LOCUS       NM_032603               3689 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens lysyl oxidase like 3 (LOXL3), transcript variant 1,
            mRNA.
ACCESSION   NM_032603
VERSION     NM_032603.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3689)
  AUTHORS   Jiang,Y., Zhou,L., Wang,Y., Ouyang,J., Li,S., Xiao,X., Jia,X.,
            Wang,J., Yi,Z., Sun,W., Jiao,X., Wang,P., Hejtmancik,J.F. and
            Zhang,Q.
  TITLE     The Genetic Confirmation and Clinical Characterization of
            LOXL3-Associated MYP28: A Common Type of Recessive Extreme High
            Myopia
  JOURNAL   Invest Ophthalmol Vis Sci 64 (3), 14 (2023)
   PUBMED   36917121
  REMARK    GeneRIF: The Genetic Confirmation and Clinical Characterization of
            LOXL3-Associated MYP28: A Common Type of Recessive Extreme High
            Myopia.
REFERENCE   2  (bases 1 to 3689)
  AUTHORS   Li,R., Shang,R., Li,S., Ren,Y., Shen,L., Yang,L., Chen,S., Chen,X.,
            Li,J. and Xu,M.
  TITLE     LOXL3-promoted hepatocellular carcinoma progression via promotion
            of Snail1/USP4-mediated epithelial-mesenchymal transition
  JOURNAL   Environ Toxicol 37 (10), 2540-2551 (2022)
   PUBMED   35841383
  REMARK    GeneRIF: LOXL3-promoted hepatocellular carcinoma progression via
            promotion of Snail1/USP4-mediated epithelial-mesenchymal
            transition.
REFERENCE   3  (bases 1 to 3689)
  AUTHORS   Wei,Q.
  TITLE     Apoptosis Activation and Autophagy Inhibition of Chondrocytes by
            Leptin by the Upregulation of LOXL3 in Osteoarthritis Pathogenesis
  JOURNAL   J Healthc Eng 2022, 4026128 (2022)
   PUBMED   35035830
  REMARK    GeneRIF: Apoptosis Activation and Autophagy Inhibition of
            Chondrocytes by Leptin by the Upregulation of LOXL3 in
            Osteoarthritis Pathogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3689)
  AUTHORS   Wang,N., Zhou,X., Tang,F., Wang,X. and Zhu,X.
  TITLE     Identification of LOXL3-associating immune infiltration landscape
            and prognostic value in hepatocellular carcinoma
  JOURNAL   Virchows Arch 479 (6), 1153-1165 (2021)
   PUBMED   34448895
  REMARK    GeneRIF: Identification of LOXL3-associating immune infiltration
            landscape and prognostic value in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 3689)
  AUTHORS   Laurentino,T.S., Soares,R.D.S., Lerario,A.M., Marie,S.K.N. and
            Oba-Shinjo,S.M.
  TITLE     LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma
            Cells
  JOURNAL   Int J Mol Sci 22 (15), 8072 (2021)
   PUBMED   34360836
  REMARK    GeneRIF: LOXL3 Silencing Affected Cell Adhesion and Invasion in
            U87MG Glioma Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3689)
  AUTHORS   Lee,J.E. and Kim,Y.
  TITLE     A tissue-specific variant of the human lysyl oxidase-like protein 3
            (LOXL3) functions as an amine oxidase with substrate specificity
  JOURNAL   J Biol Chem 281 (49), 37282-37290 (2006)
   PUBMED   17018530
  REMARK    GeneRIF: LOXL3 encodes two variants, LOXL3 and LOXL3-sv1, both of
            which function as amine oxidases with distinct tissue and substrate
            specificities from one another.
REFERENCE   7  (bases 1 to 3689)
  AUTHORS   Jourdan-Le Saux,C., Tomsche,A., Ujfalusi,A., Jia,L. and Csiszar,K.
  TITLE     Central nervous system, uterus, heart, and leukocyte expression of
            the LOXL3 gene, encoding a novel lysyl oxidase-like protein
  JOURNAL   Genomics 74 (2), 211-218 (2001)
   PUBMED   11386757
REFERENCE   8  (bases 1 to 3689)
  AUTHORS   Maki,J.M. and Kivirikko,K.I.
  TITLE     Cloning and characterization of a fourth human lysyl oxidase
            isoenzyme
  JOURNAL   Biochem J 355 (Pt 2), 381-387 (2001)
   PUBMED   11284725
REFERENCE   9  (bases 1 to 3689)
  AUTHORS   Huang,Y., Dai,J., Tang,R., Zhao,W., Zhou,Z., Wang,W., Ying,K.,
            Xie,Y. and Mao,Y.
  TITLE     Cloning and characterization of a human lysyl oxidase-like 3 gene
            (hLOXL3)
  JOURNAL   Matrix Biol 20 (2), 153-157 (2001)
   PUBMED   11334717
REFERENCE   10 (bases 1 to 3689)
  AUTHORS   Csiszar,K.
