LOCUS       NM_001320643            4747 bp    mRNA    linear   PRI 09-MAR-2025
DEFINITION  Homo sapiens salt inducible kinase 1B (putative) (LOC102724428),
            mRNA.
ACCESSION   NM_001320643 XM_006723920 XM_006726803
VERSION     NM_001320643.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4747)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY023884.1, BC038504.1, CU639417.17, AK131076.1 and AW207331.1.
            
            On May 17, 2019 this sequence version replaced NM_001320643.2.
            
            Sequence Note: NM_001320643 is annotated on a scaffold that is
            thought to be a false duplication and thus this accession is likely
            redundant with NM_173354.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038504.1, DRR138518.294290.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 HY023884.1         60-62
            4-2896              BC038504.1         1-2893
            2897-2897           CU639417.17        155335-155335
            2898-3422           BC038504.1         2895-3419
            3423-3423           AK131076.1         3231-3231
            3424-4303           BC038504.1         3421-4300
            4304-4306           CU639417.17        156742-156744
            4307-4705           BC038504.1         4301-4699
            4706-4744           AW207331.1         22-60               c
            4745-4747           CU639417.17        157183-157185
FEATURES             Location/Qualifiers
     source          1..4747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21p12"
     gene            1..4747
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /note="salt inducible kinase 1B (putative)"
                     /db_xref="GeneID:102724428"
     exon            1..122
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            123..292
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2488
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase SIK1;
                     salt-inducible kinase 1B; probable
                     serine/threonine-protein kinase SIK1B; Salt-inducible
                     kinase 1; Serine/threonine-protein kinase SNF1-like kinase
                     1; Serine/threonine-protein kinase SNF1LK"
                     /codon_start=1
                     /product="putative serine/threonine-protein kinase SIK1B"
                     /protein_id="NP_001307572.1"
                     /db_xref="GeneID:102724428"
                     /translation="MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLA
                     RHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIV
                     TEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGN
                     MDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLV
                     CGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHR
                     WMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHF
                     AAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQ
                     PQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQ
                     GPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSC
                     LTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPV
                     SFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQVPASRASRGG
                     LSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPA
                     PFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTA
                     LPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ"
