LOCUS       NM_020400               2683 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens lysophosphatidic acid receptor 5 (LPAR5), transcript
            variant 1, mRNA.
ACCESSION   NM_020400
VERSION     NM_020400.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2683)
  AUTHORS   Song,E. and Ghil,S.
  TITLE     Crosstalk between cannabinoid receptor 2 and lysophosphatidic acid
            receptor 5
  JOURNAL   Biochem Biophys Res Commun 666, 154-161 (2023)
   PUBMED   37187093
  REMARK    GeneRIF: Crosstalk between cannabinoid receptor 2 and
            lysophosphatidic acid receptor 5.
REFERENCE   2  (bases 1 to 2683)
  AUTHORS   Dacheux,M.A., Norman,D.D., Tigyi,G.J. and Lee,S.C.
  TITLE     Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5)
            in inflammatory diseases and cancer
  JOURNAL   Pharmacol Ther 245, 108414 (2023)
   PUBMED   37061203
  REMARK    GeneRIF: Emerging roles of lysophosphatidic acid receptor subtype 5
            (LPAR5) in inflammatory diseases and cancer.
            Review article
REFERENCE   3  (bases 1 to 2683)
  AUTHORS   Zhang,B., Zhang,L., Qi,P., Pang,R., Wang,Z., Liu,X., Shi,Q. and
            Zhang,Q.
  TITLE     Potential role of LPAR5 gene in prognosis and immunity of thyroid
            papillary carcinoma and pan-cancer
  JOURNAL   Sci Rep 13 (1), 5850 (2023)
   PUBMED   37037831
  REMARK    GeneRIF: Potential role of LPAR5 gene in prognosis and immunity of
            thyroid papillary carcinoma and pan-cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2683)
  AUTHORS   He,Y., Zhou,H., Huang,X., Qu,Y., Wang,Y., Pei,W., Zhang,R., Chen,S.
            and You,H.
  TITLE     Infiltration of LPAR5+ macrophages in osteosarcoma tumor
            microenvironment predicts better outcomes
  JOURNAL   Front Immunol 13, 909932 (2022)
   PUBMED   36591220
  REMARK    GeneRIF: Infiltration of LPAR5[+] macrophages in osteosarcoma tumor
            microenvironment predicts better outcomes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2683)
  AUTHORS   Sun,X.Y., Li,H.Z., Xie,D.F., Gao,S.S., Huang,X., Guan,H., Bai,C.J.
            and Zhou,P.K.
  TITLE     LPAR5 confers radioresistance to cancer cells associated with EMT
            activation via the ERK/Snail pathway
  JOURNAL   J Transl Med 20 (1), 456 (2022)
   PUBMED   36199069
  REMARK    GeneRIF: LPAR5 confers radioresistance to cancer cells associated
            with EMT activation via the ERK/Snail pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2683)
  AUTHORS   Lee,C.W., Rivera,R., Gardell,S., Dubin,A.E. and Chun,J.
  TITLE     GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid
            receptor that increases cAMP, LPA5
  JOURNAL   J Biol Chem 281 (33), 23589-23597 (2006)
   PUBMED   16774927
  REMARK    GeneRIF: GPR92 is proposed as a fifth LPA receptor, LPA5, which
            likely has distinct physiological functions in view of its
            expression pattern.
REFERENCE   7  (bases 1 to 2683)
  AUTHORS   Kotarsky,K., Boketoft,A., Bristulf,J., Nilsson,N.E., Norberg,A.,
            Hansson,S., Owman,C., Sillard,R., Leeb-Lundberg,L.M. and Olde,B.
  TITLE     Lysophosphatidic acid binds to and activates GPR92, a G
            protein-coupled receptor highly expressed in gastrointestinal
            lymphocytes
  JOURNAL   J Pharmacol Exp Ther 318 (2), 619-628 (2006)
   PUBMED   16651401
REFERENCE   8  (bases 1 to 2683)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   9  (bases 1 to 2683)
  AUTHORS   Lee,D.K., Nguyen,T., Lynch,K.R., Cheng,R., Vanti,W.B., Arkhitko,O.,
            Lewis,T., Evans,J.F., George,S.R. and O'Dowd,B.F.
