LOCUS       NM_032211               3597 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens lysyl oxidase like 4 (LOXL4), mRNA.
ACCESSION   NM_032211
VERSION     NM_032211.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3597)
  AUTHORS   Zhao,L., Pei,R., Ding,Y., Su,Z., Li,D., Zhu,S., Xu,L., Zhao,H. and
            Zhou,W.
  TITLE     LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles
            Promotes Immune Escape in Hepatocellular Carcinoma by Activating
            the STAT1/PD-L1 Axis
  JOURNAL   J Immunother 47 (2), 64-76 (2024)
   PUBMED   38047403
  REMARK    GeneRIF: LOXL4 Shuttled by Tumor Cells-derived Extracellular
            Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by
            Activating the STAT1/PD-L1 Axis.
REFERENCE   2  (bases 1 to 3597)
  AUTHORS   Wang,J., Chen,C., Huang,J., Xie,Z., Chen,X., Zheng,Z., Li,E. and
            Zou,H.
  TITLE     The possibilities of LOXL4 as a prognostic marker for carcinomas
  JOURNAL   Amino Acids 55 (11), 1519-1529 (2023)
   PUBMED   37814029
  REMARK    GeneRIF: The possibilities of LOXL4 as a prognostic marker for
            carcinomas.
            Review article
REFERENCE   3  (bases 1 to 3597)
  AUTHORS   Ma,H.Y., Li,Q., Wong,W.R., N'Diaye,E.N., Caplazi,P., Bender,H.,
            Huang,Z., Arlantico,A., Jeet,S., Wong,A., Emson,C., Brightbill,H.,
            Tam,L., Newman,R., Roose-Girma,M., Sandoval,W. and Ding,N.
  TITLE     LOXL4, but not LOXL2, is the critical determinant of pathological
            collagen cross-linking and fibrosis in the lung
  JOURNAL   Sci Adv 9 (21), eadf0133 (2023)
   PUBMED   37235663
  REMARK    GeneRIF: LOXL4, but not LOXL2, is the critical determinant of
            pathological collagen cross-linking and fibrosis in the lung.
REFERENCE   4  (bases 1 to 3597)
  AUTHORS   Vijayan,P., Hack,S., Yao,T., Qureshi,M.A., Paterson,A.D., John,R.,
            Davenport,B., Lennon,R., Pei,Y. and Barua,M.
  TITLE     LAMA2 and LOXL4 are candidate FSGS genes
  JOURNAL   BMC Nephrol 22 (1), 320 (2021)
   PUBMED   34565340
  REMARK    GeneRIF: LAMA2 and LOXL4 are candidate FSGS genes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3597)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3597)
  AUTHORS   Kim,M.S., Kim,S.S., Jung,S.T., Park,J.Y., Yoo,H.W., Ko,J.,
            Csiszar,K., Choi,S.Y. and Kim,Y.
  TITLE     Expression and purification of enzymatically active forms of the
            human lysyl oxidase-like protein 4
  JOURNAL   J Biol Chem 278 (52), 52071-52074 (2003)
   PUBMED   14551188
  REMARK    GeneRIF: LOXL4, with the four scavenger receptor cysteine rich
            domains, may also function as an active amine oxidase
REFERENCE   7  (bases 1 to 3597)
  AUTHORS   Holtmeier,C., Gorogh,T., Beier,U., Meyer,J., Hoffmann,M.,
            Gottschlich,S., Heidorn,K., Ambrosch,P. and Maune,S.
  TITLE     Overexpression of a novel lysyl oxidase-like gene in human head and
            neck squamous cell carcinomas
  JOURNAL   Anticancer Res 23 (3B), 2585-2591 (2003)
   PUBMED   12894545
  REMARK    GeneRIF: The data presented in this work might emphasize the
            involvement of LOXL4 in molecular processes of the genesis or
            progression of head and neck carcinomas.
REFERENCE   8  (bases 1 to 3597)
  AUTHORS   Molnar,J., Fong,K.S., He,Q.P., Hayashi,K., Kim,Y., Fong,S.F.,
            Fogelgren,B., Szauter,K.M., Mink,M. and Csiszar,K.