  TITLE     Lysyl oxidases: a novel multifunctional amine oxidase family
  JOURNAL   Prog Nucleic Acid Res Mol Biol 70, 1-32 (2001)
   PUBMED   11642359
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005033.1, AF284815.1 and
            DQ378059.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032603.4.
            
            Summary: This gene encodes a lysyl oxidase, which likely functions
            as an amine oxidase and plays a role in the formation of crosslinks
            in collagens and elastin. Deletion of the related gene in mouse
            causes neonatal mortality with cleft palate, spine deformity, and
            defects in collagen organization. A mutation in this gene was found
            in a family with Stickler syndrome. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.180973.1, AF311313.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264094.8/ ENSP00000264094.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC005033.1         95000-95005
            7-553               AF284815.1         9-555
            554-554             AC005033.1         98755-98755
            555-2809            AF284815.1         557-2811
            2810-3689           DQ378059.1         2114-2993
FEATURES             Location/Qualifiers
     source          1..3689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..3689
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /note="lysyl oxidase like 3"
                     /db_xref="GeneID:84695"
                     /db_xref="HGNC:HGNC:13869"
                     /db_xref="MIM:607163"
     exon            1..67
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            68..392
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2341
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lysyl oxidase homolog 3; lysyl oxidase-like
                     protein 3"
                     /codon_start=1
                     /product="lysyl oxidase homolog 3 isoform 1 precursor"
                     /protein_id="NP_115992.1"
                     /db_xref="CCDS:CCDS1953.1"
                     /db_xref="GeneID:84695"
                     /db_xref="HGNC:HGNC:13869"
                     /db_xref="MIM:607163"
                     /translation="MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRF
                     RLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGP
                     GTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEV
                     EHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG
                     FPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGP
                     AVVSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDR
                     KWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNIT
                     AEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDW
                     GTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTH
                     ITCKRTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSAR
                     SANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTP
                     NGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDIT
                     DVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANRR
                     FERYPGQTSNQII"
     exon            393..556
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            557..771
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            772..991
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1172
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1327
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1495
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1658
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1902
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2018
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2155
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2267
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..3689
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2795..2800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /note="hexamer: TATAAA"
     polyA_site      2823
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /note="major polyA site"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /note="hexamer: CATAAA"
     polyA_site      3077
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
     regulatory      3485..3490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /note="hexamer: AATAAA"
     polyA_site      3509
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
     regulatory      3666..3671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
                     /note="hexamer: AATAAA"
     polyA_site      3689
