LOCUS       NM_001363770            3237 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens ICOS ligand (LOC102723996), mRNA.
ACCESSION   NM_001363770 XM_006723900
VERSION     NM_001363770.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FP565260.4.
            
            On May 17, 2019 this sequence version replaced NM_001363770.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. NM_001363770.2 is annotated on a
            scaffold that is thought to be a false duplication and thus this
            accession is likely redundant with NM_015259.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.240617.1,
                                           SRR1660807.30703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               FP565260.4         12531-12693
            164-204             FP565260.4         15009-15049
            205-555             FP565260.4         16280-16630
            556-846             FP565260.4         17935-18225
            847-1011            FP565260.4         22053-22217
            1012-1047           FP565260.4         23408-23443
            1048-3237           FP565260.4         24582-26771
FEATURES             Location/Qualifiers
     source          1..3237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21p12"
     gene            1..3237
                     /gene="LOC102723996"
                     /note="ICOS ligand"
                     /db_xref="GeneID:102723996"
     exon            1..163
                     /gene="LOC102723996"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1058
                     /gene="LOC102723996"
                     /codon_start=1
                     /product="ICOS ligand precursor"
                     /protein_id="NP_001350699.1"
                     /db_xref="GeneID:102723996"
                     /translation="MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSR
                     FDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFN
                     VTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTS
                     INGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIE
                     NVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWV
                     CRDRCLQHSYAGAWAVSPETELTGHV"
     exon            164..204
                     /gene="LOC102723996"
                     /inference="alignment:Splign:2.1.0"
     exon            205..555
                     /gene="LOC102723996"
                     /inference="alignment:Splign:2.1.0"
     exon            556..846
                     /gene="LOC102723996"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1011
                     /gene="LOC102723996"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1047
                     /gene="LOC102723996"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..3237
                     /gene="LOC102723996"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2592
                     /gene="LOC102723996"
                     /note="major polyA site"
     polyA_site      3237
                     /gene="LOC102723996"
ORIGIN      
        1 agagcctcgg gcgcggcggg agcgcagtta gagccgatct cccgcgcccc gaggttgctc
       61 ctctccgagg tctcccgcgg cccaagttct ccgcgccccg aggtctccgc gccccgaggt
      121 ctccgcggcc cgaggtctcc gcccgcacca tgcggctggg cagtcctgga ctgctcttcc
      181 tgctcttcag cagccttcga gctgatactc aggagaagga agtcagagcg atggtaggca
      241 gcgacgtgga gctcagctgc gcttgccctg aaggaagccg ttttgattta aatgatgttt
      301 acgtatattg gcaaaccagt gagtcgaaaa ccgtggtgac ctaccacatc ccacagaaca
