LOCUS       NM_002318               3721 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens lysyl oxidase like 2 (LOXL2), mRNA.
ACCESSION   NM_002318
VERSION     NM_002318.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3721)
  AUTHORS   Hayashi,Y., Miyoshi,S., Watanabe,I., Yano,N., Nagashio,K.,
            Kaneko,M., Kaminota,T., Sanada,T., Hosokawa,Y., Kitani,T.,
            Mitani,S., Choudhury,M.E., Yano,H., Tanaka,J. and Hato,N.
  TITLE     Simultaneous disturbance of NHE1 and LOXL2 decreases tumorigenicity
            of head and neck squamous cell carcinoma
  JOURNAL   Auris Nasus Larynx 51 (3), 472-480 (2024)
   PUBMED   38520980
  REMARK    GeneRIF: Simultaneous disturbance of NHE1 and LOXL2 decreases
            tumorigenicity of head and neck squamous cell carcinoma.
REFERENCE   2  (bases 1 to 3721)
  AUTHORS   Serra-Bardenys,G., Blanco,E., Escudero-Iriarte,C.,
            Serra-Camprubi,Q., Querol,J., Pascual-Reguant,L., Morancho,B.,
            Escorihuela,M., Tissera,N.S., Sabe,A., Martin,L., Segura-Bayona,S.,
            Verde,G., Aiese Cigliano,R., Millanes-Romero,A., Jeronimo,C.,
            Cebria-Costa,J.P., Nuciforo,P., Simonetti,S., Viaplana,C.,
            Dienstmann,R., Oliveira,M., Peg,V., Stracker,T.H., Arribas,J.,
            Canals,F., Villanueva,J., Di Croce,L., Garcia de Herreros,A.,
            Tian,T.V. and Peiro,S.
  TITLE     LOXL2-mediated chromatin compaction is required to maintain the
            oncogenic properties of triple-negative breast cancer cells
  JOURNAL   FEBS J 291 (11), 2423-2448 (2024)
   PUBMED   38451841
  REMARK    GeneRIF: LOXL2-mediated chromatin compaction is required to
            maintain the oncogenic properties of triple-negative breast cancer
            cells.
REFERENCE   3  (bases 1 to 3721)
  AUTHORS   Wang,Y., Chen,Y., Yang,F., Yu,X., Chu,Y., Zhou,J., Yan,Y. and Xi,J.
  TITLE     MiR-4465-modified mesenchymal stem cell-derived small extracellular
            vesicles inhibit liver fibrosis development via targeting LOXL2
            expression
  JOURNAL   J Zhejiang Univ Sci B 25 (7), 594-604 (2024)
   PUBMED   39011679
  REMARK    GeneRIF: MiR-4465-modified mesenchymal stem cell-derived small
            extracellular vesicles inhibit liver fibrosis development via
            targeting LOXL2 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3721)
  AUTHORS   Lee,Y.S., Kim,H.S., Kim,H.J., Kang,H.W., Lee,D.E., Kim,M.J.,
            Hong,W.C., Kim,J.H., Kim,M., Cheong,J.H. and Park,J.S.
  TITLE     The role of LOXL2 induced by glucose metabolism-activated NF-kappaB
            in maintaining drug resistance through EMT and cancer stemness in
            gemcitabine-resistant PDAC
  JOURNAL   J Mol Med (Berl) 101 (11), 1449-1464 (2023)
   PUBMED   37737908
  REMARK    GeneRIF: The role of LOXL2 induced by glucose metabolism-activated
            NF-kappaB in maintaining drug resistance through EMT and cancer
            stemness in gemcitabine-resistant PDAC.
REFERENCE   5  (bases 1 to 3721)
  AUTHORS   Radic,J., Kozik,B., Nikolic,I., Kolarov-Bjelobrk,I., Vasiljevic,T.,
            Vranjkovic,B. and Despotovic,S.
  TITLE     Multiple Roles of LOXL2 in the Progression of Hepatocellular
            Carcinoma and Its Potential for Therapeutic Targeting
  JOURNAL   Int J Mol Sci 24 (14), 11745 (2023)
   PUBMED   37511503
  REMARK    GeneRIF: Multiple Roles of LOXL2 in the Progression of
            Hepatocellular Carcinoma and Its Potential for Therapeutic
            Targeting.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3721)
  AUTHORS   Hein,S., Yamamoto,S.Y., Okazaki,K., Jourdan-LeSaux,C., Csiszar,K.
            and Bryant-Greenwood,G.D.
