LOCUS       NM_012152               3515 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens lysophosphatidic acid receptor 3 (LPAR3), mRNA.
ACCESSION   NM_012152
VERSION     NM_012152.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3515)
  AUTHORS   Solis,K.H., Romero-Avila,M.T., Rincon-Heredia,R. and
            Garcia-Sainz,J.A.
  TITLE     Lysophosphatidic Acid Receptor 3 (LPA3): Signaling and
            Phosphorylation Sites
  JOURNAL   Int J Mol Sci 25 (12), 6491 (2024)
   PUBMED   38928196
  REMARK    GeneRIF: Lysophosphatidic Acid Receptor 3 (LPA3): Signaling and
            Phosphorylation Sites.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3515)
  AUTHORS   Solis,K.H., Romero-Avila,M.T., Rincon-Heredia,R. and
            Garcia-Sainz,J.A.
  TITLE     LPA3 Receptor Phosphorylation Sites: Roles in Signaling and
            Internalization
  JOURNAL   Int J Mol Sci 25 (10), 5508 (2024)
   PUBMED   38791546
  REMARK    GeneRIF: LPA3 Receptor Phosphorylation Sites: Roles in Signaling
            and Internalization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3515)
  AUTHORS   Doutt,S.W., Longo,J.F. and Carroll,S.L.
  TITLE     LPAR1 and aberrantly expressed LPAR3 differentially promote the
            migration and proliferation of malignant peripheral nerve sheath
            tumor cells
  JOURNAL   Glia 71 (3), 742-757 (2023)
   PUBMED   36416236
  REMARK    GeneRIF: LPAR1 and aberrantly expressed LPAR3 differentially
            promote the migration and proliferation of malignant peripheral
            nerve sheath tumor cells.
REFERENCE   4  (bases 1 to 3515)
  AUTHORS   Lin,K.H., Chiang,J.C., Chen,W.M., Ho,Y.H., Yao,C.L. and Lee,H.
  TITLE     Transcriptional regulation of lysophosphatidic acid receptors 2 and
            3 regulates myeloid commitment of hematopoietic stem cells
  JOURNAL   Am J Physiol Cell Physiol 320 (4), C509-C519 (2021)
   PUBMED   33406026
  REMARK    GeneRIF: Transcriptional regulation of lysophosphatidic acid
            receptors 2 and 3 regulates myeloid commitment of hematopoietic
            stem cells.
REFERENCE   5  (bases 1 to 3515)
  AUTHORS   Minami,K., Ueda,N., Ishimoto,K., Kurisu,R., Takamoto,M., Ikeda,H.
            and Tsujiuchi,T.
  TITLE     Roles of endothelial cells in the regulation of cell motility via
            lysophosphatidic acid receptor-2 (LPA2) and LPA3 in osteosarcoma
            cells
  JOURNAL   Exp Mol Pathol 118, 104596 (2021)
   PUBMED   33347862
  REMARK    GeneRIF: Roles of endothelial cells in the regulation of cell
            motility via lysophosphatidic acid receptor-2 (LPA2) and LPA3 in
            osteosarcoma cells.
REFERENCE   6  (bases 1 to 3515)
  AUTHORS   Contos,J.J., Ishii,I. and Chun,J.
  TITLE     Lysophosphatidic acid receptors
  JOURNAL   Mol Pharmacol 58 (6), 1188-1196 (2000)
   PUBMED   11093753
  REMARK    Review article
REFERENCE   7  (bases 1 to 3515)
  AUTHORS   Fitzgerald,L.R., Dytko,G.M., Sarau,H.M., Mannan,I.J., Ellis,C.,
            Lane,P.A., Tan,K.B., Murdock,P.R., Wilson,S., Bergsma,D.J.,
            Ames,R.S., Foley,J.J., Campbell,D.A., McMillan,L., Evans,N.,
            Elshourbagy,N.A., Minehart,H. and Tsui,P.
  TITLE     Identification of an EDG7 variant, HOFNH30, a G-protein-coupled
            receptor for lysophosphatidic acid
  JOURNAL   Biochem Biophys Res Commun 273 (3), 805-810 (2000)
   PUBMED   10891327
REFERENCE   8  (bases 1 to 3515)
  AUTHORS   Im,D.S., Heise,C.E., Harding,M.A., George,S.R., O'Dowd,B.F.,
            Theodorescu,D. and Lynch,K.R.
  TITLE     Molecular cloning and characterization of a lysophosphatidic acid
            receptor, Edg-7, expressed in prostate
  JOURNAL   Mol Pharmacol 57 (4), 753-759 (2000)
   PUBMED   10727522
REFERENCE   9  (bases 1 to 3515)
  AUTHORS   Bandoh,K., Aoki,J., Hosono,H., Kobayashi,S., Kobayashi,T.,
            Murakami-Murofushi,K., Tsujimoto,M., Arai,H. and Inoue,K.
