LOCUS       NM_198461              15096 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens LON peptidase N-terminal domain and ring finger 2
            (LONRF2), transcript variant 1, mRNA.
ACCESSION   NM_198461 XM_092184
VERSION     NM_198461.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15096)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 15096)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012493.9 and AC104782.5.
            
            On Jul 25, 2019 this sequence version replaced NM_198461.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4468116.1,
                                           DRR138522.296663.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393437.8/ ENSP00000377086.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1087              AC012493.9         30502-31588         c
            1088-1206           AC012493.9         18194-18312         c
            1207-1329           AC012493.9         12008-12130         c
            1330-1473           AC012493.9         9731-9874           c
            1474-1675           AC012493.9         8804-9005           c
            1676-1769           AC012493.9         8313-8406           c
            1770-1884           AC012493.9         7923-8037           c
            1885-2006           AC012493.9         4519-4640           c
            2007-2165           AC012493.9         3316-3474           c
            2166-2328           AC104782.5         147355-147517       c
            2329-2478           AC104782.5         144011-144160       c
            2479-15096          AC104782.5         128972-141589       c
FEATURES             Location/Qualifiers
     source          1..15096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..15096
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /note="LON peptidase N-terminal domain and ring finger 2"
                     /db_xref="GeneID:164832"
                     /db_xref="HGNC:HGNC:24788"
     exon            1..1087
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..2673
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /note="isoform 1 is encoded by transcript variant 1; LON
                     peptidase N-terminal domain and RING finger protein 2;
                     neuroblastoma apoptosis-related protease; RING finger
                     protein 192"
                     /codon_start=1
                     /product="LON peptidase N-terminal domain and RING finger
                     protein 2 isoform 1"
                     /protein_id="NP_940863.3"
                     /db_xref="CCDS:CCDS2046.2"
                     /db_xref="GeneID:164832"
                     /db_xref="HGNC:HGNC:24788"
                     /translation="MSPEPVPPPPPPQCPGCDRAEPIAQRLEEGDEAFRAGDYEMAAE
                     LFRSMLAGLAQPDRGLCLRLGDALARAGRLPEALGAFRGAARLGALRPEELEELAGGL
                     VRAVGLRDRPLSAENPGGEPEAPGEGGPAPEPRAPRDLLGCPRCRRLLHKPVTLPCGL
                     TVCKRCVEPGPARPQVRRVNVVLSGLLEKCFPAECRLRRLAGQARSLQRQQQPEAALL
