LOCUS       NM_001351411            3818 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens lysophosphatidic acid receptor 1 (LPAR1), transcript
            variant 17, mRNA.
ACCESSION   NM_001351411 XM_017014397
VERSION     NM_001351411.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3818)
  AUTHORS   Volkmann,E.R., Denton,C.P., Kolb,M., Wijsenbeek-Lourens,M.S.,
            Emson,C., Hudson,K., Amatucci,A.J., Distler,O., Allanore,Y. and
            Khanna,D.
  TITLE     Lysophosphatidic acid receptor 1 inhibition: a potential treatment
            target for pulmonary fibrosis
  JOURNAL   Eur Respir Rev 33 (172), 240015 (2024)
   PUBMED   39009409
  REMARK    GeneRIF: Lysophosphatidic acid receptor 1 inhibition: a potential
            treatment target for pulmonary fibrosis.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3818)
  AUTHORS   Nikolaou,S., Juin,A., Whitelaw,J.A., Paul,N.R., Fort,L., Nixon,C.,
            Spence,H.J., Bryson,S. and Machesky,L.M.
  TITLE     CYRI-B-mediated macropinocytosis drives metastasis via
            lysophosphatidic acid receptor uptake
  JOURNAL   Elife 13, e83712 (2024)
   PUBMED   38712822
  REMARK    GeneRIF: CYRI-B-mediated macropinocytosis drives metastasis via
            lysophosphatidic acid receptor uptake.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3818)
  AUTHORS   Hong,J.M., Lee,J.W., Seen,D.S., Jeong,J.Y. and Huh,W.K.
  TITLE     LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced
            signaling and cell migration
  JOURNAL   Cell Commun Signal 21 (1), 257 (2023)
   PUBMED   37749552
  REMARK    GeneRIF: LPA1-mediated inhibition of CXCR4 attenuates
            CXCL12-induced signaling and cell migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3818)
  AUTHORS   Doutt,S.W., Longo,J.F. and Carroll,S.L.
  TITLE     LPAR1 and aberrantly expressed LPAR3 differentially promote the
            migration and proliferation of malignant peripheral nerve sheath
            tumor cells
  JOURNAL   Glia 71 (3), 742-757 (2023)
   PUBMED   36416236
  REMARK    GeneRIF: LPAR1 and aberrantly expressed LPAR3 differentially
            promote the migration and proliferation of malignant peripheral
            nerve sheath tumor cells.
REFERENCE   5  (bases 1 to 3818)
  AUTHORS   Ahmadzai,M.M., McClain,J.L., Dharshika,C., Seguella,L.,
            Giancola,F., De Giorgio,R. and Gulbransen,B.D.
  TITLE     LPAR1 regulates enteric nervous system function through glial
            signaling and contributes to chronic intestinal pseudo-obstruction
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   35166239
  REMARK    GeneRIF: LPAR1 regulates enteric nervous system function through
            glial signaling and contributes to chronic intestinal
            pseudo-obstruction.
REFERENCE   6  (bases 1 to 3818)
  AUTHORS   An,S., Bleu,T., Zheng,Y. and Goetzl,E.J.
  TITLE     Recombinant human G protein-coupled lysophosphatidic acid receptors
            mediate intracellular calcium mobilization
  JOURNAL   Mol Pharmacol 54 (5), 881-888 (1998)
   PUBMED   9804623
REFERENCE   7  (bases 1 to 3818)
  AUTHORS   Fukushima,N., Kimura,Y. and Chun,J.
  TITLE     A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins
            and mediates multiple cellular responses to lysophosphatidic acid
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6151-6156 (1998)
   PUBMED   9600933
REFERENCE   8  (bases 1 to 3818)
  AUTHORS   Moolenaar,W.H., Kranenburg,O., Postma,F.R. and Zondag,G.C.
  TITLE     Lysophosphatidic acid: G-protein signalling and cellular responses
  JOURNAL   Curr Opin Cell Biol 9 (2), 168-173 (1997)
   PUBMED   9069262
REFERENCE   9  (bases 1 to 3818)
  AUTHORS   An,S., Dickens,M.A., Bleu,T., Hallmark,O.G. and Goetzl,E.J.
  TITLE     Molecular cloning of the human Edg2 protein and its identification
            as a functional cellular receptor for lysophosphatidic acid
  JOURNAL   Biochem Biophys Res Commun 231 (3), 619-622 (1997)
   PUBMED   9070858
REFERENCE   10 (bases 1 to 3818)
  AUTHORS   Hecht,J.H., Weiner,J.A., Post,S.R. and Chun,J.
  TITLE     Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid
            receptor expressed in neurogenic regions of the developing cerebral
            cortex
  JOURNAL   J Cell Biol 135 (4), 1071-1083 (1996)
   PUBMED   8922387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB477196.1, DC325182.1,
            DC340753.1, AK022808.1, BC036034.1 and AI674417.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001351411.1.
