LOCUS       NM_001388485            5144 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens lemur tyrosine kinase 3 (LMTK3), transcript variant 2,
            mRNA.
ACCESSION   NM_001388485
VERSION     NM_001388485.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5144)
  AUTHORS   Wang,C., Yang,M., Gu,X. and Gu,Y.
  TITLE     Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to
            cetuximab in colorectal cancer via the ERK/MAPK pathway
  JOURNAL   Bioengineered 12 (1), 6594-6605 (2021)
   PUBMED   34516351
  REMARK    GeneRIF: Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to
            cetuximab in colorectal cancer via the ERK/MAPK pathway.
REFERENCE   2  (bases 1 to 5144)
  AUTHORS   Jiang,T., Lu,X., Yang,F., Wang,M., Yang,H. and Xing,N.
  TITLE     LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK
            pathway
  JOURNAL   FEBS Open Bio 10 (10), 2107-2121 (2020)
   PUBMED   32865871
  REMARK    GeneRIF: LMTK3 promotes tumorigenesis in bladder cancer via the
            ERK/MAPK pathway.
            Erratum:[FEBS Open Bio. 2021 Apr;11(4):1277. doi:
            10.1002/2211-5463.13116.. PMID: 33794072]
REFERENCE   3  (bases 1 to 5144)
  AUTHORS   Cairns,J., Ingle,J.N., Kalari,K.R., Shepherd,L.E., Kubo,M.,
            Goetz,M.P., Weinshilboum,R.M. and Wang,L.
  TITLE     The lncRNA MIR2052HG regulates ERalpha levels and aromatase
            inhibitor resistance through LMTK3 by recruiting EGR1
  JOURNAL   Breast Cancer Res 21 (1), 47 (2019)
   PUBMED   30944027
  REMARK    GeneRIF: Our findings support a model in which the MIR2052HG
            regulates LMTK3 via EGR1, and LMTK3 regulates ERalpha stability via
            the PKC/MEK/ERK/RSK1 axis. These results reveal a direct role of
            MIR2052HG in LMTK3 regulation and raise the possibilities of
            targeting MIR2052HG or LMTK3 in ERalpha-positive breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5144)
  AUTHORS   Klug,L.R., Bannon,A.E., Javidi-Sharifi,N., Town,A., Fleming,W.H.,
            VanSlyke,J.K., Musil,L.S., Fletcher,J.A., Tyner,J.W. and
            Heinrich,M.C.
  TITLE     LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST
            and melanoma
  JOURNAL   Oncogene 38 (8), 1200-1210 (2019)
   PUBMED   30242244
  REMARK    GeneRIF: targeting of LMTK3 with siRNA delayed KIT-dependent GIST
            growth in a xenograft model. Our data suggest the potential of
            LMTK3 as a target for treatment of patients with KIT-mutant cancer,
            particularly after failure of KIT TKIs.
REFERENCE   5  (bases 1 to 5144)
  AUTHORS   Stebbing,J., Shah,K., Lit,L.C., Gagliano,T., Ditsiou,A., Wang,T.,
            Wendler,F., Simon,T., Szabo,K.S., O'Hanlon,T., Dean,M.,
            Roslani,A.C., Cheah,S.H., Lee,S.C. and Giamas,G.
  TITLE     LMTK3 confers chemo-resistance in breast cancer
  JOURNAL   Oncogene 37 (23), 3113-3130 (2018)
   PUBMED   29540829
  REMARK    GeneRIF: LMTK3 expression and its role in the drug resistance in
            breast cancer.
REFERENCE   6  (bases 1 to 5144)
  AUTHORS   Wakatsuki,T., LaBonte,M.J., Bohanes,P.O., Zhang,W., Yang,D.,
            Azuma,M., Barzi,A., Ning,Y., Loupakis,F., Saadat,S., Volz,N.,
            Stintzing,S., El-Khoueiry,R., Koizumi,W., Watanabe,M., Shah,M.,
            Stebbing,J., Giamas,G. and Lenz,H.J.
