LOCUS       NM_014916               8974 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens lemur tyrosine kinase 2 (LMTK2), mRNA.
ACCESSION   NM_014916
VERSION     NM_014916.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8974)
  AUTHORS   Zhang,L., Luo,P., Mao,X., Sun,J., Wei,J., Yang,Y., Zhang,Y. and
            Jiang,X.
  TITLE     Lemur tyrosine kinase 2 has a tumor-inhibition function in human
            glioblastoma by regulating the RUNX3/Notch pathway
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (7), 119509 (2023)
   PUBMED   37271222
  REMARK    GeneRIF: Lemur tyrosine kinase 2 has a tumor-inhibition function in
            human glioblastoma by regulating the RUNX3/Notch pathway.
REFERENCE   2  (bases 1 to 8974)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 8974)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8974)
  AUTHORS   Bencze,J., Szarka,M., Bencs,V., Szabo,R.N., Smajda,M., Aarsland,D.
            and Hortobagyi,T.
  TITLE     Neuropathological characterization of Lemur tyrosine kinase 2
            (LMTK2) in Alzheimer's disease and neocortical Lewy body disease
  JOURNAL   Sci Rep 9 (1), 17222 (2019)
   PUBMED   31748522
  REMARK    GeneRIF: Neuropathological characterization of Lemur tyrosine
            kinase 2 (LMTK2) in Alzheimer's disease and neocortical Lewy body
            disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8974)
  AUTHORS   Wang,S., Tang,D., Wang,W., Yang,Y., Wu,X., Wang,L. and Wang,D.
  TITLE     circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation
            and metastasis in gastric cancer
  JOURNAL   Mol Cancer 18 (1), 162 (2019)
   PUBMED   31722712
  REMARK    GeneRIF: Our findings demonstrate that circLMTK2 functions as a
            tumour promoter in GC through the miR-150-5p/c-Myc axis and could
            thus be a prognostic predictor and therapeutic target for GC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8974)
  AUTHORS   Wang,H. and Brautigan,D.L.
  TITLE     Peptide microarray analysis of substrate specificity of the
            transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic
            fibrosis transmembrane conductance regulator and phosphorylase
  JOURNAL   Mol Cell Proteomics 5 (11), 2124-2130 (2006)
   PUBMED   16887929
REFERENCE   7  (bases 1 to 8974)
  AUTHORS   Lin,T.H., Tsai,P.C., Liu,H.T., Chen,Y.C., Wang,L.H., Hsieh,F.K. and
            Huang,H.B.
  TITLE     Characterization of the protein phosphatase 1-binding motifs of
            inhibitor-2 and DARPP-32 by surface plasmon resonance
  JOURNAL   J Biochem 138 (6), 697-700 (2005)
   PUBMED   16428298
  REMARK    GeneRIF: role of the segment KLHY in binding with protein
            phosphatase 1
REFERENCE   8  (bases 1 to 8974)
  AUTHORS   Kawa,S., Fujimoto,J., Tezuka,T., Nakazawa,T. and Yamamoto,T.
  TITLE     Involvement of BREK, a serine/threonine kinase enriched in brain,
            in NGF signalling
  JOURNAL   Genes Cells 9 (3), 219-232 (2004)
   PUBMED   15005709
  REMARK    GeneRIF: BREK, Brain Enriched Kinase, is a new member of the family
            of protein serine/threonine kinases; plays important roles in
            NGF-TrkA signalling in the brain [BREK]
REFERENCE   9  (bases 1 to 8974)
  AUTHORS   Kesavapany,S., Lau,K.F., Ackerley,S., Banner,S.J., Shemilt,S.J.,
            Cooper,J.D., Leigh,P.N., Shaw,C.E., McLoughlin,D.M. and Miller,C.C.
