LOCUS       NM_005577               6431 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens lipoprotein(a) (LPA), mRNA.
ACCESSION   NM_005577 XM_926329 XM_941794
VERSION     NM_005577.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6431)
  AUTHORS   Behera,S., Belyeu,J.R., Chen,X., Paulin,L.F., Nguyen,N.Q.H.,
            Newman,E., Mahmoud,M., Menon,V.K., Qi,Q., Joshi,P., Marcovina,S.,
            Rossi,M., Roller,E., Han,J., Onuchic,V., Avery,C.L.,
            Ballantyne,C.M., Rodriguez,C.J., Kaplan,R.C., Muzny,D.M.,
            Metcalf,G.A., Gibbs,R.A., Yu,B., Boerwinkle,E., Eberle,M.A. and
            Sedlazeck,F.J.
  TITLE     Identification of allele-specific KIV-2 repeats and impact on Lp(a)
            measurements for cardiovascular disease risk
  JOURNAL   BMC Med Genomics 17 (1), 255 (2024)
   PUBMED   39449055
  REMARK    GeneRIF: Identification of allele-specific KIV-2 repeats and impact
            on Lp(a) measurements for cardiovascular disease risk.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6431)
  AUTHORS   Abdalla,H.M., Mahmoud,A.K., Khedr,A.E., Farina,J.M., Scalia,I.G.,
            Abbas,M.T., Awad,K.A., Baba Ali,N., Bismee,N.N., Attaripour
            Esfahani,S., Javadi,N., Pereyra,M., Alsidawi,S., Lester,S.J.,
            Ayoub,C. and Arsanjani,R.
  TITLE     Lipoprotein (a) as a Cardiovascular Risk Factor in Controversial
            Clinical Scenarios: A Narrative Review
  JOURNAL   Int J Mol Sci 25 (20), 11029 (2024)
   PUBMED   39456811
  REMARK    GeneRIF: Lipoprotein (a) as a Cardiovascular Risk Factor in
            Controversial Clinical Scenarios: A Narrative Review.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6431)
  AUTHORS   Nurmohamed,N.S., Gaillard,E.L., Malkasian,S., de Groot,R.J.,
            Ibrahim,S., Bom,M.J., Kaiser,Y., Earls,J.P., Min,J.K., Kroon,J.,
            Planken,R.N., Danad,I., van Rosendael,A.R., Choi,A.D.,
            Stroes,E.S.G. and Knaapen,P.
  TITLE     Lipoprotein(a) and Long-Term Plaque Progression, Low-Density
            Plaque, and Pericoronary Inflammation
  JOURNAL   JAMA Cardiol 9 (9), 826-834 (2024)
   PUBMED   39018040
  REMARK    GeneRIF: Lipoprotein(a) and Long-Term Plaque Progression,
            Low-Density Plaque, and Pericoronary Inflammation.
            Erratum:[JAMA Cardiol. 2024 Sep 1;9(9):861. doi:
            10.1001/jamacardio.2024.3130.. PMID: 39259261]
REFERENCE   4  (bases 1 to 6431)
  AUTHORS   Singh,S., Baars,D.P., Aggarwal,K., Desai,R., Singh,D. and
            Pinto-Sietsma,S.J.
  TITLE     Association between lipoprotein (a) and risk of heart failure: A
            systematic review and meta-analysis of Mendelian randomization
            studies
  JOURNAL   Curr Probl Cardiol 49 (4), 102439 (2024)
   PUBMED   38301917
  REMARK    GeneRIF: Association between lipoprotein (a) and risk of heart
            failure: A systematic review and meta-analysis of Mendelian
            randomization studies.
            Review article
REFERENCE   5  (bases 1 to 6431)
  AUTHORS   Amin,N., Devasia,T., Kamath,S.U., Paramasivam,G., Shetty,P.N.,
            Singh,A. and Prakash,G.N.S.
  TITLE     Confounding Factors Responsible for Elevated Lp(a) Levels in
            Patients with Coronary Artery Disease
  JOURNAL   Ann Card Anaesth 27 (1), 32-36 (2024)
   PUBMED   38722118
  REMARK    GeneRIF: Confounding Factors Responsible for Elevated Lp(a) Levels
            in Patients with Coronary Artery Disease.