  TITLE     Prognostic role of lemur tyrosine kinase-3 germline polymorphisms
            in adjuvant gastric cancer in Japan and the United States
  JOURNAL   Mol Cancer Ther 12 (10), 2261-2272 (2013)
   PUBMED   23918832
  REMARK    GeneRIF: harboring rs8108419 G/G genotype of the LMTK3 was
            associated with OS in the Japanese females (HR, 3.04; 95% CI,
            1.08-8.56; P = 0.035) and the U.S. males (HR, 3.39; 95% CI,
            1.31-8.80; P = 0.012).
REFERENCE   7  (bases 1 to 5144)
  AUTHORS   Stebbing,J., Filipovic,A., Lit,L.C., Blighe,K., Grothey,A., Xu,Y.,
            Miki,Y., Chow,L.W., Coombes,R.C., Sasano,H., Shaw,J.A. and
            Giamas,G.
  TITLE     LMTK3 is implicated in endocrine resistance via multiple signaling
            pathways
  JOURNAL   Oncogene 32 (28), 3371-3380 (2013)
   PUBMED   22869149
  REMARK    GeneRIF: role for LMTK3 in both innate (intrinsic) and acquired
            (adaptive) endocrine resistance in breast cancer
REFERENCE   8  (bases 1 to 5144)
  AUTHORS   Stebbing,J., Filipovic,A., Ellis,I.O., Green,A.R., D'Silva,T.R.,
            Lenz,H.J., Coombes,R.C., Wang,T., Lee,S.C. and Giamas,G.
  TITLE     LMTK3 expression in breast cancer: association with tumor phenotype
            and clinical outcome
  JOURNAL   Breast Cancer Res Treat 132 (2), 537-544 (2012)
   PUBMED   21671015
  REMARK    GeneRIF: Higher LMTK3 expression is associated with more aggressive
            breast cancers.
REFERENCE   9  (bases 1 to 5144)
  AUTHORS   Giamas,G., Filipovic,A., Jacob,J., Messier,W., Zhang,H., Yang,D.,
            Zhang,W., Shifa,B.A., Photiou,A., Tralau-Stewart,C., Castellano,L.,
            Green,A.R., Coombes,R.C., Ellis,I.O., Ali,S., Lenz,H.J. and
            Stebbing,J.
  TITLE     Kinome screening for regulators of the estrogen receptor identifies
            LMTK3 as a new therapeutic target in breast cancer
  JOURNAL   Nat Med 17 (6), 715-719 (2011)
   PUBMED   21602804
  REMARK    GeneRIF: abundance and intronic polymorphism associated with breast
            cancer survival and response to endocrine therapies
REFERENCE   10 (bases 1 to 5144)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008403.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000600059.6/ ENSP00000472020.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AC008403.8         95015-95349         c
            336-469             AC008403.8         93973-94106         c
            470-620             AC008403.8         93537-93687         c
            621-697             AC008403.8         92951-93027         c
            698-816             AC008403.8         92365-92483         c
            817-904             AC008403.8         86423-86510         c
            905-1053            AC008403.8         85947-86095         c
            1054-1138           AC008403.8         84992-85076         c
            1139-1260           AC008403.8         84797-84918         c
            1261-1410           AC008403.8         84510-84659         c
            1411-3935           AC008403.8         80907-83431         c
            3936-4351           AC008403.8         77208-77623         c
            4352-4487           AC008403.8         74918-75053         c
            4488-4625           AC008403.8         74622-74759         c
            4626-5144           AC008403.8         68785-69303         c
FEATURES             Location/Qualifiers
     source          1..5144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..5144
