LOCUS       NM_024830               3945 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens lysophosphatidylcholine acyltransferase 1 (LPCAT1),
            mRNA.
ACCESSION   NM_024830 XM_001717124 XM_001720496
VERSION     NM_024830.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3945)
  AUTHORS   Li,Z., Hu,Y., Zheng,H., Li,M., Liu,Y., Feng,R., Li,X., Zhang,S.,
            Tang,M., Yang,M., Yu,R., Xu,Y., Liao,X., Chen,S., Qian,W.,
            Zhang,Q., Tang,D., Li,B., Song,L. and Li,J.
  TITLE     LPCAT1-mediated membrane phospholipid remodelling promotes
            ferroptosis evasion and tumour growth
  JOURNAL   Nat Cell Biol 26 (5), 811-824 (2024)
   PUBMED   38671262
  REMARK    GeneRIF: LPCAT1-mediated membrane phospholipid remodelling promotes
            ferroptosis evasion and tumour growth.
REFERENCE   2  (bases 1 to 3945)
  AUTHORS   Wang,Y., Huang,Y., Wang,Y., Zhang,W., Wang,N., Bai,R., Luo,R.,
            Tuo,H. and Zheng,Y.
  TITLE     LPCAT1 promotes melanoma cell proliferation via Akt signaling
  JOURNAL   Oncol Rep 51 (5) (2024)
   PUBMED   38551165
  REMARK    GeneRIF: LPCAT1 promotes melanoma cell proliferation via Akt
            signaling.
REFERENCE   3  (bases 1 to 3945)
  AUTHORS   Liu,R., Yin,C., Zhao,P., Guo,B., Ke,W., Zheng,X., Xie,D., Wang,Y.,
            Wang,G., Jia,Y., Gao,Y., Hu,W., Liu,G.L. and Song,Z.
  TITLE     Nuclear respiratory factor 1 drives hepatocellular carcinoma
            progression by activating LPCAT1-ERK1/2-CREB axis
  JOURNAL   Biol Direct 18 (1), 67 (2023)
   PUBMED   37875967
  REMARK    GeneRIF: Nuclear respiratory factor 1 drives hepatocellular
            carcinoma progression by activating LPCAT1-ERK1/2-CREB axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3945)
  AUTHORS   Zhao,Y., Liu,Y. and Shi,X.
  TITLE     LncRNA AC012360.1 facilitates growth and metastasis by regulating
            the miR-139-5p/LPCAT1 axis in hepatocellular carcinoma
  JOURNAL   Environ Toxicol 38 (9), 2192-2203 (2023)
   PUBMED   37300846
  REMARK    GeneRIF: LncRNA AC012360.1 facilitates growth and metastasis by
            regulating the miR-139-5p/LPCAT1 axis in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 3945)
  AUTHORS   Huo,A. and Wang,F.
  TITLE     Biomarkers of ulcerative colitis disease activity CXCL1, CYP2R1,
            LPCAT1, and NEU4 and their relationship to immune infiltrates
  JOURNAL   Sci Rep 13 (1), 12126 (2023)
   PUBMED   37495756
  REMARK    GeneRIF: Biomarkers of ulcerative colitis disease activity CXCL1,
            CYP2R1, LPCAT1, and NEU4 and their relationship to immune
            infiltrates.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3945)
  AUTHORS   Mansilla,F., da Costa,K.A., Wang,S., Kruhoffer,M., Lewin,T.M.,
            Orntoft,T.F., Coleman,R.A. and Birkenkamp-Demtroder,K.
  TITLE     Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression
            in human colorectal cancer
  JOURNAL   J Mol Med (Berl) 87 (1), 85-97 (2009)
   PUBMED   18974965
  REMARK    GeneRIF: LPCAT1 may contribute to total choline metabolite
            accumulation via phosphatidylcholine remodeling, thereby altering
            the CRC lipid profile, a characteristic of malignancy.
REFERENCE   7  (bases 1 to 3945)
  AUTHORS   Harayama,T., Shindou,H., Ogasawara,R., Suwabe,A. and Shimizu,T.
  TITLE     Identification of a novel noninflammatory biosynthetic pathway of
            platelet-activating factor
  JOURNAL   J Biol Chem 283 (17), 11097-11106 (2008)
   PUBMED   18285344
REFERENCE   8  (bases 1 to 3945)
  AUTHORS   Soupene,E., Fyrst,H. and Kuypers,F.A.
