LOCUS       NM_152271               3618 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens LON peptidase N-terminal domain and ring finger 1
            (LONRF1), transcript variant 1, mRNA.
ACCESSION   NM_152271 XM_001128970
VERSION     NM_152271.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3618)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3618)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3618)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 3618)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123777.4.
            
            On Nov 23, 2018 this sequence version replaced NM_152271.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.202586.1,
                                           SRR1660809.92830.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398246.8/ ENSP00000381298.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-827               AC123777.4         105490-106316
            828-946             AC123777.4         117734-117852
            947-1069            AC123777.4         120020-120142
            1070-1219           AC123777.4         122872-123021
            1220-1460           AC123777.4         123876-124116
            1461-1557           AC123777.4         124219-124315
            1558-1672           AC123777.4         125616-125730
            1673-1794           AC123777.4         129159-129280
            1795-1953           AC123777.4         131684-131842
            1954-2116           AC123777.4         131953-132115
            2117-2269           AC123777.4         135137-135289
            2270-3618           AC123777.4         137762-139110
FEATURES             Location/Qualifiers
     source          1..3618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..3618
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /note="LON peptidase N-terminal domain and ring finger 1"
                     /db_xref="GeneID:91694"
                     /db_xref="HGNC:HGNC:26302"
     exon            1..827
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2428
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /note="isoform 1 is encoded by transcript variant 1; LON
                     peptidase N-terminal domain and RING finger protein 1;
                     RING finger protein 191"
                     /codon_start=1
                     /product="LON peptidase N-terminal domain and RING finger
                     protein 1 isoform 1"
                     /protein_id="NP_689484.3"
                     /db_xref="CCDS:CCDS5987.2"
                     /db_xref="GeneID:91694"
                     /db_xref="HGNC:HGNC:26302"
                     /translation="MSSPAVARTSPGGSREMAPAPQGRGRFWEVGGGSGHRLERAAAE
                     SERWELLLRRGELLALGGHLKGALEAFAAALRRGAPARPECLGALVDCLVFNYRLRHG
                     LGWSAAPVAGADGGAGGLLRCLGCRGFLSEPVTVPCGHSYCRRCLRRELRARCRLCRD
                     RLPPATASATDAEGTAPRPPPLAAAIAASDFRTSVVLNHLAEKWFPGQRERARAAGRL
                     GELLHQGRYREALAAACEALRAEPSDLIVKIYRAESYAGLQEFKAAIEDLNAVLFQLP
                     DWPEVYFRKGKVLCDAGFLGDALQLFLQCLALDEDFAPAKLQVQKILCDLLLPENLKE
                     GLKESSWSSLPCTKNRPFDFHSVMEESQSLNEPSPKQSEEIPEVTSEPVKGSLNRAQS
                     AQSINSTEMPAREDCLKRVSSEPVLSVQEKGVLLKRKLSLLEQDVIVNEDGRNKLKKQ
                     GETPNEVCMFSLAYGDIPEELIDVSDFECSLCMRLFFEPVTTPCGHSFCKNCLERCLD
                     HAPYCPLCKESLKEYLADRRYCVTQLLEELIVKYLPDELSERKKIYDEETAELSHLTK
                     NVPIFVCTMAYPTVPCPLHVFEPRYRLMIRRSIQTGTKQFGMCVSDTQNSFADYGCML
                     QIRNVHFLPDGRSVVDTVGGKRFRVLKRGMKDGYCTADIEYLEDVKVENEDEIKNLRE
                     LHDLVYSQACSWFQNLRDRFRSQILQHFGSMPEREENLQAAPNGPAWCWWLLAVLPVD
                     PRYQLSVLSMKSLKERLTKIQHILTYFSRDQSK"
     exon            828..946
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1069
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1219
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1460
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1557
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1672
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1794
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1953
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2116
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2269
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..3618
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3597..3602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /note="hexamer: AATAAA"
     polyA_site      3618
                     /gene="LONRF1"
                     /gene_synonym="RNF191"