  TITLE     Identification of a novel, membrane-associated neuronal kinase,
            cyclin-dependent kinase 5/p35-regulated kinase
  JOURNAL   J Neurosci 23 (12), 4975-4983 (2003)
   PUBMED   12832520
  REMARK    GeneRIF: Cprk is expressed in a number of tissues but is enriched
            in brain and muscle; Cprk displays catalytic activity in kinase
            assays and is itself phosphorylated by cdk5/p35; Cdk5/p35 inhibits
            cprk activity
REFERENCE   10 (bases 1 to 8974)
  AUTHORS   Wang,H. and Brautigan,D.L.
  TITLE     A novel transmembrane Ser/Thr kinase complexes with protein
            phosphatase-1 and inhibitor-2
  JOURNAL   J Biol Chem 277 (51), 49605-49612 (2002)
   PUBMED   12393858
  REMARK    GeneRIF: KPI-2 is a kinase with sites to associate with PP1C and
            Inh2 to form a regulatory complex that is localized to membranes
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073101.7, BC146773.1,
            AY130988.1, AC091654.4 and BE049530.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014916.3.
            
            Summary: The protein encoded by this gene belongs to the protein
            kinase superfamily and the protein tyrosine kinase family. It
            contains N-terminal transmembrane helices and a long C-terminal
            cytoplasmic tail with serine/threonine/tyrosine kinase activity.
            This protein interacts with several other proteins, such as
            Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin
            VI. It phosporylates other proteins, and is itself also
            phosporylated when interacting with cyclin-dependent kinase 5
            (cdk5)/p35 complex. This protein involves in nerve growth factor
            (NGF)-TrkA signalling, and also plays a critical role in endosomal
            membrane trafficking. Mouse studies suggested an essential role of
            this protein in spermatogenesis. [provided by RefSeq, Oct 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.60055.1,
                                           SRR1660809.228177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297293.6/ ENSP00000297293.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC073101.7         26092-26114
            24-2653             BC146773.1         1-2630
            2654-3044           AY130988.1         2338-2728
            3045-4639           BC146773.1         3022-4616
            4640-4828           AY130988.1         4324-4512
            4829-8783           AC091654.4         30024-33978
            8784-8969           BE049530.1         16-201              c
            8970-8974           AC091654.4         34165-34169
FEATURES             Location/Qualifiers
     source          1..8974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..8974
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /note="lemur tyrosine kinase 2"
                     /db_xref="GeneID:22853"
                     /db_xref="HGNC:HGNC:17880"
                     /db_xref="MIM:610989"
     exon            1..419
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..4828
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase LMTK2; protein
                     phosphatase 1, regulatory subunit 100; cyclin-dependent
                     kinase 5/p35-regulated kinase; brain-enriched kinase;
                     apoptosis-associated tyrosine kinase 2; CDK5/p35-regulated
                     kinase; kinase/phosphatase/inhibitor 2;
                     serine/threonine-protein kinase KPI-2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LMTK2 precursor"
                     /protein_id="NP_055731.2"
                     /db_xref="CCDS:CCDS5654.1"
