LOCUS       NM_001278000            4454 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens lysophosphatidic acid receptor 4 (LPAR4), transcript
            variant 1, mRNA.
ACCESSION   NM_001278000
VERSION     NM_001278000.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4454)
  AUTHORS   Wu,C., Rakhshandehroo,T., Wettersten,H.I., Campos,A., von
            Schalscha,T., Jain,S., Yu,Z., Tan,J., Mose,E., Childers,B.G.,
            Lowy,A.M., Weis,S.M. and Cheresh,D.A.
  TITLE     Pancreatic cancer cells upregulate LPAR4 in response to isolation
            stress to promote an ECM-enriched niche and support tumour
            initiation
  JOURNAL   Nat Cell Biol 25 (2), 309-322 (2023)
   PUBMED   36646789
  REMARK    GeneRIF: Pancreatic cancer cells upregulate LPAR4 in response to
            isolation stress to promote an ECM-enriched niche and support
            tumour initiation.
REFERENCE   2  (bases 1 to 4454)
  AUTHORS   Deng,Y., Zhou,Y., Shi,J., Yang,J., Huang,H., Zhang,M., Wang,S.,
            Ma,Q., Liu,Y., Li,B., Yan,J. and Yang,H.
  TITLE     Potential genetic biomarkers predict adverse pregnancy outcome
            during early and mid-pregnancy in women with systemic lupus
            erythematosus
  JOURNAL   Front Endocrinol (Lausanne) 13, 957010 (2022)
   PUBMED   36465614
  REMARK    GeneRIF: Potential genetic biomarkers predict adverse pregnancy
            outcome during early and mid-pregnancy in women with systemic lupus
            erythematosus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4454)
  AUTHORS   Kowalczyk-Zieba,I., Woclawek-Potocka,I., Wasniewski,T.,
            Boruszewska,D., Grycmacher,K., Sinderewicz,E., Staszkiewicz,J. and
            Wolczynski,S.
  TITLE     LPAR2 and LPAR4 are the Main Receptors Responsible for LPA Actions
            in Ovarian Endometriotic Cysts
  JOURNAL   Reprod Sci 26 (1), 139-150 (2019)
   PUBMED   29621954
  REMARK    GeneRIF: Study shows that due to the high LPAR2 and LPAR4
            transcript and protein expression in endometriotic ovarian cysts
            and positive correlations of both these receptors with the PR-B and
            ERbeta, respectively, those receptors seem to be the most promising
            predictors of the endometriotic cysts.
REFERENCE   4  (bases 1 to 4454)
  AUTHORS   Pan,W., Zhou,L., Ge,M., Zhang,B., Yang,X., Xiong,X., Fu,G.,
            Zhang,J., Nie,X., Li,H., Tang,X., Wei,J., Shao,M., Zheng,J.,
            Yuan,Q., Tan,W., Wu,C., Yang,M. and Lin,D.
  TITLE     Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as
            novel papillary thyroid carcinoma driver alternations
  JOURNAL   Hum Mol Genet 25 (9), 1875-1884 (2016)
   PUBMED   26941397
  REMARK    GeneRIF: Mutation in LPAR4 gene is associated with papillary
            thyroid carcinoma.
REFERENCE   5  (bases 1 to 4454)
  AUTHORS   Luttrell,L.M.
  TITLE     Reviews in molecular biology and biotechnology: transmembrane
            signaling by G protein-coupled receptors
  JOURNAL   Mol Biotechnol 39 (3), 239-264 (2008)
   PUBMED   18240029
  REMARK    Review article
REFERENCE   6  (bases 1 to 4454)
  AUTHORS   Dowal,L., Provitera,P. and Scarlata,S.
  TITLE     Stable association between G alpha(q) and phospholipase C beta 1 in
            living cells
  JOURNAL   J Biol Chem 281 (33), 23999-24014 (2006)
   PUBMED   16754659
REFERENCE   7  (bases 1 to 4454)
  AUTHORS   Noguchi,K., Ishii,S. and Shimizu,T.