REFERENCE   6  (bases 1 to 6431)
  AUTHORS   Wade,D.P., Clarke,J.G., Lindahl,G.E., Liu,A.C., Zysow,B.R.,
            Meer,K., Schwartz,K. and Lawn,R.M.
  TITLE     5' control regions of the apolipoprotein(a) gene and members of the
            related plasminogen gene family
  JOURNAL   Proc Natl Acad Sci U S A 90 (4), 1369-1373 (1993)
   PUBMED   7679504
REFERENCE   7  (bases 1 to 6431)
  AUTHORS   Salonen,E.M., Jauhiainen,M., Zardi,L., Vaheri,A. and Ehnholm,C.
  TITLE     Lipoprotein(a) binds to fibronectin and has serine proteinase
            activity capable of cleaving it
  JOURNAL   EMBO J 8 (13), 4035-4040 (1989)
   PUBMED   2531657
REFERENCE   8  (bases 1 to 6431)
  AUTHORS   Utermann,G.
  TITLE     The mysteries of lipoprotein(a)
  JOURNAL   Science 246 (4932), 904-910 (1989)
   PUBMED   2530631
  REMARK    Review article
REFERENCE   9  (bases 1 to 6431)
  AUTHORS   Frank,S.L., Klisak,I., Sparkes,R.S., Mohandas,T., Tomlinson,J.E.,
            McLean,J.W., Lawn,R.M. and Lusis,A.J.
  TITLE     The apolipoprotein(a) gene resides on human chromosome 6q26-27, in
            close proximity to the homologous gene for plasminogen
  JOURNAL   Hum Genet 79 (4), 352-356 (1988)
   PUBMED   3410459
REFERENCE   10 (bases 1 to 6431)
  AUTHORS   McLean,J.W., Tomlinson,J.E., Kuang,W.J., Eaton,D.L., Chen,E.Y.,
            Fless,G.M., Scanu,A.M. and Lawn,R.M.
  TITLE     cDNA sequence of human apolipoprotein(a) is homologous to
            plasminogen
  JOURNAL   Nature 330 (6144), 132-137 (1987)
   PUBMED   3670400
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109933.25 and AL596089.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 27, 2019 this sequence version replaced NM_005577.3.
            
            Summary: The protein encoded by this gene is a serine proteinase
            that inhibits the activity of tissue-type plasminogen activator I.
            The encoded protein constitutes a substantial portion of
            lipoprotein(a) and is proteolytically cleaved, resulting in
            fragments that attach to atherosclerotic lesions and promote
            thrombogenesis. Elevated plasma levels of this protein are linked
            to atherosclerosis. Depending on the individual, the encoded
            protein contains 2-43 copies of kringle-type domains. The allele
            represented here contains 15 copies of the kringle-type repeats and
            corresponds to that found in the reference genome sequence.
            [provided by RefSeq, Dec 2009].