                     /note="major polyA site"
ORIGIN      
        1 gtccgcgcgc cacgcccccc tgctcgcggg ccgcgtgcgg agccgcgcgc ccgggaggct
       61 ccgggaccgt ggcggcgggc ggcggcggcg cagccctccg cgggccatgt cctctccggc
      121 ggtggcgagg acctccccag gagggagtcg ggagatggcc ccagcgccgc agggccgagg
      181 ccggttctgg gaagtgggcg gcggcagcgg ccatcggctg gagcgcgcgg ccgcggagtc
      241 ggagcgctgg gagctgctgc tccgccgcgg ggagctgctg gcgctgggcg gccacctgaa
      301 gggcgcgctg gaggcgttcg cggcggcgct gcgccgcggg gccccggcca ggcccgagtg
      361 cctgggcgcc ctggtggact gcctggtgtt caactaccgg ctccgccacg ggctgggctg
      421 gagcgcggcc ccggttgcag gcgctgacgg cggcgccggc gggctcctca gatgcctggg
      481 ctgccggggc ttcctgagcg agccggtgac cgtgccctgt ggccacagct actgccgccg
      541 ctgcctgcgg agggaactcc gcgcccgctg ccgcctctgc cgggaccggc tgccgcccgc
      601 caccgccagt gccactgatg ctgaagggac cgccccgcgg ccgccgcctc tggccgccgc
      661 catcgccgct tcagacttca gaaccagcgt cgtcctcaac cacctggccg agaagtggtt
      721 tccgggccag cgcgagcggg cccgggcggc cggcaggctc ggggagctac tgcaccaggg
      781 gcgctaccgg gaggccctgg ccgccgcctg cgaggcgctg cgagcagaac ccagtgactt
      841 gattgtaaaa atttacagag cggaatcata tgctggtctc caagagttta aagcagccat
      901 agaagattta aatgcagttc tttttcaact tccagattgg cctgaggtct acttcaggaa
      961 aggaaaagta ctctgcgatg ctggtttttt aggtgatgcc ttacaactct ttcttcagtg
     1021 cttagccctt gatgaagatt ttgcacctgc aaagctgcaa gtacaaaaga ttttatgtga
     1081 tttattatta cctgaaaact taaaagaagg cctgaaggaa tcttcctgga gttcattacc
     1141 atgtactaaa aacagacctt ttgattttca ttcagtgatg gaagagtctc agtctctcaa
     1201 tgaacctagc ccaaagcaga gtgaagaaat accagaggtc acttcagagc ctgtcaaagg
     1261 aagcttaaac cgtgctcagt cagcacagtc tataaattca acagaaatgc ctgccagaga
     1321 ggactgttta aaaagagtgt cctcagaacc tgttctgtca gttcaagaaa aaggtgttct
     1381 gctgaaaaga aagttgtctc ttttagaaca ggatgtgatt gtaaatgaag atggaagaaa
     1441 taagctgaaa aaacaaggag aaactcccaa tgaagtctgt atgttttcct tagcttatgg
     1501 tgatattcca gaagaattaa tcgatgtctc agatttcgag tgttctctct gcatgaggtt
     1561 gttttttgag ccagtaacaa ccccttgcgg acattcgttc tgtaagaatt gtcttgagcg
     1621 ttgtttagat catgcaccat attgtcctct ttgcaaagaa agcttaaaag agtatctagc
     1681 agataggagg tactgtgtca cacagctgtt ggaagaatta atagtgaagt atctgcctga
     1741 tgaactgtct gagagaaaaa aaatatatga tgaagaaact gctgaactct cacacttgac
     1801 caagaatgtt ccaatatttg tttgcactat ggcctacccc actgtgcctt gccctctcca
     1861 tgtatttgag ccaagataca gattgatgat tcgaagaagt atacagactg gaaccaaaca
     1921 gtttggcatg tgtgtcagtg atacacaaaa tagttttgca gattatggtt gtatgttaca
     1981 aattagaaac gtgcatttct taccggacgg aaggtctgtg gttgatacag ttggaggaaa
     2041 gcggtttagg gttttaaaaa gaggaatgaa agatggatat tgcactgccg acattgaata
     2101 tctggaagat gttaaggttg agaatgaaga tgagattaag aatctcagag agcttcatga
     2161 tttggtttac tctcaagcct gcagctggtt tcagaattta agagacagat ttcgaagcca
     2221 aattcttcag catttcggat caatgcccga gagggaggaa aaccttcagg cagcccctaa
     2281 tggacctgca tggtgttggt ggcttcttgc agttctccct gtagacccac gataccagct
     2341 gtcggttttg tcaatgaagt ctttgaaaga acggttgacc aagatacagc atatactgac
     2401 ctatttttct agagaccaat ctaagtaact aactctttgg atctcccttt aaagtgaccc
     2461 taatctggct gcattgatgg ccagattgtc tgctgccttt gcacatctag tgctggtttc
     2521 agaaatttaa tgaaactttt ctttttcctt cgacctcctg aatcatgtgg ttctgcaaat
     2581 gaataccttc aactaggatt tagaccacta agaacttgca cagaaaaaca cgcattgaat
     2641 gtgtgtcgaa cctctacatt gtgaagttgc actatgtacc atactctaaa atgaaataag
     2701 aactctttat gtctgtgaga gagtgtgtgt gtgtgtgtgc gtgcgtgtgt gcttgtgggg
     2761 gttgggtagt gtgtgtgtat tttctctggc tttaaaattt taaaacaaac aaacaaaaaa
     2821 gccatagaga gcagaacttg ccgagggtca tttattgccc aagtttacaa gagtagcgat
     2881 acaagttttt gcaaattgaa tttgcctcag atatatctgt cctaatgctt atatttgcac
     2941 aagtatgtaa aatatcgtgt tgaggatcat tctttgttgg aaacactgct cttgctgaac
     3001 tgtcttgacc attgactatg acacagtttc ttatttatgt aaatacttgc atcacagtgg
     3061 ccgacaggca ttggatgcag aacctagagc cagttttcag gaacaattgt aaacctgaca
     3121 tggtactgtg catctattca taaaacactc aaaactgtga aaatatggtt tacatttaat
     3181 tgtacataaa ggtaaaggga gaactcaatt cagtaccagt tagtttgtac attttagggg
     3241 gcttttcaca ttaactgccc atttgtgtaa tttatagttt gacatgatgt gtttgtttta
     3301 aaaaaaaatg catagtataa acccattaag gatctgggaa aagagaagaa gtttaatata
     3361 gaactaagct tttaaagttt gtttttgttt ttaattctgg tctcggtgca aatgttagtt
     3421 atgccttatt catatcacag ttagatcacc atgctgcaac atggtttata ttcatgctgc
     3481 cctagaaact tttgtaatta tttgttgcaa atttgtgact gtccttatta actttctttt
     3541 atgtaagtaa tttgtaaaag tttcttaaaa tttttgcttt tgcttattta attttgaata
     3601 aaagctaaat tcctaata
//