  TITLE     Molecular cloning and characterization of a novel human
            G-protein-coupled receptor, EDG7, for lysophosphatidic acid
  JOURNAL   J Biol Chem 274 (39), 27776-27785 (1999)
   PUBMED   10488122
REFERENCE   10 (bases 1 to 3515)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK308283.1, BC126268.1,
            BU633960.1 and AC104169.2.
            
            On Nov 23, 2018 this sequence version replaced NM_012152.2.
            
            Summary: This gene encodes a member of the G protein-coupled
            receptor family, as well as the EDG family of proteins. This
            protein functions as a cellular receptor for lysophosphatidic acid
            and mediates lysophosphatidic acid-evoked calcium mobilization.
            This receptor couples predominantly to G(q/11) alpha proteins.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12921934.2232727.1, AK308283.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370611.4/ ENSP00000359643.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AK308283.1         8-210
            204-409             AK308283.1         214-419
            410-1298            BC126268.1         223-1111
            1299-1401           AK308283.1         1309-1411
            1402-1714           BU633960.1         18-330              c
            1715-3515           AC104169.2         85046-86846         c
FEATURES             Location/Qualifiers
     source          1..3515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..3515
                     /gene="LPAR3"
                     /gene_synonym="Edg-7; EDG7; GPCR; HOFNH30; LP-A3; LPA3;
                     RP4-678I3"
                     /note="lysophosphatidic acid receptor 3"
                     /db_xref="GeneID:23566"
                     /db_xref="HGNC:HGNC:14298"
                     /db_xref="MIM:605106"
     exon            1..191
                     /gene="LPAR3"
                     /gene_synonym="Edg-7; EDG7; GPCR; HOFNH30; LP-A3; LPA3;
                     RP4-678I3"
                     /inference="alignment:Splign:2.1.0"
     exon            192..945
                     /gene="LPAR3"
                     /gene_synonym="Edg-7; EDG7; GPCR; HOFNH30; LP-A3; LPA3;
                     RP4-678I3"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1271
                     /gene="LPAR3"
                     /gene_synonym="Edg-7; EDG7; GPCR; HOFNH30; LP-A3; LPA3;
                     RP4-678I3"
                     /note="LPA receptor EDG7; endothelial differentiation,
                     lysophosphatidic acid G-protein-coupled receptor, 7;
                     endothelial cell differentiation gene 7;
                     calcium-mobilizing lysophosphatidic acid receptor LP-A3;
                     LPA-3; LPA receptor 3; lysophosphatidic acid receptor
                     Edg-7"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 3"
                     /protein_id="NP_036284.1"
                     /db_xref="CCDS:CCDS700.1"
                     /db_xref="GeneID:23566"
                     /db_xref="HGNC:HGNC:14298"
                     /db_xref="MIM:605106"
                     /translation="MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFI
                     FFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRW
                     FLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMG
                     AVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTN
                     VLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKR
                     WFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTG
                     SQYIEDSISQGAVCNKSTS"
     exon            946..3515
                     /gene="LPAR3"
                     /gene_synonym="Edg-7; EDG7; GPCR; HOFNH30; LP-A3; LPA3;
                     RP4-678I3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3494..3499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPAR3"
                     /gene_synonym="Edg-7; EDG7; GPCR; HOFNH30; LP-A3; LPA3;
                     RP4-678I3"
                     /note="hexamer: AATAAA"
     polyA_site      3515
                     /gene="LPAR3"
                     /gene_synonym="Edg-7; EDG7; GPCR; HOFNH30; LP-A3; LPA3;
                     RP4-678I3"
                     /note="major polyA site"
ORIGIN      
        1 cctttggctc tggacgcgtc gcaggggtcg ctggagagga ggcgctccgc ccgcccgccg