                     RCDQALELAPDDNSLLLLRAELYLTMKNYEQALQDASAACQNEPLLIKGHQVKAQALS
                     GLGRSKEVLKEFLYCLALNPECNSVKKEAQKVMCEVLFSATANVHENLTSSIQSRLKA
                     QGHSHMNAQALLEEGDAGSSENSSEKSDMLGNTNSSVLYFILGLHFEEDKKALESILP
                     TAPSAGLKRQFPDDVEDAPDLNAPGKIPKKDLSLQRSPNSETEESQGLSLDVTDFECA
                     LCMRLLFEPVTTPCGHTFCLKCLERCLDHAPHCPLCKDKLSELLASRNFNITVLAEEL
                     IFRYLPDELSDRKRIYDEEMSELSNLTRDVPIFVCAMAFPTVPCPLHVFEPRYRLMIR
                     RCMETGTKRFGMCLSAEHAGLSEYGCMLEIKDVRTFPDGSSVVDAIGISRFRVLSHRH
                     RDGYNTADIEYLEDEKVEGPEYEELAALHDSVHQQSVSWFASLQDRMKEQILSHFGVM
                     PDREPEPQSNPSGPAWSWWILAVLPLERKAQLAILGMTSLKERLLAIRRILVIITRKM
                     NSRQELANARERNN"
     exon            1088..1206
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1329
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1473
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1675
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1769
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1884
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2006
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2165
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2328
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2478
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..15096
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13502..13507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /note="hexamer: AATAAA"
     polyA_site      13524
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /note="major polyA site"
     regulatory      13533..13538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /note="hexamer: AATAAA"
     regulatory      13537..13542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /note="hexamer: AATAAT"
     polyA_site      13551
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
     polyA_site      13555
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
     regulatory      15068..15073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
                     /note="hexamer: AATAAA"
     polyA_site      15096
                     /gene="LONRF2"
                     /gene_synonym="RNF192"
ORIGIN      
        1 agtcgcgcag gagccctcag gcgagtgggg gaagcatcgc aagagacgcg gacctggagc
       61 gcggtcactg cgttaccgca gcgacctggg ttacctaagc cggcgggact gagaggccgc
      121 tgcgcgtggg caggggctca gattgcgccc gcggtgcctg tcccggcccc caccccggaa
      181 cgattgcagc cctgcggggc tcgccgccca caccgcgctg aggacgctgc ccaagccagg
      241 cgcccgcccc cgcccgcggt ctcagccgct cgcagcgcgc cgcccccaga cgcgcgtggc
      301 tgctggcgag ggctgagacc gcgctcccgc cggccagttc ccagcagcag cgcatcctcc
      361 ctgctccgcg ccttcgctcc ggacccgcgt cgtcgcagcc ccgcggtgat gagccccgag
      421 ccggtcccgc cgccgccgcc gccccagtgt cctggctgcg accgcgcgga gccgatcgcc
      481 cagcgcttag aggagggcga cgaggccttc cgcgcgggcg actacgagat ggcagccgag
      541 ctctttcgct ccatgctagc cgggctggcg cagccggacc gcggcctgtg cctgaggctg
      601 ggggacgcgc tggcccgcgc cggccgcctc cccgaagccc tgggcgcgtt ccgcggcgcc
