LOCUS       NM_030650               7542 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens lunapark, ER junction formation factor (LNPK),
            transcript variant 4, mRNA.
ACCESSION   NM_030650 XM_042834
VERSION     NM_030650.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7542)
  AUTHORS   Bagchi,P., Liu,X., Cho,W.J. and Tsai,B.
  TITLE     Lunapark-dependent formation of a virus-induced ER exit site
            contains multi-tubular ER junctions that promote viral
            ER-to-cytosol escape
  JOURNAL   Cell Rep 37 (10), 110077 (2021)
   PUBMED   34879280
  REMARK    GeneRIF: Lunapark-dependent formation of a virus-induced ER exit
            site contains multi-tubular ER junctions that promote viral
            ER-to-cytosol escape.
REFERENCE   2  (bases 1 to 7542)
  AUTHORS   Tran,P.T., Asghar,N., Johansson,M. and Melik,W.
  TITLE     Roles of the Endogenous Lunapark Protein during Flavivirus
            Replication
  JOURNAL   Viruses 13 (7), 1198 (2021)
   PUBMED   34206552
  REMARK    GeneRIF: Roles of the Endogenous Lunapark Protein during Flavivirus
            Replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7542)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7542)
  AUTHORS   Yuniati,L., Lauriola,A., Gerritsen,M., Abreu,S., Ni,E.,
            Tesoriero,C., Onireti,J.O., Low,T.Y., Heck,A.J.R., Vettori,A.,
            Cardozo,T. and Guardavaccaro,D.
  TITLE     Ubiquitylation of the ER-Shaping Protein Lunapark via the
            CRL3KLHL12 Ubiquitin Ligase Complex
  JOURNAL   Cell Rep 31 (7), 107664 (2020)
   PUBMED   32433973
  REMARK    GeneRIF: Ubiquitylation of the ER-Shaping Protein Lunapark via the
            CRL3(KLHL12) Ubiquitin Ligase Complex.
REFERENCE   5  (bases 1 to 7542)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7542)
  AUTHORS   Moriya,K., Nagatoshi,K., Noriyasu,Y., Okamura,T., Takamitsu,E.,
            Suzuki,T. and Utsumi,T.
  TITLE     Protein N-myristoylation plays a critical role in the endoplasmic
            reticulum morphological change induced by overexpression of protein
            Lunapark, an integral membrane protein of the endoplasmic reticulum
  JOURNAL   PLoS One 8 (11), e78235 (2013)
   PUBMED   24223779
  REMARK    GeneRIF: Protein N-myristoylation plays a critical role in the
            endoplasmic reticulum morphological change induced by
            overexpression of protein Lunapark.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7542)
  AUTHORS   Divaris,K., Monda,K.L., North,K.E., Olshan,A.F., Lange,E.M.,
            Moss,K., Barros,S.P., Beck,J.D. and Offenbacher,S.
  TITLE     Genome-wide association study of periodontal pathogen colonization
  JOURNAL   J Dent Res 91 (7 Suppl), 21S-28S (2012)
   PUBMED   22699663
REFERENCE   8  (bases 1 to 7542)
  AUTHORS   Chen,S., Novick,P. and Ferro-Novick,S.
  TITLE     ER network formation requires a balance of the dynamin-like GTPase
            Sey1p and the Lunapark family member Lnp1p
  JOURNAL   Nat Cell Biol 14 (7), 707-716 (2012)
   PUBMED   22729086
  REMARK    GeneRIF: Propose that Lnp1p and Sey1p act antagonistically to
            balance endoplasmic reticular polygonal network formation.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7542)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   10 (bases 1 to 7542)
  AUTHORS   Spitz,F., Gonzalez,F. and Duboule,D.
  TITLE     A global control region defines a chromosomal regulatory landscape
            containing the HoxD cluster
  JOURNAL   Cell 113 (3), 405-417 (2003)
   PUBMED   12732147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC351745.1, CR936742.1 and AC016751.7.
            
            On Nov 23, 2018 this sequence version replaced NM_030650.2.