                     /db_xref="GeneID:22853"
                     /db_xref="HGNC:HGNC:17880"
                     /db_xref="MIM:610989"
                     /translation="MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVS
                     SSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSP
                     AEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGT
                     SVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCD
                     LGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSD
                     LNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWS
                     LGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWL
                     SPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHF
                     ARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVE
                     VFESSLSDPGPGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELD
                     YPPALLTTDMDNPERTGPELSQLTALRSVELEESSTDEDFFQSSTDPKDSSLPGDLHV
                     TSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGVQADFKPATLSSSLDNPKESVIT
                     GHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLLKGSLSSKE
                     HINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGLSLLQENVSTKGDDTDVML
                     TGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQPTCLDVIVPEDCLHQ
                     DISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESDSVLADDILASRVSV
                     GSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAKEAGLVSALSSDS
                     TSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADS
                     GYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVT
                     PETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSP
                     AAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASSPWSV
                     LNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIE
                     GKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPI
                     ILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGP
                     CGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNL
                     LSSKPSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQG
                     GSSEDGEKD"
     exon            420..547
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            548..692
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            693..766
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            767..885
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            886..973
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1107
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1192
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1314
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1464
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..4423
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            4424..4556
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            4557..4799
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     exon            4800..8974
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5517..5522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /note="hexamer: CATAAA"
     polyA_site      5539
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /note="major polyA site"
     regulatory      8948..8953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
                     /note="hexamer: AATATA"
     polyA_site      8974
                     /gene="LMTK2"
                     /gene_synonym="AATYK2; BREK; cprk; hBREK; KPI-2; KPI2;
