2024)
   PUBMED   37776435
  REMARK    GeneRIF: Haploinsufficiency of Lipin3 leads to hypertriglyceridemia
            and obesity by disrupting the expression and nucleocytoplasmic
            localization of Lipin1.
REFERENCE   2  (bases 1 to 4462)
  AUTHORS   Ingram,L.M., Finnerty,M.C., Mansoura,M., Chou,C.W. and
            Cummings,B.S.
  TITLE     Identification of lipidomic profiles associated with drug-resistant
            prostate cancer cells
  JOURNAL   Lipids Health Dis 20 (1), 15 (2021)
   PUBMED   33596934
  REMARK    GeneRIF: Identification of lipidomic profiles associated with
            drug-resistant prostate cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4462)
  AUTHORS   Lim,S., Kim,W.J., Kim,Y.H. and Choi,J.M.
  TITLE     Identification of a novel cell-penetrating peptide from human
            phosphatidate phosphatase LPIN3
  JOURNAL   Mol Cells 34 (6), 577-582 (2012)
   PUBMED   23263658
  REMARK    GeneRIF: a newly identified novel cell-penetrating sequence (LPIN;
            RRKRRRRRK) from the nuclear localization sequence (NLS) of human
            nuclear phosphatase, LPIN3.
REFERENCE   4  (bases 1 to 4462)
  AUTHORS   Michot,C., Hubert,L., Romero,N.B., Gouda,A., Mamoune,A., Mathew,S.,
            Kirk,E., Viollet,L., Rahman,S., Bekri,S., Peters,H., McGill,J.,
            Glamuzina,E., Farrar,M., von der Hagen,M., Alexander,I.E.,
            Kirmse,B., Barth,M., Laforet,P., Benlian,P., Munnich,A.,
            JeanPierre,M., Elpeleg,O., Pines,O., Delahodde,A., de Keyzer,Y. and
            de Lonlay,P.
  TITLE     Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and
            exercise-induced myalgia
  JOURNAL   J Inherit Metab Dis 35 (6), 1119-1128 (2012)
   PUBMED   22481384
  REMARK    GeneRIF: LPIN1-related myolysis constitutes a major cause of
            early-onset rhabdomyolysis and occasionally in adults. Heterozygous
            LPIN1 mutations may cause mild muscular symptoms. No major defects
            of LPIN2 or LPIN3 genes were associated with muscle manifestations.
REFERENCE   5  (bases 1 to 4462)
  AUTHORS   Liu,G.H., Qu,J., Carmack,A.E., Kim,H.B., Chen,C., Ren,H.,
            Morris,A.J., Finck,B.N. and Harris,T.E.
  TITLE     Lipin proteins form homo- and hetero-oligomers
  JOURNAL   Biochem J 432 (1), 65-76 (2010)
   PUBMED   20735359
  REMARK    GeneRIF: Data revealed that lipin 1 formed stable homo-oligomers
            with itself and hetero-oligomers with lipin 2/3.
REFERENCE   6  (bases 1 to 4462)
  AUTHORS   Grimsey,N., Han,G.S., O'Hara,L., Rochford,J.J., Carman,G.M. and
            Siniossoglou,S.
  TITLE     Temporal and spatial regulation of the phosphatidate phosphatases
            lipin 1 and 2
  JOURNAL   J Biol Chem 283 (43), 29166-29174 (2008)
   PUBMED   18694939
REFERENCE   7  (bases 1 to 4462)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 4462)
  AUTHORS   Peterfy,M., Phan,J., Xu,P. and Reue,K.
  TITLE     Lipodystrophy in the fld mouse results from mutation of a new gene
            encoding a nuclear protein, lipin
  JOURNAL   Nat Genet 27 (1), 121-124 (2001)
   PUBMED   11138012
REFERENCE   9  (bases 1 to 4462)
  AUTHORS   Reue,K., Xu,P., Wang,X.P. and Slavin,B.G.
  TITLE     Adipose tissue deficiency, glucose intolerance, and increased
            atherosclerosis result from mutation in the mouse fatty liver
            dystrophy (fld) gene
  JOURNAL   J Lipid Res 41 (7), 1067-1076 (2000)
   PUBMED   10884287
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL132654.15 and AL031667.21.
            
            On Feb 27, 2020 this sequence version replaced NM_022896.2.