                     /gene="LOXL3"
                     /gene_synonym="LOXL; MYP28"
ORIGIN      
        1 gaagtcctag gactgatctc caggaccagc actcttctcc cagcccttag ggtcctgctc
       61 ggccaaggcc ttccctgcca tgcgacctgt cagtgtctgg cagtggagcc cctgggggct
      121 gctgctgtgc ctgctgtgca gttcgtgctt ggggtctccg tccccttcca cgggccctga
      181 gaagaaggcc gggagccagg ggcttcggtt ccggctggct ggcttcccca ggaagcccta
      241 cgagggccgc gtggagatac agcgagctgg tgaatggggc accatctgcg atgatgactt
      301 cacgctgcag gctgcccaca tcctctgccg ggagctgggc ttcacagagg ccacaggctg
      361 gacccacagt gccaaatatg gccctggaac aggccgcatc tggctggaca acttgagctg
      421 cagtgggacc gagcagagtg tgactgaatg tgcctcccgg ggctggggga acagtgactg
      481 tacgcacgat gaggatgctg gggtcatctg caaagaccag cgcctccctg gcttctcgga
      541 ctccaatgtc attgaggtag agcatcacct gcaagtggag gaggtgcgaa ttcgacccgc
      601 cgttgggtgg ggcagacgac ccctgcccgt gacggagggg ctggtggaag tcaggcttcc
      661 tgacggctgg tcgcaagtgt gcgacaaagg ctggagcgcc cacaacagcc acgtggtctg
      721 cgggatgctg ggcttcccca gcgaaaagag ggtcaacgcg gccttctaca ggctgctagc
      781 ccaacggcag caacactcct ttggtctgca tggggtggcg tgcgtgggca cggaggccca
      841 cctctccctc tgttccctgg agttctatcg tgccaatgac accgccaggt gccctggggg
      901 gggccctgca gtggtgagct gtgtgccagg ccctgtctac gcggcatcca gtggccagaa
      961 gaagcaacaa cagtcgaagc ctcaggggga ggcccgtgtc cgtctaaagg gcggcgccca
     1021 ccctggagag ggccgggtag aagtcctgaa ggccagcaca tggggcacag tctgtgaccg
     1081 caagtgggac ctgcatgcag ccagcgtggt gtgtcgggag ctgggcttcg ggagtgctcg
     1141 agaagctctg agtggcgctc gcatggggca gggcatgggt gctatccacc tgagtgaagt
     1201 tcgctgctct ggacaggagc tctccctctg gaagtgcccc cacaagaaca tcacagctga
     1261 ggattgttca catagccagg atgccggggt ccggtgcaac ctaccttaca ctggggcaga
     1321 gaccaggatc cgactcagtg ggggccgcag ccaacatgag gggcgagtcg aggtgcaaat
     1381 agggggacct gggccccttc gctggggcct catctgtggg gatgactggg ggaccctgga
     1441 ggccatggtg gcctgtaggc aactgggtct gggctacgcc aaccacggcc tgcaggagac
     1501 ctggtactgg gactctggga atataacaga ggtggtgatg agtggagtgc gctgcacagg
     1561 gactgagctg tccctggatc agtgtgccca tcatggcacc cacatcacct gcaagaggac
     1621 agggacccgc ttcactgctg gagtcatctg ttctgagact gcatcagatc tgttgctgca
     1681 ctcagcactg gtgcaggaga ccgcctacat cgaagaccgg cccctgcata tgttgtactg
     1741 tgctgcggaa gagaactgcc tggccagctc agcccgctca gccaactggc cctatggtca
     1801 ccggcgtctg ctccgattct cctcccagat ccacaacctg ggacgagctg acttcaggcc
     1861 caaggctggg cgccactcct gggtgtggca cgagtgccat gggcattacc acagcatgga
     1921 catcttcact cactatgata tcctcacccc aaatggcacc aaggtggctg agggccacaa
     1981 agctagtttc tgtctcgaag acactgagtg tcaggaggat gtctccaagc ggtatgagtg
     2041 tgccaacttt ggagagcaag gcatcactgt gggttgctgg gatctctacc ggcatgacat
     2101 tgactgtcag tggattgaca tcacggatgt gaagccagga aactacattc tccaggttgt
     2161 catcaaccca aactttgaag tagcagagag tgactttacc aacaatgcaa tgaaatgtaa
     2221 ctgcaaatat gatggacata gaatctgggt gcacaactgc cacattggtg atgccttcag
     2281 tgaagaggcc aacaggaggt ttgaacgcta ccctggccag accagcaacc agattatcta
     2341 agtgccactg ccctctgcaa accaccactg gcccctaatg gcaggggtct gaggctgcca
     2401 ttacctcagg agcttaccaa gaaacccatg tcagcaaccg cactcatcag accatgcact
     2461 atggatgtgg aactgtcaag cagaagtttt caccctcctt cagaggccag ctgtcagtat
     2521 ctgtagccaa gcatgggaat ctttgctccc aggcccagca ccgagcagaa cagaccagag
     2581 cccaccacac cacaaagagc agcacctgac taactgccca caaaagatgg cagcagctca
     2641 ttttctttaa taggaggtca ggatggtcag ctccagtatc tcccctaagt ttagggggat
     2701 acagctttac ctctagcctt ttggtggggg aaaagatcca gccctcccac ctcatttttt
     2761 actataatat gttgctaggt ataattttat tttatataaa aagtgtttct gtgattcttc
     2821 agagcccagg agtcagtgct ggtggttgga gggacctgcc cccactggtt catttaaccc
     2881 tctgtctcgg tgccctcaga acctcagcca gaaaggcaag gaggaaatca gagcaggagc
     2941 ctcatactct tggtgatcta ttcattctgt gacctcaggg gtcacatata aggtcagtgt
     3001 ttctcgtccc cgccggatct gcactgccaa ctgggattgg gttcgaacag cttcataaac
     3061 atcttcagca ttttgtacca tctgctcccc aatggccaaa atcacatcac caggccgcag
     3121 accagcccta tagagaaaaa tggacagaga gaaaggaagg agtacaaagc ctagttcaag
     3181 gacacatgca caccttgccc atccccatat cacactgcag cctctccctc accggtgtgc
     3241 aggggagccc aggatgactt tatggatgag tacaccatgc tgaacatcgg gaaagcttgg
     3301 ttctcgaagc tgtagttcag caaggatgct gaaagtacac agatcaccct attagccaaa
     3361 cccaggcatt ctccccatcc tgagttccac ctcaagtctc tcatcaacac attgataaat
     3421 atatggacag gacatgggct aggtactaca aaatacaatg gcaactcact ttctgtcttc
     3481 tagcaataaa gtgcaacatg tacataaaag atgtacacca catgagggca ccaaatgaca
     3541 aacagtgtta aatcaatagc actaatgtca ttctagaata ctaagagaag ctttaagggg
     3601 aaagaactta agttgagcct aaaaggatgg atctgatatt aaccatataa aacaagaaca
     3661 gcataaataa aaaacatggg agtaggaaa
//