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /note="lemur tyrosine kinase 3"
                     /db_xref="GeneID:114783"
                     /db_xref="HGNC:HGNC:19295"
                     /db_xref="MIM:619624"
     exon            1..335
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..4642
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase LMTK3; protein
                     phosphatase 1, regulatory subunit 101"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LMTK3 precursor"
                     /protein_id="NP_001375414.1"
                     /db_xref="CCDS:CCDS46136.2"
                     /db_xref="GeneID:114783"
                     /db_xref="HGNC:HGNC:19295"
                     /db_xref="MIM:619624"
                     /translation="MPAPGALILLAAVSASGCLASPAHPDGFALGRAPLAPPYAVVLI
                     SCSGLLAFIFLLLTCLCCKRGDVGFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYI
                     LPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQ
                     VVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDL
                     KRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTS
                     DLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIW
                     SLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCW
                     RPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSP
                     FPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPAWQPASAPPAPHA
                     NPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPA
                     PQAPQAPSEVPQLVSETWASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGD
                     PAEVLGERGTAPWVEEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLP
                     LERGDAVAGWGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGAA
                     APQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETE
                     TPFSPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQ
                     VSTEQLLMSLREDVTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGK
                     QAPSLSLPVNGVTVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEK
                     ALENGELRSPEAGEKVLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPW
                     EKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGT
                     ERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPP
                     PPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKG
                     PEMPRLFLDLGPPQGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAG
                     GEAGGAGAPGPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADA
                     DAARPLRGLLKSPRGADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPE
                     GDTDPSTPPAPPTPPHPATPGDGFPSNDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSV
                     SPALETPGPPARAPDARPAGPVEN"
     exon            336..469
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            470..620
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            621..697
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..816
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..904
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1053
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1138
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1260
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1410
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..3935