            
            Sequence Note: alleles differ in tandem repeat copy number: This is
            a highly polymorphic gene, and the kringle IV-2 repeat varies from
            2-43 copies among individuals. X06290.1 contains 37 kringle IV-2
            repeats.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1966682, SAMEA1968832
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316300.10/ ENSP00000321334.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AL109933.25        14132-14241         c
            111-270             AL109933.25        304-463             c
            271-452             AL596089.19        129931-130112       c
            453-612             AL596089.19        128564-128723       c
            613-794             AL596089.19        124384-124565       c
            795-954             AL596089.19        123017-123176       c
            955-1136            AL596089.19        118840-119021       c
            1137-1296           AL596089.19        117470-117629       c
            1297-1478           AL596089.19        113291-113472       c
            1479-1638           AL596089.19        111924-112083       c
            1639-1820           AL596089.19        107747-107928       c
            1821-1980           AL596089.19        106380-106539       c
            1981-2162           AL596089.19        102201-102382       c
            2163-2322           AL596089.19        100834-100993       c
            2323-2504           AL596089.19        96649-96830         c
            2505-2664           AL596089.19        95279-95438         c
            2665-2846           AL596089.19        90194-90375         c
            2847-3006           AL596089.19        88763-88922         c
            3007-3188           AL596089.19        84634-84815         c
            3189-3348           AL596089.19        83217-83376         c
            3349-3530           AL596089.19        79071-79252         c
            3531-3690           AL596089.19        77675-77834         c
            3691-3848           AL596089.19        74661-74818         c
            3849-4008           AL596089.19        73270-73429         c
            4009-4190           AL596089.19        70166-70347         c
            4191-4350           AL596089.19        68763-68922         c
            4351-4532           AL596089.19        62240-62421         c
            4533-4692           AL596089.19        60853-61012         c
            4693-4874           AL596089.19        41107-41288         c
            4875-5034           AL596089.19        39742-39901         c
            5035-5216           AL596089.19        32195-32376         c
            5217-5365           AL596089.19        31506-31654         c
            5366-5459           AL596089.19        29157-29250         c
            5460-5580           AL596089.19        26405-26525         c
            5581-5655           AL596089.19        24824-24898         c
            5656-5796           AL596089.19        23760-23900         c
            5797-5903           AL596089.19        21572-21678         c
            5904-6022           AL596089.19        16248-16366         c
            6023-6431           AL596089.19        15199-15607         c
FEATURES             Location/Qualifiers
     source          1..6431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3-q26"
     gene            1..6431
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="lipoprotein(a)"
                     /db_xref="GeneID:4018"
                     /db_xref="HGNC:HGNC:6667"
                     /db_xref="MIM:152200"
     exon            1..110
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..6184
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /EC_number="3.4.21.-"
                     /note="antiangiogenic AK38 protein; apolipoprotein(a);
                     lp(a); apo(a); lipoprotein, Lp(a)"
                     /codon_start=1
                     /product="apolipoprotein(a) precursor"
                     /protein_id="NP_005568.2"
                     /db_xref="CCDS:CCDS43523.1"
                     /db_xref="GeneID:4018"
                     /db_xref="HGNC:HGNC:6667"
                     /db_xref="MIM:152200"
                     /translation="MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQSYRGTYSTTV
                     TGRTCQAWSSMTPHQHNRTTENYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNL
                     TQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTG
                     RTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQ
                     CSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRT
                     CQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCS
                     DAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQ
                     AWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDA
                     EGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAW
                     SSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEG
                     TAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSS
                     MTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTA
                     VAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMT
                     PHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVA
                     PPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPH
                     SHSRTPEYYPNAGLIMNYCRNPDPVAAPYCYTRDPSVRWEYCNLTQCSDAEGTAVAPP
                     TITPIPSLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSH
                     SRTPAYYPNAGLIKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTRCSDAEWTAFVPPNV
                     ILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSR
                     TPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLATLTVVP
                     DPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTT
                     EYYPNGGLTRNYCRNPDAEISPWCYTMDPNVRWEYCNLTQCPVTESSVLATSTAVSEQ
                     APTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTR
                     NYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPSEEAP
                     TENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNY
                     CRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPPE
                     KSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCR
                     NPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQT
                     PVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNP
                     DADTGPWCFTMDPSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGK
                     GYRGKKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYT
                     MNPRKLFDYCDIPLCASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFG
                     KHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGAHQEVNLESHVQEIEVSRLFLEP
                     TQADIALLKLSRPAVITDKVMPACLPSPDYMVTARTECYITGWGETQGTFGTGLLKEA
                     QLLVIENEVCNHYKYICAEHLARGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCAR
                     PNKPGVYARVSRFVTWIEGMMRNN"
     exon            111..270
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            271..452
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            453..612
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            613..794
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            795..954
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1136
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1296
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1478
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1638
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1820
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1980
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2162
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2322
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2504
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2664
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2846
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3006
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3188
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3348
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3530
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3690
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3848
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..4008
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4190
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..4350
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            4351..4532
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            4533..4692
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..4874
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            4875..5034