            
            Transcript Variant: This variant (4) uses an alternate splice
            junction in the 5' end compared to variant 1. The resulting isoform
            (4) has a shorter and distinct N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.234018.1, CR936742.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272748.9/ ENSP00000272748.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DC351745.1         79-107
            30-1763             CR936742.1         57-1790
            1764-6771           AC016751.7         56971-61978
            6772-7532           CR936742.1         6797-7557
            7533-7542           AC016751.7         62740-62749
FEATURES             Location/Qualifiers
     source          1..7542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..7542
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /note="lunapark, ER junction formation factor"
                     /db_xref="GeneID:80856"
                     /db_xref="HGNC:HGNC:21610"
                     /db_xref="MIM:610236"
     exon            1..108
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            109..197
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1457
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /note="isoform 4 is encoded by transcript variant 4;
                     4921514L11Rik; 2310011O18Rik; protein lunapark; limb and
                     neural patterns; ER junction formation factor lunapark;
                     endoplasmic reticulum junction formation protein lunapark"
                     /codon_start=1
                     /product="endoplasmic reticulum junction formation protein
                     lunapark isoform 4"
                     /protein_id="NP_085153.1"
                     /db_xref="CCDS:CCDS33332.1"
                     /db_xref="GeneID:80856"
                     /db_xref="HGNC:HGNC:21610"
                     /db_xref="MIM:610236"
                     /translation="MGGLFSRWRTKPSTVEVLESIDKEIQALEEFREKNQRLQKLWVG
                     RLILYSSVLYLFTCLIVYLWYLPDEFTARLAMTLPFFAFPLIIWSIRTVIIFFFSKRT
                     ERNNEALDDLKSQRKKILEEVMEKETYKTAKLILERFDPDSKKAKECEPPSAGAAVTA
                     RPGQEIRQRTAAQRNLSPTPASPNQGPPPQVPVSPGPPKDSSAPGGPPERTVTPALSS
                     NVLPRHLGSPATSVPGMGLHPPGPPLARPILPRERGALDRIVEYLVGDGPQNRYALIC
                     QQCFSHNGMALKEEFEYIAFRCAYCFFLNPARKTRPQAPRLPEFSFEKRQVVEGSSSV
                     GPLPSGSVLSSDNQFNEESLEHDVLDDNTEQTDDKIPATEQTNQVIEKASDSEEPEEK
                     QETENEEASVIETNSTVPGADSIPDPELSGESLTAE"
     exon            198..239
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            240..427
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            428..486
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            487..527
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            528..611
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            612..663
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            664..876
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            877..982
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1053
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1224
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..7542
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3642..3647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /note="hexamer: AATAAA"