  TITLE     Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 88-93 (2008)
   PUBMED   18156367
  REMARK    GeneRIF: Aytl2 gene is the phosphatidylcholine reacylating enzyme
            in RBCs; this represents the identification of a plasma membrane
            lysophospholipid acyltransferase and establishes the function of a
            LPCAT protein
REFERENCE   9  (bases 1 to 3945)
  AUTHORS   Nakanishi,H., Shindou,H., Hishikawa,D., Harayama,T., Ogasawara,R.,
            Suwabe,A., Taguchi,R. and Shimizu,T.
  TITLE     Cloning and characterization of mouse lung-type
            acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1).
            Expression in alveolar type II cells and possible involvement in
            surfactant production
  JOURNAL   J Biol Chem 281 (29), 20140-20147 (2006)
   PUBMED   16704971
REFERENCE   10 (bases 1 to 3945)
  AUTHORS   Jikuya,H., Takano,J., Kikuno,R., Hirosawa,M., Nagase,T., Nomura,N.
            and Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen. II.
            The complete sequences of 81 cDNA clones
  JOURNAL   DNA Res 10 (1), 49-57 (2003)
   PUBMED   12693554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR982813.1, AB244719.2,
            BC020166.1, BI770498.1 and CA425992.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024830.4.
            
            Summary: This gene encodes a member of the
            1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins.
            The encoded enzyme plays a role in phospholipid metabolism,
            specifically in the conversion of lysophosphatidylcholine to
            phosphatidylcholine in the presence of acyl-CoA. This process is
            important in the synthesis of lung surfactant and
            platelet-activating factor (PAF). Elevated expression of this gene
            may contribute to the progression of oral squamous cell, prostate,
            breast, and other human cancers. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2217181.1,
                                           SRR18074969.3748888.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283415.4/ ENSP00000283415.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               CR982813.1         18-133
            117-1721            AB244719.2         1-1605
            1722-2635           BC020166.1         1189-2102
            2636-2919           BI770498.1         75-358
            2920-3408           BC020166.1         2387-2875
            3409-3945           CA425992.1         23-559              c
FEATURES             Location/Qualifiers
     source          1..3945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..3945
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /note="lysophosphatidylcholine acyltransferase 1"
                     /db_xref="GeneID:79888"
                     /db_xref="HGNC:HGNC:25718"
                     /db_xref="MIM:610472"
     exon            1..251
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1721
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /EC_number="2.3.1.51"
                     /EC_number="2.3.1.23"
                     /EC_number="2.3.1.67"
                     /EC_number="2.3.1.25"
                     /note="phosphonoformate immuno-associated protein 3; LPC
                     acyltransferase 1; 1-acylglycerol-3-phosphate
                     O-acyltransferase; acyltransferase-like 2; lysoPC
                     acyltransferase 1; lyso-PAF acetyltransferase;
                     acetyl-CoA:lyso-PAF acetyltransferase;
                     1-acylglycerophosphocholine O-acyltransferase;
                     1-alkylglycerophosphocholine O-acetyltransferase;
                     acetyl-CoA:lyso-platelet-activating factor
