LOCUS       NM_001395660            1786 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens lysophosphatidic acid receptor 2 (LPAR2), mRNA.
ACCESSION   NM_001395660
VERSION     NM_001395660.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Song,M., Yan,Q. and Liu,R.
  TITLE     Circ_0007611 modulates the miR-34c-5p/LPAR2 cascade to suppress
            proliferation and enhance apoptosis of HTR-8/SVneo cells
  JOURNAL   Placenta 154, 145-152 (2024)
   PUBMED   38986295
  REMARK    GeneRIF: Circ_0007611 modulates the miR-34c-5p/LPAR2 cascade to
            suppress proliferation and enhance apoptosis of HTR-8/SVneo cells.
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Wang,Y., Qi,Z., Li,Z., Bai,S. and Damirin,A.
  TITLE     LPAR2-mediated action promotes human renal cell carcinoma via
            MAPK/NF-kappaB signaling to regulate cytokine network
  JOURNAL   J Cancer Res Clin Oncol 149 (5), 2041-2055 (2023)
   PUBMED   35857125
  REMARK    GeneRIF: LPAR2-mediated action promotes human renal cell carcinoma
            via MAPK/NF-kappaB signaling to regulate cytokine network.
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Wu,Y., Wang,H., Li,Y., Li,Y., Liang,Y., Zhong,G. and Zhang,Q.
  TITLE     Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion
            in Adenomyosis by Regulating with LPAR2
  JOURNAL   Reprod Sci 29 (10), 3026-3038 (2022)
   PUBMED   35799024
  REMARK    GeneRIF: Estrogen-increased SGK1 Promotes Endometrial Stromal Cell
            Invasion in Adenomyosis by Regulating with LPAR2.
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Sun,K., Chen,R.X., Li,J.Z. and Luo,Z.X.
  TITLE     LPAR2 correlated with different prognosis and immune cell
            infiltration in head and neck squamous cell carcinoma and kidney
            renal clear cell carcinoma
  JOURNAL   Hereditas 159 (1), 16 (2022)
   PUBMED   35241179
  REMARK    GeneRIF: LPAR2 correlated with different prognosis and immune cell
            infiltration in head and neck squamous cell carcinoma and kidney
            renal clear cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Contos,J.J. and Chun,J.
  TITLE     Genomic characterization of the lysophosphatidic acid receptor
            gene, lp(A2)/Edg4, and identification of a frameshift mutation in a
            previously characterized cDNA
  JOURNAL   Genomics 64 (2), 155-169 (2000)
   PUBMED   10729222
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   Goetzl,E.J., Dolezalova,H., Kong,Y., Hu,Y.L., Jaffe,R.B.,
            Kalli,K.R. and Conover,C.A.
  TITLE     Distinctive expression and functions of the type 4 endothelial
            differentiation gene-encoded G protein-coupled receptor for
            lysophosphatidic acid in ovarian cancer
  JOURNAL   Cancer Res 59 (20), 5370-5375 (1999)
   PUBMED   10537322
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   An,S., Bleu,T., Zheng,Y. and Goetzl,E.J.
  TITLE     Recombinant human G protein-coupled lysophosphatidic acid receptors
            mediate intracellular calcium mobilization
  JOURNAL   Mol Pharmacol 54 (5), 881-888 (1998)
   PUBMED   9804623
REFERENCE   9  (bases 1 to 1786)
  AUTHORS   An,S., Bleu,T., Hallmark,O.G. and Goetzl,E.J.
  TITLE     Characterization of a novel subtype of human G protein-coupled
            receptor for lysophosphatidic acid
  JOURNAL   J Biol Chem 273 (14), 7906-7910 (1998)
   PUBMED   9525886
REFERENCE   10 (bases 1 to 1786)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011458.7.
            
            Summary: This gene encodes a member of family I of the G
            protein-coupled receptors, as well as the EDG family of proteins.