     polyA_site      3667
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /note="major polyA site"
     regulatory      7397..7402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /note="hexamer: ATTAAA"
     polyA_site      7418
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
     regulatory      7512..7517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
                     /note="hexamer: AATAAA"
     polyA_site      7542
                     /gene="LNPK"
                     /gene_synonym="KIAA1715; LNP; LNP1; NEDEHCC; Ul; ulnaless"
ORIGIN      
        1 gtctctctgt cagtggcggc tgctgcctgc tctggaggca ggctgggcgg tggcggccga
       61 gactggcggg ggtggacgcc cgggccgggc tgcgcccgct tcttgcagct gtgaattcct
      121 ttggacaatt gatgatattt atcattgtgc ccagtttcta caaataaaag atgggtggat
      181 tattttctcg atggaggaca aaaccttcaa ctgtagaagt tctagaaagt atagataagg
      241 aaattcaagc attggaagaa tttagggaaa aaaatcagag attacaaaaa ttatgggttg
      301 gaagattaat tctgtattcc tcagttctct atctgtttac atgcttaatt gtatatttgt
      361 ggtatcttcc tgatgaattt acagcaagac ttgccatgac actcccattt tttgcttttc
      421 cattgatcat ctggagcata agaacagtaa ttattttctt cttttccaag agaacagaaa
      481 gaaataatga agcattggat gatttaaaat cccagaggaa aaaaatactt gaagaagtca
      541 tggaaaaaga aacttacaag acggctaaat taattcttga aaggtttgat ccggactcaa
      601 agaaagcaaa ggagtgtgag ccgccatctg ctggagcagc tgtaactgca agacctggac
      661 aagagattcg tcagcgaact gcagctcaaa gaaacctttc tccaacacca gcaagcccta
      721 accagggccc tcctccacaa gttccagtat ctcctggacc accaaaggac agttctgccc
      781 ctggtggacc cccagaaagg actgttactc cagccctatc atcaaatgtg ttaccaagac
      841 atcttggatc ccctgctact tcagtgcctg gaatgggtct tcatcctcca ggtccacctt
      901 tagcaagacc tattctcccc cgagaacgag gtgctttgga tagaattgtt gaatatttgg
      961 ttggtgatgg tccacaaaac aggtatgcac ttatatgtca gcagtgtttt tctcataatg
     1021 gcatggcttt gaaggaagaa tttgaataca ttgcttttcg atgtgcctac tgttttttct
     1081 tgaaccctgc aagaaaaacc agacctcagg ctccaagact tcctgagttt agttttgaga
     1141 agaggcaggt ggtggaaggt tcaagttcag ttggtccctt gccatcagga agtgtgcttt
     1201 catcagacaa ccagtttaat gaagaatctt tagaacacga tgttcttgat gataatacag
     1261 agcagacaga tgacaaaata ccagctacag aacagacaaa ccaagtgatt gaaaaagcat
     1321 ctgactcaga ggaaccagag gagaaacaag agactgagaa tgaggaagcc tcagtgattg
     1381 aaaccaactc cacagttcct ggagctgatt ctattcctga tcctgaacta agtggagaat
     1441 ctttgacggc agagtagtaa atgcttccac gtgccttcaa ctggatattt atagtcttac
     1501 tgatgtcagt tattgctttt tcggtggcac ttactttttt tgcccctcta agggtatgct
     1561 tgtgtatcat ttgaattcag attgcctagc tatttgaaca tctcaaagtt atatatactg
     1621 ggtattaaaa ttaaaagcaa gttatatcag tgaagtaaga tccttttgaa tgtacaaaga
     1681 cccacactat tgagacagct tttagatact tttttgtcca ttctaaaagt aagcaaacat
     1741 gattgccttc ttgttttctg tatgtataac ccgtaaatat ccattttgac ataggaagaa
     1801 ctttggttaa gagtaagttc tctaattgtg tttgttttaa ggaatgaaac ttggttaaga
     1861 ttttgactac ttcattatta aaaattgata gaattttagc tcctgagata tttacaactg
     1921 ggagaaatgt ctatttaggt gtttacatta agcggtatga aagttgttac cacataggca
     1981 ctggtacgaa ttctcaataa gaatgcagtg gaacagttaa gtagaactgt aactacgttg
     2041 gcactggtac gaattctcag tgagaatgca atgaaacagt caactgcagt gtttcttttt
     2101 gatgtctttt attttacaac tgggccaaag gcacattatg tatataatta gtttatattt
     2161 acacactagc atataggaaa tatttctgca cttgacccta tttgaattct gagcattatt
