LOCUS       NM_005576               2346 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lysyl oxidase like 1 (LOXL1), mRNA.
ACCESSION   NM_005576 XM_942281 XM_945877
VERSION     NM_005576.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2346)
  AUTHORS   Zhang,N., Yang,A., Zhang,W., Li,H., Xu,A., Yan,X., Han,Q., Wang,B.,
            You,H. and Chen,W.
  TITLE     Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their
            half-lives and regulates liver fibrosis through Notch signal
  JOURNAL   Hepatol Commun 8 (4), e0391 (2024)
   PUBMED   38466882
  REMARK    GeneRIF: Crosstalk of lysyl oxidase-like 1 and lysyl oxidase
            prolongs their half-lives and regulates liver fibrosis through
            Notch signal.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2346)
  AUTHORS   Li,C., Chen,S., Fang,X., Du,Y., Guan,X.Y., Lin,R., Xu,L., Lan,P.
            and Yan,Q.
  TITLE     LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell
            infiltration in colorectal cancer
  JOURNAL   Cell Biol Toxicol 40 (1), 6 (2024)
   PUBMED   38267662
  REMARK    GeneRIF: LOXL1 promotes tumor cell malignancy and restricts CD8 + T
            cell infiltration in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2346)
  AUTHORS   Hu,J., Liu,X., Xu,Q., Zhu,M., Wang,S., Quan,K., Dai,M., Mo,F. and
            Zhan,H.
  TITLE     Mechanism of lysine oxidase-like 1 promoting synovial inflammation
            mediating rheumatoid arthritis development
  JOURNAL   Aging (Albany NY) 16 (1), 928-947 (2024)
   PUBMED   38217541
  REMARK    GeneRIF: Mechanism of lysine oxidase-like 1 promoting synovial
            inflammation mediating rheumatoid arthritis development.
REFERENCE   4  (bases 1 to 2346)
  AUTHORS   Huntzinger,E., Sinteff,J., Morlet,B. and Seraphin,B.
  TITLE     HELZ2: a new, interferon-regulated, human 3'-5' exoribonuclease of
            the RNB family is expressed from a non-canonical initiation codon
  JOURNAL   Nucleic Acids Res 51 (17), 9279-9293 (2023)
   PUBMED   37602378
REFERENCE   5  (bases 1 to 2346)
  AUTHORS   Wiggs,J.L. and Pasquale,L.R.
  TITLE     Expression and regulation of LOXL1 and elastin-related genes in
            eyes with exfoliation syndrome
  JOURNAL   J Glaucoma 23 (8 Suppl 1), S62-S63 (2014)
   PUBMED   25275910
  REMARK    GeneRIF: Collectively, these results suggest that dysregulation of
            LOXL1 expression is a contributing factor to exfoliation disease
            development.
            Review article
REFERENCE   6  (bases 1 to 2346)
  AUTHORS   Kagan,H.M. and Li,W.
  TITLE     Lysyl oxidase: properties, specificity, and biological roles inside
            and outside of the cell
  JOURNAL   J Cell Biochem 88 (4), 660-672 (2003)
   PUBMED   12577300
  REMARK    GeneRIF: comparison and aa sequence alignment of human and rat
            lysyl oxidase and human LOXL1
            Review article
REFERENCE   7  (bases 1 to 2346)
  AUTHORS   Csiszar,K.
  TITLE     Lysyl oxidases: a novel multifunctional amine oxidase family
  JOURNAL   Prog Nucleic Acid Res Mol Biol 70, 1-32 (2001)
   PUBMED   11642359
  REMARK    Review article
REFERENCE   8  (bases 1 to 2346)
  AUTHORS   Goy,A., Gilles,F., Remache,Y. and Zelenetz,A.D.
  TITLE     Physical linkage of the lysyl oxidase-like (LOXL1) gene to the PML
            gene on human chromosome 15q22
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 22-24 (2000)
   PUBMED   10773658
REFERENCE   9  (bases 1 to 2346)
  AUTHORS   Kim,Y., Boyd,C.D. and Csiszar,K.
