LOCUS       NM_001375808            6052 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens lipin 2 (LPIN2), transcript variant 2, mRNA.
ACCESSION   NM_001375808 XM_005258178
VERSION     NM_001375808.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6052)
  AUTHORS   Badiger,V.A., Balan,S., Madan,S., Gogineni,K.S., Shah,H. and
            Narayanan,D.L.
  TITLE     LPIN2 -related Majeed syndrome: report of two Indian patients with
            novel variants in LPIN2 and review of literature
  JOURNAL   Clin Dysmorphol 33 (1), 27-30 (2024)
   PUBMED   37865862
  REMARK    GeneRIF: LPIN2 -related Majeed syndrome: report of two Indian
            patients with novel variants in LPIN2 and review of literature.
            Review article
REFERENCE   2  (bases 1 to 6052)
  AUTHORS   de Pablo,N., Meana,C., Martinez-Garcia,J., Martinez-Vicente,P.,
            Albert,M., Guerra,S., Angulo,A., Balsinde,J. and Balboa,M.A.
  TITLE     Lipin-2 regulates the antiviral and anti-inflammatory responses to
            interferon
  JOURNAL   EMBO Rep 24 (12), e57238 (2023)
   PUBMED   37929625
  REMARK    GeneRIF: Lipin-2 regulates the antiviral and anti-inflammatory
            responses to interferon.
REFERENCE   3  (bases 1 to 6052)
  AUTHORS   Bhuyan,F., de Jesus,A.A., Mitchell,J., Leikina,E., VanTries,R.,
            Herzog,R., Onel,K.B., Oler,A., Montealegre Sanchez,G.A.,
            Johnson,K.A., Bichell,L., Marrero,B., De Castro,L.F., Huang,Y.,
            Calvo,K.R., Collins,M.T., Ganesan,S., Chernomordik,L.V.,
            Ferguson,P.J. and Goldbach-Mansky,R.
  TITLE     Novel Majeed Syndrome-Causing LPIN2 Mutations Link Bone
            Inflammation to Inflammatory M2 Macrophages and Accelerated
            Osteoclastogenesis
  JOURNAL   Arthritis Rheumatol 73 (6), 1021-1032 (2021)
   PUBMED   33314777
  REMARK    GeneRIF: Novel Majeed Syndrome-Causing LPIN2 Mutations Link Bone
            Inflammation to Inflammatory M2 Macrophages and Accelerated
            Osteoclastogenesis.
REFERENCE   4  (bases 1 to 6052)
  AUTHORS   Ingram,L.M., Finnerty,M.C., Mansoura,M., Chou,C.W. and
            Cummings,B.S.
  TITLE     Identification of lipidomic profiles associated with drug-resistant
            prostate cancer cells
  JOURNAL   Lipids Health Dis 20 (1), 15 (2021)
   PUBMED   33596934
  REMARK    GeneRIF: Identification of lipidomic profiles associated with
            drug-resistant prostate cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6052)
  AUTHORS   Ferguson,P.J., Chen,S., Tayeh,M.K., Ochoa,L., Leal,S.M., Pelet,A.,
            Munnich,A., Lyonnet,S., Majeed,H.A. and El-Shanti,H.
  TITLE     Homozygous mutations in LPIN2 are responsible for the syndrome of
            chronic recurrent multifocal osteomyelitis and congenital
            dyserythropoietic anaemia (Majeed syndrome)
  JOURNAL   J Med Genet 42 (7), 551-557 (2005)
   PUBMED   15994876
  REMARK    GeneRIF: We conclude that homozygous mutations in LPIN2 result in
            Majeed syndrome. Understanding the aberrant immune response in this
            condition will shed light on the aetiology of other inflammatory
            disorders of multifactorial aetiology
REFERENCE   6  (bases 1 to 6052)
  AUTHORS   Zhou,J. and Young,T.L.
  TITLE     Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1
            high-grade myopia
  JOURNAL   Gene 352, 10-19 (2005)
   PUBMED   15862761
  REMARK    GeneRIF: LPIN2 gene was excluded as a candidate for myopia 2
            (MYP2), but the SNPs detected in this study will aid in future
            mapping and association studies involving this gene.