  TITLE     Discovery and mapping of ten novel G protein-coupled receptor genes
  JOURNAL   Gene 275 (1), 83-91 (2001)
   PUBMED   11574155
REFERENCE   10 (bases 1 to 2683)
  CONSRTM   ADHR Consortium
  TITLE     Autosomal dominant hypophosphataemic rickets is associated with
            mutations in FGF23
  JOURNAL   Nat Genet 26 (3), 345-348 (2000)
   PUBMED   11062477
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC072394.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020400.5.
            
            Summary: This gene encodes a member of the rhodopsin class of G
            protein-coupled transmembrane receptors. This protein transmits
            extracellular signals from lysophosphatidic acid to cells through
            heterotrimeric G proteins and mediates numerous cellular processes.
            Many G protein receptors serve as targets for pharmaceutical drugs.
            Transcript variants of this gene have been described.[provided by
            RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072394.1, SRR1803613.201329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329858.9/ ENSP00000327875.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2683              BC072394.1         163-2845
FEATURES             Location/Qualifiers
     source          1..2683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2683
                     /gene="LPAR5"
                     /gene_synonym="GPR92; GPR93; KPG_010; LPA5"
                     /note="lysophosphatidic acid receptor 5"
                     /db_xref="GeneID:57121"
                     /db_xref="HGNC:HGNC:13307"
                     /db_xref="MIM:606926"
     exon            1..53
                     /gene="LPAR5"
                     /gene_synonym="GPR92; GPR93; KPG_010; LPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            54..2683
                     /gene="LPAR5"
                     /gene_synonym="GPR92; GPR93; KPG_010; LPA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1388
                     /gene="LPAR5"
                     /gene_synonym="GPR92; GPR93; KPG_010; LPA5"
                     /note="G protein-coupled receptor 92; G-protein coupled
                     receptor 93; LPA-5; LPA receptor 5"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 5"
                     /protein_id="NP_065133.1"
                     /db_xref="CCDS:CCDS8553.1"
                     /db_xref="GeneID:57121"
                     /db_xref="HGNC:HGNC:13307"
                     /db_xref="MIM:606926"
                     /translation="MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALAL
                     WVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQ
                     MNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVH
                     RPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTL
                     ARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVR
                     GVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSER
                     SAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPAR5"
                     /gene_synonym="GPR92; GPR93; KPG_010; LPA5"
                     /note="hexamer: GATAAA"
     polyA_site      2231
                     /gene="LPAR5"
                     /gene_synonym="GPR92; GPR93; KPG_010; LPA5"
     regulatory      2659..2664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPAR5"
                     /gene_synonym="GPR92; GPR93; KPG_010; LPA5"
                     /note="hexamer: AATAAA"
     polyA_site      2683