                     LMR2; PPP1R100"
ORIGIN      
        1 gtcacatgac gcagcccatc atggcggcgg gagcgcggct tcccaggccc gccgctccgc
       61 agggctgctg gcgttgctgc tgttgagagg cggcggcggc ggcgcaggcg ggcgggaagg
      121 atggtgtttc tgcgactgga gcggcaggtg cggaccggga gccggaccga ggtttggcag
      181 aagcaacgtg tgctcgggag caaccggcgc gggtgccact gaggcagcgg agggaggcag
      241 gatcgactga cgggcgaacg gacggacgga cggaaggcga ctcgagggcc ggccccggag
      301 ccgcgccgtg ggcgagatgc cggggccgcc ggcgttgcgg cggaggctgc tgctgctgct
      361 gctggtcctc ctgatcgccg gcagtgctgg ggccgcgcca cttccgcaaa caggtgcagg
      421 ggaggcgcca cctgctgcag aagtttcctc atcttttgtg atcctgtgtg tgtgcagttt
      481 aataatatta atagtgttaa ttgcaaactg tgtatcctgc tgtaaggacc cagaaataga
      541 ctttaaggaa tttgaagata attttgatga tgagatagat ttcacaccac cagcagaaga
      601 cactccctct gttcagtccc cagcagaggt cttcacactt tcagtaccaa atatttcact
      661 cccagctccc tcgcaattcc agccttctgt agagggattg aagtctcaag ttgcccgcca
      721 cagtctaaac tacatacagg aaattggaaa tggctggttt ggaaaggttc tcttgggaga
      781 gatttacacg ggcactagcg tagcaagagt catcgtgaag gagttaaaag caagtgccaa
      841 cccaaaggaa caagatactt ttttgaaaaa tggagaacct tactacattc ttcagcatcc
      901 aaatattctt cagtgtgttg gacagtgcgt agaagcgatt ccctacctcc tggtgtttga
      961 gttctgtgac ttgggtgacc tgaaggcgta tctgcgcagc gagcaggagc acatgcgggg
     1021 ggactcacag accatgctgc tgcagaggat ggcgtgcgag gtcgccgcgg ggctggccgc
     1081 catgcacaag ctgcacttcc tgcacagtga tttagccctg cggaattgtt ttctcacctc
     1141 cgacttaaat gtgaaagtgg gagattacgg aataggattc agcaggtaca aggaggatta
     1201 tattgaaaca gatgataaaa aagttttccc tctgcgatgg actgctccag aattagtaac
     1261 cagctttcaa gacagactgc taactgcaga tcagactaag tatagtaata tctggtctct
     1321 gggtgtgaca ctttgggagc tttttgacaa tgccgcacag ccgtattcaa acctttccaa
     1381 cttagatgtc ctcaaccaag tcattagaga gagagacaca aaactcccga agccccagct
     1441 ggagcagccc tactctgata gatggtatga agtcttacag ttctgttggc tgtcaccaga
     1501 aaagagaccc gcggctgaag atgtgcacag gctgctgact tacctgcggc tgcagagcca
     1561 gcgggactca gaggtcgact ttgaacagca gtggaacgct ctgaagccga acacaaacag
     1621 cagagactcc tccaacaatg ctgcattccc aattctcgac cactttgcca gggaccggct
     1681 gggtcgtgaa atggaggaag tcctcaccgt gaccgaaacc agccagggcc tgagcttcga
     1741 gtatgtctgg gaggccgcta agcacgacca ctttgacgag cgcagccggg gccacctgga
     1801 cgaaggcttg tcctacacga gcatcttcta tccggttgaa gtttttgaga gttcgctttc
     1861 agatcctggg cccggaaagc aagatgacag cggccaggat gtccccctga gggtccctgg
     1921 agtggttcct gtttttgatg cccacaacct ttctgttgga agcgactatt atatccagtt
     1981 agaagaaaaa agtggtagta acttggagct tgattaccca ccagcgctgc tcacaaccga
     2041 catggataat ccagaaagga ctggccctga actgtcccag ctcacggcgc tcaggagcgt
     2101 tgaacttgag gagtccagta cagatgagga cttcttccaa agcagtacag accccaaaga
     2161 ctctagctta ccaggggact tacacgtgac cagtggcccc gagagccctt tcaacaatat
     2221 atttaatgat gtggacaaat cggaagattt gcccagtcac caaaaaatat tcgacttaat
     2281 ggaattaaac ggagttcaag ccgactttaa acctgccact ttaagttcca gtttggataa
     2341 ccccaaagag tcagtcataa caggccactt tgagaaagaa aagccccgta agatttttga
     2401 cagtgagcct ctctgcctat cagataatct tatgcaccaa gataattttg atccattgaa
     2461 tgttcaagaa ttgtcagaaa actttttatt tcttcaagag aaaaacttac taaaaggctc
     2521 attgtccagc aaagaacaca taaatgatct tcagacagaa cttaagaatg ctggttttac
     2581 tgaagctatg ttagaaacgt catgtagaaa ctctttagat actgagcttc agtttgctga
     2641 aaataagcca ggcttgtctt tgttgcagga aaacgtaagc acaaagggtg acgatacaga
     2701 tgtcatgctc acaggtgaca ctttgagcac ctcattgcag tcttccccgg aagtgcaggt
     2761 acctcctacc tccttcgaaa cagaagaaac gccccgtcgg gtacccccag actcactccc
     2821 aacacaggga gaaacccagc ccacgtgttt agatgttatt gtcccggagg actgtctcca
