LOCUS       NM_001387491            3872 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens lysophosphatidic acid receptor 1 (LPAR1), transcript
            variant 48, mRNA.
ACCESSION   NM_001387491
VERSION     NM_001387491.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3872)
  AUTHORS   Volkmann,E.R., Denton,C.P., Kolb,M., Wijsenbeek-Lourens,M.S.,
            Emson,C., Hudson,K., Amatucci,A.J., Distler,O., Allanore,Y. and
            Khanna,D.
  TITLE     Lysophosphatidic acid receptor 1 inhibition: a potential treatment
            target for pulmonary fibrosis
  JOURNAL   Eur Respir Rev 33 (172), 240015 (2024)
   PUBMED   39009409
  REMARK    GeneRIF: Lysophosphatidic acid receptor 1 inhibition: a potential
            treatment target for pulmonary fibrosis.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3872)
  AUTHORS   Nikolaou,S., Juin,A., Whitelaw,J.A., Paul,N.R., Fort,L., Nixon,C.,
            Spence,H.J., Bryson,S. and Machesky,L.M.
  TITLE     CYRI-B-mediated macropinocytosis drives metastasis via
            lysophosphatidic acid receptor uptake
  JOURNAL   Elife 13, e83712 (2024)
   PUBMED   38712822
  REMARK    GeneRIF: CYRI-B-mediated macropinocytosis drives metastasis via
            lysophosphatidic acid receptor uptake.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3872)
  AUTHORS   Hong,J.M., Lee,J.W., Seen,D.S., Jeong,J.Y. and Huh,W.K.
  TITLE     LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced
            signaling and cell migration
  JOURNAL   Cell Commun Signal 21 (1), 257 (2023)
   PUBMED   37749552
  REMARK    GeneRIF: LPA1-mediated inhibition of CXCR4 attenuates
            CXCL12-induced signaling and cell migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3872)
  AUTHORS   Doutt,S.W., Longo,J.F. and Carroll,S.L.
  TITLE     LPAR1 and aberrantly expressed LPAR3 differentially promote the
            migration and proliferation of malignant peripheral nerve sheath
            tumor cells
  JOURNAL   Glia 71 (3), 742-757 (2023)
   PUBMED   36416236
  REMARK    GeneRIF: LPAR1 and aberrantly expressed LPAR3 differentially
            promote the migration and proliferation of malignant peripheral
            nerve sheath tumor cells.
REFERENCE   5  (bases 1 to 3872)
  AUTHORS   Ahmadzai,M.M., McClain,J.L., Dharshika,C., Seguella,L.,
            Giancola,F., De Giorgio,R. and Gulbransen,B.D.
  TITLE     LPAR1 regulates enteric nervous system function through glial
            signaling and contributes to chronic intestinal pseudo-obstruction
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   35166239
  REMARK    GeneRIF: LPAR1 regulates enteric nervous system function through
            glial signaling and contributes to chronic intestinal
            pseudo-obstruction.
REFERENCE   6  (bases 1 to 3872)
  AUTHORS   An,S., Bleu,T., Zheng,Y. and Goetzl,E.J.
  TITLE     Recombinant human G protein-coupled lysophosphatidic acid receptors
            mediate intracellular calcium mobilization
  JOURNAL   Mol Pharmacol 54 (5), 881-888 (1998)
   PUBMED   9804623
REFERENCE   7  (bases 1 to 3872)
  AUTHORS   Fukushima,N., Kimura,Y. and Chun,J.
  TITLE     A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins
            and mediates multiple cellular responses to lysophosphatidic acid
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6151-6156 (1998)
   PUBMED   9600933
REFERENCE   8  (bases 1 to 3872)
  AUTHORS   Moolenaar,W.H., Kranenburg,O., Postma,F.R. and Zondag,G.C.
  TITLE     Lysophosphatidic acid: G-protein signalling and cellular responses
  JOURNAL   Curr Opin Cell Biol 9 (2), 168-173 (1997)
   PUBMED   9069262
REFERENCE   9  (bases 1 to 3872)
  AUTHORS   An,S., Dickens,M.A., Bleu,T., Hallmark,O.G. and Goetzl,E.J.
  TITLE     Molecular cloning of the human Edg2 protein and its identification
            as a functional cellular receptor for lysophosphatidic acid
  JOURNAL   Biochem Biophys Res Commun 231 (3), 619-622 (1997)
   PUBMED   9070858
REFERENCE   10 (bases 1 to 3872)
  AUTHORS   Hecht,J.H., Weiner,J.A., Post,S.R. and Chun,J.
  TITLE     Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid
            receptor expressed in neurogenic regions of the developing cerebral
            cortex
  JOURNAL   J Cell Biol 135 (4), 1071-1083 (1996)
   PUBMED   8922387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007157.6, AL442064.10 and
            AL157881.14.