                     acetyltransferase; 1-alkenylglycerophosphocholine
                     O-acyltransferase; lysophospholipid acyltransferase 8"
                     /codon_start=1
                     /product="lysophosphatidylcholine acyltransferase 1"
                     /protein_id="NP_079106.3"
                     /db_xref="CCDS:CCDS3864.1"
                     /db_xref="GeneID:79888"
                     /db_xref="HGNC:HGNC:25718"
                     /db_xref="MIM:610472"
                     /translation="MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKA
                     QVALMTLTLFPVRLLVAAAMMLLAWPLALVASLGSAEKEPEQPPALWRKVVDFLLKAI
                     MRTMWFAGGFHRVAVKGRQALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDI
                     PIWGTLIQYIRPVFVSRSDQDSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLI
                     TFKPGAFIPGAPVQPVVLRYPNKLDTITWTWQGPGALEILWLTLCQFHNQVEIEFLPV
                     YSPSEEEKRNPALYASNVRRVMAEALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEF
                     ARLVRGLGLKPEKLEKDLDRYSERARMKGGEKIGIAEFAASLEVPVSDLLEDMFSLFD
                     ESGSGEVDLRECVVALSVVCRPARTLDTIQLAFKMYGAQEDGSVGEGDLSCILKTALG
                     VAELTVTDLFRAIDQEEKGKITFADFHRFAEMYPAFAEEYLYPDQTHFESCAETSPAP
                     IPNGFCADFSPENSDAGRKPVRKKLD"
     exon            252..394
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            395..609
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            610..722
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            723..783
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            784..842
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            843..877
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            878..932
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1015
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1141
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1295
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1394
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1536
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..3945
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3925..3930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /note="hexamer: CATAAA"
     polyA_site      3945
                     /gene="LPCAT1"
                     /gene_synonym="AGPAT10; AGPAT9; AYTL2; lpcat; LPCAT-1;
                     LPLAT8; lysoPAFAT; PFAAP3"
                     /note="major polyA site"
ORIGIN      
        1 cccgctccag ccgccgcgca tcctcggccc gcgccccgag acccgcgccc agctagcccc
       61 ggccccgctc ggcgccccag gcagctcggc tgcgctcgcc gcgggacggc gcggccatga
      121 ggctgcgggg atgcggaccc cgggccgccc ctgcctccag cgcaggggcc agcgacgctc
      181 ggctgctggc gcccccgggg cggaacccct tcgtgcacga gctgcgcctc agcgccctgc
      241 agaaggccca ggtggccctc atgacactga cgctcttccc ggtccggctc ctggttgccg
      301 ctgccatgat gctgctggcc tggcccctcg cacttgtcgc atccctgggc tctgcggaga
      361 aggaacccga gcagcccccg gccctgtgga ggaaggttgt ggacttcctg ctgaaggcca
      421 tcatgcgcac catgtggttc gccggcggct tccaccgggt ggccgtgaag gggcggcagg
      481 cgctgcccac cgaggcggcc atcctcacgc tcgcgcctca ctcgtcctac ttcgacgcca
      541 tccctgtgac catgacgatg tcctccatcg tgatgaaggc agagagcaga gacatcccga
      601 tctggggaac tctgatccag tatatacggc ctgtgttcgt gtcccggtca gaccaggatt
      661 ctcgcaggaa aacagtagaa gaaatcaaga gacgggcgca gtccaacgga aagtggccac
      721 agataatgat ttttccagaa ggaacttgta caaacaggac ctgcctaatt accttcaaac
      781 ctggtgcatt catccctgga gcgcccgtcc agcctgtggt tttacgatat ccaaataaac
      841 tggacaccat cacatggacg tggcaaggac ctggagcgct ggaaatcctg tggctcacgc
      901 tgtgtcagtt tcacaaccaa gtggaaatcg agttccttcc tgtgtacagc ccttctgagg