     exon            293..409
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            410..473
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            474..635
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            636..760
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            761..884
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1108
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1255
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1381
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1598
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1880
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2112
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..4747
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4692..4697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /note="hexamer: AATAAA"
     polyA_site      4715
                     /gene="LOC102724428"
                     /gene_synonym="SIK; SIK-1; SIK1; SIK1B; SNF1LK"
                     /note="major polyA site"
ORIGIN      
        1 gacatgcggc gcggccccgg aggcagcagc agcggcggcg gcagccggag cagtaggcac
       61 ccgagcagcg ccagcggccg agcgggcggc ttcctggcct gggcgctccg gtggcggcgg
      121 aggtgcgcgc ggagccatgg ttatcatgtc ggagttcagc gcggaccccg cgggccaggg
      181 tcagggccag cagaagcccc tccgggtggg tttttacgac atcgagcgga ccctgggcaa
      241 aggcaacttc gcggtggtga agctggcgcg gcatcgagtc accaaaacgc aggttgcaat
      301 aaaaataatt gataaaacac gattagattc aagcaatttg gagaaaatct atcgtgaggt
      361 tcagctgatg aagcttctga accatccaca catcataaag ctttaccagg ttatggaaac
      421 aaaggacatg ctttacatcg tcactgaatt tgctaaaaat ggagaaatgt ttgattattt
      481 gacttccaac gggcacctga gtgagaacga ggcgcggaag aagttctggc aaatcctgtc
      541 ggccgtggag tactgtcacg accatcacat cgtccaccgg gacctcaaga ccgagaacct
      601 cctgctggat ggcaacatgg acatcaagct ggcagatttt ggatttggga atttctacaa
      661 gtcaggagag cctctgtcca cgtggtgtgg gagccccccg tatgccgccc cggaagtctt
      721 tgaggggaag gagtatgaag gcccccagct ggacatctgg agcctgggcg tggtgctgta
      781 cgtcctggtc tgcggttctc tccccttcga tgggcctaac ctgccgacgc tgagacagcg
      841 ggtgctggag ggccgcttcc gcatcccctt cttcatgtct caagactgtg agagcctgat
      901 ccgccgcatg ctggtggtgg accccgccag gcgcatcacc atcgcccaga tccggcagca
      961 ccggtggatg cgggctgagc cctgcttgcc gggacccgcc tgccccgcct tctccgcaca
     1021 cagctacacc tccaacctgg gcgactacga tgagcaggcg ctgggtatca tgcagaccct
     1081 gggcgtggac cggcagagga cggtggagtc actgcaaaac agcagctata accactttgc
     1141 tgccatttat tacctcctcc ttgagcggct caaggagtat cggaatgccc agtgcgcccg
     1201 ccccgggcct gccaggcagc cgcggcctcg gagctcggac ctcagtggtt tggaggtgcc
     1261 tcaggaaggt ctttccaccg accctttccg acctgccttg ctgtgcccgc agccgcagac
     1321 cttggtgcag tccgtcctcc aggccgagat ggactgtgag ctccagagct cgctgcagtg
     1381 gcccttgttc ttcccggtgg atgccagctg cagcggagtg ttccggcccc ggcccgtgtc
     1441 cccaagcagc ctgctggaca cagccatcag tgaggaggcc aggcaggggc cgggcctaga
     1501 ggaggagcag gacacgcagg agtccctgcc cagcagcacg ggccggaggc acaccctggc
     1561 cgaggtctcc acccgcctct ccccactcac cgcgccatgt atagtcgtct ccccctccac
     1621 cacggcaagt cctgcagagg gaaccagctc tgacagttgt ctgaccttct ctgcgagcaa
     1681 aagccccgcg gggctcagtg gcaccccggc cactcagggg ctgctgggcg cctgctcccc
     1741 ggtcaggctg gcctcgccct tcctggggtc gcagtccgcc accccagtgc tgcaggctca
     1801 ggggggcttg ggaggagctg ttctgctccc tgtcagcttc caggagggac ggcgggcgtc
     1861 ggacacctca ctgactcaag ggctgaaggc ctttcggcag cagctgagga agaccacgcg