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            5035..5216
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            5217..5365
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            5366..5459
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            5460..5580
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            5581..5655
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            5656..5796
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            5797..5903
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            5904..6022
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     exon            6023..6431
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6403..6408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="hexamer: AATAAA"
     polyA_site      6431
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="major polyA site"
ORIGIN      
        1 gtaagtcaac aatgtcctgg gattgggaca cactttctgg gcactgctgg ccagtcccaa
       61 aatggaacat aaggaagtgg ttcttctact tcttttattt ctgaaatcag cagcacctga
      121 gcaaagccat gtggtccagg attgctacca tggtgatgga cagagttatc gaggcacgta
      181 ctccaccact gtcacaggaa ggacctgcca agcttggtca tctatgacac cacatcaaca
      241 taataggacc acagaaaact acccaaatgc tggcttgatc atgaactact gcaggaatcc
      301 agatgctgtg gcagctcctt attgttatac gagggatccc ggtgtcaggt gggagtactg
      361 caacctgacg caatgctcag acgcagaagg gactgccgtc gcgcctccga ctgttacccc
      421 ggttccaagc ctagaggctc cttccgaaca agcaccgact gagcaaaggc ctggggtgca
      481 ggagtgctac catggtaatg gacagagtta tcgaggcaca tactccacca ctgtcacagg
      541 aagaacctgc caagcttggt catctatgac accacactcg catagtcgga ccccagaata
      601 ctacccaaat gctggcttga tcatgaacta ctgcaggaat ccagatgctg tggcagctcc
      661 ttattgttat acgagggatc ccggtgtcag gtgggagtac tgcaacctga cgcaatgctc
      721 agacgcagaa gggactgccg tcgcgcctcc gactgttacc ccggttccaa gcctagaggc
      781 tccttccgaa caagcaccga ctgagcaaag gcctggggtg caggagtgct accatggtaa
      841 tggacagagt tatcgaggca catactccac cactgtcaca ggaagaacct gccaagcttg
      901 gtcatctatg acaccacact cgcatagtcg gaccccagaa tactacccaa atgctggctt
      961 gatcatgaac tactgcagga atccagatgc tgtggcagct ccttattgtt atacgaggga
     1021 tcccggtgtc aggtgggagt actgcaacct gacgcaatgc tcagacgcag aagggactgc
     1081 cgtcgcgcct ccgactgtta ccccggttcc aagcctagag gctccttccg aacaagcacc
     1141 gactgagcag aggcctgggg tgcaggagtg ctaccacggt aatggacaga gttatcgagg
     1201 cacatactcc accactgtca ctggaagaac ctgccaagct tggtcatcta tgacaccaca
     1261 ctcgcatagt cggaccccag aatactaccc aaatgctggc ttgatcatga actactgcag
     1321 gaatccagat gctgtggcag ctccttattg ttatacgagg gatcccggtg tcaggtggga
     1381 gtactgcaac ctgacgcaat gctcagacgc agaagggact gccgtcgcgc ctccgactgt
     1441 taccccggtt ccaagcctag aggctccttc cgaacaagca ccgactgagc aaaggcctgg
     1501 ggtgcaggag tgctaccatg gtaatggaca gagttatcga ggcacatact ccaccactgt
     1561 cacaggaaga acctgccaag cttggtcatc tatgacacca cactcgcata gtcggacccc
     1621 agaatactac ccaaatgctg gcttgatcat gaactactgc aggaatccag atgctgtggc
     1681 agctccttat tgttatacga gggatcccgg tgtcaggtgg gagtactgca acctgacgca
     1741 atgctcagac gcagaaggga ctgccgtcgc gcctccgact gttaccccgg ttccaagcct
     1801 agaggctcct tccgaacaag caccgactga gcaaaggcct ggggtgcagg agtgctacca
     1861 tggtaatgga cagagttatc gaggcacata ctccaccact gtcacaggaa gaacctgcca
     1921 agcttggtca tctatgacac cacactcgca tagtcggacc ccagaatact acccaaatgc
     1981 tggcttgatc atgaactact gcaggaatcc agatgctgtg gcagctcctt attgttatac
     2041 gagggatccc ggtgtcaggt gggagtactg caacctgacg caatgctcag acgcagaagg
     2101 gactgccgtc gcgcctccga ctgttacccc ggttccaagc ctagaggctc cttccgaaca
     2161 agcaccgact gagcaaaggc ctggggtgca ggagtgctac catggtaatg gacagagtta
     2221 tcgaggcaca tactccacca ctgtcacagg aagaacctgc caagcttggt catctatgac
     2281 accacactcg catagtcgga ccccagaata ctacccaaat gctggcttga tcatgaacta
     2341 ctgcaggaat ccagatgctg tggcagctcc ttattgttat acgagggatc ccggtgtcag
     2401 gtgggagtac tgcaacctga cgcaatgctc agacgcagaa gggactgccg tcgcgcctcc
     2461 gactgttacc ccggttccaa gcctagaggc tccttccgaa caagcaccga ctgagcagag
     2521 gcctggggtg caggagtgct accacggtaa tggacagagt tatcgaggca catactccac
     2581 cactgtcact ggaagaacct gccaagcttg gtcatctatg acaccacact cgcatagtcg
     2641 gaccccagaa tactacccaa atgctggctt gatcatgaac tactgcagga atccagatcc
     2701 tgtggcagcc ccttattgtt atacgaggga tcccagtgtc aggtgggagt actgcaacct
     2761 gacacaatgc tcagacgcag aagggactgc cgtcgcgcct ccaactatta ccccgattcc
     2821 aagcctagag gctccttctg aacaagcacc aactgagcaa aggcctgggg tgcaggagtg