            
            Summary: The integral membrane protein encoded by this gene is a
            lysophosphatidic acid (LPA) receptor from a group known as EDG
            receptors. These receptors are members of the G protein-coupled
            receptor superfamily. Utilized by LPA for cell signaling, EDG
            receptors mediate diverse biologic functions, including
            proliferation, platelet aggregation, smooth muscle contraction,
            inhibition of neuroblastoma cell differentiation, chemotaxis, and
            tumor cell invasion. Many transcript variants encoding a few
            different isoforms have been identified for this gene. [provided by
            RefSeq, Oct 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660809.216457.1, SRR1803613.229896.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC007157.6         86051-86354         c
            305-384             AC007157.6         84006-84085         c
            385-438             AL442064.10        158485-158538       c
            439-516             AL442064.10        122818-122895       c
            517-664             AL442064.10        121410-121557       c
            665-1412            AL442064.10        90758-91505         c
            1413-3872           AL157881.14        105983-108442       c
FEATURES             Location/Qualifiers
     source          1..3872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..3872
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="lysophosphatidic acid receptor 1"
                     /db_xref="GeneID:1902"
                     /db_xref="HGNC:HGNC:3166"
                     /db_xref="MIM:602282"
     exon            1..304
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..384
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..438
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..516
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..664
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             620..1714
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="isoform a is encoded by transcript variant 48;
                     endothelial differentiation, lysophosphatidic acid
                     G-protein-coupled receptor, 2; ventricular zone gene 1;
                     LPA-1; LPA receptor 1; lysophosphatidic acid receptor
                     Edg-2"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 1 isoform a"
                     /protein_id="NP_001374420.1"
                     /db_xref="CCDS:CCDS6777.1"
                     /db_xref="GeneID:1902"
                     /db_xref="HGNC:HGNC:3166"
                     /db_xref="MIM:602282"
                     /translation="MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATE
                     WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY
                     FYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMS
                     NRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTF
                     VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLV
                     LLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENP
                     TGPTEGSDRSASSLNHTILAGVHSNDHSVV"
     exon            665..1412
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..3872
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3341..3346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="hexamer: AATAAA"
     polyA_site      3361
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="major polyA site"
     regulatory      3854..3859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="hexamer: AATAAA"
     polyA_site      3872
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="major polyA site"
ORIGIN      
        1 agtaggggcc gactggcggc tgacgctccc tgagtggcga ctccgtctcc agccccgctg
       61 cggagcgcgg gccggatctg gggcggccag ggcccggagc cgcggagccc tccccgccgc
      121 ccggccgagc acgggacccc ggcggggtgg gcgcaggggg cggccccgct ctgggcgact
      181 gccgaggggc gggcggaggg ccgggctcgg ctggcggtgg ggcgggggcc gccgggactg
      241 ggcgcgcggc ctgaagccag cccgggggcg gcaggagagg gacgcgcggc ggcagcgagc
      301 gcagggaaca gctcctgccc aggtctgtgg gcactcagca tggatttcag tctccctgtg
      361 agtgatggga aagaactaac agaggaaccc tgtttctatt tttattttag gaaccctgtt
      421 tacatcttct taaaagttgt ggacgtctga tttatgaagc tccccatcca cctatctgag
