LOCUS       NM_005768               2235 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lysophosphatidylcholine acyltransferase 3 (LPCAT3),
            mRNA.
ACCESSION   NM_005768
VERSION     NM_005768.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Kondreddy,V., Banerjee,R., Devi,B.L.A.P., Muralidharan,K. and
            Piramanayagam,S.
  TITLE     Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration
            and osteoarthritis
  JOURNAL   Cell Commun Signal 22 (1), 189 (2024)
   PUBMED   38519981
  REMARK    GeneRIF: Inhibition of the MALT1-LPCAT3 axis protects cartilage
            degeneration and osteoarthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Habaxi,K., Wang,W., Taximaimaiti,M. and Wang,L.
  TITLE     Methylation Regulation of LPCAT3 Improves Osteoarthritis by
            Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (2), 77-86 (2024)
   PUBMED   38073444
  REMARK    GeneRIF: Methylation Regulation of LPCAT3 Improves Osteoarthritis
            by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
REFERENCE   3  (bases 1 to 2235)
  AUTHORS   Cui,J., Wang,Y., Tian,X., Miao,Y., Ma,L., Zhang,C., Xu,X., Wang,J.,
            Fang,W. and Zhang,X.
  TITLE     LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and
            Collaborates with ACSL4 and YAP to Determine Ferroptosis
            Sensitivity
  JOURNAL   Antioxid Redox Signal 39 (7-9), 491-511 (2023)
   PUBMED   37166352
  REMARK    GeneRIF: LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and
            Collaborates with ACSL4 and YAP to Determine Ferroptosis
            Sensitivity.
REFERENCE   4  (bases 1 to 2235)
  AUTHORS   Zhang,H., Wu,H., Qian,J., Sun,L., Sang,L., Wang,P., Yuan,B. and
            Zhang,J.
  TITLE     The regulation of LPCAT3 by miR-124-3p.1 in acute kidney injury
            suppresses cell proliferation by disrupting phospholipid metabolism
  JOURNAL   Biochem Biophys Res Commun 604, 37-42 (2022)
   PUBMED   35286868
  REMARK    GeneRIF: The regulation of LPCAT3 by miR-124-3p.1 in acute kidney
            injury suppresses cell proliferation by disrupting phospholipid
            metabolism.
REFERENCE   5  (bases 1 to 2235)
  AUTHORS   Liu,N., Sun,Q., Xu,H., Yu,X., Chen,W., Wei,H., Jiang,J., Xu,Y. and
            Lu,W.
  TITLE     Hyperuricemia induces lipid disturbances mediated by LPCAT3
            upregulation in the liver
  JOURNAL   FASEB J 34 (10), 13474-13493 (2020)
   PUBMED   32780898
  REMARK    GeneRIF: Hyperuricemia induces lipid disturbances mediated by
            LPCAT3 upregulation in the liver.
REFERENCE   6  (bases 1 to 2235)
  AUTHORS   Zhao,Y., Chen,Y.Q., Bonacci,T.M., Bredt,D.S., Li,S., Bensch,W.R.,
            Moller,D.E., Kowala,M., Konrad,R.J. and Cao,G.
  TITLE     Identification and characterization of a major liver
            lysophosphatidylcholine acyltransferase
  JOURNAL   J Biol Chem 283 (13), 8258-8265 (2008)
   PUBMED   18195019
  REMARK    GeneRIF: LPCAT3 is primarily responsible for hepatic LPCAT activity
REFERENCE   7  (bases 1 to 2235)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   8  (bases 1 to 2235)
  AUTHORS   Maurel-Zaffran,C., Chauvet,S., Jullien,N., Miassod,R., Pradel,J.
            and Aragnol,D.
  TITLE     nessy, an evolutionary conserved gene controlled by Hox proteins
            during Drosophila embryogenesis
  JOURNAL   Mech Dev 86 (1-2), 159-163 (1999)
   PUBMED   10446276
REFERENCE   9  (bases 1 to 2235)
  AUTHORS   Ansari-Lari,M.A., Shen,Y., Muzny,D.M., Lee,W. and Gibbs,R.A.
  TITLE     Large-scale sequencing in human chromosome 12p13: experimental and
            computational gene structure determination
  JOURNAL   Genome Res 7 (3), 268-280 (1997)
   PUBMED   9074930
REFERENCE   10 (bases 1 to 2235)
  AUTHORS   Ansari-Lari,M.A., Muzny,D.M., Lu,J., Lu,F., Lilley,C.E., Spanos,S.,
            Malley,T. and Gibbs,R.A.