      961 aggagaagag gaaccccgcg ctgtatgcca gcaacgtgcg gcgagtcatg gccgaggcct
     1021 tgggtgtctc cgtgactgac tacacgttcg aggactgcca gctggccctg gcggaaggac
     1081 agctccgtct ccccgctgac acttgccttt tagaatttgc caggctcgtg cggggcctcg
     1141 ggctaaaacc agaaaagctt gaaaaagatc tggacagata ctcagaaaga gccaggatga
     1201 agggaggaga gaagataggt attgcggagt ttgccgcctc cctggaagtc cccgtttctg
     1261 acttgctgga agacatgttt tcactgttcg acgagagcgg cagcggcgag gtggacctgc
     1321 gagagtgtgt ggttgccctg tctgtcgtct gccggccggc ccggaccctg gacaccatcc
     1381 agctggcttt caagatgtac ggagcgcaag aggacggcag cgtcggcgaa ggtgacctgt
     1441 cctgcatcct caagacggcc ctgggggtgg cagagctcac cgtgaccgac ctattccgag
     1501 ccattgacca agaggagaag gggaagatca cattcgctga cttccacagg tttgcagaaa
     1561 tgtaccctgc cttcgcagag gaatacctgt acccggatca gacacatttc gaaagctgtg
     1621 cagagacctc acctgcgcca atcccaaacg gcttctgtgc cgatttcagc ccggaaaact
     1681 cagacgctgg gcggaagcct gttcgcaaga agctggatta ggacccaggg ttgcggagag
     1741 acgcggcccc tcccgcgtgg acatcaccgc catgagcctc tttgcgagtg acctctgggc
     1801 tccgctcctc actcctgctg tacaggcact gtcttcagcc cgagttccag gggcctcggg
     1861 ggctgtttgt atcttgttcc tttgtgaagt gtgttgcaga accgacgctt actgtgcgag
     1921 aatcggaggg cgcgcacgcg gatcccccgc ctggcctgga ccccgtgggg tcaggttccc
     1981 tgccgggcgg ggggcaccgg tgccgccccg tgttctccca cggggccctg gtttcgagtc
     2041 tctgtcacag cctcttccgg cggcagcgtg caccgggcgg gcctccgtgc acactcagca
     2101 cacgcctgcc acacagcgtg cgcttgcgtg tcactctggc acgaaacctg tctgcctctg
     2161 tggatccaca gcctggcaga gccgagccgt cacctgattt ttcagtgttt ctacctgtgt
     2221 gctggagctc atgagtattt tataaactcc atttaggtac ttcaggaaac atgcagcatt
     2281 ttttaaaaaa tgaaaattgt ttttctactt catttttcct tttagagtca aaggatattt
     2341 atttataggc cttttttttt ttaatataga atctgaggct gtttgggctt tgacttaaat
     2401 ttccatcagg cctctctcca gcaggtaatc cctctccttc cgctgggtcc cctggggagg
     2461 tgtgaactca agggcctagc cccaaaacac tttttctgct tttcttaatc cttttccagt
     2521 cccctctttt tttataaacg ttggcagttt gatgtttctg tttcggcata acgtaatcca
     2581 tttcactgta gcctaaactc cagtccgagg ttggatattg ttcaaatgag cagggcccga
     2641 gctggaagcg caaggcagcc gccgccgtgc cgctcctccc ttgccctcag gccaggtccc
     2701 tgctggaagc ggctgcatct tcctgtcagc cctggtttcc atggtgactg gcgtcacgct
     2761 gccacccgag tatggctgac cttcctgcag agagaggagc cgcagtcttt tgcttgtgga
     2821 aggagacgct gggctgtgcg gtgcggaggg tgatgaggat gtctggtgac agccgtgcgg
     2881 acaccactcc tctctgcagc actgcctccc agcgccaggg tcgcgggcac atcccactga
     2941 gagcgggggt cctgccccat cttagagtca aaggcagagg ggcttccagg ccctggatgg
     3001 ggtattttgg tgtcacctga agtccctctg acatcacctt gtttcatcat tttttatgac
     3061 agaattagaa acccatcctt caagcacaat aatcatcaca gacttgagtt tgcttcctaa
     3121 agcaaaggct ccgggtttgt ttggaaaatt tttttgattt ctgaaatgaa ttgattttta
     3181 tatttggggc atctctatag aaagtgacca ccaaggccag taagtacggg aaaaaatgtt
     3241 tactaacttc ctcagagatt cgtgatacgc gtttctccac tgacagacat ttaaaaacaa
     3301 ccttcagctc cgtttcaatc aatcacctcg acttgttttt tagcatggac actgccagca
     3361 ggacagacag ggatggagta aaccgaagtc aatttcaggg ctcttggcgt gttggacaca
     3421 gaagaaatcc tagtgcagcc tttggtagct aacagtcact gattttataa ttggagaatg
     3481 cgtaaagatt catttttcaa ggagaagagc ctgcaaatgg ccaatgaagg aggtaaataa
     3541 actaagatat tccgagggaa gggacccagg ccacctccct tccgcaggtc tgcagatgaa
     3601 gggttttttg aatgaaatgc cactgtgcat tttcagaaaa aaaaatctct gataaacaga
     3661 ctttgaatgg atgtttgttc ctcctgattc tcttttctct tcgtggcgac ttagagttgg
     3721 cggatattcg gaactgtgaa tgtacatagc gttgagttaa accccttgtg tgtgagacag
     3781 gacgcagcgg gcccctggtg gcctgggggc cagacccgtg ggcaggtggg gcatgggccc
     3841 tggcctgcgg ggacctgctg gggtgtgagg gcagagggag ggttgccatg aaggaacttg
     3901 ggattttcaa tggaataagt aaaacataaa gtctatactt gggaa
//