      361 gctccttgga aaacgtggac agccgctacc ggaaccgagc cctgatgtca ccggccggca
      421 tgctgcgggg cgacttctcc ctgcgcttgt tcaacgtcac cccccaggac gagcagaagt
      481 ttcactgcct ggtgttgagc caatccctgg gattccagga ggttttgagc gttgaggtta
      541 cactgcatgt ggcagcaaac ttcagcgtgc ccgtcgtcag cgccccccac agcccctccc
      601 aggatgagct caccttcacg tgtacatcca taaacggcta ccccaggccc aacgtgtact
      661 ggatcaataa gacggacaac agcctgctgg accaggctct gcagaatgac accgtcttct
      721 tgaacatgcg gggcttgtat gacgtggtca gcgtgctgag gatcgcacgg acccccagcg
      781 tgaacattgg ctgctgcata gagaacgtgc ttctgcagca gaacctgact gtcggcagcc
      841 agacaggaaa tgacatcgga gagagagaca agatcacaga gaatccagtc agtaccggcg
      901 agaaaaacgc ggccacgtgg agcatcctgg ctgtcctgtg cctgcttgtg gtcgtggcgg
      961 tggccatagg ctgggtgtgc agggaccgat gcctccaaca cagctatgca ggtgcctggg
     1021 ctgtgagtcc ggagacagag ctcactggcc acgtttgacc ggagctcacc gcccagagcg
     1081 tggacagggc ttccgtgaga cgccaccgtg agaggccagg tggcagcttg agcatggact
     1141 cccagactgc aggggagcac ttggggcagc ccccagaagg accactgctg gatcccaggg
     1201 agaacctgct ggcgttggct gtgatcctgg aatgaggccc tttcaaaagc gtcatccaca
     1261 ccaaaggcaa atgtccccaa gtgagtgggc tccccgctgt cactgccagt cacccacagg
     1321 aagggactgg tgatgggctg tctctacccg gagcgtgcgg gattcagcac caggctcttc
     1381 ccagtacccc agacccactg tgggtcttcc cgtgggatgc gggatcctga gaccgaaggg
     1441 tgtttggttt aaaaagaaga ctgggcgtcc gctcttccag gacggcctct gtgctgctgg
     1501 ggtcacgcga ggctgtttgc aggggacacg gtcacaggag ctcttctgcc ctgaacgctc
     1561 ccaacctgcc tcccgcccgg aagccacagg acccactcat gtgtgtgccc acaagtgtag
     1621 ttagccgtcc acaccgagga gcccccggaa gtccccactg ggcttcagtg tcctctgcca
     1681 cattccctgg gaggaacaat gtccctcggc tgttccggtg aaaagttgag ccacctttgg
     1741 aagacgcacg ggtggagttt gccagaagaa aggctgtgcc agggccgtgt ttggctacag
     1801 gggctgccgg ggctcttggc tctgcagcga gaaagacaca gcccagcagg gctggagacg
     1861 cccatgtcca gcaggcgcag gcctggcaac acggtcccca gagtcctgag cagcagttag
     1921 gtgcatggag agggtatcac ctggtggcca cagtccccct tctcacctca gcaatgatcc
     1981 ccaaagtgag aggtggctcc cccggccccc accaccctca gcagccccac cccactcaac
     2041 cctgagggtc cccagggtcc tgatgaagac ctccgacccc agcgccaggc tcctcggagc
     2101 ccaacagtcc caagggggca gtgctgaggg gtacagccct gggccctgac cagccccggc
     2161 acctgccatg ctggttcccg gaatgaatca gctgctgact gtctccagaa gggctggaaa
     2221 ggatgctgcc aggtgacccg aggtgcactc gccccaggga gatggagtag acagcctggc
     2281 ctggccctcg ggacacattg tctgccccgg ggctatgggc aaatgcccct ccttcttact
     2341 tcccagaatc ccctgacatt cccagggtca gccaggacct gttacagccc tggtcacttg
     2401 gaactgacag ctgtgtgagg cctgcacttc tcagacccag acttagaaca aaaggaggag
     2461 tgaggactca aggctacaat gaggttccag tacttgttac aagaaattgg ttttctgcaa
     2521 aaaaagtccc tacctgggcc tttaggtgaa tgtgggatcc actcccgctt ttaacatgaa
     2581 agcattagaa gatgtgtggt gtttataaaa gaacagttgt catcaccggg cattgattgg
     2641 cagggacaag gagctgcttg ggtgtggaaa gttggggcgt tggaaagtgg gctgtggtgc
     2701 ccatttgcag tgactgtgaa gtgactccag gacggacctg cgggggcacc cagagatcct
     2761 aagccccagg actgagggtc gtgcatcacc actcgggtgt cccgggaggt gccctgggcc
     2821 cggggacctc acaggcagga cggcgacact aatgcaggga gagggagtct ggccccagct
     2881 tttcctatca gaggcgattt tccttcacca ggggatgggc aggaaagagg caggggcccc
     2941 agaagcttct gtccctcatg cctgagggca cgggggacac ttggaggctg ctgtcaccac
     3001 tgtgcgtcca aggccatgct ctctgcgggt cagtgcctga gtctcgcctc cctgctggtc
     3061 cctgaagccc cctcagaagc cctgcctgtc acgtcggcat ttgtgagacc taccctgtaa
     3121 cgcctgcccc tctcagccca acatcagctt cctctttctc ccttgctgta gacaggctgg
     3181 attccagtgt tgggacagcc atctccagaa acctgactta agagagtaag atgcaaa
//