  TITLE     Identification of p2y9/GPR23 as a novel G protein-coupled receptor
            for lysophosphatidic acid, structurally distant from the Edg family
  JOURNAL   J Biol Chem 278 (28), 25600-25606 (2003)
   PUBMED   12724320
  REMARK    GeneRIF: identified as the fourth lysophosphatidic acid (LPA)
            receptor; shares only 20-24% amino acid identities with Edg-2/LPA1,
            Edg-4/LPA2, and Edg-7/LPA3, and phylogenetic analysis also shows
            that p2y9/GPR23 is far distant from the Edg family
REFERENCE   8  (bases 1 to 4454)
  AUTHORS   Adrian,K., Bernhard,M.K., Breitinger,H.G. and Ogilvie,A.
  TITLE     Expression of purinergic receptors (ionotropic P2X1-7 and
            metabotropic P2Y1-11) during myeloid differentiation of HL60 cells
  JOURNAL   Biochim Biophys Acta 1492 (1), 127-138 (2000)
   PUBMED   11004484
REFERENCE   9  (bases 1 to 4454)
  AUTHORS   Janssens,R., Boeynaems,J.M., Godart,M. and Communi,D.
  TITLE     Cloning of a human heptahelical receptor closely related to the
            P2Y5 receptor
  JOURNAL   Biochem Biophys Res Commun 236 (1), 106-112 (1997)
   PUBMED   9223435
REFERENCE   10 (bases 1 to 4454)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Jung,B.P., Marchese,A., Cheng,R.,
            Heng,H.H., Kolakowski,L.F. Jr., Lynch,K.R. and George,S.R.
  TITLE     Cloning and chromosomal mapping of four putative novel human
            G-protein-coupled receptor genes
  JOURNAL   Gene 187 (1), 75-81 (1997)
   PUBMED   9073069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590083.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 29, 2020 this sequence version replaced NM_001278000.2.
            
            Summary: This gene encodes a member of the lysophosphatidic acid
            receptor family. It may also be related to the P2Y receptors, a
            family of receptors that bind purine and pyrimidine nucleotides and
            are coupled to G proteins. The encoded protein may play a role in
            monocytic differentiation. [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.646473.1,
                                           SRR18074967.3591286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614823.5/ ENSP00000478261.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AL590083.8         24525-24839
            316-365             AL590083.8         26979-27028
            366-428             AL590083.8         27535-27597
            429-530             AL590083.8         28015-28116
            531-4454            AL590083.8         31596-35519
FEATURES             Location/Qualifiers
     source          1..4454
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..4454
                     /gene="LPAR4"
                     /gene_synonym="GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9"
                     /note="lysophosphatidic acid receptor 4"
                     /db_xref="GeneID:2846"
                     /db_xref="HGNC:HGNC:4478"
                     /db_xref="MIM:300086"
     exon            1..315
                     /gene="LPAR4"
                     /gene_synonym="GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9"
                     /inference="alignment:Splign:2.1.0"
     exon            316..365
                     /gene="LPAR4"
                     /gene_synonym="GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9"
                     /inference="alignment:Splign:2.1.0"
     exon            366..428
                     /gene="LPAR4"
                     /gene_synonym="GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9"
                     /inference="alignment:Splign:2.1.0"
     exon            429..530
                     /gene="LPAR4"
                     /gene_synonym="GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9"