REFERENCE   7  (bases 1 to 6052)
  AUTHORS   Peterfy,M., Phan,J., Xu,P. and Reue,K.
  TITLE     Lipodystrophy in the fld mouse results from mutation of a new gene
            encoding a nuclear protein, lipin
  JOURNAL   Nat Genet 27 (1), 121-124 (2001)
   PUBMED   11138012
REFERENCE   8  (bases 1 to 6052)
  AUTHORS   Lehner,R. and Kuksis,A.
  TITLE     Biosynthesis of triacylglycerols
  JOURNAL   Prog Lipid Res 35 (2), 169-201 (1996)
   PUBMED   8944226
  REMARK    Review article
REFERENCE   9  (bases 1 to 6052)
  AUTHORS   Narayanan,D.L., Gogineni,K.S. and Badiger,V.A.
  TITLE     LPIN2-Related Majeed Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36877799
REFERENCE   10 (bases 1 to 6052)
  AUTHORS   El-Shanti,H. and Ferguson,P.
  TITLE     Majeed Syndrome - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301735
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP005431.3 and AP000919.6.
            
            On May 6, 2020 this sequence version replaced NM_001375808.1.
            
            Summary: Mouse studies suggest that this gene functions during
            normal adipose tissue development and may play a role in human
            triglyceride metabolism. This gene represents a candidate gene for
            human lipodystrophy, characterized by loss of body fat, fatty
            liver, hypertriglyceridemia, and insulin resistance. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.13060.1,
                                           SRR11853558.11556.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000677752.1/ ENSP00000504857.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AP005431.3         70375-70432         c
            59-259              AP000919.6         141933-142133       c
            260-355             AP000919.6         135788-135883       c
            356-657             AP000919.6         132339-132640       c
            658-765             AP000919.6         121889-121996       c
            766-889             AP000919.6         120764-120887       c
            890-1235            AP000919.6         118976-119321       c
            1236-1335           AP000919.6         115635-115734       c
            1336-1523           AP000919.6         112540-112727       c
            1524-1617           AP000919.6         110349-110442       c
            1618-1687           AP000919.6         109875-109944       c
            1688-1777           AP000919.6         109006-109095       c
            1778-1860           AP000919.6         108007-108089       c
            1861-2005           AP000919.6         106508-106652       c
            2006-2154           AP000919.6         105682-105830       c
            2155-2241           AP000919.6         105059-105145       c
            2242-2394           AP000919.6         103331-103483       c
            2395-2509           AP000919.6         102817-102931       c
            2510-2613           AP000919.6         102062-102165       c
            2614-6052           AP000919.6         98283-101721        c
FEATURES             Location/Qualifiers
     source          1..6052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..6052
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /note="lipin 2"
                     /db_xref="GeneID:9663"
                     /db_xref="HGNC:HGNC:14450"
                     /db_xref="MIM:605519"
     exon            1..58
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            59..259
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2758
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /EC_number="3.1.3.4"