      661 gcgcggctcg gggcgctgcg gccggaggag ctggaagagc tggcgggcgg cctggtgcgc
      721 gccgtgggcc tgcgcgaccg gccgctgtcc gcggagaacc cgggcggcga gcccgaggcg
      781 cccggcgagg gagggccggc cccggagccc cgcgcgcccc gcgacctgct cggctgcccg
      841 cgctgccggc ggctgctgca taagccggtg acgctgccct gcgggctcac agtctgcaag
      901 cgctgcgtgg agccagggcc cgcgcggccg caggtgcggc gcgtgaacgt ggtgctgagc
      961 ggcctgctgg agaagtgctt cccggccgag tgccggctgc gcaggctggc aggccaggcg
     1021 cggagcctgc agcgccagca gcagccggag gccgcgctgc tcaggtgcga ccaggccctg
     1081 gagctggctc ctgatgataa ttcattattg ctgctgcggg cggagttata tttgaccatg
     1141 aagaactatg agcaagctct ccaagatgcc agtgcagctt gtcagaatga acctctcttg
     1201 attaagggac atcaagtaaa agctcaggct ctttctggat tgggaagaag taaggaagtg
     1261 ttaaaggaat ttctctactg ccttgctctg aatcctgaat gtaactctgt gaagaaagaa
     1321 gcacagaagg taatgtgtga agtgctgttt tcagctacag caaatgtgca tgaaaattta
     1381 acatcttcca tccaaagcag attaaaggct cagggtcaca gccacatgaa tgcccaggct
     1441 ctgctggaag aaggtgatgc agggagctcg gagaattcat ctgagaaatc tgatatgctt
     1501 ggaaatacca attcttcagt tttgtatttt atactgggtc tacactttga agaggataaa
     1561 aaggcgttag aaagcatcct tccaacagca cccagcgctg gcttaaagag acagtttccg
     1621 gatgacgtgg aggatgcacc tgacctgaac gcccctggaa aaattcccaa gaaagatctc
     1681 tcacttcaaa ggagcccaaa ctctgagaca gaagaaagtc aggggctctc gcttgatgta
     1741 actgactttg agtgtgccct ctgcatgaga ttgctctttg aacctgtcac tacgccctgt
     1801 ggacacacat tttgcctaaa atgccttgag cgctgccttg accacgcccc acactgtcct
     1861 ttgtgcaaag acaaactttc ggaattattg gcaagcagaa actttaacat aactgttctg
     1921 gccgaagaat taatatttcg atatttgccg gatgaattgt ctgataggaa gagaatttat
     1981 gatgaagaaa tgtcagaact gtcaaatctg accagagacg tccccatctt tgtgtgtgcc
     2041 atggccttcc ccacggtccc atgtccactc cacgtttttg agccccgcta tcggcttatg
     2101 ataagaagat gcatggaaac tggcaccaag cggtttggca tgtgtttatc tgctgagcac
     2161 gcggggcttt cagagtatgg atgcatgctg gagattaagg acgtgagaac gtttcctgat
     2221 ggaagttctg ttgtagacgc gattggcatc agtcggttcc gagtgctaag ccaccgccac
     2281 agagatggct ataacacagc ggacattgaa tatcttgaag atgaaaaggt ggagggtcca
     2341 gagtatgaag aacttgccgc tctccacgat tctgtgcatc aacagtctgt ttcctggttc
     2401 gcgtctctcc aggatcgcat gaaagaacaa attttaagtc attttggggt aatgccagac
     2461 agagaacctg agcctcagag taatcccagc ggccctgcct ggtcctggtg gatcctggcc
     2521 gtgctgcccc tggagcgcaa ggctcagctg gccatcctcg gcatgacctc gctcaaagag
     2581 cggctccttg ccatccgacg gatattagtc atcatcacgc gtaagatgaa tagtcggcaa
     2641 gagctggcta atgccaggga gagaaataat tgatttttct ctctgtcaag gtttctggca
     2701 gcccttgtgc ttttataaat gtcaggcatg gacgaatagc cgtccattca ttgtgcttca
     2761 tcaagtgctt gtggatgagg ttccaaaatg ggacgcttgc caaacattga gtcctcctca
     2821 aaaatgacaa ttctgtgtct ggtgggatct gaccttgtgt gaggttagcc tgaagtctga
     2881 atggagccca tagttggaaa acaacctaag aaaatctctt agaagcaggt gcttggggaa
     2941 tgcagttcac tgacagcaca ggaccctgca gatggtttac atgtggtttg ggtttcacga
     3001 gaaagaagga ttcacttccc agtcagcatc tggctctgcc agatggtaaa ggcgtgcttt
