LOCUS       NM_001162498            1976 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens lysophosphatidic acid receptor 6 (LPAR6), transcript
            variant 3, mRNA.
ACCESSION   NM_001162498
VERSION     NM_001162498.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Lee,S., Bondaruk,J., Wang,Y., Chen,H., Lee,J.G., Majewski,T.,
            Mullen,R.D., Cogdell,D., Chen,J., Wang,Z., Yao,H., Kus,P.,
            Jeong,J., Lee,I., Choi,W., Navai,N., Guo,C., Dinney,C.,
            Baggerly,K., Mendelsohn,C., McConkey,D., Behringer,R.R., Kimmel,M.,
            Wei,P. and Czerniak,B.
  TITLE     Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal
            urothelial differentiation program, contributing to bladder
            carcinogenesis
  JOURNAL   Cell Rep 43 (5), 114146 (2024)
   PUBMED   38676926
  REMARK    GeneRIF: Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal
            urothelial differentiation program, contributing to bladder
            carcinogenesis.
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Yanagida,K., Masago,K., Yasuda,D., Hamano,F., Kurikawa,Y.,
            Shimizu,T. and Ishii,S.
  TITLE     Cell-trafficking impairment in disease-associated LPA6 missense
            mutants and a potential pharmacoperone therapy for autosomal
            recessive woolly hair/hypotrichosis
  JOURNAL   Hum Mol Genet 32 (5), 825-834 (2023)
   PUBMED   36173926
  REMARK    GeneRIF: Cell-trafficking impairment in disease-associated LPA6
            missense mutants and a potential pharmacoperone therapy for
            autosomal recessive woolly hair/hypotrichosis.
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   He,J., Gao,R., Meng,M., Yu,M., Liu,C., Li,J., Song,Y. and Wang,H.
  TITLE     Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker
            Associated with Lung Adenocarcinoma
  JOURNAL   Int J Environ Res Public Health 18 (21), 11038 (2021)
   PUBMED   34769557
  REMARK    GeneRIF: Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential
            Biomarker Associated with Lung Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Piquer-Garcia,J., Torres-Navarro,I., Martinez-Castellano,F. and
            Evole-Buselli,M.
  TITLE     Autosomal recessive woolly hair and hypotrichosis in two Caucasian
            dizygotic twins. Description of a novel biallelic mutation in the
            LPAR6 gene
  JOURNAL   Int J Dermatol 60 (2), e68-e70 (2021)
   PUBMED   33017051
  REMARK    GeneRIF: Autosomal recessive woolly hair and hypotrichosis in two
            Caucasian dizygotic twins. Description of a novel biallelic
            mutation in the LPAR6 gene.
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Lippolis,R., Gnocchi,D., Santacroce,L., Siciliano,R.A.,
            Mazzeo,M.F., Scacco,S., Sabba,C. and Mazzocca,A.
  TITLE     A distinctive protein signature induced by lysophosphatidic acid
            receptor 6 (LPAR6) expression in hepatocellular carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 526 (4), 1150-1156 (2020)
   PUBMED   32321639
  REMARK    GeneRIF: A distinctive protein signature induced by
            lysophosphatidic acid receptor 6 (LPAR6) expression in
            hepatocellular carcinoma cells.
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Adrian,K., Bernhard,M.K., Breitinger,H.G. and Ogilvie,A.
  TITLE     Expression of purinergic receptors (ionotropic P2X1-7 and
            metabotropic P2Y1-11) during myeloid differentiation of HL60 cells
  JOURNAL   Biochim Biophys Acta 1492 (1), 127-138 (2000)
   PUBMED   11004484
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Ralevic,V. and Burnstock,G.
  TITLE     Receptors for purines and pyrimidines
  JOURNAL   Pharmacol Rev 50 (3), 413-492 (1998)
   PUBMED   9755289
  REMARK    Review article
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Li,Q., Schachter,J.B., Harden,T.K. and Nicholas,R.A.
  TITLE     The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not
            mediate nucleotide-promoted second messenger responses
  JOURNAL   Biochem Biophys Res Commun 236 (2), 455-460 (1997)
   PUBMED   9240460
  REMARK    GeneRIF: Expression of turkey (Meleagris gallopavo) 6H1/p2y5
            receptor in human astrocytoma cells and measurement of second
            mesenger levels indicate it is not a member of the P2Y receptor
            family.
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Herzog,H., Darby,K., Hort,Y.J. and Shine,J.
  TITLE     Intron 17 of the human retinoblastoma susceptibility gene encodes
            an actively transcribed G protein-coupled receptor gene
  JOURNAL   Genome Res 6 (9), 858-861 (1996)
   PUBMED   8889552
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Toguchida,J., McGee,T.L., Paterson,J.C., Eagle,J.R., Tucker,S.,
            Yandell,D.W. and Dryja,T.P.
  TITLE     Complete genomic sequence of the human retinoblastoma
            susceptibility gene
  JOURNAL   Genomics 17 (3), 535-543 (1993)
   PUBMED   7902321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL392048.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 10, 2020 this sequence version replaced NM_001162498.2.