                     /codon_start=1
                     /product="phosphatidate phosphatase LPIN2"
                     /protein_id="NP_001362737.1"
                     /db_xref="CCDS:CCDS11829.1"
                     /db_xref="GeneID:9663"
                     /db_xref="HGNC:HGNC:14450"
                     /db_xref="MIM:605519"
                     /translation="MNYVGQLAGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQ
                     CSPFHVRFGKLGVLRSKEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAY
                     LATSPIPTEDQFFKDIDTPLVKSGGDETPSQSSDISHVLETETIFTPSSVKKKKRRRK
                     KYKQDSKKEEQAASAAAEDTCDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSG
                     DHYPLSDGDWSPLETTYPQTACPKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVS
                     KRERSDHHPRTATITPSENTHFRVIPSEDNLISEVEKDASMEDTVCTIVKPKPRALGT
                     QMSDPTSVAELLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAKVDSPSKKKGVH
                     KRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSA
                     AADSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNP
                     NLVIRIYNRYYNWALAAPMILSLQVFQKSLPKATVESWVKDKMPKKSGRWWFWRKRES
                     MTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQELEESITVDPIPT
                     EPLSHGSTTSYKKSLRLSSDQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWN
                     DKIIISDIDGTITKSDALGQILPQLGKDWTHQGIAKLYHSINENGYKFLYCSARAIGM
                     ADMTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLF
                     APSKQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQERTKGNKSSYHRLSEL
                     VEHVFPLLSKEQNSAFPCPEFSSFCYWRDPIPEVDLDDLS"
     exon            260..355
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            356..657
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            658..765
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            766..889
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1235
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1335
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1523
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1617
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1687
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1777
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1860
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2005
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2154
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2241
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2394
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2509
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2613
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..6052
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6032..6037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /note="hexamer: AATAAA"
     polyA_site      6052
                     /gene="LPIN2"
                     /gene_synonym="CRMO1; MJDS"
                     /note="major polyA site"
ORIGIN      
        1 gcagtccagc cgccgcctgc cctcagccgc ccgctggccg ggagcggagc ccctgtggtc
       61 tcaaaccatg aattatgtgg gacagctggc tgggcaggtg attgtcactg tgaaggaact
      121 ctacaagggc attaaccagg ccaccctctc tgggtgcatt gatgtcatcg tggtacagca
      181 gcaggatggc agctatcagt gttcaccttt tcacgttcgg tttggaaagc tgggagtcct
      241 gagatccaaa gagaaagtga ttgatataga aatcaacggc agtgcagtgg atcttcacat
      301 gaagttgggt gataacggag aagctttctt tgttgaggag actgaagaag aatatgaaaa