     3061 agtgtgtaga caatatgggg gaaccacgtt tttatctgga agtggatttc ttagaacaca
     3121 ggctaaccaa aactacgctt aggctttgcg tgttgctgtg aagttgtctg tgaaatcgaa
     3181 taatcacacc attgttcagt gcaggagccc aaactagtcc ttacccaaga agtagtagcc
     3241 tctggataga actgtgttta atgtcctgtt gtagtcccag gtgttgtaaa ttgcatgttg
     3301 taatcaaacg aatgtcaaaa cataagaaag tataccttgg atatagaaaa acctgagaac
     3361 agtatcattc acttgaggat atatatatat atatttacac acaataaagt gagttaaaat
     3421 tgtatatgca ttgggatgtc aaacataaaa ccaccaagtg caaagaatgc tttgaaagta
     3481 gaaccttgtc tcattgatca gtggttacta agcatttagg aaacagtcat ctttttctat
     3541 tgggatttgc attagaaatt agccccatca gtaaatttca gtttactatc catttattaa
     3601 tatacaaaaa cattaaaaaa tctgccatgc catggtaatc tatctattcc aggaaaatag
     3661 atcagaatat atgaagggag gatggccggt atgggatgta aatattcagt aagtttttct
     3721 ccaacaccaa cctaaaatta tctttatttt tttgaaagaa agttttacgg tgatcagacc
     3781 aggtgttatc tgttaaagga cagtagtatg acttccatcc tgtaatgcac gttggtgata
     3841 ttgattggaa taactgaatc tgagatactc atatgttctc tctggcccaa ccagctggtg
     3901 catttggttg gcttcctcgt ctgtaaggtg gacattctta accagagggt cacgaccaca
     3961 tcacagctgc aagttttgct ttgttcattg aaggtgattt tttagtttta aaatatatat
     4021 atctcataat atacaatgtt gatggtatat caatccatca agcattttat tagaaagact
     4081 ttataatatt attaattttt ctttagtttt cagtagataa agtagtttca gtagataaag
     4141 actttataat attattaatt tttcttttag ttttcagtct catcatggga gttagaaaat
     4201 accagcatca cttaattgta aagagaaaat gtgaaagtat tttccaatcc aatgtttcaa
     4261 gtgcctcact tattgtgaat ctcaaatatc atcttgagat ggtttaatgg cagtttggcc
     4321 aagtgatttc taagagattt tattaattta tgcattaaca atagtattca actttcttag
     4381 gcattataac ctaacccgat catttgattg gaataactga atcattcatt gattggaata
     4441 aaataaagaa aacaaaatgc atctcacatg ccagaagacc tttaccagaa gtggttcatg
     4501 aaaatcagta tgcattgacc attctctgcc tttccctttt ggaaaatttt tttgtacctt
     4561 catatcacag ctgaatagtt atcaatgcca tttccatttg gaagtatcta aataaccaca
     4621 atgtgatcac agcttctcca cgagccttcc tgaagtaaag ctggtatgct tgctataata
     4681 cttggaacct gttgctttct cttcctcact ctttaaatgt cataaggtca cacagttctt
     4741 ggaatcagaa ctattcagtt atttcttcat gattctgcct ggctttctga gtcttctcct
     4801 tcggcatgtt atgtaaaagt ctgaacaaca atgatgacgc agacgagagc aacatacgtt
     4861 tttatttttt gataggtttt tatttttttg ataccagagg gaattaacta tgatcacatc
     4921 gtgctctctc tgttcagcat cacacgccca catactgcag tgtgggagta gattggtact
     4981 tactgagcac ttagaaacat cacgcatcag gaaccgggtc agggtgacag catcctacgg
     5041 tcatatcatg aaggaagcct cccttacaaa cctaaaaaaa aaaaacccca gcttcagttt
     5101 gctaccaatt aagctaaagc agaacggtct gcttcctcct ccgcctgccc ccttctgcct
     5161 cttttctgtt ggggagatgc caattctaag gatttctcag aaaataatgt aatctctcat
     5221 tcaatgtcag gacattccag cttaattgta ctgaaagtgc tccaataggc atgctctcgt
     5281 tacattggaa tcaaagcaga aaagagtaat agcagcgtgg gggagtcatt tttcttcttg
     5341 aggaacaata catgctgttc tgtatttttc cattcatcgc ccaaacctgc ctgtgtcttt
     5401 gaaatgcaag taagatccca aaggcagctt tctgaaagcc cgtggcattt ttagcttatc
