LOCUS       NM_001368238            3188 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens periodic tryptophan protein 2 homolog (LOC102724159),
            transcript variant 1, mRNA.
ACCESSION   NM_001368238 XM_006723910
VERSION     NM_001368238.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   2  (bases 1 to 3188)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3188)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   4  (bases 1 to 3188)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3188)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3188)
  AUTHORS   Lafreniere,R.G., Rochefort,D.L., Chretien,N., Neville,C.E.,
            Korneluk,R.G., Zuo,L., Wei,Y., Lichter,J. and Rouleau,G.A.
  TITLE     Isolation and genomic structure of a human homolog of the yeast
            periodic tryptophan protein 2 (PWP2) gene mapping to 21q22.3
  JOURNAL   Genome Res 6 (12), 1216-1226 (1996)
   PUBMED   8973917
REFERENCE   7  (bases 1 to 3188)
  AUTHORS   Lalioti,M.D., Chen,H., Rossier,C., Shafaatian,R., Reid,J.D. and
            Antonarakis,S.E.
  TITLE     Cloning the cDNA of human PWP2, which encodes a protein with WD
            repeats and maps to 21q22.3
  JOURNAL   Genomics 35 (2), 321-327 (1996)
   PUBMED   8661145
REFERENCE   8  (bases 1 to 3188)
  AUTHORS   Yamakawa,K., Gao,D.Q. and Korenberg,J.R.
  TITLE     A periodic tryptophan protein 2 gene homologue (PWP2H) in the
            candidate region of progressive myoclonus epilepsy on 21q22.3
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 140-145 (1996)
   PUBMED   8893822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FP565260.4.
            
            On Jan 30, 2019 this sequence version replaced XM_006723910.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. NM_001368238 is annotated on a
            scaffold that is thought to be a false duplication and thus this
            accession is likely redundant with NM_005049.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.198355.1,
                                           SRR1803613.116752.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                FP565260.4         144623-144658       c
            37-149              FP565260.4         142961-143073       c
            150-244             FP565260.4         138210-138304       c
            245-344             FP565260.4         137779-137878       c
            345-488             FP565260.4         137289-137432       c
            489-624             FP565260.4         136658-136793       c
            625-854             FP565260.4         136137-136366       c
            855-998             FP565260.4         134091-134234       c
            999-1069            FP565260.4         133222-133292       c
            1070-1206           FP565260.4         132532-132668       c
            1207-1355           FP565260.4         131559-131707       c
            1356-1503           FP565260.4         131277-131424       c
            1504-1654           FP565260.4         130953-131103       c
            1655-1835           FP565260.4         129698-129878       c
            1836-1983           FP565260.4         127327-127474       c
            1984-2092           FP565260.4         125935-126043       c
            2093-2158           FP565260.4         125089-125154       c
            2159-2377           FP565260.4         123902-124120       c
            2378-2528           FP565260.4         123655-123805       c
            2529-2603           FP565260.4         123426-123500       c
            2604-3188           FP565260.4         120871-121455       c
FEATURES             Location/Qualifiers
     source          1..3188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21p12"
     gene            1..3188
                     /gene="LOC102724159"
                     /note="periodic tryptophan protein 2 homolog"
                     /db_xref="GeneID:102724159"
     exon            1..36
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2778
                     /gene="LOC102724159"
                     /codon_start=1
                     /product="periodic tryptophan protein 2 homolog"
                     /protein_id="NP_001355167.1"
                     /db_xref="GeneID:102724159"
                     /translation="MKFAYRFSNLLGTVYRRGNLNFTCNGNSVISPVGNRVTVFDLKN
                     NKSDTLPLATRYNVKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGSVHSV
                     SFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFV
                     VGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCD
                     TPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSR
                     LAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIA
                     SVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGG
                     DDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNF
                     RTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLC
                     FNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQ
                     ITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHSILAGG
                     MSKFVCIYHVREQILMKRFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGQEDGV
                     AIPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATTTEGLLIYSLDTRVLFDPFE
                     LDTSVTPGRVREALRQQDFTRAILMALRLNESKLVQEALEAVPRGEIEVVTSSLPELY
                     VEKVLEFLASSFEVSRHLEFYLLWTHKLLMLHGQKLKSRAGTLLPVIQFLQKSIQRHL
                     DDLSKLCSWNHYNMQYALAVSKQRGTKRSLDPLGSEEEAEASEDDSLHLLGGGGRDSE
                     EEMLA"
     exon            37..149
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            150..244