     2221 tataagtata aaatgatgat atataagtga attttgtgct cttgtttgta ttttattaag
     2281 gaaaatgaaa ataatctggc atcagtttca ttttgctaaa tatctagtct tcttcaaaca
     2341 gtatcttggt gggtgacttg gctacctgaa aaatcttagg aggaatagct cacaatacaa
     2401 taaatctgta gattctgctt agagcaaatt atggtacttt tattcagact tgtttccttt
     2461 ctagttaaca gaaatagtga catttagagg ttttaatcag aagttaggtt tttctgattc
     2521 aggaacatcg taggccagcc atttgtaatt tttaactttg agaaacaaat tttgtgagaa
     2581 taggtagtgg gttgctggta gttaattgga tttaatattt gtattaagga ttaactggaa
     2641 aaaatgtgtc tcagtgctaa ttcttggacc tttaatacag tgtgcttatc tgttacggcc
     2701 tccttttatc tctcttctcc aatattaaaa aaaatggaaa tcaaattatt atgctgaagg
     2761 gaaaaatata cctgtataag aatggtgtgt ttggctaatg tttctaagtt gcacacagtt
     2821 tattaacaac tgaacaaaac atttttatca tttaaaaatc tatttttatg atttaatatc
     2881 tcatatgtga cagttttttt tttttttttt ttttggaact caatctgtta acagtctggg
     2941 acatccggta tagtaaccag agtttttgag cctgccgtat tgggcttaaa tttcaggtct
     3001 gtagtcttgg gcaagtcacc tataaactca ctgagattat tttttcatct gtaaaatggg
     3061 aagagttatg tttatttttg aagggtatta ggataattaa aaataatgta atgtgcctag
     3121 cacactacct gaaaacgatg gcatttgttc ttattaatgt ctttaaaata tgcaaggacc
     3181 ataagttttt cctcttgcag atgaggaaag taaaaaataa tacgaacatg taattcagct
     3241 tctcagattc aagccaatgt tttttgcatc aacttttcta tattgtatgt atgtatataa
     3301 atacatagat taaggaaata ggaaactgaa actctgtgga atataaactt tttaaaaata
     3361 atttcatcag gttttttgta tgttactgac ccatatggat tttagtaaca tcttgcttag
     3421 tcatgttgtt ataaaacatt caaattctga tatacattgc ttgaaaatga gtgagtacct
     3481 cagagaaatt tgatagactc aaacagatag tatgagaaat atctttgaaa gaaatatgga
     3541 ggaaggttaa aaggggatta gtaaaattaa tgcgataggt aacatgtttg taaccatata
     3601 gtatcctttt agatacaaaa gcttattttc attattatta taataaacag ttaatggttg
     3661 aaacttagta aaatgtccta tttctgatta ttaagactag tataaatgag aaaatccaag
     3721 ctattaagta ccattagcta cagtgatctt agcttccttg cttacaattg ttcagtgggt
     3781 catctaaatt cttctatgtc ctgagcatga tctacaaaca tggtctagct tctgtctctc
     3841 cgtcttcccg ccatcattgt gctgtagcca tatggaactc ctttcagttc tctgaccatg
     3901 ccctttcctg cctcagattt cagcttaaat tttgcctcct cagagagatg ccttcccaaa
     3961 ctccccatct gaagctggcc tctgcctttt actccctatc atgtcactct ctgctcacca
     4021 tccttatcac aatgtgtatt tgatttgttt gctagtttac tgtcttcaca acataatgtc
     4081 cgtttgtgca agggtcttat ttttcttatt catgtctgta tctcaagggt ctagcacaat
     4141 gcttgatgca tattgtgtga ataaatactt tgttgccaaa tccagtgaaa actctcagtt
     4201 cttgtttcac tgcttggcag tattgacatt gaatattctc tgagatactt tttttctttt
     4261 ggcttttcat atatcacact attattctct tatttctctg gcctcttgct ctcaacgtcc
     4321 tgtaagtgtt ggtgttcctt aagttctacc tagtgtcatc atttcttcat tctgcatatt
     4381 ctttccctag ggtttcttcc caacaccaaa ggacttacca tctgtctctc tgaatctcag
     4441 atctccagct ttgatctgtt tcctttactt tagagctata tatttgcctg cctactggcc
     4501 tgtctctcac aatccatata ttcaagaatg aacactatac tttgcttcaa accttcagaa
     4561 cattcaaacc gtttatgttt ctcatctaat caaatagagt tactctctaa gccagaagct
     4621 gtaaactcat ctcttttccc tttattcaag ctgtcaattt ttgtctccta aacatcttct
     4681 agttatattc tcatttctct gttcacattg cattaataat gatgataaac atttgcattc
     4741 ttattctgtg ccaggcaaca tgctaactgc tgtatatata ttattatatt tgtactttgg
     4801 caagaatcct gtgaagattt ttatctttgg actactagaa gagaaagctg agttgtagag