     5461 ccatcccccg tgtgtgtcct catcttcaga attgaaagtt aggatacttt ttaaagtttc
     5521 aaaagaaaat aatttaaaat gttaaggttt atccatagaa acacaataat tcttaaccaa
     5581 ttcatgtacc aaattcaaca gtattatctc atttttaggg tcacaaatgt gtcctttttg
     5641 cacttaaacc tcctccctct ctcaaaaaca aaaacaaaca aacaaacaaa aaacacacca
     5701 agactgttta acaaattgta tctcaactct taatatatgt taagtcttac cacaggacat
     5761 ttgaatcatc aaggaacagt tgaagtttat ggatggtaga ataacaatga actatgatat
     5821 tatcacttta ttataaactt tttggaaaat tggcagttgc taccatcgaa atactccatt
     5881 gcctgtgtta catagaattt gttataattt ttaagggctt taaaaaaata cccatctgtt
     5941 tcttctcctt cttgttttct tttgtgcccc accacttaaa ttacttgggt aaataccact
     6001 cttcaaaatt tgaatactgt ctatcaaata agaagaagtg tgaaagatat gaagaagaaa
     6061 ggtgatagca aattagaaga aaataaatgt gggtgatttc ttttagttga aagcacagag
     6121 ttttattttt ccccagtata actattgagt agggtaggga ggtccctgta tccccatttt
     6181 tatttttttt gagatggggt ctcactctgt cacccaggct ggagtgcaat ggcgcaatct
     6241 cgtctcacca caacctccgc ctcctgggtt caagtgattc tcttgccttg gccccctgag
     6301 tagctgggat tacaggcacg cgccaccaca cccagctaat ttttgtattt ttttttttta
     6361 gtagagatgg ggtttcacca tgttggtcag gctggtctcg aactcctgac cccatgatct
     6421 gcccgcctcg gcctcccaca gtgctgggat tacaggcgtg agccaccgtg cccggcccat
     6481 ctccccatgt tttagcatag acagcagcgg cattcagtgg aaggagttct tccccttcaa
     6541 catcgtcctt cccaaaggcc acattctgat tctattgttc accaaaaact aattcccagg
     6601 gaagcccgct ctggatggga aggatgagct gcgtgagcca tcgcccacac agggagataa
     6661 ccgaacccct ttgccagcat caccccctct ctactggggt gagacacttc attcagagca
     6721 ctggctctga ctcccagggg aaagtctttt tccctttaca actcctcacc tcagcctcac
     6781 cttgactttc acttctcaac tgctgaattc tataaaatag ccttttagca gtgactcagc
     6841 ttttaggtga gcacagataa tgaagaaatt gaagtgccac cattgcactc ccccaagttg
     6901 gggacataaa ctcgaatttg cacccaggtc tgataaaagt aactgattga ggacgcagaa
     6961 aggtggatgc cattgacagc gttgactgtt ctcacaattc ctacagaaat gaaagaagga
     7021 gaggcccagc agaccacacc gggccatgag gggaagcatg ggagacaggc agaagcagga
     7081 gtgaggagga acgtggctca gaccctctac tgtatgttct gcaggaaagg gcagggaaat
     7141 agctaagact ggctggtctg aataacagct cagactctag gctatacagg tggtctctag
     7201 ccatctggca cctagccccg ggtcgttagg gtgggggata ttgcttccta ggttgtaaga
     7261 gccagataga ggaggatggg ctctggattg gtcactttgc tcccagggta gccctttgct
     7321 gtatctaaga attggctcac cctgggatgg gcagtttctc ctgggtcagc gaggcccctg
     7381 agatgtcaaa atatcataaa atatagaaat catgattaat acaattggtc ctctgctgtt
     7441 ttgacatact aaggtcactt ttgatagcag aaacttttaa agagtagggc atacgttgcc
     7501 ctgaagagca tagaaaacat tttattctga gagtagaaag gaggaagaca cgtggagata
     7561 caggagtccc ttaggctggc ccatagctga gtctctcatg tgtgtggcat tagtcaagaa
     7621 tgtagttctg cagtttgcgg ggggggggtc tctaacattt cttggtgcag ttgttaacat
     7681 gtgttaaaca tatgagtctg atgatgatat cgcggtgttt ctcggctcgg ggtggcaggt
     7741 ctggcggttg tgtggctggg ggtgtgcact gatagttcag taaaggataa gtagagactc
     7801 gtggtgttca tgtgtcacca cagggaggga gtggctgtgg agacccagga caggaagtcg