            
            Summary: The protein encoded by this gene is a member of the lipin
            family of proteins, and all family members share strong homology in
            their C-terminal region. This protein is thought to form
            hetero-oligomers with other lipin family members, while one family
            member, lipin 1, can also form homo-oligomers. This protein
            contains conserved motifs for phosphatidate phosphatase 1 (PAP1)
            activity as well as a domain that interacts with a transcriptional
            co-activator. Lipin complexes act in the cytoplasm to catalyze the
            dephosphorylation of phosphatidic acid to produce diacylglycerol,
            which is the precursor of both triglycerides and phospholipids.
            Lipin complexes are also thought to regulate gene expression as
            transcriptional co-activators in the nucleus. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.21278.1,
                                           SRR11853563.20514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373257.8/ ENSP00000362354.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AL132654.15        12248-12429
            183-382             AL132654.15        17223-17422
            383-478             AL132654.15        18979-19074
            479-747             AL132654.15        20046-20314
            748-828             AL132654.15        20519-20599
            829-949             AL132654.15        21201-21321
            950-1292            AL132654.15        21482-21824
            1293-1392           AL132654.15        23248-23347
            1393-1553           AL132654.15        23487-23647
            1554-1647           AL132654.15        24033-24126
            1648-1717           AL132654.15        24225-24294
            1718-1810           AL132654.15        26072-26164
            1811-1854           AL132654.15        26247-26290
            1855-1993           AL132654.15        27323-27461
            1994-2142           AL132654.15        28467-28615
            2143-2229           AL132654.15        28788-28874
            2230-2382           AL031667.21        246-398
            2383-2497           AL031667.21        601-715
            2498-2601           AL031667.21        803-906
            2602-4462           AL031667.21        1086-2946
FEATURES             Location/Qualifiers
     source          1..4462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q12"
     gene            1..4462
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /note="lipin 3"
                     /db_xref="GeneID:64900"
                     /db_xref="HGNC:HGNC:14451"
                     /db_xref="MIM:605520"
     exon            1..182
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            183..382
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2746
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /EC_number="3.1.3.4"
                     /note="isoform 2 is encoded by transcript variant 3;
                     phosphatidate phosphatase LPIN3"
                     /codon_start=1
                     /product="phosphatidate phosphatase LPIN3 isoform 2"
                     /protein_id="NP_075047.1"
                     /db_xref="CCDS:CCDS93041.1"
                     /db_xref="GeneID:64900"
                     /db_xref="HGNC:HGNC:14451"
                     /db_xref="MIM:605520"
                     /translation="MNYVGQLAETVFGTVKELYRGLNPATLSGGIDVLVVKQVDGSFR
                     CSPFHVRFGKLGVLRSREKVVDIELNGEPVDLHMKLGDSGEAFFVQELESDDEHVPPG
                     LCTSPIPWGGLSGFPSDSQLGTASEPEGLVMAGTASTGRRKRRRRRKPKQKEDAVATD
                     SSPEELEAGAESELSLPEKLRPEPPGVQLEEKSSLQPKDIYPYSDGEWPPQASLSAGE
                     LTSPKSDSELEVRTPEPSPLRAESHMQWAWGRLPKVARAERPESSVVLEGRAGATSPP