  TITLE     A new gene with sequence and structural similarity to the gene
            encoding human lysyl oxidase
  JOURNAL   J Biol Chem 270 (13), 7176-7182 (1995)
   PUBMED   7706256
REFERENCE   10 (bases 1 to 2346)
  AUTHORS   Kenyon,K., Modi,W.S., Contente,S. and Friedman,R.M.
  TITLE     A novel human cDNA with a predicted protein similar to lysyl
            oxidase maps to chromosome 15q24-q25
  JOURNAL   J Biol Chem 268 (25), 18435-18437 (1993)
   PUBMED   7689553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC068542.1, BC015090.2 and
            BE205920.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005576.3.
            
            Summary: This gene encodes a member of the lysyl oxidase family of
            proteins. The prototypic member of the family is essential to the
            biogenesis of connective tissue, encoding an extracellular
            copper-dependent amine oxidase that catalyzes the first step in the
            formation of crosslinks in collagen and elastin. The encoded
            preproprotein is proteolytically processed to generate the mature
            enzyme. A highly conserved amino acid sequence at the C-terminus
            end appears to be sufficient for amine oxidase activity, suggesting
            that each family member may retain this function. The N-terminus is
            poorly conserved and may impart additional roles in developmental
            regulation, senescence, tumor suppression, cell growth control, and
            chemotaxis to each member of the family. Mutations in this gene are
            associated with exfoliation syndrome. [provided by RefSeq, Jan
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015090.2, BC068542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261921.8/ ENSP00000261921.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-779               BC068542.1         5-783
            780-2146            BC015090.2         763-2129
            2147-2346           BE205920.1         2-201               c
FEATURES             Location/Qualifiers
     source          1..2346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2346
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /note="lysyl oxidase like 1"
                     /db_xref="GeneID:4016"
                     /db_xref="HGNC:HGNC:6665"
                     /db_xref="MIM:153456"
     exon            1..1424
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2047
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /note="lysyl oxidase homolog 1; lysyl oxidase-like protein
                     1"
                     /codon_start=1
                     /product="lysyl oxidase homolog 1 preproprotein"
                     /protein_id="NP_005567.2"
                     /db_xref="CCDS:CCDS10253.1"
                     /db_xref="GeneID:4016"
                     /db_xref="HGNC:HGNC:6665"
                     /db_xref="MIM:153456"
                     /translation="MALARGSRQLGALVWGACLCVLVHGQQAQPGQGSDPARWRQLIQ
                     WENNGQVYSLLNSGSEYVPAGPQRSESSSRVLLAGAPQAQQRRSHGSPRRRQAPSLPL
                     PGRVGSDTVRGQARHPFGFGQVPDNWREVAVGDSTGMARARTSVSQQRHGGSASSVSA
                     SAFASTYRQQPSYPQQFPYPQAPFVSQYENYDPASRTYDQGFVYYRPAGGGVGAGAAA
                     VASAGVIYPYQPRARYEEYGGGEELPEYPPQGFYPAPERPYVPPPPPPPDGLDRRYSH
                     SLYSEGTPGFEQAYPDPGPEAAQAHGGDPRLGWYPPYANPPPEAYGPPRALEPPYLPV
                     RSSDTPPPGGERNGAQQGRLSVGSVYRPNQNGRGLPDLVPDPNYVQASTYVQRAHLYS
                     LRCAAEEKCLASTAYAPEATDYDVRVLLRFPQRVKNQGTADFLPNRPRHTWEWHSCHQ
                     HYHSMDEFSHYDLLDAATGKKVAEGHKASFCLEDSTCDFGNLKRYACTSHTQGLSPGC