            
            Summary: The integral membrane protein encoded by this gene is a
            lysophosphatidic acid (LPA) receptor from a group known as EDG
            receptors. These receptors are members of the G protein-coupled
            receptor superfamily. Utilized by LPA for cell signaling, EDG
            receptors mediate diverse biologic functions, including
            proliferation, platelet aggregation, smooth muscle contraction,
            inhibition of neuroblastoma cell differentiation, chemotaxis, and
            tumor cell invasion. Many transcript variants encoding a few
            different isoforms have been identified for this gene. [provided by
            RefSeq, Oct 2020].
            
            Transcript Variant: This variant (17) differs in the 5' UTR,
            compared to variant 1. Variants 1-70 all encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.78762.1,
                                           SRR1803616.155032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683809.1/ ENSP00000506912.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               DB477196.1         11-186
            177-304             DC325182.1         1-128
            305-565             DC340753.1         62-322
            566-2904            AK022808.1         349-2687
            2905-3307           BC036034.1         2725-3127
            3308-3818           AI674417.1         12-522              c
FEATURES             Location/Qualifiers
     source          1..3818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..3818
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="lysophosphatidic acid receptor 1"
                     /db_xref="GeneID:1902"
                     /db_xref="HGNC:HGNC:3166"
                     /db_xref="MIM:602282"
     exon            1..304
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..384
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..462
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..610
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             566..1660
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="isoform a is encoded by transcript variant 17;
                     endothelial differentiation, lysophosphatidic acid
                     G-protein-coupled receptor, 2; ventricular zone gene 1;
                     LPA-1; LPA receptor 1; lysophosphatidic acid receptor
                     Edg-2"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 1 isoform a"
                     /protein_id="NP_001338340.1"
                     /db_xref="CCDS:CCDS6777.1"
                     /db_xref="GeneID:1902"
                     /db_xref="HGNC:HGNC:3166"
                     /db_xref="MIM:602282"
                     /translation="MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATE
                     WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY
                     FYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMS
                     NRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTF
                     VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLV
                     LLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENP
                     TGPTEGSDRSASSLNHTILAGVHSNDHSVV"
     exon            611..1358
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..3818
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3287..3292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="hexamer: AATAAA"
     polyA_site      3307
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="major polyA site"
     regulatory      3800..3805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="hexamer: AATAAA"
     polyA_site      3818
                     /gene="LPAR1"
                     /gene_synonym="edg-2; EDG2; Gpcr26; LPA1; Mrec1.3;
                     rec.1.3; vzg-1; VZG1"
                     /note="major polyA site"
ORIGIN      
        1 agtaggggcc gactggcggc tgacgctccc tgagtggcga ctccgtctcc agccccgctg
       61 cggagcgcgg gccggatctg gggcggccag ggcccggagc cgcggagccc tccccgccgc
      121 ccggccgagc acgggacccc ggcggggtgg gcgcaggggg cggccccgct ctgggcgact
      181 gccgaggggc gggcggaggg ccgggctcgg ctggcggtgg ggcgggggcc gccgggactg
      241 ggcgcgcggc ctgaagccag cccgggggcg gcaggagagg gacgcgcggc ggcagcgagc
      301 gcagggaaca gctcctgccc aggtctgtgg gcactcagca tggatttcag tctccctgtg