      481 tacctgactt ctcaggactg acacctacag catcaggtac acagcttctc ctagcatgac
      541 ttcgatctga tcagcaaaca agaaaatttg tctcccgtag ttctggggcg tgttcaccac
      601 ctacaaccac agagctgtca tggctgccat ctctacttcc atccctgtaa tttcacagcc
      661 ccagttcaca gccatgaatg aaccacagtg cttctacaac gagtccattg ccttctttta
      721 taaccgaagt ggaaagcatc ttgccacaga atggaacaca gtcagcaagc tggtgatggg
      781 acttggaatc actgtttgta tcttcatcat gttggccaac ctattggtca tggtggcaat
      841 ctatgtcaac cgccgcttcc attttcctat ttattaccta atggctaatc tggctgctgc
      901 agacttcttt gctgggttgg cctacttcta tctcatgttc aacacaggac ccaatactcg
      961 gagactgact gttagcacat ggctccttcg tcagggcctc attgacacca gcctgacggc
     1021 atctgtggcc aacttactgg ctattgcaat cgagaggcac attacggttt tccgcatgca
     1081 gctccacaca cggatgagca accggcgggt agtggtggtc attgtggtca tctggactat
     1141 ggccatcgtt atgggtgcta tacccagtgt gggctggaac tgtatctgtg atattgaaaa
     1201 ttgttccaac atggcacccc tctacagtga ctcttactta gtcttctggg ccattttcaa
     1261 cttggtgacc tttgtggtaa tggtggttct ctatgctcac atctttggct atgttcgcca
     1321 gaggactatg agaatgtctc ggcatagttc tggaccccgg cggaatcggg ataccatgat
     1381 gagtcttctg aagactgtgg tcattgtgct tggggccttt atcatctgct ggactcctgg
     1441 attggttttg ttacttctag acgtgtgctg tccacagtgc gacgtgctgg cctatgagaa
     1501 attcttcctt ctccttgctg aattcaactc tgccatgaac cccatcattt actcctaccg
     1561 cgacaaagaa atgagcgcca cctttaggca gatcctctgc tgccagcgca gtgagaaccc
     1621 caccggcccc acagaaggct cagaccgctc ggcttcctcc ctcaaccaca ccatcttggc
     1681 tggagttcac agcaatgacc actctgtggt ttagaacgga aactgagatg aggaaccagc
     1741 cgtcctctct tggaggataa acagcctccc cctacccaat tgccagggca aggtggggtg
     1801 tgagagagga gaaaagtcaa ctcatgtact taaacactaa ccaatgacag tatttgttcc
     1861 tggaccccac aagacttgat atatattgaa aattagctta tgtgacaacc ctcatcttga
     1921 tccccatccc ttctgaaagt aggaagttgg agctcttgca atggaattca agaacagact
     1981 ctggagtgtc catttagact acactaacta gacttttaaa agattttgtg tggtttggtg
     2041 caagtcagaa taaattctgg ctagttgaat ccacaacttc atttatatac aggcttccct
     2101 tttttatttt taaaggatac gtttcactta ataaacacgt ttatgcctat cagcatgttt
     2161 gtgatggatg agactatgga ctgcttttaa actaccataa ttccattttt tcccttacat
     2221 aggaaaactg taagttggaa ttatcttttg tttagaaagc atgcatgtaa tgtatgtatg
     2281 cagtatgcct tacttaaaaa gattaaaagg atactaatgt taaatcttct aggaaataga
     2341 acctagactt caaagccagt atttgtttag gtcatgaagc aaacaatgct ctaatcacaa
     2401 tattaactgt ttaattaaaa tgttgtaaca agtataaaac agggaatgta agtttattac
     2461 caaagtgata tgtattccaa aaaagtcata gaagatgaag cactataata ttgttcccat
     2521 atatttaaaa tacccaagta cattctaatt accagtatat cagaggaaaa ttttcgtagt
     2581 ctttgtaaaa taatatactc atcatagaaa acttgaaaaa tgcagaaatg tataaaaaag
     2641 caaaaatgat tactgataat atcacaaccc agaagtaacc acctttaaaa agcaaccccc
     2701 atgtatgcct atatgtgtat tgtatacttt ttttacataa ttggagtcat actgtaaaca
     2761 gttttataag tagatctttt tcattgcaaa attgccacat tttcttatgg cattaaaaat
     2821 tttacaaaaa cataatttta atggctatat tatattccat ttaatggatg caactcagtt
     2881 tatttaacca ttcccatgtt gttaactatt taggttgttt ctaattttca ttattataaa
     2941 gttgcagaaa tttggtgtac ataaaactgt ctccatataa ttgattatta ggatatattc
     3001 ccatgaagga ttcttttttt aaaaaaatgt gaaatgtcat cttgtactta cacctttcat
     3061 gaaaagggat ttcctgcttt tgtactgcat gggtggcagt tgtgaggaaa agccagtcaa
     3121 atgacctttt tacaaaagaa atgcagtggt cacttcagtt gagagtgact ttttaataca
     3181 acaagatcaa ctagaagaat tcaactgtct caagaatcaa ggtaccccaa tatatctcgc
     3241 aattccaaac tttgtttgag ggactcgtta tccagctctt ggtagccaca cctgcaatgt
     3301 aaaatggaag aaaatgcaaa gaaaccaaat gtgccgagtg aataaaggat tgtcatatca
     3361 attagtgtgg gtccatctgt agcaaatggg ttgagtgtgt cagtatgtgg ttggttactg
     3421 tgtattcgcc aggaatcacc ccgataggct gccaccctat taggtgatac ctgtttaata
     3481 tgttgtccag gtagactagt agttgcatca gtttgctgta acaagtaacc agtgaggtaa
     3541 cacagtggtg aagcaggtca ggggaggtca ggaggatgtc tgagagaaag aagtccggga
     3601 gatgaatggc tgtctaggaa ggaggatgtc agtgcacggt tagtgtttga gcagagggca
     3661 gacttgtaaa gtacctgtag tgaaaagaat gtggggaccc gattagcaga aaggtgtttg
     3721 cacgtacttt atacaaaata cagaatactt tatattggaa gtgaaagaaa tgaacgtgga
     3781 cttttacaca tgtgcatatt tttctggagg ctatatggat tatttgaaat gaaaagcata
     3841 ctaattggac tttaataaat cattttcaat ca
//