      361 gcttcctgct taccttgcca cctcaccaat tcctactgaa gatcagttct ttaaagatat
      421 tgacacccct ttggtgaaat cgggtggaga tgaaacacca tctcagagtt cagacatctc
      481 acacgtcttg gaaacagaga caatttttac tccaagttct gtgaaaaaga aaaaacgaag
      541 gagaaagaaa tacaaacagg acagtaagaa ggaagagcag gccgcatctg ctgctgcaga
      601 agacacatgt gatgtaggcg tgagctccga tgatgacaag ggggcccagg cagcacgagg
      661 atcttcaaat gcttccttga aagaagaaga atgtaaagag cctttgctct tccattctgg
      721 ggatcattac cccttatctg atggagattg gtccccttta gagaccacct atccccagac
      781 agcgtgtcct aagagtgatt cagagctgga ggtgaaacct gcggagagcc tgctcagatc
      841 agagtctcac atggagtgga cgtggggcgg attcccagag tccaccaagg tcagcaaaag
      901 agaacgatct gaccatcatc ctaggacagc tacaattaca ccatcagaaa atactcattt
      961 tcgggtaatt cccagtgagg acaacctcat cagtgaagtt gagaaggatg cttccatgga
     1021 agacactgtc tgtaccatag tgaagcccaa acccagagcc ctgggtacac agatgagcga
     1081 cccaacatct gtggcagagc ttctcgaacc tcctcttgag agtactcaga tttcatctat
     1141 gttagatgct gaccaccttc ccaacgcagc cttagcggag gcgccctcag aatccaaacc
     1201 ggcagctaaa gtagactcgc cgtcaaagaa gaaaggtgtt cacaaaagaa gccaacacca
     1261 gggacctgat gatatttacc ttgatgactt aaagggtcta gaacctgaag ttgcagctct
     1321 ttatttccct aaaagtgaat cggagcccgg ttccaggcag tggcccgagt ctgacacact
     1381 ctctggctcc cagtccccac agtccgtggg aagcgcagct gcagatagcg gcaccgagtg
     1441 cctctcagat tctgccatgg acttgcctga cgttaccctc tccctttgcg ggggcctcag
     1501 tgaaaatgga gaaatttcaa aagaaaaatt catggagcat atcattactt atcacgaatt
     1561 tgcagaaaac cctggactta tagacaatcc taaccttgta ataaggatat ataatcgtta
     1621 ctataactgg gctttggcag ctcccatgat ccttagcttg caagtattcc agaagagctt
     1681 gcctaaggcc acagttgagt cctgggtgaa agacaagatg ccaaagaaat ctggtcgctg
     1741 gtggttttgg cgaaagagag aaagcatgac caaacagctg ccagaatcca aggagggaaa
     1801 atctgaggca ccgccagcca gtgacctgcc atccagctcc aaggagccgg ccggtgccag
     1861 gccggccgag aatgactcct cgagtgacga gggatcacag gagctcgaag aatccatcac
     1921 agtggacccc atccccacag agcccctgag ccacggcagc acaacttcat ataagaagtc
     1981 tctccgcctc tcctcagacc agatcgcaaa actgaagctc cacgatggcc caaatgatgt
     2041 tgtgtttagt attacaaccc agtatcaagg cacctgtcgc tgtgcaggga ccatttacct
     2101 gtggaactgg aatgacaaga tcatcatttc tgatattgat gggacaataa ccaagtcgga
     2161 tgctttggga cagattctcc cacagctggg caaagactgg acccaccagg gtatagcaaa
     2221 gctctaccat tccatcaatg agaatggcta caagtttctg tactgctcgg ctcgtgccat
     2281 cggcatggcc gacatgaccc gtggctacct gcactgggtc aatgacaagg gcacaatctt
     2341 gccccggggc cccctgatgc tgtcccccag cagcttgttc tccgccttcc acagagaagt
     2401 gatagaaaag aaaccagaga agttcaaaat tgagtgtcta aatgatatca agaatctgtt
     2461 tgccccgtct aagcagccct tctatgctgc ctttggaaac cgtccaaatg atgtctatgc
     2521 ctacacacaa gttggagttc cagactgtag aatattcacc gtgaacccca agggtgaatt
     2581 aatacaagaa agaaccaaag gaaacaagtc atcgtatcac aggctgagtg agctcgtgga
     2641 gcatgtgttc ccccttctca gtaaggagca gaattccgct tttccctgcc cggagttcag
     2701 ctccttctgc tactggcgag acccgatccc tgaagtggac ctggatgacc tgtcttgagg
     2761 cggcacctca gtgggtgggc agggcttggt ccccctcccc acagcaaggg aaggcagctg
     2821 gctcttctgc tgacctcaga taccagcctt ccccagcggg gacgggtgct tctggagctg
     2881 gtcccgccat cctcctttgc cttcccaggc cagctgctca ggctcggcag gtctgcagct
     2941 cagctcctgg aaggagaagg gaggaactgg gcctggggct ggaggcctgg gatccctcct
     3001 ttgtgggtcg cacacatgtt tcctgctgtg agctggggcc tccttccatt gcatcatttt
     3061 aaaggaagaa aaaagcagct aaaaaagagt ggaccaaaac actgcacaca gtgaagtgtt
     3121 ccagtttcca ctgggcagtt gaggtggctt ctgtaaccag ggctgtcttc agatgtcagg
     3181 gtccctgaac tgctgcgggc ccagtcagtg atgctggctg aagctgcctg tgcacgtttc
