LOCUS       NM_001204811            1872 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens MAGEA10-MAGEA5 readthrough (LOC100533997), mRNA.
ACCESSION   NM_001204811
VERSION     NM_001204811.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Cappell,K.M., Sinnott,R., Taus,P., Maxfield,K., Scarbrough,M. and
            Whitehurst,A.W.
  TITLE     Multiple cancer testis antigens function to support tumor cell
            mitotic fidelity
  JOURNAL   Mol Cell Biol 32 (20), 4131-4140 (2012)
   PUBMED   22869527
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   De Plaen,E., Arden,K., Traversari,C., Gaforio,J.J., Szikora,J.P.,
            De Smet,C., Brasseur,F., van der Bruggen,P., Lethe,B., Lurquin,C.
            et al.
  TITLE     Structure, chromosomal localization, and expression of 12 genes of
            the MAGE family
  JOURNAL   Immunogenetics 40 (5), 360-369 (1994)
   PUBMED   7927540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116666.2, BX109673.1 and AF274856.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001204811.2.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring MAGEA10 (melanoma antigen
            family A, 10) and MAGEA5 (melanoma antigen family A, 5) genes on
            chromosome X. The read-through transcript is predicted to encode
            the downstream gene product. [provided by RefSeq, Mar 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX109673.1, ERR4368409.432723.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2148874,
                                           SAMEA2149398 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 4104, 4109
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC116666.2         73068-73123         c
            57-533              BX109673.1         1-477
            534-1872            AF274856.3         155877-157215       c
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1872
                     /gene="LOC100533997"
                     /gene_synonym="CT1.5; MAGEA10-MAGEA5; MAGEA5P"
                     /note="MAGEA10-MAGEA5 readthrough"
                     /db_xref="GeneID:100533997"
     exon            1..103
                     /gene="LOC100533997"
                     /gene_synonym="CT1.5; MAGEA10-MAGEA5; MAGEA5P"
                     /inference="alignment:Splign:2.1.0"
     exon            104..228
                     /gene="LOC100533997"
                     /gene_synonym="CT1.5; MAGEA10-MAGEA5; MAGEA5P"
                     /inference="alignment:Splign:2.1.0"
     exon            229..315
                     /gene="LOC100533997"
                     /gene_synonym="CT1.5; MAGEA10-MAGEA5; MAGEA5P"
                     /inference="alignment:Splign:2.1.0"
     exon            316..1872
                     /gene="LOC100533997"
                     /gene_synonym="CT1.5; MAGEA10-MAGEA5; MAGEA5P"
                     /inference="alignment:Splign:2.1.0"
     CDS             381..755
                     /gene="LOC100533997"
                     /gene_synonym="CT1.5; MAGEA10-MAGEA5; MAGEA5P"
                     /note="melanoma-associated antigen 5; MAGE-5 antigen;
                     cancer/testis antigen 1.5; MAGE family member A5
                     pseudogene"
                     /codon_start=1
                     /product="putative melanoma-associated antigen 5P"
                     /protein_id="NP_001191740.1"
                     /db_xref="GeneID:100533997"
                     /translation="MSLEQKSQHCKPEEGLDTQEEALGLVGVQAATTEEQEAVSSSSP
                     LVPGTLGEVPAAGSPGPLKSPQGASAIPTAIDFTLWRQSIKGSSNQEEEGPSTSPDPE
                     SVFRAALSKKVADLIHFLLLKY"
     regulatory      1852..1857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LOC100533997"
                     /gene_synonym="CT1.5; MAGEA10-MAGEA5; MAGEA5P"
                     /note="hexamer: ATTAAA"
     polyA_site      1872
                     /gene="LOC100533997"
                     /gene_synonym="CT1.5; MAGEA10-MAGEA5; MAGEA5P"
                     /note="major polyA site"
ORIGIN      
        1 ctaacttacg cctcggggat cagagagaag cgaggttctc gttctgaggg acaggcttga
       61 gatcggctga agagagcggg cccaggctct gtgaggaggc aagcatcatg cactatcctg
      121 ttgggagcat cctcacctcc aagacactgt ttgggcctga ggagaaggag tctgcagtga
      181 ccctgtcgtg gtattttcca caagaattct gaaatgaagc aagcacaggt tctcagggga
      241 caggctgacc aggatcacca ggaagctcca gaggatcccc aggaggccct agaggagcac
      301 caaaggagaa gatctgccag tgggtctcca ttgcccagct cctgcccaca ctcctgcctg
      361 ttgcggtgac cagagtcgtc atgtctcttg agcagaagag tcagcactgc aagcctgagg
      421 aaggccttga cacccaagaa gaggccctgg gcctggtggg tgtgcaggct gccactactg
      481 aggagcagga ggctgtgtcc tcctcctctc ctctggtccc aggcaccctg ggggaggtgc
      541 ctgctgctgg gtcaccaggt cctctcaaga gtcctcaggg agcctccgcc atccccactg
      601 ccatcgattt cactctatgg aggcaatcca ttaagggctc cagcaaccaa gaagaggagg
      661 ggccaagcac ctcccctgac ccagagtctg tgttccgagc agcactcagt aagaaggtgg
      721 ctgacttgat tcattttctg ctcctcaagt attaagtcaa ggagccggtc acaaaggcag
      781 aaatgctgga gagagtcatc aaaaattaca agcgctgctt tcctgtgatc ttcggcaaag
      841 cctccgagtc cttgcagctg gtctttggca ttgacgtgaa ggaagcggac cccaccagca
      901 acacctacac ccttgtcacc tgcctgggac tcctatgatg gcctggtggt tgataataat
      961 cagatcatgc ccaagacggg cctcctgata atcgtcttgg gcatgattgc aatggagggc
     1021 aaatgcgtcc ctgaggagaa aatctgggag gagctgagtg tgatgaaggt gtatgttggg
     1081 agggagcaca gtgtctgtgg ggagcccagg aagctgctca cccaagattt ggtgcaggaa
     1141 aactacctgg agtaccggca ggtgcccagc agtgatccca tatgctatga gttactgtgg
     1201 ggtccaaggg cactcgctgc ttgaaagtac tggagcacgt ggtcagggtc aatgcaagag
     1261 ttctcatttc ctacccatcc ctgcatgaag cagctttgag agaggaggaa gagggagtct
     1321 gagcatgagc tgcagccagg gccactgcga ggggggctgg gccagtgcac cttccagggc
     1381 tccgtccact agtttcccct gccttaatgt gacatgaggc ccattcttct ctctttgaag
     1441 agagcagtca acattcttag tagtgggttt ctgttctatt ggatgacttt gagatttgtc
     1501 tttgtttcct tttggaattg ttcaaatgtt ccttttaatg ggtggttgaa tgaacttcag
     1561 cattcaaatt tatgaatgac agtagtcaca catagtgctg tttatatagt ttaggagtaa
     1621 gagtcttgtt ttttattcag attgggaaat ccattccatt ttgtgaattg ggacatagtt
     1681 acagcagtgg aataagtatt catttagaaa tgtgaatgag cagtaaaact gatgacataa
     1741 agaaattaaa agatatttaa ttcttgcctt atactcagtc tactcggtaa aatttttttt
     1801 aaaaaatgtg catacctgga tttccttggc ttctttgaga atgtaagaca aattaaatct
     1861 gaataaatca tt
//