  TITLE     Structural and functional diversity of lysyl oxidase and the
            LOX-like proteins
  JOURNAL   Biochim Biophys Acta 1647 (1-2), 220-224 (2003)
   PUBMED   12686136
  REMARK    Review article
REFERENCE   9  (bases 1 to 3597)
  AUTHORS   Maki,J.M., Tikkanen,H. and Kivirikko,K.I.
  TITLE     Cloning and characterization of a fifth human lysyl oxidase
            isoenzyme: the third member of the lysyl oxidase-related subfamily
            with four scavenger receptor cysteine-rich domains
  JOURNAL   Matrix Biol 20 (7), 493-496 (2001)
   PUBMED   11691589
REFERENCE   10 (bases 1 to 3597)
  AUTHORS   Asuncion,L., Fogelgren,B., Fong,K.S., Fong,S.F., Kim,Y. and
            Csiszar,K.
  TITLE     A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24
            has an altered scavenger receptor cysteine rich domain
  JOURNAL   Matrix Biol 20 (7), 487-491 (2001)
   PUBMED   11691588
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013153.1, AK172781.1 and
            W44920.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032211.6.
            
            Summary: This gene encodes a member of the lysyl oxidase gene
            family. The prototypic member of the family is essential to the
            biogenesis of connective tissue, encoding an extracellular
            copper-dependent amine oxidase that catalyses the first step in the
            formation of crosslinks in collagens and elastin. A highly
            conserved amino acid sequence at the C-terminus end appears to be
            sufficient for amine oxidase activity, suggesting that each family
            member may retain this function. The N-terminus is poorly conserved
            and may impart additional roles in developmental regulation,
            senescence, tumor suppression, cell growth control, and chemotaxis
            to each member of the family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013153.1, AK172781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260702.4/ ENSP00000260702.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               BC013153.1         57-157
            102-1801            AK172781.1         101-1800
            1802-3594           BC013153.1         1858-3650
            3595-3597           W44920.1           5-7                 c
FEATURES             Location/Qualifiers
     source          1..3597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..3597
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /note="lysyl oxidase like 4"
                     /db_xref="GeneID:84171"
                     /db_xref="HGNC:HGNC:17171"
                     /db_xref="MIM:607318"
     exon            1..63
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            64..372
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2366
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /EC_number="1.4.3.13"
                     /note="lysyl oxidase related C; lysyl oxidase homolog 4;
                     lysyl oxidase-like protein 4; lysyl oxidase-related
                     protein C; lysyl oxidase-like 4 pseudogene"
                     /codon_start=1
                     /product="lysyl oxidase homolog 4 precursor"
                     /protein_id="NP_115587.6"
                     /db_xref="CCDS:CCDS7473.1"
                     /db_xref="GeneID:84171"
                     /db_xref="HGNC:HGNC:17171"
                     /db_xref="MIM:607318"