            This protein functions as a lysophosphatidic acid (LPA) receptor
            and contributes to Ca2+ mobilization, a critical cellular response
            to LPA in cells, through association with Gi and Gq proteins. An
            alternative splice variant has been described but its full length
            sequence has not been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF197929.1, AF011466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153946 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000407877.8/
                                                ENSP00000384665.3
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC011458.7         7447-7575           c
            130-871             AC011458.7         5898-6639           c
            872-1786            AC011458.7         3010-3924           c
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1786
                     /gene="LPAR2"
                     /gene_synonym="EDG-4; EDG4; LPA-2; LPA2"
                     /note="lysophosphatidic acid receptor 2"
                     /db_xref="GeneID:9170"
                     /db_xref="HGNC:HGNC:3168"
                     /db_xref="MIM:605110"
     exon            1..129
                     /gene="LPAR2"
                     /gene_synonym="EDG-4; EDG4; LPA-2; LPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            130..871
                     /gene="LPAR2"
                     /gene_synonym="EDG-4; EDG4; LPA-2; LPA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1185
                     /gene="LPAR2"
                     /gene_synonym="EDG-4; EDG4; LPA-2; LPA2"
                     /note="G protein-coupled receptor; LPA receptor EDG4;
                     endothelial differentiation, lysophosphatidic acid
                     G-protein-coupled receptor, 4; lysophosphatidic acid
                     receptor EDG4; LPA receptor 2; lysophosphatidic acid
                     receptor Edg-4"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 2"
                     /protein_id="NP_001382589.1"
                     /db_xref="CCDS:CCDS12407.2"
                     /db_xref="GeneID:9170"
                     /db_xref="HGNC:HGNC:3168"
                     /db_xref="MIM:605110"
                     /translation="MGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVL
                     LTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWF
                     LRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGL
                     LPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQR
                     MAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKY
                     FLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRI
                     MLPENGHPLMDSTL"
     exon            872..1786
                     /gene="LPAR2"
                     /gene_synonym="EDG-4; EDG4; LPA-2; LPA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1752..1757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPAR2"
                     /gene_synonym="EDG-4; EDG4; LPA-2; LPA2"
                     /note="hexamer: AGTAAA"
     polyA_site      1786
                     /gene="LPAR2"
                     /gene_synonym="EDG-4; EDG4; LPA-2; LPA2"
                     /note="major polyA site"
ORIGIN      
        1 ctctcagcaa cccgcacagg gcgcacccgg acgctctacc gctcccgccg cagtcgccgg
       61 gccatgggcc tcgagcccgc cccgaacccc cgcgagcccg ccttgtctgc ggcgtgactg
      121 gaggcccaga tggtcatcat gggccagtgc tactacaacg agaccatcgg cttcttctat
      181 aacaacagtg gcaaagagct cagctcccac tggcggccca aggatgtggt cgtggtggca
      241 ctggggctga ccgtcagcgt gctggtgctg ctgaccaatc tgctggtcat agcagccatc
      301 gcctccaacc gccgcttcca ccagcccatc tactacctgc tcggcaatct ggccgcggct
      361 gacctcttcg cgggcgtggc ctacctcttc ctcatgttcc acactggtcc ccgcacagcc
      421 cgactttcac ttgagggctg gttcctgcgg cagggcttgc tggacacaag cctcactgcg
      481 tcggtggcca cactgctggc catcgccgtg gagcggcacc gcagtgtgat ggccgtgcag
      541 ctgcacagcc gcctgccccg tggccgcgtg gtcatgctca ttgtgggcgt gtgggtggct
      601 gccctgggcc tggggctgct gcctgcccac tcctggcact gcctctgtgc cctggaccgc
      661 tgctcacgca tggcacccct gctcagccgc tcctatttgg ccgtctgggc tctgtcgagc
      721 ctgcttgtct tcctgctcat ggtggctgtg tacacccgca ttttcttcta cgtgcggcgg
      781 cgagtgcagc gcatggcaga gcatgtcagc tgccaccccc gctaccgaga gaccacgctc
      841 agcctggtca agactgttgt catcatcctg ggggcgttcg tggtctgctg gacaccaggc
      901 caggtggtac tgctcctgga tggtttaggc tgtgagtcct gcaatgtcct ggctgtagaa
      961 aagtacttcc tactgttggc cgaggccaac tccctggtca atgctgctgt gtactcttgc
     1021 cgagatgctg agatgcgccg caccttccgc cgccttctct gctgcgcgtg cctccgccag
     1081 tccacccgcg agtctgtcca ctatacatcc tctgcccagg gaggtgccag cactcgcatc
     1141 atgcttcccg agaacggcca cccactgatg gactccaccc tttagctacc ttgaacttca
     1201 gcggtacgcg gcaagcaaca aatccacagc ccctgatgac ttgtgggtgc tcctggctca
     1261 acccaaccaa caggactgac tgactggcag gacaaggtct ggcatggcac agcaccactg
     1321 ccaggcctcc ccaggcacac cactctgccc agggaatggg ggctttgggt catctcccac
     1381 tgcctggggg agtcagatgg ggtgcaggaa tctggctctt cagccatctc aggtttaggg
     1441 ggtttgtaac agacattatt ctgttttcac tgcgtatcct tggtaagccc tgtggactgg
     1501 ttcctgctgt gtgatgctga gggttttaag gtggggagag ataagggctc tctcgggcca
     1561 tgctacccgg tatgactggg taatgaggac agactgtgga caccccatct acctgagtct
     1621 gattctttag cagcagagac tgaggggtgc agagtgtgag ctgggaaagg tttgtggctc
     1681 cttgcagcct ccagggactg gcctgtcccc gatagaattg aagcagtcca cggggagggg
     1741 atgatacaag gagtaaacct ttctttacac tctgaggtct ccaaaa
//