  TITLE     Lysyl oxidases: expression in the fetal membranes and placenta
  JOURNAL   Placenta 22 (1), 49-57 (2001)
   PUBMED   11162352
REFERENCE   7  (bases 1 to 3721)
  AUTHORS   Csiszar,K.
  TITLE     Lysyl oxidases: a novel multifunctional amine oxidase family
  JOURNAL   Prog Nucleic Acid Res Mol Biol 70, 1-32 (2001)
   PUBMED   11642359
  REMARK    Review article
REFERENCE   8  (bases 1 to 3721)
  AUTHORS   Jourdan-Le Saux,C., Tronecker,H., Bogic,L., Bryant-Greenwood,G.D.,
            Boyd,C.D. and Csiszar,K.
  TITLE     The LOXL2 gene encodes a new lysyl oxidase-like protein and is
            expressed at high levels in reproductive tissues
  JOURNAL   J Biol Chem 274 (18), 12939-12944 (1999)
   PUBMED   10212285
REFERENCE   9  (bases 1 to 3721)
  AUTHORS   Jourdan-Le Saux,C., Le Saux,O., Donlon,T., Boyd,C.D. and Csiszar,K.
  TITLE     The human lysyl oxidase-related gene (LOXL2) maps between markers
            D8S280 and D8S278 on chromosome 8p21.2-p21.3
  JOURNAL   Genomics 51 (2), 305-307 (1998)
   PUBMED   9722957
REFERENCE   10 (bases 1 to 3721)
  AUTHORS   Saito,H., Papaconstantinou,J., Sato,H. and Goldstein,S.
  TITLE     Regulation of a novel gene encoding a lysyl oxidase-related protein
            in cellular adhesion and senescence
  JOURNAL   J Biol Chem 272 (13), 8157-8160 (1997)
   PUBMED   9079631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104561.3, U89942.1,
            BC020481.1 and AC090197.23.
            
            On May 17, 2019 this sequence version replaced NM_002318.2.
            
            Summary: This gene encodes a member of the lysyl oxidase gene
            family. The prototypic member of the family is essential to the
            biogenesis of connective tissue, encoding an extracellular
            copper-dependent amine oxidase that catalyses the first step in the
            formation of crosslinks in collagens and elastin. A highly
            conserved amino acid sequence at the C-terminus end appears to be
            sufficient for amine oxidase activity, suggesting that each family
            member may retain this function. The N-terminus is poorly conserved
            and may impart additional roles in developmental regulation,
            senescence, tumor suppression, cell growth control, and chemotaxis
            to each member of the family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222477.1, AK312266.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389131.8/ ENSP00000373783.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC104561.3         121143-121145
            4-555               U89942.1           1-552
            556-1552            BC020481.1         565-1561
            1553-2793           U89942.1           1550-2790
            2794-3721           AC090197.23        103046-103973       c
FEATURES             Location/Qualifiers
     source          1..3721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..3721
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /note="lysyl oxidase like 2"
                     /db_xref="GeneID:4017"
                     /db_xref="HGNC:HGNC:6666"
                     /db_xref="MIM:606663"
     exon            1..167
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            168..605
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..2575
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /EC_number="1.4.3.-"
                     /note="lysyl oxidase related 2; lysyl oxidase homolog 2;
                     lysyl oxidase-related protein 2; lysyl oxidase-related
                     protein WS9-14; lysyl oxidase-like protein 2; lysyl
                     oxidase-like 2 delta e13; lysyl oxidase-like 2 protein"