                     /translation="MAWSPPATLFLFLLLLGQPPPSRPQSLGTTKLRLVGPESKPEEG
                     RLEVLHQGQWGTVCDDNFAIQEATVACRQLGFEAALTWAHSAKYGQGEGPIWLDNVRC
                     VGTESSLDQCGSNGWGVSDCSHSEDVGVICHPRRHRGYLSETVSNALGPQGRRLEEVR
                     LKPILASAKQHSPVTEGAVEVKYEGHWRQVCDQGWTMNNSRVVCGMLGFPSEVPVDSH
                     YYRKVWDLKMRDPKSRLKSLTNKNSFWIHQVTCLGTEPHMANCQVQVAPARGKLRPAC
                     PGGMHAVVSCVAGPHFRPPKTKPQRKGSWAEEPRVRLRSGAQVGEGRVEVLMNRQWGT
                     VCDHRWNLISASVVCRQLGFGSAREALFGARLGQGLGPIHLSEVRCRGYERTLSDCPA
                     LEGSQNGCQHENDAAVRCNVPNMGFQNQVRLAGGRIPEEGLLEVQVEVNGVPRWGSVC
                     SENWGLTEAMVACRQLGLGFAIHAYKETWFWSGTPRAQEVVMSGVRCSGTELALQQCQ
                     RHGPVHCSHGGGRFLAGVSCMDSAPDLVMNAQLVQETAYLEDRPLSQLYCAHEENCLS
                     KSADHMDWPYGYRRLLRFSTQIYNLGRTDFRPKTGRDSWVWHQCHRHYHSIEVFTHYD
                     LLTLNGSKVAEGHKASFCLEDTNCPTGLQRRYACANFGEQGVTVGCWDTYRHDIDCQW
                     VDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCKYDGHRVWLHNCHTGNSYPAN
                     AELSLEQEQRLRNNLI"
     exon            373..551
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            552..757
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            758..796
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1016
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1200
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1355
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1523
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1686
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1930
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2046
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2183
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2295
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..3597
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3470..3475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /note="hexamer: AATAAA"
     polyA_site      3493
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /note="major polyA site"
     regulatory      3566..3571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /note="hexamer: AATAAA"
     polyA_site      3597
                     /gene="LOXL4"
                     /gene_synonym="LOXC"
                     /note="major polyA site"
ORIGIN      
        1 gagcccgtta gcgctgctcc gccgcggcgc ccgcccagcc ccggactgtc cgcgctccat
       61 ctggtatctt ggcctcagct gtccttgaag tcaccatggc gtggtcccca ccagccaccc
      121 tctttctgtt cctgctgctg ctaggccagc cccctcccag caggccacag tcactgggca
      181 ccactaagct ccggctggtg ggcccagaga gcaagccaga ggagggccgc ctggaggtgc
      241 tgcaccaggg ccagtggggc accgtgtgtg atgacaactt tgctatccag gaggccacag
      301 tggcttgccg ccagctgggc ttcgaagctg ccttgacctg ggcccacagt gccaagtacg
      361 gccaagggga gggacccatc tggctggaca atgtgcgctg tgtgggcaca gagagctcct
      421 tggaccagtg cgggtctaat ggctggggag tcagtgactg cagtcactca gaagacgtag
      481 gggtgatatg ccacccccgg cgccatcgtg gctacctttc tgaaactgtc tccaatgccc
      541 ttgggcccca gggccggcgg ctggaggagg tgcggctcaa gcccatcctt gccagtgcca
      601 agcagcatag cccagtgacc gagggagccg tggaggtgaa gtatgagggc cactggcggc
      661 aggtgtgtga ccagggctgg accatgaaca acagcagggt ggtgtgcggg atgctgggct
      721 tccccagcga ggtgcctgtc gacagccact actacaggaa agtctgggat ctgaagatga
      781 gggaccctaa gtctaggctg aagagcctga cgaataagaa ctccttctgg atccaccagg
