LOCUS       NM_002317               5076 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens lysyl oxidase (LOX), transcript variant 1, mRNA.
ACCESSION   NM_002317
VERSION     NM_002317.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5076)
  AUTHORS   Zhang,Y., Zhang,Y., He,S. and Wang,W.
  TITLE     Lysyl oxidase-mediated elastin upregulation promotes the
            proliferation and migration of human retinal endothelial cells
  JOURNAL   Adv Clin Exp Med 33 (6), 641-651 (2024)
   PUBMED   38353503
  REMARK    GeneRIF: Lysyl oxidase-mediated elastin upregulation promotes the
            proliferation and migration of human retinal endothelial cells.
REFERENCE   2  (bases 1 to 5076)
  AUTHORS   Lewinska,M., Zhuravleva,E., Satriano,L., Martinez,M.B., Bhatt,D.K.,
            Oliveira,D.V.N.P., Antoku,Y., Keggenhoff,F.L., Castven,D.,
            Marquardt,J.U., Matter,M.S., Erler,J.T., Oliveira,R.C.,
            Aldana,B.I., Al-Abdulla,R., Perugorria,M.J., Calvisi,D.F.,
            Perez,L.A., Rodrigues,P.M., Labiano,I., Banales,J.M. and
            Andersen,J.B.
  TITLE     Fibroblast-Derived Lysyl Oxidase Increases Oxidative
            Phosphorylation and Stemness in Cholangiocarcinoma
  JOURNAL   Gastroenterology 166 (5), 886-901 (2024)
   PUBMED   38096955
  REMARK    GeneRIF: Fibroblast-Derived Lysyl Oxidase Increases Oxidative
            Phosphorylation and Stemness in Cholangiocarcinoma.
REFERENCE   3  (bases 1 to 5076)
  AUTHORS   Zhang,N., Yang,A., Zhang,W., Li,H., Xu,A., Yan,X., Han,Q., Wang,B.,
            You,H. and Chen,W.
  TITLE     Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their
            half-lives and regulates liver fibrosis through Notch signal
  JOURNAL   Hepatol Commun 8 (4), e0391 (2024)
   PUBMED   38466882
  REMARK    GeneRIF: Crosstalk of lysyl oxidase-like 1 and lysyl oxidase
            prolongs their half-lives and regulates liver fibrosis through
            Notch signal.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5076)
  AUTHORS   Yao,X., Liu,Y., Jiao,H., Ma,W. and Chen,M.
  TITLE     Association of LOX gene G473A polymorphism with the occurrence of
            allergic rhinitis and efficacy of montelukast sodium in children
  JOURNAL   Cell Cycle 22 (20), 2280-2287 (2023)
   PUBMED   38009683
  REMARK    GeneRIF: Association of LOX gene G473A polymorphism with the
            occurrence of allergic rhinitis and efficacy of montelukast sodium
            in children.
REFERENCE   5  (bases 1 to 5076)
  AUTHORS   Barker,H.E., Cox,T.R. and Erler,J.T.
  TITLE     The rationale for targeting the LOX family in cancer
  JOURNAL   Nat Rev Cancer 12 (8), 540-552 (2012)
   PUBMED   22810810
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5076)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   7  (bases 1 to 5076)
  AUTHORS   Svinarich,D.M., Twomey,T.A., Macauley,S.P., Krebs,C.J., Yang,T.P.
            and Krawetz,S.A.
  TITLE     Characterization of the human lysyl oxidase gene locus
  JOURNAL   J Biol Chem 267 (20), 14382-14387 (1992)
   PUBMED   1352776
REFERENCE   8  (bases 1 to 5076)
  AUTHORS   Mariani,T.J., Trackman,P.C., Kagan,H.M., Eddy,R.L., Shows,T.B.,
            Boyd,C.D. and Deak,S.B.
  TITLE     The complete derived amino acid sequence of human lysyl oxidase and
            assignment of the gene to chromosome 5 (extensive sequence homology
            with the murine ras recision gene)
  JOURNAL   Matrix 12 (3), 242-248 (1992)
   PUBMED   1357535
REFERENCE   9  (bases 1 to 5076)
  AUTHORS   Murawaki,Y., Kusakabe,Y. and Hirayama,C.