                     /gene="LPAR5"
                     /gene_synonym="GPR92; GPR93; KPG_010; LPA5"
                     /note="major polyA site"
ORIGIN      
        1 agagcaggca gcggaagcca gcttggggca gcgcagagca acacggagca caggtctctg
       61 ctgctgatga agctgtgacc aaacgcaccc aacccttggc agccatctgt ccctgcagcc
      121 atagcccaca ttcccatgac ctccctctgc ttgttttggg accatgtctg tacagcctct
      181 aggccccagc cccggaggtg aatgccatgc catgattctg gtgtgctcca tggcatcccc
      241 agcctagctc ccaatcccac tttggcacga tgttagccaa cagctcctca accaacagtt
      301 ctgttctccc gtgtcctgac taccgaccta cccaccgcct gcacttggtg gtctacagct
      361 tggtgctggc tgccgggctc cccctcaacg cgctagccct ctgggtcttc ctgcgcgcgc
      421 tgcgcgtgca ctcggtggtg agcgtgtaca tgtgtaacct ggcggccagc gacctgctct
      481 tcaccctctc gctgcccgtt cgtctctcct actacgcact gcaccactgg cccttccccg
      541 acctcctgtg ccagacgacg ggcgccatct tccagatgaa catgtacggc agctgcatct
      601 tcctgatgct catcaacgtg gaccgctacg ccgccatcgt gcacccgctg cgactgcgcc
      661 acctgcggcg gccccgcgtg gcgcggctgc tctgcctggg cgtgtgggcg ctcatcctgg
      721 tgtttgccgt gcccgccgcc cgcgtgcaca ggccctcgcg ttgccgctac cgggacctcg
      781 aggtgcgcct atgcttcgag agcttcagcg acgagctgtg gaaaggcagg ctgctgcccc
      841 tcgtgctgct ggccgaggcg ctgggcttcc tgctgcccct ggcggcggtg gtctactcgt
      901 cgggccgagt cttctggacg ctggcgcgcc ccgacgccac gcagagccag cggcggcgga
      961 agaccgtgcg cctcctgctg gctaacctcg tcatcttcct gctgtgcttc gtgccctaca
     1021 acagcacgct ggcggtctac gggctgctgc ggagcaagct ggtggcggcc agcgtgcctg
     1081 cccgcgatcg cgtgcgcggg gtgctgatgg tgatggtgct gctggccggc gccaactgcg
     1141 tgctggaccc gctggtgtac tactttagcg ccgagggctt ccgcaacacc ctgcgcggcc
     1201 tgggcactcc gcaccgggcc aggacctcgg ccaccaacgg gacgcgggcg gcgctcgcgc
     1261 aatccgaaag gtccgccgtc accaccgacg ccaccaggcc ggatgccgcc agtcaggggc
     1321 tgctccgacc ctccgactcc cactctctgt cttccttcac acagtgtccc caggattccg
     1381 ccctctgaac acacatgcca ttgcgctgtc cgtgcccgac tcccaacgcc tctcgttctg
     1441 ggaggcttac agggtgtaca cacaagaagg tgggctgggc acttggacct ttgggtggca
     1501 attccagctt agcaacgcag aagagtacaa agtgtggaag ccagggccca gggaaggcag
     1561 tgctgctgga aatggcttct ttaaactgtg agcacgcaga gcaccccttc tccagcggtg
     1621 ggaagtgatg cagagagccc acccgtgcag agggcagaag aggacgaaat gcctttgggt
     1681 gggcagggca ttaaactgct aaaagctggt tagatggaac agaaaatggg cattctggat
     1741 ctaaaccgcc acaggggcct gagagctgaa gagcaccagg tttggtggac aaagctactg
     1801 agatgcctgt tcatctgctg acttctgtct aggctcatgg atgccacccc ctttcatttc
     1861 ggcctaggct tcccctgctc accactgagg cctaatacaa gagttcctat ggacagaact
     1921 acattctttc tcgcatagtg acttgtgaca atttagactt ggcatccagc atgggatagt
     1981 tggggcaagg caaaactaac ttagagtttc cccctcaaca acatccaagt ccaaaccctt
     2041 tttaggttat cctttcttcc atcacatccc cttttccagg cctcctccat tttaggtcct
     2101 taatattctt tctttttctc tctctctcgt ttctctcttc tctctcctct cctctcctct
     2161 ctcttctcct cttctctctc tctccctctc tctcctttgt ccagagtaag gataaaattc
     2221 tttctactaa agcactggtt ctcaaacttt ttggtctcag accccactct tagaaattga
     2281 ggatctcaaa gagctttgct tatattttgt tcttttgata cttaccatac tagaaattaa
     2341 agcgaataca tttttaaaat aaatacacat gcacacatta cattagccat gggagcaata
     2401 atgtcaccac acacacttca tgaagcctct ggaaaactct acagtatact tgtgagagaa
     2461 tgagagtgaa agggacaaat aacatctgtg tagcagtatt atgaaaatag cttgacctcg
     2521 tggacttcct cagagggttg gtccctggat cacactttga gaaccatact tgtcctgaag
     2581 tattggagtt catgtctaac ttcttcccag ggcattatgt acagtgcttt ttattactgt
     2641 ggggagaggg cagtgctaaa taaattaatc actactgata gtc
//
