LOCUS       NM_001031855            3108 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens LON peptidase N-terminal domain and ring finger 3
            (LONRF3), transcript variant 1, mRNA.
ACCESSION   NM_001031855
VERSION     NM_001031855.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3108)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3108)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3108)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   4  (bases 1 to 3108)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   5  (bases 1 to 3108)
  AUTHORS   Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S.
  TITLE     Does this have a familiar RING?
  JOURNAL   Trends Biochem Sci 21 (6), 208-214 (1996)
   PUBMED   8744354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA249558.1, BC100671.1 and
            AK290198.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001031855.2.
            
            Summary: The protein encoded by this gene contains a RING finger
            domain, a motif present in a variety of functionally distinct
            proteins and known to be involved in protein-protein and
            protein-DNA interactions. Multiple alternatively spliced transcript
            variants have been suggested, but their full length natures are not
            clear. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.49765.1,
                                           SRR1660807.68776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371628.8/ ENSP00000360690.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               DA249558.1         5-209
            206-2682            BC100671.1         74-2550
            2683-3108           AK290198.1         2560-2985
FEATURES             Location/Qualifiers
     source          1..3108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..3108
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /note="LON peptidase N-terminal domain and ring finger 3"
                     /db_xref="GeneID:79836"
                     /db_xref="HGNC:HGNC:21152"
     exon            1..980
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2443
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 127"
                     /codon_start=1
                     /product="LON peptidase N-terminal domain and RING finger
                     protein 3 isoform 1"
                     /protein_id="NP_001027026.1"
                     /db_xref="CCDS:CCDS35374.1"
                     /db_xref="GeneID:79836"
                     /db_xref="HGNC:HGNC:21152"
                     /translation="MESVRIEQMLSLPAEVSSDNLESAERGASAAQVDMGPHPKVAAE
                     GPAPLPTREPEQEQSPGTSTPESKVLLTQADALASRGRIREALEVYRQLSERQQLVAE
                     QLEQLVRCLAEKVPQGEALAPAPPDEGSTASGTVAAEETGAAAAAAATEVWDGFKCRK
                     CHGFLSDPVSLSCGHTFCKLCLERGRAADRRCALCGVKLSALMVATGRARGARRAGQQ
                     PPPPLRVNVVLSGLLGKLFPGPARASQLRHEGNRLYRERQVEAALLKYNEAVKLAPND
                     HLLYSNRSQIYFTLESHENALHDAEIACKLRPMGFKAHFRKAQALATLGKVEEALREF
                     LYCVSLDGKNKRARCEAQRDNLELPHCSSQEEAAARGDGSSLMDPAKVKGDGQQHHMK
                     DQEEEEEKWDATSPKAASSKTGKCQEKKRKHCQIESQEETGMPNKASKQDPPTDQGDK
                     PALSLPLASFDASDLECALCMRLFYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDGL
                     SQCLASRKYSKNVIMEELIAKFLPEELKERRKLYEEEMEELSNLNKNVPIFVCTMAYP
                     TVPCPLHIFEPCYRLMIRRCIETGTRQFGMCLGDPVKGFAEYGCILEIRNVQFFADGR
                     SVVDSIGKRRFRVLHQSQRDGYNTADIEYIEDQKVQGEDCAELMGLHNCVYQQASLWF
                     HSLKLSLKNRILNHFGPMPEKDADPQMNPNGPAWCWWMLAVLPLESRAQLPFLAMRSL
                     KDRLNGIRRVLAFISRNQN"
     exon            981..1099
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1222
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1487
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1578
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1693
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1815
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1974
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2137
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2287
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..3108