     3241 ttctctggtc gcctcatttc ctgctacact gaaggggtca gctgctccag tgggccaagt
     3301 tgggcaggac ccccgcccct gcagggccca tgcaccagag ccactgagcc cagtcccata
     3361 aacctggccc tctttgggga aagatcccca cagagcatcc tcctctcatc tgtgacaact
     3421 ccacgagccc ttaatttctt agtcctcacc agaagaacag gtctcacaag tatatatttg
     3481 atgtctgtaa taaaagtggg aaggtgggtc ttaaaacaga ccaaaccccg ccccgccccc
     3541 aacaactctg cttttaggga ggcctccgaa atgcagatag gcggttgagt ggggtcctgg
     3601 gaagagcgct gaatccctct gcttgctgcc tggtgtgggc ctttggaaag catcttgcct
     3661 tgggacagga tttctaaaat tctgtgattc agatttgtca gggaagcaca gtgaagcttg
     3721 cttaaaggca ctggccagca gtgtgtgact ttggcttttg ggatcacacc ctgtaatcgg
     3781 gcccgtggaa gcagcgtcaa agaggggtct tggagctcct atggagcaga ctgccccccg
     3841 agcagtgtcc ccagcctagc cctgtgagac cccatgggga cacgggtgcc tatgtatttt
     3901 cactaaaata tacatggtag ctccatttac tgatgcggtt gtaatgagct cacatcgtgt
     3961 ctgaagagat ggcaccaggg aaaggtgtgc cataagctgc tccagagctt ttggtatgct
     4021 gagtgttgac agagctgcac tcttaacatc aagagaactg tcaggagccc agaaccaacc
     4081 ccaggtcttg gtctccattg gcgagaacac aggacgtggt ggttcctgag cagagaggga
     4141 tctgcagata caggcttggc gctcggggtg gtctcgtggc caactcttca tgcccctgcc
     4201 gttgtagtgg aacctctaca tgttttagtt tgcttcacct aaaataatgc tgatctagag
     4261 atagagaaat aggggtggtt atttttccag attggagagt tgaaagtccc tgactgattt
     4321 cagccatttt cctagtgctt gtcggatgca gagacaatgt tgaaatcccc taaacacagt
     4381 tctcagtggc aaaacctagg aaggctcatg ttcccagaga agggaccaca tgagccttct
     4441 cccatgcaaa gcttccccca gcttaaatag ttgataagga ctaattgttt aatgagttta
     4501 tttatctaca gtaggttagg gatcctgggt tctgtttata tgaagttctt cccagtttgt
     4561 gaattctagt acagcagcca tgcagccacc ttatttcata gatgccatct gtgtgtcctc
     4621 ttgactacct tctatttaga ggaagaatga gagctttgtg tgtttaactg agcttatagt
     4681 aggacttctt tgcatatgta tggtactgaa aaatcttaat atacatcttt aatccttttt
     4741 aggttgtcct ttaaagagtt tttgactagt ttctttttct tgacagctct tctctttgga
     4801 cacatgggcc ttcttagagg gttcagtcta ggacccggct ctcctggccc tgtgttgagg
     4861 gtagctggtc cctctgtccc tgtgtctgct agcactagac tttgttgctg cagattgatc
     4921 cagtgggtac ataggctaat taatgtgagt ctttttcctt gtttaaagga gtccctcttg
     4981 ctgaaagtag atgattacta ttgctgtagt gttaggaaag tattaagttt gtgctgaaaa
     5041 tccattgcca tttggtacaa atgacatttg ttctttctgt gaaagagatg ccctcgagtg
     5101 tgtttgtaca caaaccctta ggatggtgag ttgaagcatc accctcgcgc tatcttcagt
     5161 gacgggtgac ggctcaggga gatggcaggc agattgggct ctaagtcatt attctctcag
     5221 ttactccatt ggtgaaatgg ccctttccct ctttgcagtt cagtctaagt ctcgtatttg
     5281 ctttgctgtc tgtgtgctga agctcgtccc gtgtgagttg ctgtctgccc cttgtcaggc
     5341 tgtgaggtgc tcgtgtagac ctggagcatg caggctgcct ccgtttttgg gtactgtgtt
     5401 gtgttttgct ctgtctaaaa acatctgcat agttttcaac tggaaaaaga aaaaacttaa
     5461 aaatgggatg tcctaaaatg aaagctgctc aaagtcacag aacaaccgag ggacaaagga
     5521 gattggatga ctgggaagcg ctggcccgga acagcccctg caactgtggg gcctgcacac
     5581 agcccttcca cagttggcac tgcaggtgca ggccaaccct ttaaagaata aacaaggaag
     5641 tcagctcttt cactttttac aagttggcaa aaacagactt ccggggaatt tcgatgtttt
     5701 cccgtgttgt agagcttcca gggtttaata aaactggtta aaaattgagt ctttccctga
     5761 agtaagtgct ctttccagat gaaaactact cttttggttt tgtttgaaag taagaaaggg
     5821 aggggaaact ttgctctttt aataattatg ttcagcctat gatgaagtat ttgattatta
     5881 gacagcaatg tcactaataa gttttaagtt gtccaaagtt aattgtaaac atcatcagta
     5941 cagtactctt agttacagta aagcaattgt tgcaagatga atggctaata ttttggtgca
     6001 gtgtttgatg ttcaaaacaa aatgttacaa caataaacga acataacata aa
//
