LOCUS       NM_153371               4750 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ligand of numb-protein X 2 (LNX2), mRNA.
ACCESSION   NM_153371
VERSION     NM_153371.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4750)
  AUTHORS   Liu,G.B., Zhan,T., Pan,Y.M., Zhang,D.W., Zheng,H.Z., Xu,B.,
            Li,T.T., Dong,C.L. and Cheng,Y.X.
  TITLE     LNX2 involves in the role of ghrelin to promote the neuronal
            differentiation of adipose tissue-derived mesenchymal stem cells
  JOURNAL   J Bioenerg Biomembr 55 (3), 195-205 (2023)
   PUBMED   37237241
  REMARK    GeneRIF: LNX2 involves in the role of ghrelin to promote the
            neuronal differentiation of adipose tissue-derived mesenchymal stem
            cells.
REFERENCE   2  (bases 1 to 4750)
  AUTHORS   Caillet-Saguy,C., Durbesson,F., Rezelj,V.V., Gogl,G., Tran,Q.D.,
            Twizere,J.C., Vignuzzi,M., Vincentelli,R. and Wolff,N.
  TITLE     Host PDZ-containing proteins targeted by SARS-CoV-2
  JOURNAL   FEBS J 288 (17), 5148-5162 (2021)
   PUBMED   33864728
REFERENCE   3  (bases 1 to 4750)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4750)
  AUTHORS   de la Rocha-Munoz,A., Nunez,E., Arribas-Gonzalez,E.,
            Lopez-Corcuera,B., Aragon,C. and de Juan-Sanz,J.
  TITLE     E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the
            presynaptic glycine transporter GlyT2
  JOURNAL   Sci Rep 9 (1), 14944 (2019)
   PUBMED   31628376
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4750)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4750)
  AUTHORS   D'Agostino,M., Tornillo,G., Caporaso,M.G., Barone,M.V., Ghigo,E.,
            Bonatti,S. and Mottola,G.
  TITLE     Ligand of Numb proteins LNX1p80 and LNX2 interact with the human
            glycoprotein CD8alpha and promote its ubiquitylation and
            endocytosis
  JOURNAL   J Cell Sci 124 (Pt 21), 3545-3556 (2011)
   PUBMED   22045731
  REMARK    GeneRIF: LNX1 and LNX2 interact with CD8alpha and promote its
            ubiquitylation and endocytosis
REFERENCE   7  (bases 1 to 4750)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 4750)
  AUTHORS   Kumar,V., Matsuo,K., Takahashi,A., Hosono,N., Tsunoda,T.,
            Kamatani,N., Kong,S.Y., Nakagawa,H., Cui,R., Tanikawa,C., Seto,M.,
            Morishima,Y., Kubo,M., Nakamura,Y. and Matsuda,K.
  TITLE     Common variants on 14q32 and 13q12 are associated with DLBCL
            susceptibility
  JOURNAL   J Hum Genet 56 (6), 436-439 (2011)
   PUBMED   21471979
REFERENCE   9  (bases 1 to 4750)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   10 (bases 1 to 4750)
  AUTHORS   Rice,D.S., Northcutt,G.M. and Kurschner,C.
  TITLE     The Lnx family proteins function as molecular scaffolds for Numb
            family proteins
  JOURNAL   Mol Cell Neurosci 18 (5), 525-540 (2001)
   PUBMED   11922143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB220129.1, BC036755.2, DN990012.1 and AK022995.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153371.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036755.2, SRR1660803.239226.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316334.5/ ENSP00000325929.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               DB220129.1         55-172
            119-121             BC036755.2         1-3
            122-123             BC036755.2         5-6
            124-654             DN990012.1         113-643
            655-2816            BC036755.2         538-2699
            2817-2937           AK022995.1         644-764
            2938-2987           BC036755.2         2821-2870
            2988-3511           AK022995.1         815-1338
            3512-4750           BC036755.2         3395-4633
FEATURES             Location/Qualifiers
     source          1..4750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.2"
     gene            1..4750
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /note="ligand of numb-protein X 2"
                     /db_xref="GeneID:222484"
                     /db_xref="HGNC:HGNC:20421"
                     /db_xref="MIM:609733"
     exon            1..155