     7861 cggtggaaag caggctgggg tggtaggaga aggcaccggg ggtgggtgct cctcccccag
     7921 gggttgagga gttgactgat agggggcagt tacctcctgg gaaagcaaga cgctccctta
     7981 agttttagaa tggtacagag agtagtccct tctaccagag tttccattta gacatgggag
     8041 tgtagggggc catgtttcgg cagaagcagg gcatgtatca gcattagtgg actcctcagt
     8101 attaaaagga agaacagcaa acatgtcatg tgcccacttt gtgcctcagg agaggtagcc
     8161 cgtggacatc gctagggcag aggttttaat atctgggaca aagttatctc ccacggcgag
     8221 gtcgtggctg ggaccatgtc atcttcagcc gtgagctgct gggctgggca atgtcttctg
     8281 ggatgtgaga cgtggggtct cctttctaag cggaccccca ctcgtgctga tgtgggtccc
     8341 agcatttgcc gcgtttggtt gaaacagtgg cttacctgga gggtctgggt ctctggatca
     8401 taaaccagcg aaagccccca catcagtggt gacaagatca atagacccca gaatgtgtgc
     8461 agctgtgctt gatagggttt tggttcttgc tttttggtgg aagtttaggc tcaagtgggt
     8521 cccgtatcgg atgagcagct gcacggcctg tgggagccct ggggttagtg ggtccaggag
     8581 agaatgtgtt ctctctctgg gctccagccc tgatggggtg gggataagat gcaagattta
     8641 taggaatagg gggaaacatt atggaaggcc ccaatatgta atgagctttt atatacaaga
     8701 atgcaagaca tagccctctt tttatgttta aaggggacta tggtaatgtt ttttaaagtt
     8761 tgtgtgaggt gtgagtcaac cgaaaggccc taaattaaga gagattcagg tttgtggtgc
     8821 aagatagagg cccatttcgg ggtctgtttg cagaccagaa tttgaaatgg agttgtttga
     8881 ggagaccatt gtgtgtcttc gtgaaaccga ttgtgtggaa cctatcaggg ctgtggaagt
     8941 tgtagcgaat gccttttccc agagcccagc attgtggatt ccgagaagtg gcatgtgtgt
     9001 ctcagtgact tccagtgatg cctgccactc tgaagagatg aaggagtgtc ctggcaagac
     9061 ctggaatccc agctgtagca cctgtggaga gatgtgattt agatttggat ttggggtatc
     9121 tgtgaggaag agtcccagag tttttcatcc tgaagggggc aactcttggg cagtggtcca
     9181 acagttggcc ataaatgtga agctggggcg ctgtgctgac cagggcatcc agcgttaaga
     9241 cgactgccta actttggcca catgcgttgt tttttgggtt ccgtttcgta tcagggcatg
     9301 ctggctaaaa gatgggaagc agcaacattc tcttgggctc catcatttat atgagggttg
     9361 gcaatgccat ctgtaccctc tgtgaactcc cactgctgtt cactcagtta atctaaggga
     9421 caccaagggg tctgcgggag gatgacctca caagggactg aggacatggg agaccaccct
     9481 cctgtgggta gaatacacca gagggcccag gcttgactct gtcctgtgtt aaggaggcat
     9541 cggtagtttt gctgagcttg tcaggtgttt ataatggaca gttggagatt ggggtcctag
     9601 gcttaggtct ttgagagcct ctgtgtccag gagagcccag taggcatcca gccatttact
     9661 gctttaatag ggtagcatga ggctgagagg gatagtttct tgcatccaaa gcccttaggc
     9721 accttatgtc catcctaagt gggccagaga ctccagggct gcatagagct tgccagagct
     9781 tctataatga aggggtctct gagggcacca acaggagtgc ccatggattt taaggtttga
     9841 ttatagaggt tgtttatgga gggtgcccca tttaaagcaa gctgatttgt aagcagcagc
     9901 aagaagatta agtaaaattt gtaaatgagg actacattgc catcagaacc tcgaaagtat
     9961 ctaaagatgt tggacttgta tgtccttaat gagtgtgaca atgagtttcc tcatttgtgc
    10021 tcctggagaa ggcggatgtg gtgaagaccc tgtctgcaga cattgtgtgc catggcaaag
    10081 ccgtggagct ccctgtgggt ggcctgcaaa ggtgtatgtg cccctcaggg cagaaggcaa
    10141 acggcagcca agaagctgtg caagtagaca cttaatggga catgttagcc aaatctgtaa
    10201 gagcaaaata ttggccagtt atttattgtg tagaattaat aattttaata ataatggaaa