                     YDTYNADIDCQWIDITDVQPGNYILKVHVNPKYIVLESDFTNNVVRCNIHYTGRYVSA
                     TNCKIVQS"
     exon            1425..1533
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1671
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1828
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1924
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2040
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2346
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2327..2332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /note="hexamer: AATAAA"
     polyA_site      2346
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /note="major polyA site"
ORIGIN      
        1 attcagagtg ggaaagcgcc agccgagcgg ccagccagtg cggggctggc catgtaaggc
       61 ccacaggcgg tcctgcccgc ccggtgccct gcggagagcc tcgtgcagcc ctgggcaccg
      121 cccctgccct gccctgaccc cttggccttg aaatgctgtc atcggaggag ccgtcccgct
      181 cgggacaagg ccagcatgga caaagctaga gctggggcaa gcaaggagcc ttcctgtcct
      241 cgaggccgtg ggaagagaag cacgcccagg gggccactcc tgagagcctc tctgtccacc
      301 aggcctctgc agaggggtca ccatggctct ggcccgaggc agccggcagc tgggggccct
      361 ggtgtggggc gcctgcctgt gcgtgctggt gcacgggcag caggcgcagc ccgggcaggg
      421 ctcggacccc gcccgctggc ggcagctgat ccagtgggag aacaacgggc aggtgtacag
      481 cttgctcaac tcgggctcag agtacgtgcc ggccggacct cagcgctccg agagtagctc
      541 ccgggtgctg ctggccggcg cgccccaggc ccagcagcgg cgcagccacg ggagcccccg
      601 gcgtcggcag gcgccgtccc tgcccctgcc ggggcgcgtg ggctcggaca ccgtgcgcgg
      661 ccaggcgcgg cacccattcg gctttggcca ggtgcccgac aactggcgcg aggtggccgt
      721 cggggacagc acgggcatgg cccgggcccg cacctccgtc tcccagcaac ggcacggggg
      781 ctccgcctcc tcggtctcgg cttcggcctt cgccagcacc taccgccagc agccctccta
      841 cccgcagcag ttcccctacc cgcaggcgcc cttcgtcagc cagtacgaga actacgaccc
      901 cgcgtcgcgg acctacgacc agggtttcgt gtactaccgg cccgcgggcg gcggcgtggg
      961 cgcgggggcg gcggccgtgg cctcggcggg ggtcatctac ccctaccagc cccgggcgcg
     1021 ctacgaggag tacggcggcg gcgaagagct gcccgagtac ccgcctcagg gcttctaccc
     1081 ggcccccgag aggccctacg tgccgccgcc gccgccgccc cccgacggcc tggaccgccg
     1141 ctactcgcac agtctgtaca gcgagggcac ccccggcttc gagcaggcct accctgaccc
     1201 cggtcccgag gcggcgcagg cccatggcgg agacccacgc ctgggctggt acccgcccta
     1261 cgccaacccg ccgcccgagg cgtacgggcc gccgcgcgcg ctggagccgc cctacctgcc
     1321 ggtgcgcagc tccgacacgc ccccgccggg tggggagcgg aacggcgcgc agcagggccg
     1381 cctcagcgtg ggcagcgtgt accggcccaa ccagaacggc cgcggtctcc ctgacttggt
     1441 cccagacccc aactatgtgc aagcatccac ttatgtgcag agagcccacc tgtactccct
     1501 gcgctgtgct gcggaggaga agtgtctggc cagcacagcc tatgcccctg aggccaccga
     1561 ctacgatgtg cgggtgctac tgcgcttccc ccagcgcgtg aagaaccagg gcacagcaga
     1621 cttcctcccc aaccggccac ggcacacctg ggagtggcac agctgccacc agcattacca
     1681 cagcatggac gagttcagcc actacgacct actggatgca gccacaggca agaaggtggc
     1741 cgagggccac aaggccagtt tctgcctgga ggacagcacc tgtgacttcg gcaacctcaa
     1801 gcgctatgca tgcacctctc atacccaggg cctgagccca ggctgctatg acacctacaa
     1861 tgcggacatc gactgccagt ggatcgacat aaccgacgtg cagcctggga actacatcct
     1921 caaggtgcac gtgaacccaa agtatattgt tttggagtct gacttcacca acaacgtggt
     1981 gagatgcaac attcactaca caggtcgcta cgtttctgca acaaactgca aaattgtcca
     2041 atcctgatct ccgggaggga cagatggcca atctctcccc ttccaaagca ggccctgctc
     2101 cccgggcagc ctcccgccga ggggcccagc ccccaaccca caggcacgga ggggcatccc
     2161 tccctgccgg cctcagggag cgaacgtgga tgaaaaccac agggattccg gacgccagac
     2221 cccattttat acttcacttt tctctacagt gttgttttgt tgttgttggt ttttattttt
     2281 tatactttgg ccataccaca gagctagatt gcccaggtct gggctgaata aaacaaggtt
     2341 tttcta
//