  TITLE     A gene-rich cluster between the CD4 and triosephosphate isomerase
            genes at human chromosome 12p13
  JOURNAL   Genome Res 6 (4), 314-326 (1996)
   PUBMED   8723724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU125262.1 and BX648009.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005768.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648009.1, BC065194.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261407.9/ ENSP00000261407.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-521               AU125262.1         135-655
            522-2235            BX648009.1         555-2268
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2235
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /note="lysophosphatidylcholine acyltransferase 3"
                     /db_xref="GeneID:10162"
                     /db_xref="HGNC:HGNC:30244"
                     /db_xref="MIM:611950"
     exon            1..203
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1516
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /EC_number="2.3.1.23"
                     /EC_number="2.3.1.n6"
                     /EC_number="2.3.1.n7"
                     /note="O-acyltransferase (membrane bound) domain
                     containing 5; membrane bound O-acyltransferase domain
                     containing 5; lyso-PS acyltransferase; lyso-PC
                     acyltransferase 3; lysophosphatidylserine acyltransferase;
                     1-acylglycerophosphoserine O-acyltransferase;
                     1-acylglycerophosphocholine O-acyltransferase;
                     O-acyltransferase domain-containing protein 5;
                     membrane-bound O-acyltransferase domain-containing protein
                     5; putative protein similar to nessy;
                     1-acylglycerophosphoethanolamine O-acyltransferase;
                     lysophospholipid acyltransferase 12"
                     /codon_start=1
                     /product="lysophospholipid acyltransferase 5"
                     /protein_id="NP_005759.4"
                     /db_xref="CCDS:CCDS8572.1"
                     /db_xref="GeneID:10162"
                     /db_xref="HGNC:HGNC:30244"
                     /db_xref="MIM:611950"
                     /translation="MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRL
                     IISIFLGYPFALFYRHYLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFL
                     ILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYF
                     DGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELID
                     IPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIW
                     GKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPRFTGTI
                     ASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVI
                     VERQAARLIQESPTLSKLAAITVLQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKV
                     YKSIYFLGHIFFLSLLFILPYIHKAMVPRKEKLKKME"
     exon            204..311
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            312..418
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            419..512
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            513..550
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            551..729
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            730..838
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            839..925
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1092
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1240
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1399
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1528
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..2235
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2204..2209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /note="hexamer: GATAAA"
     polyA_site      2235
                     /gene="LPCAT3"
                     /gene_synonym="C3F; LPCAT; LPLAT 5; LPLAT12; LPSAT;
                     MBOAT5; nessy; OACT5"
                     /note="major polyA site"
ORIGIN      
        1 gcattcgggg cgcgcggagc tggggggtcc ctgtggggct cccggagtta agatggcgtc
       61 ctcagcggag ggggacgagg ggactgtggt ggcgctggcg ggggttctgc agtcgggttt
      121 ccaggagctg agccttaaca agttggcgac gtccctgggc gcgtcagaac aggcgctgcg
      181 gctgatcatc tccatcttcc tgggttaccc ctttgctttg ttttatcggc attacctttt
      241 ctacaaggag acctacctca tccacctctt ccataccttt acaggcctct caattgctta
      301 ttttaacttt ggaaaccagc tctaccactc cctgctgtgt attgtgcttc agttcctcat
      361 ccttcgacta atgggccgca ccatcactgc cgtcctcact accttttgct tccagatggc
      421 ctaccttctg gctggatact attacactgc caccggcaac tacgatatca agtggacaat
      481 gccacattgt gttctgactt tgaagctgat tggtttggct gttgactact ttgacggagg
      541 gaaagatcag aattccttgt cctctgagca acagaaatat gccatacgtg gtgttccttc
      601 cctgctggaa gttgctggtt tctcctactt ctatggggcc ttcttggtag ggccccagtt
      661 ctcaatgaat cactacatga agctggtgca gggagagctg attgacatac caggaaagat
      721 accaaacagc atcattcctg ctctcaagcg cctgagtctg ggccttttct acctagtggg
      781 ctacacactg ctcagccccc acatcacaga agactatctc ctcactgaag actatgacaa
      841 ccaccccttc tggttccgct gcatgtacat gctgatctgg ggcaagtttg tgctgtacaa
      901 atatgtcacc tgttggctgg tcacagaagg agtatgcatt ttgacgggcc tgggcttcaa
      961 tggctttgaa gaaaagggca aggcaaagtg ggatgcctgt gccaacatga aggtgtggct
     1021 ctttgaaaca aacccccgct tcactggcac cattgcctca ttcaacatca acaccaacgc
     1081 ctgggtggcc cgctacatct tcaaacgact caagttcctt ggaaataaag aactctctca
     1141 gggtctctcg ttgctattcc tggccctctg gcacggcctg cactcaggat acctggtctg
     1201 cttccagatg gaattcctca ttgttattgt ggaaagacag gctgccaggc tcattcaaga
     1261 gagccccacc ctgagcaagc tggccgccat tactgtcctc cagcccttct actatttggt
     1321 gcaacagacc atccactggc tcttcatggg ttactccatg actgccttct gcctcttcac
     1381 gtgggacaaa tggcttaagg tgtataaatc catctatttc cttggccaca tcttcttcct
     1441 gagcctacta ttcatattgc cttatattca caaagcaatg gtgccaagga aagagaagtt
     1501 aaagaagatg gaataatcca tttccctggt ggcctgtgcg ggactggtgc agaaactact
     1561 cgtctccctt ttcacagcac tcctttgccc cagagcagag aatggaaaag ccagggaggt
     1621 ggaagatcga tgcttccagc tgtgcctctg ctgccagcca agtcttcatt tggggccaaa
     1681 ggggaaactt ttttttggag aaggcgtctt gctttgtcac ccacgctgga atgcagtggc
     1741 gggatctcag ctcaccgcaa cctccacctc ctgggttcaa gtgattttcc tgcctcagcc
     1801 tcccaagtag ctgggaatac aggcacgcca ccatgcccag ctaatttttg tattttcagt
     1861 agaaacggga tttcaccacg ttggccaggc tggtctcgaa ctcctgaccg caagtgatcc
     1921 acccgcctcc gcctcccaaa gtgctgggat tacaggcgtg agccaccgtg cccggcccaa
     1981 aggggaaact cttgtgggag gagcagaggg gctcacatct cccctctgat tcccccatgc
     2041 acattgcctt atctctcccc atctagccag gaatctattg tgtttttctt ctgccaattt
     2101 actatgattg tgtatgtgcc gctaccacca ccccccccat gggggggtgg agaggggtgc
     2161 aaggccctgc ctgctccact ttttctacct tggaactgta ttagataaaa tcacttctgt
     2221 ttgttcagtt tttca
//