                     /codon_start=1
                     /product="lysyl oxidase homolog 2 precursor"
                     /protein_id="NP_002309.1"
                     /db_xref="CCDS:CCDS34864.1"
                     /db_xref="GeneID:4017"
                     /db_xref="HGNC:HGNC:6666"
                     /db_xref="MIM:606663"
                     /translation="MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEY
                     HQPQAPANVAKIQLRLAGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGY
                     VEAKSWTASSSYGKGEGPIWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSD
                     KRIPGFKFDNSLINQIENLNIQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQIC
                     DKHWTAKNSRVVCGMFGFPGERTYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCK
                     LGPQVSLDPMKNVTCENGLPAVVSCVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYI
                     GEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGSAKEAVTGSRLGQGIGPIHLNE
                     IQCTGNEKSIIDCKFNAESQGCNHEEDAGVRCNTPAMGLQKKLRLNGGRNPYEGRVEV
                     LVERNGSLVWGMVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGDVNSNKVVMSG
                     VKCSGTELSLAHCRHDGEDVACPQGGVQYGAGVACSETAPDLVLNAEMVQQTTYLEDR
                     PMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHD
                     CHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKNYECANFGDQGIT
                     MGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEVAESDYSNNIMKCRSRYDGHR
                     IWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ"
     exon            606..781
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            782..993
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1216
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1400
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1552
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1720
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1886
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2130
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2246
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2383
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2495
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..3721
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3422..3427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /note="hexamer: AAGAAA"
     polyA_site      3438
                     /gene="LOXL2"
                     /gene_synonym="LOR; LOR2; WS9-14"
                     /note="major polyA site"
ORIGIN      
        1 gcgactccag cgcgcggcta cctacgcttg gtgcttgctt tctccagcca tcggagacca
       61 gagccgcccc ctctgctcga gaaaggggct cagcggcggc ggaagcggag ggggaccacc
      121 gtggagagcg cggtcccagc ccggccactg cggatccctg aaaccaaaaa gctcctgctg
      181 cttctgtacc ccgcctgtcc ctcccagctg cgcagggccc cttcgtggga tcatcagccc
      241 gaagacaggg atggagaggc ctctgtgctc ccacctctgc agctgcctgg ctatgctggc
      301 cctcctgtcc cccctgagcc tggcacagta tgacagctgg ccccattacc ccgagtactt
      361 ccagcaaccg gctcctgagt atcaccagcc ccaggccccc gccaacgtgg ccaagattca
      421 gctgcgcctg gctgggcaga agaggaagca cagcgagggc cgggtggagg tgtactatga
      481 tggccagtgg ggcaccgtgt gcgatgacga cttctccatc cacgctgccc acgtcgtctg
      541 ccgggagctg ggctacgtgg aggccaagtc ctggactgcc agctcctcct acggcaaggg
      601 agaagggccc atctggttag acaatctcca ctgtactggc aacgaggcga cccttgcagc
      661 atgcacctcc aatggctggg gcgtcactga ctgcaagcac acggaggatg tcggtgtggt
      721 gtgcagcgac aaaaggattc ctgggttcaa atttgacaat tcgttgatca accagataga
      781 gaacctgaat atccaggtgg aggacattcg gattcgagcc atcctctcaa cctaccgcaa
