LOCUS       NM_001085451            1864 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens leukemia NUP98 fusion partner 1 (LNP1), mRNA.
ACCESSION   NM_001085451 XM_379203 XM_931896 XM_931908 XM_937188 XM_943217
VERSION     NM_001085451.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1864)
  AUTHORS   Romana,S.P., Radford-Weiss,I., Ben Abdelali,R., Schluth,C.,
            Petit,A., Dastugue,N., Talmant,P., Bilhou-Nabera,C., Mugneret,F.,
            Lafage-Pochitaloff,M., Mozziconacci,M.J., Andrieu,J., Lai,J.L.,
            Terre,C., Rack,K., Cornillet-Lefebvre,P., Luquet,I., Nadal,N.,
            Nguyen-Khac,F., Perot,C., Van den Akker,J., Fert-Ferrer,S.,
            Cabrol,C., Charrin,C., Tigaud,I., Poirel,H., Vekemans,M.,
            Bernard,O.A. and Berger,R.
  CONSRTM   Groupe Francophone de Cytogenetique Hematologique
  TITLE     NUP98 rearrangements in hematopoietic malignancies: a study of the
            Groupe Francophone de Cytogenetique Hematologique
  JOURNAL   Leukemia 20 (4), 696-706 (2006)
   PUBMED   16467868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC040562.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001085451.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040562.1, SRR1803617.242062.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383693.8/ ENSP00000373191.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1864              BC040562.1         349-2212
FEATURES             Location/Qualifiers
     source          1..1864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.2"
     gene            1..1864
                     /gene="LNP1"
                     /gene_synonym="NP3"
                     /note="leukemia NUP98 fusion partner 1"
                     /db_xref="GeneID:348801"
                     /db_xref="HGNC:HGNC:28014"
     exon            1..901
                     /gene="LNP1"
                     /gene_synonym="NP3"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1090
                     /gene="LNP1"
                     /gene_synonym="NP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             935..1471
                     /gene="LNP1"
                     /gene_synonym="NP3"
                     /codon_start=1
                     /product="leukemia NUP98 fusion partner 1"
                     /protein_id="NP_001078920.1"
                     /db_xref="CCDS:CCDS43120.1"
                     /db_xref="GeneID:348801"
                     /db_xref="HGNC:HGNC:28014"
                     /translation="MEHKDDDDDDVSFAKWMSSFWGHSWREEDQRGLRERHRLQATSH
                     RKTSLPCPLPVLPRIPSSDCHPRRHSHEDQEFRCRSHVRDYRKYSEDGSFKEPLESKG
                     RSHSKIEKFSESFERQLCFRTKRSASLGPESRKERNERECLRMEIKSRKKVEEERSSR
                     KEEHGEAHMAPLFEKGPE"
     exon            1091..1321
                     /gene="LNP1"
                     /gene_synonym="NP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1864
                     /gene="LNP1"
                     /gene_synonym="NP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LNP1"
                     /gene_synonym="NP3"
                     /note="hexamer: AATAAA"
     polyA_site      1864
                     /gene="LNP1"
                     /gene_synonym="NP3"
                     /note="major polyA site"
ORIGIN      
        1 agttttccag ttatagccac gttggcacct cttgaacctc tgtggccgtt agcacggttt
       61 tctgcccgcg tgcccgagaa accaacggat tagaaggact tttaaagatg tgtgaggaaa
      121 gagctcaccg ctgaagaagg ctgctgcatc actgaacttc ttatcactaa catagcgaga
      181 ttttagtttg gacgaatttg aggttatagg ggagatagcg atggcagaag actaggtgga
      241 aatggcacat ctaggttggc tgcagtcgaa acggtttgag cgtggtcgct gtggctcatc
      301 gtcggcacca attaacgaag cgatgacatc tgcgttgtta ggggtttctt aaactgagtt
      361 ggtagaaatg cgaagcgtca gggttcccgc cggcttcgag cctttcttgg cgtatttgta
      421 tcttgagctg atttctgcgt cagcccacat ctcgctctga tccgcacgcc ccccgggttg
      481 ttttgcagta gcagtctcag ccctcttctc gtctcattcc caaatcgtaa tttcagttca
      541 cagcttttta tctataatag ctttatcaac tctttttccg atgctctgca ccagatctct
      601 taaaatataa aattaccttg caaggtattg tttggaatac acggtatttt catgaagaca
      661 actattaata gaaaaatcag agtccagaac tatggttctc catttctggt atactggttt
      721 gcagaagcct tacattaaga tttcataaat gattgttttg ctgttaagtg caacaacatc
      781 acagtagagc tacataaaga ttgaaaggag atattttatc aagtggcacc agaatggact
      841 gattaaaata gaatggccta attggaaaga atttcaggat caccggtttc tcctgcttca
      901 tggacaggcc ttcagtattt ggcatcacct ttacatggag cacaaagatg atgatgatga
      961 tgatgtgtct tttgccaaat ggatgagcag cttctggggc cacagctgga gagaggagga
     1021 tcagagagga ctccgggaac gccaccgact gcaagccacc agtcacagga aaacctccct
     1081 gccctgccca cttcctgtgc ttcccagaat tccatcatct gactgccatc ctagaaggca
     1141 ttctcatgag gaccaagaat ttcgatgccg tagccacgta cgggattaca gaaaatactc
     1201 agaggatggg tcattcaagg agccactgga atcaaaagga agatcccatt ccaaaattga
     1261 gaaattttca gagtcctttg aacggcaact gtgctttaga accaagcgtt ctgcctcttt
     1321 gggacctgaa agcagaaagg agagaaatga aagagaatgc ctgaggatgg agataaaatc
     1381 ccgaaagaaa gtagaggaag aaaggagctc taggaaagaa gagcatggag aagcacacat
     1441 ggctcccctg tttgaaaaag ggcctgaata atactctgct tctgcctcat gacatcagat
     1501 gctactgttt tggttttttt ctttgagccc caattcacca tttcaggatg tggatggggg
     1561 cggggttggg ggtaaaaaca gctataaaaa gcaactgcag atgctgactg actgcagtgg
     1621 gcagggtatg tagctgctcc aagatgactt gcatcatacc ccaattactg ctggcatctt
     1681 agttgagagt ataatctgct tggttgcctt tttatgggaa taaagagaat aaaaggtatt
     1741 ttaatagaat aaagaaaaat ttgaaaatat aatggaaggt atttaaagag ccacccacat
     1801 agcttcacca acccttctca cacatcaact cataaatcat cttaaataaa agtcattggt
     1861 atga
//