    10261 ttgggtaatg gatgggactg cagcaataag gttgtagtaa tccaccatga ggcacacttg
    10321 tttttttcca ggtttaagga taggaaagat tgggctgttc aatggagaaa caagggtata
    10381 atcacccctt tattaattag taagttttaa tccttgaata cctcatatta actgttttaa
    10441 ctggaggtcc atggggcatc attttatcaa gctagtttat aactgccaaa gactgacttt
    10501 aattttaatt tattatttgt tttattagag tgtctgtgtt caatatggga tattagggcg
    10561 ttgggtacta tgaccacagg aaatttagac aggctacagt taaagtgaag cataccttac
    10621 ccatccaccc cccattttat atttagttgc ctttttaaaa agattatagg ggtacaatgt
    10681 ttagatttag tgggatctcc aggtataact gtaatttgag ccccagtgtt aagactatga
    10741 agctttgtca atgggtacat tttagcaaat gttacaatta atttagaacc taagttatgg
    10801 agacacaaaa gccaataggc acccttttat gttttggtta aatgtttcag tatatacatc
    10861 ttatttattt gtaatattag tatataattt gttgtataca tttttagtgt ataagcgttg
    10921 gatttctaat tggatcagat tagggacctt ccgtttagct gcatatgtac atatacatgt
    10981 acaatttatt atatatttgc gttaaaatag cctatctgca tgtgtatata tgtgtgtatg
    11041 tgtatgtata tgcactcaca cgcataaata cacagtctat ttagttacct ttaatgtttt
    11101 ttcccttgta cctaggcttt ttctcgcttt ttcctttttt tctgattttg tggcaattta
    11161 gttggaagga ggcggtccca gcatgttgac aggcagggtg ttcagagtgc ccaggcacac
    11221 tggtgggggg tggttacagg ctcacgtagc tcaggggctt ctgcaggtct caggggagtg
    11281 ggaacaaagt gtcccacccc ttcccctttt cctcaaacct caagccactg gtctctatgg
    11341 atagatcctt tgcatcccac cggattgagg aatgagtcac aacagctgca aggctcttaa
    11401 agcaacattt aaaccttttg gcggctgtca tttctgtgag gagggtgcct ctcaccggcc
    11461 gcatggccgg aggatccctg cagcgctttg gagaccaaca cccagatcct ttgcccagga
    11521 gtgcgattaa ttcctcactg gatgctgggg gagggcccct caggtgagca gcccaccact
    11581 gacttcagcg ttgctggctc ggttatcaga ctctcatcca acacaagctc acagggaaag
    11641 ccgttccttg ctccttgtgg agggagctac cgtcattgcc ctgagaccac cagccaagaa
    11701 agtaggtatg tccaggtagg gaattcagag ggacccagtg catccaatta tacaattata
    11761 cccagaaggt cctgtgtagg ggactgcgat tgacatcacc ctagtctgca gcaccaagga
    11821 ctgaatgagc tcagtcctct tataatttag gctggactgt cacagacact ggcagacaca
    11881 gcatacgtgg tgcagccaaa gtgcaaacat gccagcagcg gccatgctcc ccagggtggg
    11941 ggtccagtta gtaagccacg cgcagccaag aggcgaggca tgccctgtgc cacacacgga
    12001 ctcaccctgc tcactgtgcc cgtggtatcg aaatgtaccc acgtttaatt cataaaggag
    12061 aggctgctgt cattgaaaga aaagtttgtt acttgcattt ctggagaaaa ggagcgcacc
    12121 aggccacgca gggccacagg aggaggacgc accagagtgg tcaggaggca gaactaggcg
    12181 agcagctttc cactgtgtct ccatggcaaa ggcgaagatg ggcgggggca gagtgtagga
    12241 ttggcaggtt tgaatgtctt gggcagtagc tacaggggtg gtctccagct gcctggtgcc
    12301 tggccctggg tgatcagggt gaggggatac tgccttctgc agtggaagag tcaaatcgag
    12361 gagatggact ctgagttggt tagtgtgcaa aggtgcactc ccaagggacc cctttgctat
    12421 ctctaagaat tggcctgccc tgggaagggc agtctctccc cagtcagtga ggtccccaag
    12481 atgtgaaaac attatacatt ataaaaaagc atgattaata taagctcatt ctagcatttc
    12541 aggttacagc ttctagaaga ggtttgtagt ctcaaatgag taggtttttc ctctagagag
    12601 gggcgggcct ggaccttcaa gcaccccttg gtgtgtttag gagctcagga gcagaagcac
    12661 ctgcctgcag ccctgcagct aaggaagttc tctcagtcac tcagagcagg gaggggctga