                     RGGPSTPSTSVAGGVDPLGLPIQQTEAGADLQPDTEDPTLVGPPLHTPETEESKTQSS
                     GDMGLPPASKSWSWATLEVPVPTGQPERVSRGKGSPKRSQHLGPSDIYLDDLPSLDSE
                     NAALYFPQSDSGLGARRWSEPSSQKSLRDPNPEHEPEPTLDTVDTIALSLCGGLADSR
                     DISLEKFNQHSVSYQDLTKNPGLLDDPNLVVKINGKHYNWAVAAPMILSLQAFQKNLP
                     KSTMDKLEREKMPRKGGRWWFSWRRRDFLAEERSAQKEKTAAKEQQGEKTEVLSSDDD
                     APDSPVILEIPSLPPSTPPSTPTYKKSLRLSSDQIRRLNLQEGANDVVFSVTTQYQGT
                     CRCKATIYLWKWDDKVVISDIDGTITKSDALGHILPQLGKDWTHQGITSLYHKIQLNG
                     YKFLYCSARAIGMADLTKGYLQWVSEGGCSLPKGPILLSPSSLFSALHREVIEKKPEV
                     FKVACLSDIQQLFLPHGQPFYAAFGNRPNDVFAYRQVGLPESRIFTVNPRGELIQELI
                     KNHKSTYERLGEVVELLFPPVARGPSTDLANPEYSNFCYWREPLPAVDLDTLD"
     exon            383..478
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..747
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..828
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..949
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1292
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1392
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1553
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1647
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1717
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1810
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1854
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1993
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2142
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2229
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2382
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2497
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2601
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..4462
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4441..4446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /note="hexamer: AATAAA"
     polyA_site      4462
                     /gene="LPIN3"
                     /gene_synonym="dJ620E11.2; LIPN3L; SMP2"
                     /note="major polyA site"
ORIGIN      
        1 agattggggc ctgtggaggc cgcactagga tcgtagaagg agtggagccg tgctctcacc
       61 ctgtcttaga ggacccggaa gcgccaagtg actgagggcc gaagacactc acctgtggag
      121 cctgtgcacg taggtagagg cggcggctct gagtccagga gctccagtgg gcagctcccc
      181 agcaccagcc atgaactacg tggggcagct ggcggagacg gtgtttggga cggtgaagga
      241 gctgtaccgg ggcctgaacc cagccacact gagcggcggc attgacgtgc tggtggtgaa
      301 gcaggtggac ggctcgttcc ggtgctcacc cttccacgtg cgttttggca agctgggcgt
      361 cctgcggtcg cgggagaagg tggtagacat tgagctcaat ggggagcctg tggacttgca
      421 catgaagctt ggggacagcg gggaggcctt ctttgttcag gagctggaga gcgatgatga
      481 acatgtgcct cccggcctgt gcacctcacc catcccttgg gggggtctgt ctggcttccc
      541 ctcggactcc cagctgggca ctgccagtga gcctgagggc ctcgtcatgg caggcacggc
      601 ctccactggg cggaggaaga ggcgtcgcag gaggaaaccc aagcagaaag aggatgcagt
      661 ggcaactgat tctagtccag aggaactgga ggcaggcgct gagagtgagc tatccctgcc
      721 ggaaaagctg aggccagagc ccccaggtgt ccagttggaa gagaagtctt cactgcagcc
      781 caaagacatc tacccctact cggatggcga gtggcccccc caggccagcc tctcagcagg
      841 tgagctaaca tcccctaaga gcgactcgga gctggaggtg cggaccccgg agcccagtcc
      901 cctaagagcc gagtcccaca tgcagtgggc ctgggggagg ctgcctaagg tggccagagc
      961 tgagcggccc gagtcctcag tggtccttga aggcagagct ggggcaacct ctcctcctcg
     1021 gggaggaccc agcactccct ctacctctgt ggctggcggc gtggaccctt tgggactccc
     1081 aatccagcaa acagaggctg gtgccgacct tcagcctgac acagaggatc ccactctagt
     1141 gggtccccct ctccacaccc cagagacaga ggaaagcaag actcagagct ctggggacat
     1201 gggcctccct cctgcctcca agtcatggag ctgggccact ctggaggttc cagttcccac
     1261 cgggcagcca gagagggtct ccagggggaa aggctcccca aagagaagcc agcacctggg
     1321 ccccagtgac atctacctgg atgacttgcc ctccctggac tctgagaatg cagcgcttta