     2881 ctaccacgga aatggacaga gttatcaagg cacatacttc attactgtca caggaagaac
     2941 ctgccaagct tggtcatcta tgacaccaca ctcgcatagt cggaccccag catactaccc
     3001 aaatgctggc ttgatcaaga actactgccg aaatccagat cctgtggcag ccccttggtg
     3061 ttatacaaca gatcccagtg tcaggtggga gtactgcaac ctgacacgat gctcagatgc
     3121 agaatggact gccttcgtcc ctccgaatgt tattctggct ccaagcctag aggctttttt
     3181 tgaacaagca ctgactgagg aaacccccgg ggtacaggac tgctactacc attatggaca
     3241 gagttaccga ggcacatact ccaccactgt cacaggaaga acttgccaag cttggtcatc
     3301 tatgacacca caccagcata gtcggacccc agaaaactac ccaaatgctg gcctgaccag
     3361 gaactactgc aggaatccag atgctgagat tcgcccttgg tgttacacca tggatcccag
     3421 tgtcaggtgg gagtactgca acctgacaca atgcctggtg acagaatcaa gtgtccttgc
     3481 aactctcacg gtggtcccag atccaagcac agaggcttct tctgaagaag caccaacgga
     3541 gcaaagcccc ggggtccagg attgctacca tggtgatgga cagagttatc gaggctcatt
     3601 ctctaccact gtcacaggaa ggacatgtca gtcttggtcc tctatgacac cacactggca
     3661 tcagaggaca acagaatatt atccaaatgg tggcctgacc aggaactact gcaggaatcc
     3721 agatgctgag attagtcctt ggtgttatac catggatccc aatgtcagat gggagtactg
     3781 caacctgaca caatgtccag tgacagaatc aagtgtcctt gcgacgtcca cggctgtttc
     3841 tgaacaagca ccaacggagc aaagccccac agtccaggac tgctaccatg gtgatggaca
     3901 gagttatcga ggctcattct ccaccactgt tacaggaagg acatgtcagt cttggtcctc
     3961 tatgacacca cactggcatc agagaaccac agaatactac ccaaatggtg gcctgaccag
     4021 gaactactgc aggaatccag atgctgagat tcgcccttgg tgttatacca tggatcccag
     4081 tgtcagatgg gagtactgca acctgacgca atgtccagtg atggaatcaa ctctcctcac
     4141 aactcccacg gtggtcccag ttccaagcac agagcttcct tctgaagaag caccaactga
     4201 aaacagcact ggggtccagg actgctaccg aggtgatgga cagagttatc gaggcacact
     4261 ctccaccact atcacaggaa gaacatgtca gtcttggtcg tctatgacac cacattggca
     4321 tcggaggatc ccattatact atccaaatgc tggcctgacc aggaactact gcaggaatcc
     4381 agatgctgag attcgccctt ggtgttacac catggatccc agtgtcaggt gggagtactg
     4441 caacctgaca cgatgtccag tgacagaatc gagtgtcctc acaactccca cagtggcccc
     4501 ggttccaagc acagaggctc cttctgaaca agcaccacct gagaaaagcc ctgtggtcca
     4561 ggattgctac catggtgatg gacggagtta tcgaggcata tcctccacca ctgtcacagg
     4621 aaggacctgt caatcttggt catctatgat accacactgg catcagagga ccccagaaaa
     4681 ctacccaaat gctggcctga ccgagaacta ctgcaggaat ccagattctg ggaaacaacc
     4741 ctggtgttac acaaccgatc cgtgtgtgag gtgggagtac tgcaatctga cacaatgctc
     4801 agaaacagaa tcaggtgtcc tagagactcc cactgttgtt ccagttccaa gcatggaggc
     4861 tcattctgaa gcagcaccaa ctgagcaaac ccctgtggtc cggcagtgct accatggtaa
     4921 tggccagagt tatcgaggca cattctccac cactgtcaca ggaaggacat gtcaatcttg
     4981 gtcatccatg acaccacacc ggcatcagag gaccccagaa aactacccaa atgatggcct
     5041 gacaatgaac tactgcagga atccagatgc cgatacaggc ccttggtgtt ttaccatgga
     5101 ccccagcatc aggtgggagt actgcaacct gacgcgatgc tcagacacag aagggactgt
     5161 ggtcgctcct ccgactgtca tccaggttcc aagcctaggg cctccttctg aacaagactg
     5221 tatgtttggg aatgggaaag gataccgggg caagaaggca accactgtta ctgggacgcc
     5281 atgccaggaa tgggctgccc aggagcccca tagacacagc acgttcattc cagggacaaa
     5341 taaatgggca ggtctggaaa aaaattactg ccgtaaccct gatggtgaca tcaatggtcc
     5401 ctggtgctac acaatgaatc caagaaaact ttttgactac tgtgatatcc ctctctgtgc
     5461 atcctcttca tttgattgtg ggaagcctca agtggagccg aagaaatgtc ctggaagcat
     5521 tgtagggggg tgtgtggccc acccacattc ctggccctgg caagtcagtc tcagaacaag
     5581 gtttggaaag cacttctgtg gaggcacctt aatatcccca gagtgggtgc tgactgctgc
     5641 tcactgcttg aagaagtcct caaggccttc atcctacaag gtcatcctgg gtgcacacca
     5701 agaagtgaac ctcgaatctc atgttcagga aatagaagtg tctaggctgt tcttggagcc
     5761 cacacaagca gatattgcct tgctaaagct aagcaggcct gccgtcatca ctgacaaagt
     5821 aatgccagct tgtctgccat ccccagacta catggtcacc gccaggactg aatgttacat
     5881 cactggctgg ggagaaaccc aaggtacctt tgggactggc cttctcaagg aagcccagct
     5941 ccttgttatt gagaatgaag tgtgcaatca ctataagtat atttgtgctg agcatttggc
     6001 cagaggcact gacagttgcc agggtgacag tggagggcct ctggtttgct tcgagaagga
     6061 caaatacatt ttacaaggag tcacttcttg gggtcttggc tgtgcacgcc ccaataagcc
     6121 tggtgtctat gctcgtgttt caaggtttgt tacttggatt gagggaatga tgagaaataa
     6181 ttaattggac gggagacaga gtgaagcatc aacctactta gaagctgaaa cgtgggtaag
     6241 gatttagcat gctggaaata atagacagca atcaaacgaa gacactgttc ccagctacca
     6301 gctatgccaa accttggcat ttttggtatt tttgtgtata agcttttaag gtctgactga
     6361 caaattctgt attaaggtgt catagctatg acatttgtta aaaataaact ctgcacttat
     6421 tttgatttga a
//