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            156..662
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2328
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /note="PDZ domain containing ring finger 1; numb-binding
                     protein 2; PDZ domain-containing RING finger protein 1"
                     /codon_start=1
                     /product="ligand of Numb protein X 2"
                     /protein_id="NP_699202.1"
                     /db_xref="CCDS:CCDS9323.1"
                     /db_xref="GeneID:222484"
                     /db_xref="HGNC:HGNC:20421"
                     /db_xref="MIM:609733"
                     /translation="MGTTSDEMVSVEQTSSSSLNPLCFECGQQHWTRENHLYNYQNEV
                     DDDLVCHICLQPLLQPLDTPCGHTFCYKCLRNFLQEKDFCPLDRKRLHFKLCKKSSIL
                     VHKLLDKLLVLCPFSSVCKDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIE
                     NENGPTLLDPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGAD
                     TTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGR
                     LLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPR
                     EEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAING
                     HDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYS
                     RPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLA
                     RDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAE
                     EQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHT
                     NQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV
                     ICWPGSLV"
     exon            663..910
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1110
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1479
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1623
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1801
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..2033
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2192
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..4750
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4728..4733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /note="hexamer: AATAAA"
     polyA_site      4750
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /note="major polyA site"
ORIGIN      
        1 aggaaatccg cggcggcggc ggcggcggcg gcgattcctg gcggagcgga gccgggcagg
       61 ctctccgctc cctcagcggg ccgcggagag cgggagctgg tgccgagcag cggcgccagg
      121 agcccgtgcg cggcccgggc agccgcgctt tcccaaaaaa cacaccttga ctttagtcag
      181 atacatcact gtctgttaaa ggaaaccaag cgtgaagtgg aagtctaaca catgaggata
      241 cagaattgat tcaaaatggg aacaacaagt gatgagatgg tgtctgtgga acagacctcc
      301 tcctcttctc taaaccccct gtgttttgaa tgtggccaac agcactggac aagagaaaac
      361 catttgtaca attaccagaa tgaagtggat gatgacctag tctgccatat ttgccttcaa
      421 cctctgctgc agccactaga cacaccctgt ggacatacat tctgctacaa gtgcctcaga
      481 aactttttac aagagaaaga tttctgtccg ttggaccgga aaagacttca ttttaagttg
      541 tgcaagaagt ctagtattct agttcataaa ctcctagaca aattattagt tttatgtcca
      601 ttttcttcag tgtgcaaaga tgtaatgcaa cgttgtgatc tggaggcaca tctcaaaaac
      661 agatgtcctg gagcttctca tcggagagtt gccctggaga gaaggaaaac tagtagaact
      721 caagcagaga ttgagaatga aaatgggccc actctactag atcctgcagg taccttatct
      781 ccagaagcag actgtttggg gacaggcgca gtgcctgtgg agcggcactt gacatcagcg
      841 tctctttcca catggagtga ggagcctggc cttgacaacc ctgcctttga ggagagcgct
      901 ggagctgaca ccacacaaca gccacttagt ttaccagaag gagaaatcac cacgattgaa
      961 attcatcggt ccaatcctta cattcagtta ggaatcagca ttgtgggtgg caacgaaaca
     1021 cctttgatta acattgtcat ccaggaggtc tatcgggatg gggtcattgc cagagacggg
     1081 agacttcttg ctggagacca gattcttcag gtcaacaact acaatatcag caatgtgtcc
     1141 cataactatg cccgagctgt cctttcccag ccctgcaaca cactgcatct tactgtgctt
     1201 cgagagaggc gctttggcaa ccgagcacac aaccattctg atagtaactc tccacgagaa
     1261 gagattttcc aagtggctct tcataaacgg gactctggtg aacagcttgg cattaaattg
     1321 gtgcgaagga cagatgagcc aggggttttt attcttgacc tgttggaagg ggggttggct
     1381 gcccaggacg gcaggctaag cagcaatgac cgagtgctgg ccatcaatgg gcacgacctg