      361 agtgatggga aagaactaac agaggtggac gtctgattta tgaagctccc catccaccta
      421 tctgagtacc tgacttctca ggactgacac ctacagcatc aggtacacag cttctcctag
      481 catgacttcg atctgatcag caaacaagaa aatttgtctc ccgtagttct ggggcgtgtt
      541 caccacctac aaccacagag ctgtcatggc tgccatctct acttccatcc ctgtaatttc
      601 acagccccag ttcacagcca tgaatgaacc acagtgcttc tacaacgagt ccattgcctt
      661 cttttataac cgaagtggaa agcatcttgc cacagaatgg aacacagtca gcaagctggt
      721 gatgggactt ggaatcactg tttgtatctt catcatgttg gccaacctat tggtcatggt
      781 ggcaatctat gtcaaccgcc gcttccattt tcctatttat tacctaatgg ctaatctggc
      841 tgctgcagac ttctttgctg ggttggccta cttctatctc atgttcaaca caggacccaa
      901 tactcggaga ctgactgtta gcacatggct ccttcgtcag ggcctcattg acaccagcct
      961 gacggcatct gtggccaact tactggctat tgcaatcgag aggcacatta cggttttccg
     1021 catgcagctc cacacacgga tgagcaaccg gcgggtagtg gtggtcattg tggtcatctg
     1081 gactatggcc atcgttatgg gtgctatacc cagtgtgggc tggaactgta tctgtgatat
     1141 tgaaaattgt tccaacatgg cacccctcta cagtgactct tacttagtct tctgggccat
     1201 tttcaacttg gtgacctttg tggtaatggt ggttctctat gctcacatct ttggctatgt
     1261 tcgccagagg actatgagaa tgtctcggca tagttctgga ccccggcgga atcgggatac
     1321 catgatgagt cttctgaaga ctgtggtcat tgtgcttggg gcctttatca tctgctggac
     1381 tcctggattg gttttgttac ttctagacgt gtgctgtcca cagtgcgacg tgctggccta
     1441 tgagaaattc ttccttctcc ttgctgaatt caactctgcc atgaacccca tcatttactc
     1501 ctaccgcgac aaagaaatga gcgccacctt taggcagatc ctctgctgcc agcgcagtga
     1561 gaaccccacc ggccccacag aaggctcaga ccgctcggct tcctccctca accacaccat
     1621 cttggctgga gttcacagca atgaccactc tgtggtttag aacggaaact gagatgagga
     1681 accagccgtc ctctcttgga ggataaacag cctcccccta cccaattgcc agggcaaggt
     1741 ggggtgtgag agaggagaaa agtcaactca tgtacttaaa cactaaccaa tgacagtatt
     1801 tgttcctgga ccccacaaga cttgatatat attgaaaatt agcttatgtg acaaccctca
     1861 tcttgatccc catcccttct gaaagtagga agttggagct cttgcaatgg aattcaagaa
     1921 cagactctgg agtgtccatt tagactacac taactagact tttaaaagat tttgtgtggt
     1981 ttggtgcaag tcagaataaa ttctggctag ttgaatccac aacttcattt atatacaggc
     2041 ttcccttttt tatttttaaa ggatacgttt cacttaataa acacgtttat gcctatcagc
     2101 atgtttgtga tggatgagac tatggactgc ttttaaacta ccataattcc attttttccc
     2161 ttacatagga aaactgtaag ttggaattat cttttgttta gaaagcatgc atgtaatgta
     2221 tgtatgcagt atgccttact taaaaagatt aaaaggatac taatgttaaa tcttctagga
     2281 aatagaacct agacttcaaa gccagtattt gtttaggtca tgaagcaaac aatgctctaa
     2341 tcacaatatt aactgtttaa ttaaaatgtt gtaacaagta taaaacaggg aatgtaagtt
     2401 tattaccaaa gtgatatgta ttccaaaaaa gtcatagaag atgaagcact ataatattgt
     2461 tcccatatat ttaaaatacc caagtacatt ctaattacca gtatatcaga ggaaaatttt
     2521 cgtagtcttt gtaaaataat atactcatca tagaaaactt gaaaaatgca gaaatgtata
     2581 aaaaagcaaa aatgattact gataatatca caacccagaa gtaaccacct ttaaaaagca
     2641 acccccatgt atgcctatat gtgtattgta tacttttttt acataattgg agtcatactg
     2701 taaacagttt tataagtaga tctttttcat tgcaaaattg ccacattttc ttatggcatt
     2761 aaaaatttta caaaaacata attttaatgg ctatattata ttccatttaa tggatgcaac
     2821 tcagtttatt taaccattcc catgttgtta actatttagg ttgtttctaa ttttcattat
     2881 tataaagttg cagaaatttg gtgtacataa aactgtctcc atataattga ttattaggat
     2941 atattcccat gaaggattct ttttttaaaa aaatgtgaaa tgtcatcttg tacttacacc
     3001 tttcatgaaa agggatttcc tgcttttgta ctgcatgggt ggcagttgtg aggaaaagcc
     3061 agtcaaatga cctttttaca aaagaaatgc agtggtcact tcagttgaga gtgacttttt
     3121 aatacaacaa gatcaactag aagaattcaa ctgtctcaag aatcaaggta ccccaatata
     3181 tctcgcaatt ccaaactttg tttgagggac tcgttatcca gctcttggta gccacacctg
     3241 caatgtaaaa tggaagaaaa tgcaaagaaa ccaaatgtgc cgagtgaata aaggattgtc
     3301 atatcaatta gtgtgggtcc atctgtagca aatgggttga gtgtgtcagt atgtggttgg
     3361 ttactgtgta ttcgccagga atcaccccga taggctgcca ccctattagg tgatacctgt
     3421 ttaatatgtt gtccaggtag actagtagtt gcatcagttt gctgtaacaa gtaaccagtg
     3481 aggtaacaca gtggtgaagc aggtcagggg aggtcaggag gatgtctgag agaaagaagt
     3541 ccgggagatg aatggctgtc taggaaggag gatgtcagtg cacggttagt gtttgagcag
     3601 agggcagact tgtaaagtac ctgtagtgaa aagaatgtgg ggacccgatt agcagaaagg
     3661 tgtttgcacg tactttatac aaaatacaga atactttata ttggaagtga aagaaatgaa
     3721 cgtggacttt tacacatgtg catatttttc tggaggctat atggattatt tgaaatgaaa
     3781 agcatactaa ttggacttta ataaatcatt ttcaatca
//