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4351
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            4352..4487
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            4488..4625
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     exon            4626..5144
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5144
                     /gene="LMTK3"
                     /gene_synonym="AATYK3; LMR3; PPP1R101; TYKLM3"
                     /note="major polyA site"
ORIGIN      
        1 accccagcaa ccccggctcc ccagcatctc tcctctgtcc gcctctccat cccttcatcc
       61 gtctgtccct tcaaagaggg ggaggggggt acctgagcca gcaagcagcc cctccctccc
      121 cctgtcctgc gtctcctgcc cctctcctgg gccgggagga ggccagggtc gcgcgggtcc
      181 ccatggctgg gggctgaggg cccgcccccc cctcctcccc agccgccacc acctccacct
      241 ccctgccatc ctcgacaaga tgcctgcccc cggcgccctc atcctccttg cggccgtctc
      301 cgcctccggc tgcctggcgt ccccggccca ccccgatgga ttcgccctgg gccgggctcc
      361 tctggctcct ccctacgctg tggtcctcat ttcctgctcc ggcctgctgg ccttcatctt
      421 cctcctcctc acctgtctgt gctgcaaacg gggcgatgtc ggcttcaagg aatttgagaa
      481 ccctgaaggg gaggactgct ccggggagta cactccccct gcggaggaga cctcctcctc
      541 acagtcgctg cctgatgtct acattctccc gctggctgag gtctccctgc caatgcctgc
      601 cccgcagcct tcacactcag acatgaccac ccccctgggc cttagccggc agcacctgag
      661 ctacctgcag gagattggga gtggctggtt tgggaaggtg atcctgggag agattttctc
      721 cgactacacc cccgcccagg tggtggtgaa ggagctccga gccagcgcgg ggcccctgga
      781 gcaacgcaag ttcatctcgg aagcacagcc gtacaggagc ctgcagcacc ccaatgtcct
      841 ccagtgcctg ggtctgtgcg tggagacgct gccgtttctg ctgattatgg agttctgtca
      901 actgggggac ctgaagcgtt acctccgagc ccagcggccc cccgagggcc tgtcccctga
      961 gctaccccct cgagacctgc ggacgctgca gaggatgggc ctggagatcg cccgcgggct
     1021 ggcgcacctg cattcccaca actacgtgca cagcgacctg gccctgcgca actgcctgct
     1081 gacctctgac ctgaccgtgc gcatcggaga ctacgggctg gcccacagca actacaagga
     1141 ggactactac ctgaccccag agcgcctgtg gatcccactg cgctgggcgg cgcccgagct
     1201 cctcggggag ctccacggga ccttcatggt ggtggaccag agccgcgaga gcaacatctg
     1261 gtccctgggg gtgaccctgt gggagctgtt tgagtttggg gcccagccct accgccacct
     1321 gtcagacgag gaggtcctcg ccttcgtggt ccgccagcag catgtgaagc tggcccggcc
     1381 gaggctcaag ctgccttacg cggactactg gtatgacatt cttcagtcct gctggcggcc
     1441 acctgcccag cgcccttcag cctctgatct ccaattgcag ctcacctact tgctctccga
     1501 gcggcctccc cggcccccac cgccgccacc cccaccccga gacggtccct tcccctggcc
     1561 ctggccccct gcacacagtg cgccccgccc ggggaccctc tcctcaccgt tccccctact
     1621 ggatggcttc cctggagccg accccgacga tgtgctcacg gtcaccgaga gtagccgcgg
     1681 cctcaacctc gagtgcctgt gggagaaggc ccggcgtggg gccggccggg gtgggggggc
     1741 acctgcctgg cagccggcgt cggccccccc ggccccccac gccaacccct ccaacccttt
     1801 ctacgaggcg ctgtccacgc ccagcgtgct gcctgtcatc agcgcccgca gcccctccgt
     1861 gagcagcgag tactacatcc gcttggagga gcacggctcc cctcctgagc ccctcttccc
     1921 caacgactgg gaccccctgg acccaggagt gcccgcccct caggcccccc aggccccctc
     1981 cgaggtcccc cagctggtgt ccgagacctg ggcctccccc ctcttccctg cgccccggcc
     2041 cttcccagcc cagtcctcag cgtcaggcag cttcctgctg agcggctggg accccgaggg
     2101 ccggggcgcc ggggagaccc tggcgggaga ccctgccgag gtcttggggg agcgggggac
     2161 cgccccgtgg gtggaagaag aagaggagga ggaggagggc agctccccag gggaagacag
     2221 cagcagcctt ggaggtggcc caagccgccg gggtccccta ccctgtcccc tgtgcagccg
     2281 cgagggggcc tgctcctgcc tgccactgga gcggggggac gccgtagcag gctggggagg