     4861 agagtatgta tttaagtccg tttgggctgc tataacagaa taccacagac tgggtaacgt
     4921 gatgaacaaa aatttatttg gctcacagtt ctggaacctg ggaaatccaa aggcatgatg
     4981 ctagcatctg gtgagggcct ttgtgctttg tcatcccatg ccagaaggca gaagggtaag
     5041 agagggcaag agtgagcaag agatggaagt tgcaacctca agctctttta taatgagcat
     5101 taatccattc atgagggctt caccctcatg acctaaacat ctccattagg ctccaccttc
     5161 caatgcaaca gttagcataa gttttcaaca catgcttttt gtagcattca aaccatagca
     5221 ggaagcaact ttgcttaaaa ttgtatacct ggtaagtgga aaaagaggga tttgaatata
     5281 ggcaaatgac ttcagaggat ttactcttaa tttctgttgt actgccttct aatcttggcc
     5341 tccatcattt cagattacca aagctgtctc ttaactggtt tctttgtctc caaccttgtg
     5401 cacttgctat ctattctgtg tgctgcagcc tgagttttta aaaaacagaa aatgaggggc
     5461 caggtgtggt ggtggctcac gcctgtaatc ccagcaagtt gggaggctga ggcgggcaga
     5521 tcatctgggg tcaggagttc gagaccagcc tgaccaacgt ggagaaacac tatctctact
     5581 aaaaatacaa aattagccag gcgtggtggt gcatgcctgt aatcctagct actcaggagc
     5641 ctgaggcagg agaattgctt gaacacggga ggcagaggtt gcagtgagca gagattgcgc
     5701 cattgtactc cagcctgggc aacaagagtg aaactccatc tcaaaaaaaa aaaagaaaga
     5761 aagaaaatga atctgccacg ccattgctta gaccctttaa tgactcttga gtgttcttgg
     5821 gatgaggtcc aaatttacta ataaggcctg caaagccctg tgtaattttg ctcctagtta
     5881 tggctggcat ctgcaccaca actacagcca ctgccacctc cccctgccac acacacattt
     5941 taaaagtaac aatagtagtg ttttctgtgt tttgcatatg cagtcttttc tcatctccca
     6001 gccttcttga gcttttcctc tgcctgagat acgctcccac tcacatagac attgggggca
     6061 ctaaataaaa atagctgttt aattgaattg gaatcgttcc acttggaacc caagtttgga
     6121 aattttgcta cttcttgtta agctaggcct tttattcttg aagttgctat ttctcataca
     6181 aactcatttt atgcattaga cacacagtca ctattgttat ggagaacata gttgtatcag
     6241 aagaggtata gctttgggtg tggatgtgcg tgtgtcaggg gaaagatatt ctgattatat
     6301 gatgattttc ataaaatata gtatgctgag tttccgaaaa tcctaaatga cttagaaatg
     6361 gtgctatatg tggtttgttt gacccctgca aatctcatgt tgaaatttga tccccattgc
     6421 tggaggtgtt ttgagcatgg agcggatccc tcatgaatgt cttggcgttg tccttgcagt
     6481 aatgagttct tgctctattt ttcctcccct ggaagctgat tgtttaaaag agcctggtat
     6541 cctccctccc tttcttcttt gcttcctctc tcttgctgtg tgatctctgc acacaccagc
     6601 tcccctttgc tttctgccat gagtggtctg aggctctcac cagaagccaa gcagaggctg
     6661 gcaccatgct tctagtacag cctgcagaac tgtaagccaa ataaacttct tctttgtttt
     6721 ttttttttgt ttgttttgtt tttttttcag taaattaccc agcctcaggt attccttaac
     6781 aacacaaatg ggctaagaca cagggtcata gggatagcag gcacctgagc caagccagaa
     6841 cttagatctc aactgttaat gcaggatgat ttgtattgaa ccatgaattt tacactgcct
     6901 ctcaatgttg gtgtcagcat ttaaggttat ttaaaaaata caacctgaag gttacataaa
     6961 gtttcattta aaaaataaga ccttataagt ctacttttat ttccagtgga cagcaactac
     7021 ttaatcgtct taaaactttc ttcttacaat attactttac aatattacct gttggattta
     7081 ttatctgtgt acaaatcagt tagttgaagg gccaaagaat aaaggcattt tgtgaattat
     7141 gaatagctat tttgaaatgg tcatggagac tagctactct agaaaattgg gagaatatac
     7201 tgtattaagt tactatctgg tataacttca attaattgtg aaaattgtag cagagatcta
     7261 gatatagttt atgaacttct aaagagacat taaagggaat tcaagtactt gtgtaaagat
     7321 gaaccaaggt agagatgatt gtgaattggt gatctgctgt atgttacagt tatgtaattt
     7381 gacttgtttc aaaattatta aagttttaag tgtatgcatt ctactggtca ataagtaaat
     7441 atattcaggc tctgaatgta gacagataaa tatataaata tagaaagtac atttgttaga
     7501 atacaaacaa gaataaaaat tgagtacaga atgaaaacct ta
//