  TITLE     Serum lysyl oxidase activity in chronic liver disease in comparison
            with serum levels of prolyl hydroxylase and laminin
  JOURNAL   Hepatology 14 (6), 1167-1173 (1991)
   PUBMED   1683640
REFERENCE   10 (bases 1 to 5076)
  AUTHORS   Hamalainen,E.R., Jones,T.A., Sheer,D., Taskinen,K., Pihlajaniemi,T.
            and Kivirikko,K.I.
  TITLE     Molecular cloning of human lysyl oxidase and assignment of the gene
            to chromosome 5q23.3-31.2
  JOURNAL   Genomics 11 (3), 508-516 (1991)
   PUBMED   1685472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC299494.1, BC089436.1,
            AK307732.1, AC010255.9 and AI351010.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002317.6.
            
            Summary: This gene encodes a member of the lysyl oxidase family of
            proteins. Alternative splicing results in multiple transcript
            variants, at least one of which encodes a preproprotein that is
            proteolytically processed to generate a regulatory propeptide and
            the mature enzyme. The copper-dependent amine oxidase activity of
            this enzyme functions in the crosslinking of collagens and elastin,
            while the propeptide may play a role in tumor suppression. In
            addition, defects in this gene have been linked with predisposition
            to thoracic aortic aneurysms and dissections. [provided by RefSeq,
            Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.12617.1,
                                           SRR1660805.180662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231004.5/ ENSP00000231004.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               DC299494.1         253-568
            317-1588            BC089436.1         331-1602
            1589-2474           AK307732.1         658-1543
            2475-4660           AC010255.9         130357-132542
            4661-5076           AI351010.1         15-430              c
FEATURES             Location/Qualifiers
     source          1..5076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.1"
     gene            1..5076
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /note="lysyl oxidase"
                     /db_xref="GeneID:4015"
                     /db_xref="HGNC:HGNC:6664"
                     /db_xref="MIM:153455"
     exon            1..905
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1528
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /EC_number="1.4.3.13"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; protein-lysine 6-oxidase"
                     /codon_start=1
                     /product="protein-lysine 6-oxidase isoform 1
                     preproprotein"
                     /protein_id="NP_002308.2"
                     /db_xref="CCDS:CCDS4129.1"
                     /db_xref="GeneID:4015"
                     /db_xref="HGNC:HGNC:6664"
                     /db_xref="MIM:153455"
                     /translation="MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQ
                     QIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAA
                     RTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPP
                     SRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVAD
                     PYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSD
                     FLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGY
                     HRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYT
                     NNVVRCDIRYTGHHAYASGCTISPY"
     exon            906..1014
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1152
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1309