     2341 ccaccctgct cttggctgcc cccacccccc cgaggacgac tcctcgctgc gggcagagcg
     2401 gggctccctg gccgacttgc ccatggcccc ccccgcctcg gccccccccg agtttctgga
     2461 ccccctcatg ggggcggcgg cgccccagta ccccgggcgg gggccacctc ccgctccccc
     2521 ccccccgccg ccacctcctc gggcccccgc ggacccggcc gcgtcccccg accccccttc
     2581 ggccgtggcc agtcccggtt caggcctctc gtcgccgggc cccaagccgg gggacagcgg
     2641 ctacgagacc gagacccctt tttccccaga gggagccttc ccaggtgggg gggcggccga
     2701 ggaggaaggg gtccctcggc cgcgggctcc ccccgagcca cccgacccag gagcgccccg
     2761 gccacctcca gacccgggtc cgctcccact cccggggccc cgggagaagc cgaccttcgt
     2821 ggttcaagtg agcacggaac agctgctgat gtccctgcgg gaggatgtga caaggaacct
     2881 cctgggggag aagggggcga cagcccggga gacaggaccc aggaaggcgg ggagaggccc
     2941 cgggaacaga gagaaagtcc cgggcctgaa cagggacccg acagtcctgg gcaacgggaa
     3001 acaagcccca agcctgagcc tcccagtgaa cggggtgaca gtgctggaga acggggacca
     3061 gagagcccca ggcatcgagg agaaggcggc ggagaatggg gccctggggt cccccgagag
     3121 agaagagaaa gtgctggaga atggggagct gacaccccca aggagggagg agaaagcgct
     3181 ggagaatggg gagctgaggt ccccagaggc cggggagaag gtgctggtga atgggggcct
     3241 gacaccccca aagagcgagg acaaggtgtc agagaatggg ggcctgagat tccccaggaa
     3301 cacggagagg ccaccagaga ctgggccttg gagagcccca gggccctggg agaagacgcc
     3361 cgagagttgg ggtccagccc ccacgatcgg ggagccagcc ccagagacct ctctggagag
     3421 agcccctgca cccagcgcag tggtctcctc ccggaacggc ggggagacag cccctggccc
     3481 ccttggccca gcccccaaga acgggacgct ggaacccggg accgagagga gagcccccga
     3541 gactgggggg gcgccgagag ccccaggggc tgggaggctg gacctcggga gtgggggccg
     3601 agccccagtg ggcacgggga cggcccccgg cggcggcccc ggaagcggcg tggacgcaaa
     3661 ggccggatgg gtagacaaca cgaggccgca gccaccgccg ccaccgctgc caccgccacc
     3721 ggaggcacag ccgaggaggc tggagccagc gcccccgaga gccaggccgg aggtggcccc
     3781 cgagggagag cccggggccc cagacagcag ggccggcgga gacacggcac tcagcggaga
     3841 cggggacccc cccaagcccg agaggaaggg ccccgagatg ccacgactat tcttggactt
     3901 gggaccccct caggggaaca gcgagcagat caaagccagg ctctcccggc tctcgctggc
     3961 gctgccgccg ctcacgctca cgccattccc ggggccgggc ccgcggcggc ccccgtggga
     4021 gggcgcggac gccggggcgg ctggcgggga ggccggcggg gcgggagcgc cggggccggc
     4081 ggaggaggac ggggaggacg aggacgagga cgaggaggag gacgaggagg cggcggcgcc
     4141 gggcgcggcg gcggggccgc ggggccccgg gagggcgcga gcagccccgg tgcccgtcgt
     4201 ggtgagcagc gccgacgcgg acgcggcccg cccgctgcgg gggctgctca agtctccgcg
     4261 cggggccgac gagccagagg acagcgagct ggagaggaag cgcaagatgg tctccttcca
     4321 cggggacgtg accgtctacc tcttcgacca ggagacgcca accaacgagc tgagcgtcca
     4381 ggcccccccc gagggggaca cggacccgtc aacgcctcca gcgcccccga cacctcccca
     4441 ccccgccacc cccggagatg ggtttcccag caacgacagc ggctttggag gcagtttcga
     4501 gtgggcggag gatttccccc tcctcccccc tccaggcccc ccgctgtgct tctcccgctt
     4561 ctccgtctcg cctgcgctgg agaccccggg gccacccgcc cgggcccccg acgcccggcc
     4621 cgcaggcccc gtggagaatt gattccccga agacccgacc ccgctgcacc ctcagaagag
     4681 gggttgagaa tggaatcctc tgtggatgac ggcgccactg ccaccaccgc agacgccgcc
     4741 tctggggagg cccccgaggc tgggccctcc ccctcccact cccctaccat gtgccaaacg
     4801 ggaggccccg ggcccccgcc ccccagcccc ccagatggct cccctgaccc ccctgacccc
     4861 ctcggagcca aatgaggcag gaatcccccc gcccctccat agagagccgc ctttctcgga
     4921 actgaactga actcttttgg gcctggagcc cctcgacaca gcggaggtcc ctcctcaccc
     4981 actcctggcc caagacaggg gccgcaggct tcggggaccc ggacccccca tttcgcgtct
     5041 cccctttccc tccccagccc ggcccctgga ggggcctctg gttcaaacct tcgcgtggca
     5101 ttttcacatt atttaaaaaa gacaaaaaca actttttgga ggaa
//