      841 tcacctgcct ggggacagag ccccacatgg ccaactgcca ggtgcaggtg gctccagccc
      901 ggggcaagct gcggccagcc tgcccaggtg gcatgcacgc tgtggtcagc tgtgtggcag
      961 ggcctcactt ccgcccaccg aagacaaagc cacaacgcaa agggtcctgg gcagaggagc
     1021 cgagggtgcg cctgcgctcc ggggcccagg tgggcgaggg ccgggtggaa gtgctcatga
     1081 accgccagtg gggcacggtc tgtgaccaca ggtggaacct catctctgcc agtgtcgtgt
     1141 gtcgtcagct gggctttggc tctgctcggg aggccctctt tggggcccgg ctgggccaag
     1201 ggctagggcc catccacctg agtgaggtgc gctgcagggg atatgagcgg accctcagcg
     1261 actgccctgc cctggaaggg tcccagaatg gttgccaaca tgagaatgat gctgctgtca
     1321 ggtgcaatgt ccctaacatg ggctttcaga atcaggtgcg cttggctggt gggcgtatcc
     1381 ctgaggaggg gctattggag gtgcaggtgg aggtgaacgg ggtcccacgc tgggggagcg
     1441 tgtgcagtga aaactggggg ctcaccgaag ccatggtggc ctgccgacag ctcggcctgg
     1501 gttttgccat ccatgcctac aaggaaacct ggttctggtc ggggacgcca agggcccagg
     1561 aggtggtgat gagtggggtg cgctgctcag gcacagagct ggccctgcag cagtgccaga
     1621 ggcacgggcc ggtgcactgc tcccacggtg gcgggcgctt cctggctgga gtctcctgca
     1681 tggacagtgc accagacctg gtgatgaacg cccagctagt gcaggagacg gcctacttgg
     1741 aggaccgccc gctcagccag ctgtattgtg cccacgagga gaactgcctc tccaagtctg
     1801 cggatcacat ggactggccc tacggatacc gccgcctatt gcgcttctcc acacagatct
     1861 acaatctggg ccggactgac tttcgtccaa agactggacg cgatagctgg gtttggcacc
     1921 agtgccacag gcattaccac agcattgagg tcttcaccca ctacgacctc ctcactctca
     1981 atggctccaa ggtggctgag gggcacaagg ccagcttctg tctggaggac acaaactgcc
     2041 ccacaggact gcagcggcgc tacgcatgtg ccaactttgg agaacaggga gtgactgtag
     2101 gctgctggga cacctaccgg catgacattg attgccagtg ggtggatatc acagatgtgg
     2161 gccccgggaa ttatatcttc caggtgattg tgaaccccca ctatgaagtg gcagagtcag
     2221 atttctccaa caatatgctg cagtgccgct gcaagtatga tgggcaccgg gtctggctgc
     2281 acaactgcca cacagggaat tcatacccag ccaatgcaga actctccctg gagcaggaac
     2341 agcgtctcag gaacaacctc atctgaagct gtcactgcac actcctagct gctgccgata
     2401 caccagatac ctcagcttat tggagccatg cccttcacag agtcccaact cagaggaaaa
     2461 gggccagtgc caaggggcac caagaacctg ctcaggaagc cttttgatgg caagatcacc
     2521 aatccagatg gtattgctcc ctcaggatgg ctctgggcct gcccctaagg gcctgtggcc
     2581 tatggaatat gtcctccagg ctttgctcag ctgagctcct cttctgtaag gaaacccagt
     2641 catccctgaa tcttgccaca gagatccggg attcaggagc tctcagtttc ttagggatgg
     2701 actatggccc agtcccccat ctaagtggtg ctttgcaaat gtcttggagg agtataggac
     2761 agaggaccaa aatacacagc aggtagtgtt agctctctgc taggagctca aagcaacaca
     2821 acttgtatca aaatcacaac tggcagagaa gctggtggat ccaatccttt cttcatctgt
     2881 tgttatttag aactcacctc tcacactctg ttctttagtg tccttacctt tatcttacca
     2941 cacacatggg tgtttctatt atccttggaa gcacagacct cgggcatccc cttattgcct
     3001 gatgggccaa caccaacagt tacggagtgc ttgagaaggg gcaagtttca cagaaatggc
     3061 cagatagggc cttcctacag agcagcaaga gtaggccaag cagaaagact gctgaggtaa
     3121 cacggacccc agcccctgtc agggcctctg ccaaggaaat aatatggacc atttacctgg
     3181 caggcagtct gctctctctc aggatcacca cgcatctcag gattggtcta aacttcaagt
     3241 ctcaaccaag tgtctgaagt gaactttgca ttgaataaat ttttgccatg gaaagaacat
     3301 caaacaagcc actcatctct acagagataa gaaaacaagt ttggcagagc aagagacaga
     3361 agaccgtgga gaaatcagaa gggggaacag tcagtttagt taaggatgga acctgggaaa
     3421 ggccaccatt cctgcttgat ggggctctga tttgctcttg ctcaagtgga ataaaacccc
     3481 atggtcttct tgacatgatt cttgatcttt tctccactga gacacactta agtgatgatc
     3541 cttacaggac tgacacccta atgccaataa aagttgctca ttatggactg ctacaaa
//