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1405
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1521
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..5076
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /note="hexamer: ATTACA"
     polyA_site      1808
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /note="major polyA site"
     regulatory      3742..3747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /note="hexamer: ATTAAA"
     polyA_site      3767
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /note="major polyA site"
     regulatory      5042..5047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /note="hexamer: TATAAA"
     regulatory      5057..5062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /note="hexamer: AATAAA"
     polyA_site      5065
                     /gene="LOX"
                     /gene_synonym="AAT10"
     polyA_site      5076
                     /gene="LOX"
                     /gene_synonym="AAT10"
                     /note="major polyA site"
ORIGIN      
        1 agacactgcc cgctctccgg gactgccgcg ccgctccccg ttgccttcca ggactgagaa
       61 aggggaaagg gaagggtgcc acgtccgagc agccgccttg actggggaag ggtctgaatc
      121 ccacccttgg cattgcttgg tggagactga gatacccgtg ctccgctcgc ctccttggtt
      181 gaagatttct ccttccctca cgtgatttga gccccgtttt tattttctgt gagccacgtc
      241 ctcctcgagc ggggtcaatc tggcaaaagg agtgatgcgc ttcgcctgga ccgtgctcct
      301 gctcgggcct ttgcagctct gcgcgctagt gcactgcgcc cctcccgccg ccggccaaca
      361 gcagcccccg cgcgagccgc cggcggctcc gggcgcctgg cgccagcaga tccaatggga
      421 gaacaacggg caggtgttca gcttgctgag cctgggctca cagtaccagc ctcagcgccg
      481 ccgggacccg ggcgccgccg tccctggtgc agccaacgcc tccgcccagc agccccgcac
      541 tccgatcctg ctgatccgcg acaaccgcac cgccgcggcg cgaacgcgga cggccggctc
      601 atctggagtc accgctggcc gccccaggcc caccgcccgt cactggttcc aagctggcta
      661 ctcgacatct agagcccgcg aagctggcgc ctcgcgcgcg gagaaccaga cagcgccggg
      721 agaagttcct gcgctcagta acctgcggcc gcccagccgc gtggacggca tggtgggcga
      781 cgacccttac aacccctaca agtactctga cgacaaccct tattacaact actacgatac
      841 ttatgaaagg cccagacctg ggggcaggta ccggcccgga tacggcactg gctacttcca
      901 gtacggtctc ccagacctgg tggccgaccc ctactacatc caggcgtcca cgtacgtgca
      961 gaagatgtcc atgtacaacc tgagatgcgc ggcggaggaa aactgtctgg ccagtacagc
     1021 atacagggca gatgtcagag attatgatca cagggtgctg ctcagatttc cccaaagagt
     1081 gaaaaaccaa gggacatcag atttcttacc cagccgacca agatattcct gggaatggca
     1141 cagttgtcat caacattacc acagtatgga tgagtttagc cactatgacc tgcttgatgc
     1201 caacacccag aggagagtgg ctgaaggcca caaagcaagt ttctgtcttg aagacacatc
     1261 ctgtgactat ggctaccaca ggcgatttgc atgtactgca cacacacagg gattgagtcc
     1321 tggctgttat gatacctatg gtgcagacat agactgccag tggattgata ttacagatgt
     1381 aaaacctgga aactatatcc taaaggtcag tgtaaacccc agctacctgg ttcctgaatc
     1441 tgactatacc aacaatgttg tgcgctgtga cattcgctac acaggacatc atgcgtatgc
     1501 ctcaggctgc acaatttcac cgtattagaa ggcaaagcaa aactcccaat ggataaatca
     1561 gtgcctggtg ttctgaagtg ggaaaaaata gactaacttc agtaggattt atgtattttg
     1621 aaaaagagaa cagaaaacaa caaaagaatt tttgtttgga ctgttttcaa taacaaagca
     1681 cataactgga ttttgaacgc ttaagtcatc attacttggg aaatttttaa tgtttattat
     1741 ttacatcact ttgtgaatta acacagtgtt tcaattctgt aattacatat ttgactcttt
     1801 caaagaaatc caaatttctc atgttccttt tgaaattgta gtgcaaaatg gtcagtatta
     1861 tctaaatgaa tgagccaaaa tgactttgaa ctgaaacttt tctaaagtgc tggaacttta
     1921 gtgaaacata ataataatgg gtttatatat gtcatagcat agatgaattt agaaacaatg
     1981 ctcctactgt ttaaatacat atggacacat ctggtgctga gaaagaaaca aacacattac
     2041 cattggtgtc aagaaatatt actatatagc agagaaatgg caatacatgt actcagatag