    12721 gagagtcatg tgaggctccc ggggtactac gacagccctc gaggtgaagg attggccctg
    12781 atcataatag agaaccctga ggaagtttac tgtcatgagt ctcggctggt tggcgcatgt
    12841 gacctttgaa ggatgaagat ggagtttgca acatgagtat ctctaacctt ttgcttttca
    12901 gggatcattt tcaaaaattg cattggggcc ttcgttattt accatagtat tttcactttc
    12961 atagttttgt cacctttttg tactgtgaac agttcaacca gtgaccgact tctctctcat
    13021 gctgtttacc ccacacacaa tttcccactc aattctgaaa ataagaacct gttaataggt
    13081 tggaaagctg tgtactctat tcatatattg ttctttcatg ctagtggaga gtggtgtcat
    13141 tagcatctta attttagagt tgtgaaatga ttttaccaat taggaattga atgtgtattt
    13201 tttttctgtt taataagaag agcaaatttg aataaataag ctggtgtaga taaacttaat
    13261 aatcatgctt tttcttgttt ggagataggt gatgtgttgt catatcctgt gatacaggtc
    13321 actcatctgg ccttctgttt ctgaagttta agtctggttt gaatatgtaa taatactact
    13381 cagcatttct tgttgcctaa gtgagacgaa acttaaatgt tatgatattt acttcatgta
    13441 ttcttgtact gttcatttca attaattggt attgtatatc taatatgtga tatttgaact
    13501 gaataaaact tacagtgttg taaatgttct ttaataaata atcacaccta agtaataggc
    13561 tagactgatg agaaattaga tcaaatcagt gcctaggcct ttgtgtttgt gtcgtaggga
    13621 tgtactaaca catcaccaca gactgacggc ttttcacaat aaatcagttt tcttcgctca
    13681 catttctgga cattagaaat ccaaagccaa ggtgccagta gggccgggct ttctctgaag
    13741 gccccaggaa aactcctcct tcatctcctc cagctggtgt ggctgctggc cgacctcggc
    13801 cttcctcggc cagcggctgc atcactccag tttccgtgtc catcgtcaca tggccttctt
    13861 ccctctgtgt gtctgtgtcc agatatccct ttccttatat aaggacacca gtcattagat
    13921 ttaacttcca ccctaatcca ggatgacctc atcttaactt gattacatct gcaaagactg
    13981 tatttccaaa taaggttata tccacaggtt ctagtggaca tgaattttag aggaacagta
    14041 ttcaacacag tgcagatgtg gaacgattcc aatttaattt tagtaggaaa aaaaaggaaa
    14101 gagggctgcc aatggctttg gcttaaaacc ataattactt ttaaaaatca tttctatcca
    14161 aggcagataa gatttaataa gaactgaagc ttgtatagtt gtttatttgg gaggaagggg
    14221 gtagtgcttc ttaagaaaag gaatatgaat tgcaaatact gagttaacta tgaaagcata
    14281 tatttatttg gaatttttag aggcataaat tacaatattt aaaacagcat aacactctac
    14341 aaaatactga aaagtatttt tattaacttc ctggcacctt tatgatacct ttcccatctt
    14401 tttttttctt ttttttaacc tacatactct ggttagtttg tttgtttatt tatttattta
    14461 ttttcttctt gggggacatg gtcttgctgt gtcatccagg ctggagggca gtggtacaag
    14521 catagctcac tgcagcctca acctcttggg ttcaaaggat tgtcctgcct caaccttctg
    14581 agtagctggg accacaggtg catgccgcta tacccggcta atttttttac tttctatgga
    14641 gacgaggtct agctgtgttg cccaagctgg tctcaaattc ctgggctcaa gcagttctcc
    14701 caccttggcc tcccaaagtg tgagattgca ggcataagcc actgcaccta accctgcata
    14761 ctctttgatc atctttttct tcttaggaca atcttgtgtt ggttactaaa gagagaatga
    14821 tatttaagtt cttcctctaa catggatatg gggcaaaaat catagactaa aagtttcagt
    14881 tttcacaagt cattattggt aatgtcattt aaataggatg gttgtcaaat ctgggaaaac
    14941 ctctgatgaa gtcttttata tgtgagttgt aaggatcagg cattttcccg cttcctcatg
    15001 cagtgactaa tcttaactcc ttcagcactg ttggatgaaa ctttctgtga tgacggacat
    15061 tgttggaaat aaagctcgga gtcataagga aaatga
//