                     /inference="alignment:Splign:2.1.0"
     exon            531..4454
                     /gene="LPAR4"
                     /gene_synonym="GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9"
                     /inference="alignment:Splign:2.1.0"
     CDS             610..1722
                     /gene="LPAR4"
                     /gene_synonym="GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9"
                     /note="P2Y purinoceptor 9; purinergic receptor 9; LPA-4;
                     LPA receptor 4; P2Y5-like receptor; G-protein coupled
                     receptor 23"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 4"
                     /protein_id="NP_001264929.1"
                     /db_xref="CCDS:CCDS14441.1"
                     /db_xref="GeneID:2846"
                     /db_xref="HGNC:HGNC:4478"
                     /db_xref="MIM:300086"
                     /translation="MGDRRFIDFQFQDSNSSLRPRLGNATANNTCIVDDSFKYNLNGA
                     VYSVVFILGLITNSVSLFVFCFRMKMRSETAIFITNLAVSDLLFVCTLPFKIFYNFNR
                     HWPFGDTLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCA
                     GVWILVLSGGISASLFSTTNVNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLI
                     LNVSCSSVVLRTLRKPATLSQIGTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVR
                     SQAITNCFLERFAKIMYPITLCLATLNCCFDPFIYYFTLESFQKSFYINAHIRMESLF
                     KTETPLTTKPSLPAIQEEVSDQTTNNGGELMLESTF"
     regulatory      4435..4440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPAR4"
                     /gene_synonym="GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9"
                     /note="hexamer: AATAAA"
     polyA_site      4454
                     /gene="LPAR4"
                     /gene_synonym="GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9"
                     /note="major polyA site"
ORIGIN      
        1 ctttttgtgt cctgtttgct aaaggcatgc gggctacagc attcaagaga gggagtcgtt
       61 aacaaaggga aagagataaa tgtaaataag ctcacattta cagaatgagc ggtttgcagt
      121 aaaaagctgc ggcagcccag agtctgctac tttaggctgg gctaaccttt ccctgtaaaa
      181 aaaaaaaaaa aaaaaaaaaa aaaaaaatgg ataaaaatat gcacttccaa agggcgagtt
      241 gcccatttac atgtttatta gctaattatc tacaggcatc agcacattct ctcatctagc
      301 acactctttc ttggggaaga cagatttctg gaggagtgtg aaaatcaact ctccttaata
      361 ttaaggaccc tgcccaatgg taacagttgt tgccaagaaa agaaaaaaag aaaaaaaaaa
      421 gacccaatca cccattggag gaaatctcta actacagtgc ctccaggaaa ctcattggtt
      481 attccagtct tagataaaat tggtgccagg atttggttcg aactaatgtg gaggaaaata
      541 tttcctaccg gtccatagtg tcagagtggt gaacccctgc agccagcagg cctcctgaaa
      601 aaaaagtcca tgggtgacag aagattcatt gacttccaat tccaagattc aaattcaagc
      661 ctcagaccca ggttgggcaa tgctactgcc aataatactt gcattgttga tgattccttc
      721 aagtataatc tcaatggtgc tgtctacagt gttgtattca tcttgggtct gataaccaac
      781 agtgtctctc tgtttgtctt ctgtttccgc atgaaaatga gaagtgagac tgctattttt
      841 atcaccaatc tagctgtctc tgatttgctt tttgtctgta cactaccttt taaaatattt
      901 tacaacttca accgccactg gccttttggt gacaccctct gcaagatctc tggaactgca
      961 ttccttacca acatctatgg gagcatgctc tttctcacct gtattagtgt ggatcgtttc
     1021 ctggccattg tctatccttt tcgatctcgt actattagga ctaggaggaa ttctgccatt
     1081 gtgtgtgctg gtgtctggat cctagtcctc agtggcggta tttcagcctc tttgttttcc
     1141 accactaatg tcaacaatgc aaccaccacc tgctttgaag gcttctccaa acgtgtctgg
     1201 aagacttatt tatccaagat cacaatattt attgaagttg ttgggtttat cattcctcta
     1261 atattgaatg tctcttgctc ttctgtggtg ctgagaactc ttcgcaagcc tgctactctg
     1321 tctcaaattg ggaccaataa gaaaaaagta ctgaaaatga tcacagtaca tatggcagtc
     1381 tttgtggtat gctttgtacc ctacaactct gtcctcttct tgtatgccct ggtgcgctcc