      841 gcgcacccca gtgatggagg gctacgtgga ggtgaaggag ggcaagacct ggaagcagat
      901 ctgtgacaag cactggacgg ccaagaattc ccgcgtggtc tgcggcatgt ttggcttccc
      961 tggggagagg acatacaata ccaaagtgta caaaatgttt gcctcacgga ggaagcagcg
     1021 ctactggcca ttctccatgg actgcaccgg cacagaggcc cacatctcca gctgcaagct
     1081 gggcccccag gtgtcactgg accccatgaa gaatgtcacc tgcgagaatg ggctaccggc
     1141 cgtggtgagt tgtgtgcctg ggcaggtctt cagccctgac ggaccctcaa gattccggaa
     1201 agcgtacaag ccagagcaac ccctggtgcg actgagaggc ggtgcctaca tcggggaggg
     1261 ccgcgtggag gtgctcaaaa atggagaatg ggggaccgtc tgcgacgaca agtgggacct
     1321 ggtgtcggcc agtgtggtct gcagagagct gggctttggg agtgccaaag aggcagtcac
     1381 tggctcccga ctggggcaag ggatcggacc catccacctc aacgagatcc agtgcacagg
     1441 caatgagaag tccattatag actgcaagtt caatgccgag tctcagggct gcaaccacga
     1501 ggaggatgct ggtgtgagat gcaacacccc tgccatgggc ttgcagaaga agctgcgcct
     1561 gaacggcggc cgcaatccct acgagggccg agtggaggtg ctggtggaga gaaacgggtc
     1621 ccttgtgtgg gggatggtgt gtggccaaaa ctggggcatc gtggaggcca tggtggtctg
     1681 ccgccagctg ggcctgggat tcgccagcaa cgccttccag gagacctggt attggcacgg
     1741 agatgtcaac agcaacaaag tggtcatgag tggagtgaag tgctcgggaa cggagctgtc
     1801 cctggcgcac tgccgccacg acggggagga cgtggcctgc ccccagggcg gagtgcagta
     1861 cggggccgga gttgcctgct cagaaaccgc ccctgacctg gtcctcaatg cggagatggt
     1921 gcagcagacc acctacctgg aggaccggcc catgttcatg ctgcagtgtg ccatggagga
     1981 gaactgcctc tcggcctcag ccgcgcagac cgaccccacc acgggctacc gccggctcct
     2041 gcgcttctcc tcccagatcc acaacaatgg ccagtccgac ttccggccca agaacggccg
     2101 ccacgcgtgg atctggcacg actgtcacag gcactaccac agcatggagg tgttcaccca
     2161 ctatgacctg ctgaacctca atggcaccaa ggtggcagag ggccacaagg ccagcttctg
     2221 cttggaggac acagaatgtg aaggagacat ccagaagaat tacgagtgtg ccaacttcgg
     2281 cgatcagggc atcaccatgg gctgctggga catgtaccgc catgacatcg actgccagtg
     2341 ggttgacatc actgacgtgc cccctggaga ctacctgttc caggttgtta ttaaccccaa
     2401 cttcgaggtt gcagaatccg attactccaa caacatcatg aaatgcagga gccgctatga
     2461 cggccaccgc atctggatgt acaactgcca cataggtggt tccttcagcg aagagacgga
     2521 aaaaaagttt gagcacttca gcgggctctt aaacaaccag ctgtccccgc agtaaagaag
     2581 cctgcgtggt caactcctgt cttcaggcca caccacatct tccatgggac ttccccccaa
     2641 caactgagtc tgaacgaatg ccacgtgccc tcacccagcc cggcccccac cctgtccaga
     2701 cccctacagc tgtgtctaag ctcaggagga aagggaccct cccatcattc atggggggct
     2761 gctacctgac ccttggggcc tgagaaggcc ttgcgggggt ggggtttgtc cacagagctg
     2821 ctggagcagc accaagagcc agtcttgacc gggatgaggc ccacagacag gttgtcatca
     2881 gcttgtccca ttcaagccac cgagctcacc acagacacag tggagccgcg ctcttctcca
     2941 gtgacacgtg gacaaatgcg ggctcatcag cccccccaga gagggtcagg ccgaacccca
     3001 tttctcctcc tcttaggtca ttttcagcaa acttgaatat ctagacctct cttccaatga
     3061 aaccctccag tctattatag tcacatagat aatggtgcca cgtgttttct gatttggtga
     3121 gctcagactt ggtgcttccc tatccacagc ccccacccct tgtttttcaa gatactatta
     3181 ttatattttc acagactttt gaagcacaaa tttattggca tttaatattg gacatctggg
     3241 cccttggaag tacaaatcta aggaaaaacc aacccactgt gtaagtgact catcttcctg
     3301 ttgttccaat tctgtgggtt tttgattcaa cggtgctata accagggtcc tgggtgacag
     3361 ggcgctcact gagcaccatg tgtcatcaca gacacttaca catacttgaa acttggaata
     3421 aaagaaagat ttatgaaacg tgtctgtgtt tcctttgacc cacagcacct gggccctgag
     3481 cagcaggctt cctatgttca gtggccagaa gcagagcttc aggtacattc gtggttttct
     3541 ccggtggaca tgggtcctca gatcccctcc agcccagtgt ggccaccagg gcacctcctt
     3601 caatagactc caaaaggggc agctcctacc atctgggaga agcaatctaa ggagatcaca
     3661 aaaagtaacg gaacaggagt cataatcttt cttgaactcc tgtggttttt actgaaactt
     3721 g
//