       61 cgtcctccgc tgcttctccg cgcccggctg gagcccggcg cccggtcgcc ccgtcgcgct
      121 cgaccccgag ggcatgcggc agccgcaggg gcccccgctc ccgggctcgg cggcgcgggt
      181 gaacgtgagc ggatgttcac ttctccacaa tgaatgagtg tcactatgac aagcacatgg
      241 acttttttta taataggagc aacactgata ctgtcgatga ctggacagga acaaagcttg
      301 tgattgtttt gtgtgttggg acgtttttct gcctgtttat ttttttttct aattctctgg
      361 tcatcgcggc agtgatcaaa aacagaaaat ttcatttccc cttctactac ctgttggcta
      421 atttagctgc tgccgatttc ttcgctggaa ttgcctatgt attcctgatg tttaacacag
      481 gcccagtttc aaaaactttg actgtcaacc gctggtttct ccgtcagggg cttctggaca
      541 gtagcttgac tgcttccctc accaacttgc tggttatcgc cgtggagagg cacatgtcaa
      601 tcatgaggat gcgggtccat agcaacctga ccaaaaagag ggtgacactg ctcattttgc
      661 ttgtctgggc catcgccatt tttatggggg cggtccccac actgggctgg aattgcctct
      721 gcaacatctc tgcctgctct tccctggccc ccatttacag caggagttac cttgttttct
      781 ggacagtgtc caacctcatg gccttcctca tcatggttgt ggtgtacctg cggatctacg
      841 tgtacgtcaa gaggaaaacc aacgtcttgt ctccgcatac aagtgggtcc atcagccgcc
      901 ggaggacacc catgaagcta atgaagacgg tgatgactgt cttaggggcg tttgtggtat
      961 gctggacccc gggcctggtg gttctgctcc tcgacggcct gaactgcagg cagtgtggcg
     1021 tgcagcatgt gaaaaggtgg ttcctgctgc tggcgctgct caactccgtc gtgaacccca
     1081 tcatctactc ctacaaggac gaggacatgt atggcaccat gaagaagatg atctgctgct
     1141 tctctcagga gaacccagag aggcgtccct ctcgcatccc ctccacagtc ctcagcagga
     1201 gtgacacagg cagccagtac atagaggata gtattagcca aggtgcagtc tgcaataaaa
     1261 gcacttccta aactctggat gcctctcggc ccacccaggc ctcctctggg aaaagagctg
     1321 ttaagaatga ttacctgtct ctaacaaagc ccatgtacag tgttatttga ggtctccatt
     1381 aatcactgct agatttcttt aaaaaatttt ttttcatagt ttaaaagcat gggcagtaaa
     1441 gagaggacct gctgcattta gagaaagcac agaaacggga gaggttcggc gggtccctgc
     1501 ttgtcctatg aactgctcag agctcctgtc agtccagctg ggccttctgg gttctggcac
     1561 catttcgtag ccattctctt tgtattttaa aaggacgtta tgaaagggct tagaccaaaa
     1621 taaatcataa tgttacttga gccaccttat atagctgctt ggagagtcta tgtagttctt
     1681 tctgcatgca ttaaaaatgt ttagaaatgc ttcagcaatg gtgttttttt cctcaaagaa
     1741 accatggcca gtagctaggt gttcagtagg aatcaaagaa aaatcagtaa gagctccaga
     1801 ttaaacctga tttttaactg aaggaacatt ctgaggaaaa atacttaaaa gtaaaaaagg
     1861 tcaatgtgaa aacccttttt gacctgaaaa aggccttagt atggtcctcc atgcatgtgt
     1921 gtgtatatgc atgtgtgtgt gtgtgtgtgt gtgtgtctat atatatatat atatatatat
     1981 atatatatat tcctgttttt actgattttt attgattttg ttcaaagata tctggggatt
     2041 ggattgggga atgcttaatc tgactattga aagaaacatg gatccctgga gtatttcaga
     2101 tacggggtta ccgccccaga ctgcctcccg ccagtccaca ttagttctca ttttccctca
     2161 tgatggtgaa aaacagtgga gagctagtaa agggtttatg cagaaaacaa ggagaagaga
     2221 atgtgaagtt tgaagtgcct atggaacatc cagctgataa tcttgcctag taagagcaaa
     2281 agaagccaag agaacaccaa cgtttaagga gcaggtagag aaaacccagc aaaaggacag
     2341 aggaataaga ggaccaaaga acaatgttaa gaatcaagga gagaggtcag gcacgctggc
     2401 tcatgcctgt aatcccagca ctttgggagg ctgaggcagg tggatcactt gaggccagga
     2461 gtatgagacc agcctgggca atgtggtgaa attgcatctt tactaaaaat acaaaaacta
     2521 gccaggcatg gtggcacatg cctgtaatac caggtacttg ggaagctgag gcataagaat
     2581 cacttgaacc cgggaggtgg aggttgcaga gtgagccaag atcgcagcac tgcactctag
     2641 tctgggtgac agagcaagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa aaagactaga
     2701 gaatgtcagg gaacacatgt gtatatttaa acaacttcac tttgcattta aaaactcgaa
     2761 ggacagcgaa ggtgaaatca attcacgggc cacctagact ttccagtcta ggactagagc
     2821 tgtagcaatg atctgttgtg ctgtacaaga aaagagaaag aggtgttcat ttgagaacag
     2881 atgtttttat acatcagagt aaaagctgta ttgaagagca ggctgaatcc cttccatata
     2941 gaatgaaata tgagcttgac cccagtcctt atcttcagtt acctccatac caactggtgg
     3001 catgttggat ttagcatgta gaataatttc ccatctctta tttttcccaa ggttaatggc
     3061 atccttctgg tacctggctt acatgtgaac tgaattttga tctgggttct attttgaatt
     3121 tttctccttc agagacctaa gtaggcaaca tgaaagacaa gtagttaaga aagaaaaaat
     3181 gatgtttcat acacacaggc taccaacgag agttttctat gtaaaacatt tagagtgtat
     3241 tctgatttaa aatgagaata acttcaaggt agatattata gtatttatgt agtttgcaaa
     3301 agaagtttac atttttttgc tattgtgata taacatttat gtgcaagaac tacttgtaat
     3361 aaaaggattt gagatgtcat gcttctaaat ataatagcct aaaatagaga atattatgat
     3421 ttgaaagtgt agatttcaca aactctgtat agtatgtggg tctatctgaa gcttttatcg
     3481 aagctaccta taaaataaaa ttttaaaaga tctgt
//