     1441 caagctatta ctaattgctt tttggaaaga tttgcaaaga tcatgtaccc aatcaccttg
     1501 tgccttgcaa ctctgaactg ttgttttgac cctttcatct attacttcac ccttgaatcc
     1561 tttcagaagt ccttctacat caatgcccac atcagaatgg agtccctgtt taagactgaa
     1621 acacctttga ccacaaagcc ttcccttcca gctattcaag aggaagtgag tgatcaaaca
     1681 acaaataatg gtggtgaatt aatgctagaa tccacctttt aggtatgaga aatgtgttca
     1741 ggtccagata tggtttctcc tataattttt cctatgctat aaactaaaga tttgaagcta
     1801 atgatactga gaataatgca ccaaatccag tcagatacat ttgtttgaag gtatactgta
     1861 gagtttttat tgctgttttg ttcagtaatt ataggtcaaa tctaattaca acaaccaaga
     1921 tggattgcca aactcttctg cttggttgga atttcattgt atcgcattat ccaggtggct
     1981 agtggcattt gataatatag agatgacttt gaaactttca aaaaggtatt tctattccaa
     2041 tgatatttgg taattaggtt gggcctataa atatagaaca aattcaggga tttttaaaaa
     2101 attgtgttac tactgatata tgctagtttt attttatttt tttgaactgt cattgagttt
     2161 attttagcac aagaatattt ttagcctaac attattaata agaaatgtgt caaattttta
     2221 acattggtaa aatatgttat gtgcattttg aaaacagaaa acaaattgcg ttggcatgta
     2281 cgtgggtggg aagaaaaaga aaattaacag gatttacaca attataatca ccagcagtgt
     2341 gagtttaaaa aacttcgttg tttttacacc aaattaaaat tttcatgtca aacttcaaag
     2401 ccagaaagct gctaaatacg tgtctggcag gtaaaagctg gaaaattact taaaacagga
     2461 aagtgtcaat aaaaaaactt gagcaacacc aacatatttt ttcttaaaat gtcacgttat
     2521 cttcattttg ggaaactagg ttctataaaa tatttatcct ccctgttata ctttggagca
     2581 cagcacagcc agaaaggggc tgcatttgtg cccaggtcag gagcaaattg aaaaaaaaaa
     2641 taaagtaata caaaaaaatc aaactataaa gcaaaaacat ttattaaaac ctgaattaat
     2701 cctttttgga gggaggagta gagatatata acctgaaaat acttattctt tcttatcgaa
     2761 ttttggagcc taatatagcc aggagctgct gaatttgtgc ccctggattg gaagcaaata
     2821 aaaaaaaaaa acaacacata aactaaacca aaccaaaaca aaaaaaccag agaaccccaa
     2881 gaaaaataaa aataaaaaaa cctcaacaat aatttgtaac actttcatta ctatttgttg
     2941 aggttctgta aatgtaaaaa tactatgtca tttgcataac attttgaagc acaacgcagc
     3001 taccaagtgg ctaaattcgt ctcctggtta ggaacaagtt gtgggaaaaa aaggtcaaaa
     3061 atcaaactgc gataaaacaa acaaaacaag cacaaacaaa atttagaact tgcattttct
     3121 gagcatctgc gaaacttaca aaacactata acattcatat aatgctttgg atcaaattgc
     3181 aactaagaag ctgctaaaat ggcacccagt ttaaaaggaa ttaaaaacag tattttaaaa
     3241 tctacaaaaa aagagaaaat ttttttataa tttacttaaa ccgcaaaaat ctttaaaact
     3301 cttactagtt tttaaactaa agtggatatt taagaatatt agaacttgta aatataactt
     3361 ctgagcttga aagatgctac atttgtgctc aagtcaggag cagtggaaat aaaccctcgt
     3421 atacacacat acacagcagc agcaacaaca aaaaccaaaa ttaaatgtta aaccctgaaa
     3481 aacaacaaaa atattttaaa atgtgcatta atcaattttt aaaatatttg gataacatgg
     3541 caatttaaaa atgctaagaa ttttaaaaca aaacttccag gaaaaatgta tcctgcaagt
     3601 tgctgaactt gtgccagaaa gtggttaaac aattataaag cacagaacaa taacaaaaaa
     3661 gtaaaacttc taaaacaata agcaaatttt taaaactcat taacttgttt ttctttctga
     3721 tgatatgcag acttaaaaat actgagactt ttaagtaaaa atctgttagc ataatgtaac
     3781 tttaaaaact gtaaaatctg tgtctgggtt aggaacaaag tgaaaaaatg ctaaaacaat
     3841 agtaaaaaca aattcttaaa actggcatta ctttttccca atgaaagtcc taaaagtaat
     3901 tatgcattat gtagtcttat gaaaagaggc tatagatgga atatataagg cattagattc
     3961 agttaaataa aattaggtta agataagttc agttgttaga ttatatggta agatcaaatc
     4021 agtaataaaa gcgtgaataa tcttttgttt ctttcagtat tcatgttttt ccatttcttg
     4081 ttaagtataa aatatatgtg aacatttgtt tgtgcccttg cttcttaaca ttataaaatt
     4141 ttatgattat gacaccaaac catttaatgg gatattaact aagttgaaat aaaatatatt
     4201 attaaatgtt tcttgtgtaa tttccatgtt tagttttaat ttttttatat ttcacttctc
     4261 aaatttccat ttttatagtt aatataaatt gctaataata aaacttgtca cattaacaat
     4321 gtaaccaaga aaatgtaaag tataactaaa tataaaagtg actatgttac atcgaaagga
     4381 aaagcaattt tgcagctgta attgcaactt ggattttaaa tgtttattaa atgtaataaa
     4441 atatatttga atta
//