     1921 gaccaaaggg tttctgggac tgaacaaaat caaggggctg gctcgccagg tgtgccaggt
     1981 ccctgccagc cgggccagca ggggcggcct gagccccttc cacgcccctg cacagagccc
     2041 aggcctgcac ggcggcgcag ccggcagccg ggagggctgg agcctgctgg aggaggtgct
     2101 agagcagcag aggctgctcc agttacagca ccacccggcc gctgcacccg gctgctccca
     2161 ggccccccag ccggcccctg ccccgtttgt gatcgccccc tgtgatggcc ctggggctgc
     2221 cccgctcccc agcaccctcc tcacgtcggg gctcccgctg ctgccgcccc cactcctgca
     2281 gaccggcgcg tccccggtgg cctcagcggc gcagctcctg gacacacacc tgcacattgg
     2341 caccggcccc accgccctcc ccgctgtgcc cccaccacgc ctggccaggc tggccccagg
     2401 ttgtgagccc ctggggctgc tgcaggggga ctgtgagatg gaggacctga tgccctgctc
     2461 cctaggcacg tttgtcctgg tgcagtgagg gcagccctgc atcctggcac ggacactgac
     2521 tcttacagca ataacttcag aggaggtgaa gacatctggc ctcaaagcca agaactttct
     2581 agaagcgaaa taagcaatac gttaggtgtt ttggcttttt agtttatttt tgttttattt
     2641 ttttcttgca ctgagtgacc tcaactttga gtagggactg gaaactttag gaagaaagat
     2701 aattgagggg cgtgtctggg ggcgggggca ggaggggagc ggggtggagg gaacacgtgc
     2761 agtgccgtgg tgtggggatc tcggcccctc tctctgggtt cgtcgtggtt gagatgatta
     2821 cctcggacgt ctacggaaac gagcgggcgc attgttgtcc gcttgtgtgt gtgtgtgtgt
     2881 gtgtgtgtgt gcgcgtacat tgattactat ccatttcttt agtcaacgct ctccacttcc
     2941 tgatttctgc tttaaggaaa actgtgaact ttctgcttca tgtatcagtt ttaaagcagc
     3001 ccaggcaaag atcatctaca gattctagga attctctccc ctgaaatcaa aacctggaag
     3061 actttttttt cttattttag ttgagaagtt tcataaactg ctcaaggatt agttttccag
     3121 gactctgcgg aggaacggca ggaagaacct cagagagggc agaggtgact tcaaagtgct
     3181 ggggactccg tcctgagggt cacttggccc tgagcccctg cgtgcccttg cggaagccca
     3241 gaagcttctt cctgctgcac ctcccgtttc cgctgctgct gacgtttatg catttcatga
     3301 tggggtccaa caagaacacc tgacttgggt gaagttgtgc aatattggag gctgactgta
     3361 gggctgggca gctgggagac aggctcatgg ctcatggctc atggctcagg gcggtgcctg
     3421 ccctgggccg ggacccccct ccccaccccc cacctaggct ttttgggttt tgttcaagga
     3481 aggtaaagtg agaggtttag gtcagtgttt ttaagttttt gttttttttt taaagcaaat
     3541 cctgtatatg tatctacatg ggagacaggt agacactact tatttgttac attttgtact
     3601 acacgtttgt gttccaggtt tcagcttccc tcgctcctgt tgttaagaag cgtccctgtc
     3661 agcacaggtg tgcattgagg aaggggcccc agggccttcg ctccctcagc actggggtgg
     3721 aggcggcagg aaggggcggc ccttacctgg caggtctggg cgcaccttta gcaggtggac
     3781 tccgtggggc tccaccagcc agaagccttt ggaaggcaac gaaggcaatg ctgctccctg
     3841 agtccagtcc ccgcccccaa acccagccca ggtgccttca gctacttcgg cttcttaaac
     3901 cctgcagtgt taaacagagg cattgagaaa ggggaaaggc gggtattttt aaaagccaaa
     3961 gattgaccca gttacttgag ggtagggagg cgggcccagt gcaggaggct gcatccctgg
     4021 cctgctggtg cccaccgggg gctgtgcctg tgccgggccg cagggaagct ggctgccccc
     4081 attcctgctg ctgctgctgc tgctgctctg tggctgtttc aaagactggg cgaaaggctg
     4141 tccggagggc agaccaggtg ccttgccgca gagaaaacac caaagtctcc tgttcgctca
     4201 taaagaagtt tttgggatgg gagagaatcc agaccatctt ggggcagcca ggcccttgcc
     4261 ttcattttta cagaggtagc acaattgatt ccaacacaaa actccttccc ctttttaaaa
     4321 tgatttctgt tctaatgcca tagatcaaag gcctcagaaa ccattgtgtg tttcctcttt
     4381 gaagcaatga caagcacttt actttcacgg tggtttttgt tttttcttat tgctgtggaa
     4441 cctcttttgg aggacgttaa aggcgtgttt tacttgtttt tttaagagtg tgtgatgtgt
     4501 gttttgtaga tttcttgaca gtgctgtaat acagacggca atgcaatagc ctatttaaag
     4561 acactacgtg atctgattga gatgtacata gttttttttt ttaccataac tgaattattt
     4621 tatctcttat gttaacatga gaaatgtatg ccaaatgatt agttgatgta tgttttttaa
     4681 tttaatattt aaataaaata tttggaagga aaaaaccttg actttttccc ttcctctctc
     4741 tctcatc
//