     1441 aagtatggaa ctccggagct tgctgcccag attattcagg ccagtggaga gagagtgaat
     1501 ttaacaattg ctagaccagg gaaaccccag cctggtaaca ccattagaga agcaggaaat
     1561 catagcagca gcagccagca ccacacacca ccaccgtatt atagcagacc aagctcacat
     1621 aaggatctta ctcagtgtgt tacatgccaa gaaaaacaca ttactgtaaa gaaggaacca
     1681 catgaatccc ttggcatgac cgttgctggg ggcaggggaa gtaagagtgg tgagctgccc
     1741 atctttgtga ccagtgtgcc accccatggc tgccttgcac gagatggcag aataaagaga
     1801 ggtgatgtgt tgctaaatat caacggcatt gatttgacca atttaagtca cagtgaggca
     1861 gttgcaatgc tgaaagccag tgccgcgtcc cctgctgttg cccttaaagc acttgaggtc
     1921 cagattgttg aggaggcgac tcagaacgcg gaggagcagc cgagtacttt cagcgaaaat
     1981 gagtatgatg ccagttggtc cccatcatgg gtcatgtggc ttgggcttcc cagcacactt
     2041 catagctgcc acgatatagt tttacgaaga agttacttgg gaagttgggg ctttagtatc
     2101 gttggtggat atgaagagaa ccacaccaat cagccttttt tcattaaaac tattgtcttg
     2161 ggaactcctg cttattatga tggaagatta aagtgtggtg acatgattgt ggccgtaaat
     2221 gggctgtcaa ccgtgggcat gagccactct gcactagttc ccatgttgaa ggagcagagg
     2281 aacaaagtca ctctgaccgt tatttgttgg cctggcagcc ttgtatagat tttggaaatt
     2341 ggtttcaaat cttgcatctt ccttttttag atttttgaaa gaaaaccctt tggtttcatt
     2401 gtgtttgtgg tttaggagct gctgacactg ctggtataca cagggccaaa acccactaag
     2461 attgtccgtt tatgtttatt taaatggttt cctaagttag ttacatttct tttagcttgg
     2521 aaacagtctt ccactaacct ttgtgagttt atattttcag aattcagact tagttgttaa
     2581 aatgttacct atggtaatga gcaaagctca cccaaactgt gccccagatg gagtaaagac
     2641 cttctggtgg gtctttgttt tcagtaactg aatcatagaa cgagttctgt atccctcagg
     2701 cctgatgtca gcaaagccag taacaacagc gtgtactgcc actgtcataa ccaataccat
     2761 gaatgaatat actttaaatt ttggtgataa ctgttcccca tttttttttg aaccacagtc
     2821 tcactctcac ccaggctgga gtgcagtggc acaatctcag ctcactgcaa gctccgcctc
     2881 ctgggttcac gccattctcc cacctcagcc tcccgagtag ctgggactac aggcgtgtgc
     2941 caccatgccc agctaatttt ttgtactttt agtagagacg gggtttcacc gtgttagcca
     3001 ggatggtctc gatctcctga ccttgtgatc tgcccgcctc agcctcccaa agtgctggga
     3061 ttacaggtgt gagctgccgc acccggccgt tcccattttt tattggtgcc aacatttcaa
     3121 aacttcatac tgtttataaa ctgattttct ggtttatttc tactgtaatc tctcaatatt
     3181 catagaagat gaagaaataa gtctgacaac actaaagaaa tttcttaata tactattatt
     3241 agaatagtag aggataaaag ataatgttat ccagttacaa aggaatttgg atgataatta
     3301 taacttaatg ttagagatgg taaagctgca cttacttgaa cagcccaaaa gcattaaaaa
     3361 tctatttcca gaggaatgtt ttgctatgta gggaaatttt gaagtagttt ttgctaaaaa
     3421 attatttcta gagttgtgtt attcttagca gtaatcttgg ctagaaatgt ttttgtgatt
     3481 tatgcgatta aacgaaatga taaagataaa accatattat taaataccta tatatcacag
     3541 ctaagtagga gaaagggaga cctttttatt ttgttcaggt aggagtattt cttgtgtatt
     3601 ttagaaacaa ttatttttcc cattatttct tatgagatta gttgtttcaa gtaggagaca
     3661 gaaaagttct gttttgttgg aaatgtaggt tttagatgta tctttcagtc agctctcagt
     3721 cactagacta tttcatattt tttgaaatgt ttttgaaaat tatgactagc ccattttttg
     3781 tcctttattc aacatactta tcctctgaac acataaataa gtgaataaga taaaaatatc
     3841 tttaccttat taatattata catacttgaa aaaaatttca tttagaaacc tagttcagaa
     3901 tctgagcaaa tttacaagtg acctctgtaa taaatggtat tgataatcag agaatgtatt
     3961 tcagaatact acagtacaat atattatgaa gcatgaccac tttattttga aacttagcaa
     4021 ttgtattgct ggggtttatt gtatctgtag catgtcactg attatttcag ttagttttat
     4081 aatgattttt aaaaaacata tctatttgga ataagataca gcaacaatca ttgctactga
     4141 cttgttcaac cccttagtta cactgtatga tcaacatata acaagataca gtggaatggc
     4201 ccatacagta tattactgtt gtgtgatgat tggctttgga agcagtttga ttttgaaatg
     4261 ctttgatatt ctaattgaca tggaacaagt tttttccctg ctccccaaat agaattttgt
     4321 aaccaacttt gctatttttt taaagtttgt aagaatgtgt catttcttgg ggagtagcca
     4381 tccatcaaca aatatcctga ctgctacttt gttatataca aaatacttac attgaacctg
     4441 gtggcataat gagtattttg aaagaagaaa tttcttcact ctcattttta tagaaatctt
     4501 ggaatcagct taagctgtag cttttatgac aaaagacagt catttttggt cagagtgata
     4561 tttggtgacg gaaacttgtt cataatttat tgttactata gaactatttg gattttctca
     4621 tttttagttc tgatagttaa atattttggt ttgttctgtg ccttcagttt aaattatttc
     4681 aggatttttc agatgtttaa ataatggtgt gaatcattca ggatggaaat aaaagtcatc
     4741 ctttctgtaa
//
