LOCUS       NM_001363758            1584 bp    mRNA    linear   PRI 09-MAR-2025
DEFINITION  Homo sapiens glutamine amidotransferase class 1 domain containing
            3B (LOC102724023), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001363758 XM_006723901
VERSION     NM_001363758.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1584)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1584)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1584)
  AUTHORS   Lafreniere,R.G., Rochefort,D.L., Kibar,Z., Fon,E.A., Han,F.,
            Cochius,J., Kang,X., Baird,S., Korneluk,R.G., Andermann,E.,
            Rommens,J.M. and Rouleau,G.A.
  TITLE     Isolation and characterization of GT335, a novel human gene
            conserved in Escherichia coli and mapping to 21q22.3
  JOURNAL   Genomics 38 (3), 264-272 (1996)
   PUBMED   8975701
REFERENCE   4  (bases 1 to 1584)
  AUTHORS   Nagamine,K., Kudoh,J., Minoshima,S., Kawasaki,K., Asakawa,S.,
            Ito,F. and Shimizu,N.
  TITLE     Isolation of cDNA for a novel human protein KNP-I that is
            homologous to the E. coli SCRP-27A protein from the autoimmune
            polyglandular disease type I (APECED) region of chromosome 21q22.3
  JOURNAL   Biochem Biophys Res Commun 225 (2), 608-616 (1996)
   PUBMED   8753807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN291933.1, BX353477.2 and FP565260.4.
            
            On May 17, 2019 this sequence version replaced NM_001363758.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. NM_001363758
            is annotated on a scaffold that is thought to be a false
            duplication and thus this accession is likely redundant with
            NM_004649.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.621076.1,
                                           SRR3476690.538667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-577               CN291933.1         70-646
            578-842             BX353477.2         613-877
            843-1584            FP565260.4         106341-107082       c
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21p12"
     gene            1..1584
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /note="glutamine amidotransferase class 1 domain
                     containing 3B"
                     /db_xref="GeneID:102724023"
     exon            1..156
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..822
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /note="isoform 1 is encoded by transcript variant 1; ES1
                     protein homolog, mitochondrial; keio novel protein-I;
                     Protein GT335; Protein HES1; glutamine
                     amidotransferase-like class 1 domain-containing protein
                     3B, mitochondrial; glutamine amidotransferase like class 1
                     domain containing 3B; putative glutamine
                     amidotransferase-like class 1 domain-containing protein
                     3B, mitochondrial"
                     /codon_start=1
                     /product="putative glutamine amidotransferase-like class 1
                     domain-containing protein 3B, mitochondrial isoform 1"
                     /protein_id="NP_001350687.1"
                     /db_xref="GeneID:102724023"
                     /translation="MAAVRALVASRLAAASAFTSLSPGGRTPSQRAALHLSVPRPAAR
                     VALVLSGCGVYDGTEIHEASAILVHLSRGGAEVQIFAPDVPQMHVIDHTKGQPSEGES
                     RNVLTESARIARGKITDLANLSAANHDAAIFPGGFGAAKNLSTFAVDGKDCKVNKEVE
                     RVLKEFHQAGKPIGLCCIAPVLAAKVLRGVEVTVGHEQEEGGKWPYAGTAEAIKALGA
                     KHCVKEVVEAHVDQKNKVVTTPAFMCETALHYIHDGIGAMVRKVLELTGK"
     exon            157..209
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            210..323
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            324..443
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            444..536
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            537..693
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /inference="alignment:Splign:2.1.0"
     exon            694..1584
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1563..1568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /note="hexamer: AATAAA"
     polyA_site      1584
                     /gene="LOC102724023"
                     /gene_synonym="GATD3B; HES1; KNP-I; KNPI"
                     /note="major polyA site"
ORIGIN      
        1 gctgtcctca ccgcaatggc ggctgtgagg gccctggtgg cctcgaggct cgctgcggca
       61 tctgcattca cgtccctgtc ccccggcggt cggacgcctt cccagcgcgc agcccttcac
      121 ctctccgtgc cgcgccccgc ggccagggtc gcgctggtgc tgtctggatg cggagtctac
      181 gatgggaccg agatccacga ggcctcggcg atcctggtgc acctgagccg tggaggggct
      241 gaagtccaga tctttgctcc tgacgtccct cagatgcacg tgattgacca caccaagggg
      301 cagccgtccg aaggcgagag caggaatgtt ttgaccgagt ctgcgaggat cgcccgtggc
      361 aaaatcacag acctggccaa cctcagtgca gccaaccatg atgctgccat ctttccagga
      421 ggctttggag cggctaaaaa cctgagcacg tttgccgtgg acgggaaaga ttgcaaggtg
      481 aataaagaag tggagcgtgt cctgaaggag ttccaccagg ccgggaagcc catcggcttg
      541 tgctgcattg cacctgtcct cgcggccaag gtgctcagag gcgtcgaggt gactgtgggc
      601 cacgagcagg aggaaggtgg caagtggcct tatgccggga ccgcagaggc catcaaggcc
      661 ctgggtgcca agcactgcgt gaaggaagtg gtcgaagctc acgtggacca gaaaaacaag
      721 gtggtcacga ccccagcctt catgtgcgag acggcactcc actacatcca tgatgggatc
      781 ggagccatgg tgaggaaggt gctggaactc actggaaagt gacgcgcatg gacggggccc
      841 agctaggcgc caggacttgg cctcaccctc tggctgagga gctgtcggct gctttccatc
      901 cagctgggag tctggcaggc cctttttttt ttttctttgc cgaaacctgc aggcgttctc
      961 tctctaagga ggatgtgctg cagtgcatgg gggatgtttc ttcctgggtg tggctgggct
     1021 gctctcacat acagaggccg aggggccaat tcgttctctg ccacagggac ttgcctcact
     1081 gtgtcccaaa aacaaatcgc agccagcttt tccagaaata gaaaattctg ccgtctgagg
     1141 ttttatactt caggttagtt agtttttgga aggaagaaca tttttaggtt tgcaagcctc
     1201 ctgatcagga aaccagaaat accacattta tggaccatga aaggttggtt cttgactctg
     1261 aagggacttt tgagttaatc agcgtaaggg gatttctaaa gcaggcaatc cctgtagccg
     1321 cagagaataa acgccttccc aaaatggcaa cttcccacag ccacatttca gacctgctga
     1381 gactgctgag tgaggaatgg cagtgaggtt tcttcaatta gtctcagttc tcttaatttt
     1441 caggaagaaa gggaaattgc agctcctcag cccccaggat tgacctctgg ggagtgatgg
     1501 tagcgttggt gccaggccgt gggttcaggt gtggcagaag cttgcagatg cgtccgaagg
     1561 gaaataaagt gtgttggcgt taga
//