     2101 ttacatccct atataaaaag tatgtttaca tttaaaaaat tagtagataa cttcctttct
     2161 ttcaagtgca caatttcatt ttgacttgag tcaacttttg ttttggaaca aattaagtaa
     2221 gggagctgcc caatcctgtc tgatatttct tgaggctgcc ctctatcatt ttatctttcc
     2281 catgggcaga gatgttgtaa gtgggattct taatatcacc attcttggga ctggtataca
     2341 taaggcagcc gtgaaactgg aaagtcattt tgatgactga tgtgatacat ccagaggtaa
     2401 aatgcattta aacatattaa agtatttgcc aaagatacaa ttttcttgct gacataaaaa
     2461 tcacacaaac aagtcccccc caaaccacaa ctgtctctca aatagcttaa aaaaattgaa
     2521 aaacatttta ggatttttca agttttctag attttaaaaa gatgttcagc tattagagga
     2581 atgttaaaaa ttttatatta tctagaacac aggaacatca tcctgggtta ttcaggaatc
     2641 agtcacacat gtgtgtgtgt ctgagatata gtctaaatta gcaaagcaca tagtattaca
     2701 tacttgaggg gttggtgaac aaaggaaaaa tatactttct gcaaaaccaa ggactgtgct
     2761 gcgtaatgag acagctgtga tttcatttga aactgtgaaa ccatgtgcca taatagaatt
     2821 ttgagaattt tgcttttacc taaattcaag aaaatgaaat tacactttta agttagtggt
     2881 gcttaagcat aatttttcct atattaacca gtattaaaat ctcaagtaag attttccagt
     2941 gccagaacat gttaggtgga attttaaaag tgcctcggca tcctgtatta catgtcatag
     3001 aattgtaaag tcaacatcaa ttactagtaa tcattctgca ctcactgggt gcatagcatg
     3061 gttagagggg ctagagatgg acagtcatca actggcggat atagcggtac atatgatcct
     3121 tagccaccag ggcacaagct taccagtaga caatacagac agagcttttg ttgagctgta
     3181 actgagctat ggaatagctt ctttgatgta cctctttgcc ttaaattgct ttttagttct
     3241 aagattgtag aatgatcctt tcaaattgta atcttttcta acagagatat tttaatatac
     3301 ttgctttctt aaaaaacaaa aaaactactg tcagtattaa tactgagcca gactggcatc
     3361 tacagatttc agatctatca ttttattgat tcttaagctt gtattaaaaa ctaggcaata
     3421 tcatcatgga tacataggag aagacacatt tacaatcatt cattgggcct tttatctgtc
     3481 tatccatcca tcatcatttg aaggcctaat atatgccaag tactcacatg gtatgcattg
     3541 agacataaaa aagactgtct ataacctcaa taagtattaa aaatcccatt attacccata
     3601 aggttcatct tatttcattt ttagggaata aaattacatg tctatgaaat ttcaatttta
     3661 agcactattg tttttcatga ccataattta tttttaaaaa taaattaaag gttaattata
     3721 tgcatgtatg tatttctaat aattaaaaat gtgttcaatc cctgaaatgt ctgcctttta
     3781 aatataacac ctactatttg gttaattttg acgatttttt tttttcaatt aggaagctaa
     3841 aaatactact ttattcctta tatgaacatt catccccctc ctggcacctc taaacacacc
     3901 caaataactc acaagtactg atttaacact ctgtattact gaacttcttt gaactatttt
     3961 gaactttgaa tctcttctct gaataactgc cgaaactcaa agataataat tagttgatga
     4021 aggttatcaa ttaataaaat aacacagacc agtcttacca aactctaaat acattttaaa
     4081 aaataggaac tggcaatgat aaaaagaatg ttgagtactg acaggagatt ggcttttaca
     4141 ctaaaaaaga cagaaaatgg actaaatagg aacataattt cagagtttat gagtcagttt
     4201 acaatatgcc atattagcga tctcatgatg attcagacca cagtctgggt taaagatgtc
     4261 ttgacctctg aggctagcat aacatatatg agaatacaac ttgcctattt ccagaaaatc
     4321 tgtatatttt tatagaataa ctttatttac aatttctatc atccaattac tcactaggca
     4381 ttatttgtag tacttttttt ctctttgaaa tctcatagga tagtcacact tataaacatt
     4441 cccaatattc ggattctaga agaaatgcaa ttcattaaaa ttttcctggc actgagagtt
     4501 aatctttagc agattgcatg aaaatactga attcctggta aggagatatt ttgttttaaa
     4561 aataatgtgt tttgatacga atcagtgtat taactgataa ctaaaaagta ctcttttttc
     4621 tatatataca tatttttttg aactcatatt cacaatcaac atattcaatc agtgagttaa
     4681 gtctcattcc tagctaccaa aattcctggg ccacttttaa acactaaaca tttcatttat
     4741 cctctaagct aaaatggtgc tgagttattt aaatctgaat gtaaaatgca ttaaatctta
     4801 gcttgtggta tataaacatt taattaatat aaaactgctt gctataaact aagtaacatg
     4861 tcatttggtg ttaggttttt agtgaagttt tagcttctcc caaatttttc aggaatgtta
     4921 tttgtaagac gtgtaacttt tttgaagaac tcttatttta aatgctcaga cattggcttt
     4981 atgttcctct ttgcattctc atattctttt attatacatc tatactatga ttgcaagatt
     5041 atataaaaat gccttgaata aatgatttca agtgtc
//