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            245..344
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            345..488
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            489..624
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            625..854
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            855..998
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1069
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1206
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1355
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1503
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1654
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1835
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1983
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2092
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2158
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2377
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2528
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2603
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..3188
                     /gene="LOC102724159"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3117..3122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOC102724159"
                     /note="hexamer: ATTAAA"
     polyA_site      3147
                     /gene="LOC102724159"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOC102724159"
                     /note="hexamer: ATTAAA"
     polyA_site      3188
                     /gene="LOC102724159"
                     /note="major polyA site"
ORIGIN      
        1 acacgtgcga cagccgtgat gaagttcgct taccggtttt caaatttgct gggtacggtg
       61 taccggcgtg ggaacctaaa ttttacctgc aatggaaatt cagttatcag tcccgtgggc
      121 aatagagtca ctgtatttga ccttaaaaac aacaaatctg acacgctgcc cctggccact
      181 cggtacaacg tcaagtgcgt ggggctgtcc ccggatggcc gcctcgctat catcgtcgat
      241 gaagggggcg atgcgctgct ggtcagcctg gtctgcaggt ctgtgctgca ccacttccac
      301 ttcaagggct ctgtgcacag tgtgtccttc tcccctgatg gcaggaagtt tgttgtcaca
      361 aagggtaaca ttgcccagat gtatcatgcc cctgggaaga agcgggagtt caacgccttc
      421 gttctggaca agacctattt tgggccctac gatgagacca cctgcatcga ctggacggat
      481 gactccaggt gctttgtggt tgggagcaaa gacatgtcca cctgggtgtt cggagccgag
      541 cgctgggaca acctcatcta ctatgcactg gggggacata aggatgccat cgtggcctgc
      601 ttctttgaat ccaacagcct ggacctgtac tcactcagcc aggacggagt gctgtgcatg
      661 tggcagtgtg acacgccccc cgagggcttg cggctgaagc cccctgcggg ctggaaagca
      721 gacctgttgc agcgggagga ggaagaggag gaggaggagg accaggaggg cgacagagag
      781 accaccatcc ggggaaaagc cactccggcc gaggaggaga agacaggaaa agtgaagtac
      841 tcacggctgg ccaagtactt cttcaataaa gaaggggatt ttaacaacct gacagctgca
      901 gcatttcata agaagtctca cctcttggtc actggctttg cttctggaat cttccatctt
      961 catgagctgc cagagtttaa cctcatccac tccctgagca tctcagatca gagcatcgcc
     1021 tcagtggcca tcaatagctc gggggactgg attgcttttg gctgttcagg cctgggccag
     1081 ctgctggtgt gggagtggca gagtgagtcc tacgtgctca agcagcaggg ccacttcaac
     1141 agcatggtgg ccctggccta ctcgcccgac ggacagtaca tcgtgactgg cggggacgac
     1201 ggcaaggtca aggtgtggaa caccctcagc ggcttctgct tcgtcacttt tacggagcac
     1261 tccagcgggg tgaccggtgt gacctttact gccaccggct acgttgtggt gacctcatcc
     1321 atggacggga ccgtgcgagc ctttgacctt cacaggtacc gaaacttccg caccttcacc
     1381 tctccacgcc ccacccagtt ctcctgtgtg gcggtggatg cgagcggtga gatcgtctct
     1441 gcaggggcgc aggactcctt tgagattttc gtgtggtcca tgcagacagg caggctcctt
     1501 gatgttttgt ctggacacga agggcccatc agtggtctgt gttttaaccc aatgaagtcc
     1561 gtcctggcca gtgcctcctg ggacaagacg gtgcgcctat gggacatgtt tgacagctgg
     1621 aggaccaagg agacgctggc cctgacctct gatgctctgg ctgtgacttt tcgccctgat
     1681 ggtgcggagc tggctgtggc cacactgaac tcacagatca ccttctggga ccctgagaac
     1741 gcggtgcaga cgggctccat tgagggcagg catgacctca agactggcag gaaggagctg
     1801 gacaagatta cagccaagca cgcggccaag gggaaggcct tcaccgccct gtgctactct
     1861 gcagacggcc acagcatcct ggcgggaggc atgtccaagt tcgtgtgcat ctaccacgtc
     1921 cgtgagcaga ttctcatgaa gaggttcgag atctcttgca acctgtctct ggacgccatg
     1981 gaggaatttt tgaaccgaag aaaaatgaca gagtttggca acctggcact aattgatcag
     2041 gatgctgggc aggaggatgg agtcgcgata ccactgccag gcgtcaggaa aggtgacatg
     2101 agttctcggc acttcaaacc tgagatcagg gtgacctcac tccgcttctc tcccactggg
     2161 cgctgctggg cggccaccac cacggaggga ctcctcatct actccctgga cacccgcgtg
     2221 ctctttgacc cgtttgagct ggacaccagc gtcacccccg ggagggtgcg cgaggcactg
     2281 cgccagcagg acttcaccag ggccatcctc atggccctcc ggctcaacga gagcaaactg
     2341 gtgcaggagg ccctggaggc ggtgcccagg ggcgagattg aagtggtcac ctcctccctt
     2401 cctgaactgt atgtggagaa agtgctggag tttttagctt cctcctttga agtgtctcgc
     2461 cacctggaat tctacctcct ctggactcac aaactgctca tgttgcacgg acagaagctg
     2521 aagtccagag ccgggacgct gctgcctgtc attcagttcc tccagaagag catccagcgg
     2581 cacctggacg acctgtcgaa actctgtagc tggaaccact ataacatgca gtacgcacta
     2641 gcagtttcca agcagcgggg cacaaaacgc tccctagacc cgctgggaag tgaggaggag
     2701 gcagaagcat ctgaagatga cagcctgcat ctgcttggag gaggaggcag agactcagaa
     2761 gaagagatgc tggcctagag ccagccggtt gcagcgttgg attgtgccgg ctaagacctg
     2821 ccagggagat gggacccttg tgccacctgg gccagcaaag aggaggggtc cagagaacag
     2881 ctgaaatact gtcactagtg gtagtgactt gcttttcctg tgcacacatg tagcccatca
     2941 ggacagcgag ccgacgggtc acgccagggg ccggcacgca ctggcacctg gccccaggag
     3001 cggggccgtg tgaacggtga tgaatgttga aaatgcgtct cagagaggta ttcacatgaa
     3061 ctttgtatga gacttattta tatttttaac ataaaggttt gataaagaac ttagggatta
     3121 aaaaaaagat ggagttttct aacgtgagga tgaagtctac acttcagatt aaaaagggtt
     3181 atgttgta
//