     1381 cttcccccaa agtgactctg ggctgggggc cagaagatgg agtgaaccca gcagtcagaa
     1441 gtccctgagg gaccccaacc ctgaacatga acctgaaccc actctggaca cagtggatac
     1501 aatagcactg tccctctgtg gtggactggc tgacagccgg gacatctccc tagagaaatt
     1561 caaccagcac agcgtctctt accaggacct caccaaaaac cccggacttt tggatgaccc
     1621 aaacctagtg gtgaaaatca atggaaagca ttataactgg gctgtggctg cccccatgat
     1681 cctctccctg caagccttcc agaaaaactt gcccaagagc accatggaca agctggagag
     1741 ggagaagatg ccccggaagg gtgggcgatg gtggttttcc tggcgacgca gggacttcct
     1801 ggccgaggag cgcagtgccc agaaggagaa gactgcagcc aaggagcagc agggggagaa
     1861 gacagaagtc ctgagcagtg atgacgatgc cccagacagc cctgtgatcc tggagatccc
     1921 ctccttgcca ccctccactc caccctccac tcctacctac aagaagtccc tccgcctctc
     1981 ctccgatcag atccggcgcc tgaacctgca agaaggtgcc aatgatgtgg tcttcagcgt
     2041 gaccactcag taccagggca cctgccgctg caaggccacc atctacctgt ggaaatggga
     2101 cgacaaggtg gtcatctctg acatcgacgg caccatcacc aagtcagatg ctctgggcca
     2161 tatcctgccc cagctgggga aagactggac acaccagggc atcaccagtc tctatcacaa
     2221 aatccaacta aatgggtaca agttcctgta ctgctcggcg cgggccattg gcatggcgga
     2281 cctcaccaag gggtacctgc agtgggtgag cgaggggggc tgtagcctcc ccaagggccc
     2341 catccttctg tctcccagca gcctcttctc tgccctccac agagaggtga tcgagaagaa
     2401 accagaggtg ttcaaggtcg cctgcctgag tgacatccag cagctgtttc tgccccacgg
     2461 acagcccttc tatgctgcct ttgggaatag gcccaatgat gtctttgcct accggcaggt
     2521 gggcctgcct gagtcacgca tcttcacagt caacccccgg ggagagctca tccaggagct
     2581 cataaagaac cacaaatcca cgtatgagcg gcttggtgaa gtggtcgagc tcctcttccc
     2641 acctgtggcc cgtggcccca gcacagacct ggccaaccct gaatacagta acttctgcta
     2701 ctggcgggag ccactgcctg ctgtggacct tgataccctg gactgaacct gccctggctg
     2761 gctcctcctc cctggcccgg cccaggactg gctaggtgtc ctggggtata ggagggtggg
     2821 aattggagtg tcatggggca aacccactga aggggaagga ggaggctgca ggttggttgg
     2881 cagctagaga gactccccca tcttccccgt catatttttg ccagctaagc tgcagctgct
     2941 ccaggcgtca gtgtggcact gtcctggggc aattagcttg tcatctgggc ccttgcaggg
     3001 ttcttttttt tttttttttt ttttttttcc tgagacaggg tcttgttctg ttgcccaggc
     3061 tggagtgcag tggcatgatc tctcggctca ctgcaacctc cgcctcccgg gttcaagcga
     3121 ttcacctgcc tcagcctccc aagtagctgg gattacaggc gtgtaccacc acgcctggct
     3181 aattttcgtg tttttagtag agatgggttt tcaccacatt ggccaggctg gtctcgaact
     3241 cctgacctca agtgatttgc ccacctcggc ctcccaaagt gctgggatta caggcatgag
     3301 ctaccatgcc aggcctcctt gcagggtttt ctatgccctt gatatctgtc tccctgtcaa
     3361 cctgggacct tgctgtaagt cttgatagga cagggagaag agggaggccc taccgaggct
     3421 cgaggcttca gtgaagggtg acagcagtgg gagtgtggta cagcctctgg aaggacacag
     3481 tgttctcccc gccccttgtc tgggagccag gactgtaccc tccgaagcca gacatcactg
     3541 ccaacatatc ccccttgctg gtgccctggc atctcagcac atgacacaca cccacacctg
     3601 caggctgtgg ttccggcttg gcctgctccc cgtccggctg ctgccgctgc ctctctccag
     3661 acctcgctta aggacagtcc caaactcagc tggggcaggt gttggcctga aagtcctccc
     3721 ccagcctctg ctggccagct tggtgctcac agctgctggg taagctcttg cctaaggagc
     3781 tgtgggaagc agggctgatg ccccagcaac ctctcctccc actgtctttg aagaaagtag
     3841 ctttagaccg gctaaaagct ttaatccaga gcctgcccta ctctgatagt accagagtgg
     3901 agggcagaat accaaatgtc caggaaccaa aggcagggct gtggggacct gaagagcagc
     3961 acagtggggc ccgtgctgct gtgggggaaa ctgaggctgg gagcctcagc agagaccggt
     4021 gtcaagagtc tctgggaact gcataggcct gaggaacatg cattttcaag ttgtccattg
     4081 atggtttcgt acctgaattt ctcacctttt gtgaacatct tgggagggtg ggggttttgc
     4141 aggggtgtta aaagcaaggc ttggagcccc tttcctccag ctggtggctc cttctcaggg
     4201 cctggcctca ttcaggccac tttgtagaga aatgccctga cctcgcagga aggatttccc
     4261 cacccccaag tggaaggaag aggacagtgt gggcaccaga gggccctgga aacatcttag
     4321 gggaaggaaa ggaaaaggat aaatttggag tggggggtct ctaaacagat tgcctggatt
     4381 ccgttctttc ctggggttct acagctgcct aagccctcac cttgggggag gatcaaaggg
     4441 aataaagaga actcttggct ga
//