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2718..2723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /note="hexamer: ATTAAA"
     polyA_site      2733
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
                     /note="major polyA site"
     polyA_site      3062
                     /gene="LONRF3"
                     /gene_synonym="RNF127"
ORIGIN      
        1 attaggcggc gcggggcggc cggcatggag ctcccggagg cgcggcaggg tcaggagctc
       61 ggtggcatgg cggcggtggc tgccccgatt tcctccagct gccactcctt gcttcgtgtc
      121 cccggtccct agacgcctcg tctcctcccg tgtccctctt cccatggagt cagtacggat
      181 cgaacagatg ctgagcttgc ccgctgaggt cagcagcgac aacttggagt cggcggagcg
      241 aggggcatca gcggcccaag tagacatggg cccccaccca aaggtggctg cagagggccc
      301 cgcacctcta ccgacgcggg agccagagca agagcagtct ccggggacct caacgccgga
      361 gagcaaagtc ctgctcacgc aggcagacgc cttggcgtcc cgggggcgaa tccgtgaagc
      421 cctcgaggtg tatagacagc tctccgagcg gcagcagctg gtggctgagc agctggagca
      481 gctggtgcgc tgcctggcgg agaaagtccc gcaaggcgag gcgctggcgc cggcgccccc
      541 ggacgagggt agcactgcaa gcggcaccgt ggcggcggaa gagacggggg ccgccgcggc
      601 tgcggcggcc accgaggtgt gggacggctt taagtgccgg aaatgtcatg ggtttctatc
      661 agaccccgtg tccttgtcgt gtggccacac cttttgtaaa ctgtgcctgg aacgtgggcg
      721 ggccgccgac cggcgctgtg cgctgtgcgg ggtcaagctc tccgccttga tggtggccac
      781 tgggcgggcg cgtggagccc ggcgggctgg gcagcagccg ccgccgccgc tgcgagtcaa
      841 cgtggtgctc agcggcctcc tcggcaagtt gtttccaggc ccagcgcgag cgtcgcaact
      901 ccggcacgag ggcaaccgac tgtaccgcga gcgccaggtg gaggcggcac tgctcaagta
      961 caacgaggca gttaagttgg ctccaaatga ccacttgctt tatagcaatc ggtctcagat
     1021 ttatttcacc ttggagtctc atgagaatgc actgcatgat gcagaaatag catgtaagct
     1081 ccgcccgatg ggttttaagg cacatttcag aaaagcccaa gccttagcca ccctaggcaa
     1141 ggtggaggag gcactaaggg agtttctcta ctgtgtatcc cttgatggaa agaacaagag
     1201 agcaagatgt gaagcccaaa gagacaatct ggagctccca cattgttcta gtcaggagga
     1261 agcagcagcc aggggagatg gcagcagtct gatggaccca gctaaagtga agggggatgg
     1321 tcagcagcac cacatgaaag accaggaaga agaggaggag aagtgggatg ctacctctcc
     1381 aaaagctgct tccagcaaga ctggaaaatg ccaggaaaag aaaaggaaac attgccagat
     1441 tgaatcccaa gaagaaacgg ggatgcctaa taaagcctcc aagcaagatc ctcccactga
     1501 tcagggggac aaacctgctc tcagtttacc acttgcatct ttcgacgcat ctgaccttga
     1561 atgcgctcta tgtatgagat tattctatga gccagtcaca acaccttgcg ggcatacttt
     1621 ttgcttaaaa tgcctagaaa gatgcctaga tcacaacgca aagtgtccat tgtgcaaaga
     1681 cggtctttca cagtgcttgg catcaagaaa atacagcaaa aatgtaataa tggaggagct
     1741 catagctaaa ttccttccag aagaactgaa ggaacgaagg aagctttatg aagaggaaat
     1801 ggaagaactt tctaacctta ataagaatgt gcctattttc gtgtgtacta tggcctatcc
     1861 caccgttcct tgtcccctgc acatctttga gccttgttac cgcctgatga ttcgtagatg
     1921 cattgagaca ggcacgagac agtttggcat gtgccttgga gatcctgtca aagggtttgc
     1981 agaatatggc tgcatcctag agatcagaaa tgttcaattc tttgctgatg gccgctcagt
     2041 ggttgacagc ataggcaaga ggcgcttcag ggtgctccat cagagccagc gggatggcta
     2101 caacacagcc gacattgaat acattgaaga ccaaaaggtt cagggagagg attgtgctga
     2161 gctcatggga ttacataact gtgtctatca gcaagcatca ttgtggtttc attcgctcaa
     2221 attatcccta aagaatcgga tactcaatca ctttggtccc atgccggaga aagacgccga
     2281 tcctcagatg aacccgaatg gcccagcctg gtgctggtgg atgttagcag ttcttccctt
     2341 ggaaagccga gctcagctcc ccttcctagc aatgaggtcc ttaaaggaca gactgaatgg
     2401 tattcgacga gtcctggcct tcatatcccg aaaccaaaac tagtgagtgg attgccgaag
     2461 aggagctccc accttcccca ctgccgtcgg ggggagtctt cttgtaaata tatctaattg
     2521 caataatatc ttaacagaag ggggtgtcaa acagaggcat cagcctgctg ttgatcacag
     2581 agagaaattg agtagaaaga ccaaaagaat gtgacctatt tgaaactttc tgtcttaaga
     2641 tgcttcttga catgctgcat aactacataa acagcagagg tgtttaagag cccagaaaaa
     2701 cataatttga ttttaacatt aaaatttcca aaagtttaaa gtggttttgc tttaatattc
     2761 tttctttcat agatcaatga ctgtgtggtt gaaatgtgaa aacaaagata ctaataatgt
     2821 tgctgtataa tttcactgac ttgaggtctc attccaaatg gttcaggttt tatagagcat
     2881 tgtgtaaaat aatgttcata cttctttctg ttttaataat ttattttttg cactactgta
     2941 tccttttttc tacatgtatg tttgtaacta tttaagcgta cattgctgaa aagtccattg
     3001 ctttatttat tgatgtggtt taccatgtac ctagggggaa ataacaatac tagaagtgtg
     3061 cagtttttgc ttttatcttt tttttactac aatgacacta gttcttag
//