            
            Summary: The protein encoded by this gene belongs to the family of
            G-protein coupled receptors, that are preferentially activated by
            adenosine and uridine nucleotides. This gene aligns with an
            internal intron of the retinoblastoma susceptibility gene in the
            reverse orientation. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            represents use of an alternate promoter, compared to variant 1. All
            five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BX537392.1, BX537438.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620633.5/ ENSP00000482660.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1976              AL392048.9         122696-124671       c
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..1976
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /note="lysophosphatidic acid receptor 6"
                     /db_xref="GeneID:10161"
                     /db_xref="HGNC:HGNC:15520"
                     /db_xref="MIM:609239"
     exon            1..1976
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /inference="alignment:Splign:2.1.0"
     CDS             691..1725
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /note="purinergic receptor P2Y, G-protein coupled, 5; P2Y
                     purinoceptor 5; RB intron encoded G-protein coupled
                     receptor; purinergic receptor 5; purinergic receptor P2Y G
                     protein-coupled protein 5; G-protein coupled purinergic
                     receptor P2Y5; LPA receptor 6;
                     oleoyl-L-alpha-lysophosphatidic acid receptor"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 6"
                     /protein_id="NP_001155970.1"
                     /db_xref="CCDS:CCDS9410.1"
                     /db_xref="GeneID:10161"
                     /db_xref="HGNC:HGNC:15520"
                     /db_xref="MIM:609239"
                     /translation="MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLISNCVAIYIFIC
                     VLKVRNETTTYMINLAMSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNMYG
                     SILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHSQ
                     GNNASEACFENFPEATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKPVTLS
                     RSKINKTKVLKMIFVHLIIFCFCFVPYNINLILYSLVRTQTFVNCSVVAAVRTMYPIT
                     LCIAVSNCCFDPIVYYFTSDTIQNSIKMKNWSVRRSDFRFSEVHGAENFIQHNLQTLK
                     SKIFDNESAA"
     regulatory      1953..1958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /note="hexamer: ATTAAA"
     polyA_site      1976
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /note="major polyA site"
ORIGIN      
        1 agagaaagcg acctcaagat acaactggca actgaggaaa aggcctcaat tcaacaagag
       61 ctaacaagct tgggagttta tttcggaatc tttaaaagac tcttctgctt acccacaatc
      121 tgggatccac tgcaggaaaa caaaaaagga aaacttcatt taaaagaagc aagaagtaaa
      181 atgggacaaa ttgggaatgt ttaagtctct gaaactctgc actgaaaaga aaataagatt
      241 gataacttaa gcttaacatt ctgaggcata aagaaacatt aactttggag tattcatctt
      301 gactactgaa atacaagttt agaagacaag tggtttcatt ctggtcacag atcacagctt
      361 ttctttaaat ttataatcct atgggttgga ctcgttgact gtatttttta aaggttgctc
      421 gtcagttaac tgagccttgg aattcatgga ttttctaaag actaacaaat gaaaatattt
      481 tcctgttgaa gaacccagcg gaaattttac agcaacaaat ttcatgtttc ttttgggtat
      541 ttctgagaaa aaggaaatat ttataaaacc atccaaagat ccagataatt tgcaaataaa
      601 ttggaggtta tagaggttat aatctgaatc ccaaaggaga ctgcagctga tgaaagtgct
      661 tccaaactga aaattggacg tgcctttacg atggtaagcg ttaacagctc ccactgcttc
      721 tataatgact cctttaagta cactttgtat gggtgcatgt tcagcatggt gtttgtgctt
      781 gggttaatat ccaattgtgt tgccatatac attttcatct gcgtcctcaa agtccgaaat
      841 gaaactacaa cttacatgat taacttggca atgtcagact tgctttttgt ttttacttta
      901 cccttcagga ttttttactt cacaacacgg aattggccat ttggagattt actttgtaag
      961 atttctgtga tgctgtttta taccaacatg tacggaagca ttctgttctt aacctgtatt
     1021 agtgtagatc gatttctggc aattgtctac ccatttaagt caaagactct aagaaccaaa
     1081 agaaatgcaa agattgtttg cactggcgtg tggttaactg tgatcggagg aagtgcaccc
     1141 gccgtttttg ttcagtctac ccactctcag ggtaacaatg cctcagaagc ctgctttgaa
     1201 aattttccag aagccacatg gaaaacatat ctctcaagga ttgtaatttt catcgaaata
     1261 gtgggatttt ttattcctct aattttaaat gtaacttgtt ctagtatggt gctaaaaact
     1321 ttaaccaaac ctgttacatt aagtagaagc aaaataaaca aaactaaggt tttaaaaatg
     1381 atttttgtac atttgatcat attctgtttc tgttttgttc cttacaatat caatcttatt
     1441 ttatattctc ttgtgagaac acaaacattt gttaattgct cagtagtggc agcagtaagg
     1501 acaatgtacc caatcactct ctgtattgct gtttccaact gttgttttga ccctatagtt
     1561 tactacttta catcggacac aattcagaat tcaataaaaa tgaaaaactg gtctgtcagg
     1621 agaagtgact tcagattctc tgaagttcat ggtgcagaga attttattca gcataaccta
     1681 cagaccttaa aaagtaagat atttgacaat gaatctgctg cctgaaataa aaccattagg
     1741 actcactggg acagaacttt caagttcctt caactgtgaa aagtgtcttt ttggacaaac
     1801 tatttttcca cctccaaaag aaattaacac atggacattt taaagtcttt agtataaaga
     1861 aaatttgtat tcaatgtgtt aagcattaac atgtatttta tttgtgtatc cactccatct
     1921 gatttttctg agccattttg atttgttcct tcattaaaaa aaatctctta aagtta
//