     2881 ccaggacatc agtccagacg ctgtgactgt cccggttgaa attctctcaa ctgatgccag
     2941 aacccacagc ctggataaca ggtcccagga ctctcctggc gagagtgagg agaccctgcg
     3001 actcaccgaa agtgactctg ttcttgctga tgacatcctt gccagcaggg tgagtgtagg
     3061 gagtagtctc ccggaactgg gacaggaatt gcacaataaa ccattttcgg aagaccatca
     3121 cagtcatcgc cggctagaga aaaacttaga ggctgtggag actttaaatc agctcaattc
     3181 taaagacgca gcaaaagaag caggcttggt gtctgccctc tcctcggact caaccagtca
     3241 ggacagcctc ctggaggaca gcttgtcagc acccttccca gcctctgagc cgtccctgga
     3301 aaccccggac tctctggagt cagtggatgt ccacgaagcg ctactggact ctttaggatc
     3361 tcacactccc cagaaactag tgccccccga taagccggca gacagtggct acgaaacaga
     3421 gaacttggag tctcccgagt ggaccttgca tcccgctccc gagggcaccg cagactcaga
     3481 accagccacc acgggcgatg gcggccacag cggtctgcct cccaacccgg tcattgtcat
     3541 ctcagatgcc ggcgatggtc acagaggcac agaagtgacc cctgagacgt tcacagctgg
     3601 ctcccagggt tcataccgag actctgcgta cttctcagac aatgactctg agcccgagaa
     3661 aaggtctgag gaggtcccgg gaacctcccc atccgccttg gtgttggtac aggagcagcc
     3721 cctacccgag ccagtcctcc ccgagcaaag tcctgctgcc caggatagct gcctggaagc
     3781 cagaaagagc cagccagatg aaagttgtct gtctgctttg cacaactcca gtgacctgga
     3841 attaagagcc acgccggagc cagcacagac tggtgttccc cagcaggtgc atcccacgga
     3901 agacgaggcc agcagtccct ggagtgtgct gaatgcagaa cttagcagcg gcgatgactt
     3961 cgagacacag gacgatcgcc cctgcaccct cgcttccacg gggaccaaca cgaacgaact
     4021 ccttgcctac accaattctg cgctggacaa gtccctgtcc agccactccg agggcccgaa
     4081 gttgaaggag ccggacatcg aagggaagta cctggggaaa ctcggggtgt cagggatgct
     4141 cgacctctca gaggacggga tggatgcaga cgaggaggac gaaaacagcg acgactcgga
     4201 cgaggacctg cgggccttca acctgcatag cctcagctcc gagtcggagg acgagaccga
     4261 gcaccccgtg cccatcatcc tcagcaacga ggacggaagg cacctgcgga gtctgttgaa
     4321 gcccacagcg gccaatgccc ccgacccact gcccgaggac tggaagaagg aaaagaaggc
     4381 agtcacgttt ttcgatgatg tcacagtcta cctgtttgac caggagaccc caaccaaaga
     4441 gctggggccc tgtggaggag aggcgtgcgg cccggacctg agcggcccag ccccagcctc
     4501 aggctctccc tacctgagca ggtgcatcaa ctccgaaagc tccaccgacg aagaaggtgg
     4561 tggctttgag tgggatgatg acttctcccc agatcctttt atgtcaaaga caacaagtaa
     4621 cctgctcagc tccaagcctt ctctccaaac atccaagtac ttttctccgc cgccaccggc
     4681 ccggagcacg gagcagagct ggccgcactc ggcgccttac tcccggttct ccatctctcc
     4741 cgccaacatt gccagctttt ccctcacaca cctgaccgac tcggacatcg agcagggcgg
     4801 aagcagcgaa gacggagaaa aggactaggt ggctgccaac gcgcacgctc gggtccgagg
     4861 ctgctcccct ggagcggcgc ccctgcgccc tcagcccgag cagcgacatc cactcgccat
     4921 ttgctgacat gagattggga ggaagaatcc agaggtgaag agggagacgg ctcttagctg
     4981 cgttcaaggc ggggccctcg ggagcccagg tgcagagcga ggccgtgtcc aggagccggc
     5041 gtccctcagt gccccgtgca cccgcggccg cggcctccca ggcagtgctc atgcgctggc
     5101 cgtcggggga ggcaggggca cagcctccat gtgcgcgcgc gtgtggagct gtgtgcaccg
     5161 catgtgtgct ttccacaggg gcgtctctgc gtccacgcct gcacatcccg gcgcacgtgt
     5221 gggcaccaca gaggacacgt gaggggaatg gtcaccagtg agccatattt attatttcta
     5281 gagaaatcac gaactgcttt ctgtaattgc actgtggata aatgttccga gagtctccat
     5341 tgttgtacag gatcttcagt tattcgaggg gaatgaggca ggtcaagccg atgctagcca
     5401 ctagtttgat tttttttctg ttttatagtt tgcgctgcat ggtacttgtg aagcttaaat
     5461 attttgagtg ttctactgtg tctaggattg ttgggattgt acatatggta ctctttcata
     5521 aatgataaat gattctgaat gttagtgttt tatgttcata taggaaatat tttcattgag
     5581 tccaaaatac cactgttttg ttgatggact tgaatgcatt tttgtctctt cttgatgaag
     5641 cggctttgcc gcagcaaatg aggcttctct ctgaggagct gagaggtctt gcagcctctc
     5701 cttgtcattc tcccacccca catcccattt tttaaagccc ttttggtaaa aaccaacagg
     5761 ttgtggccgc agacctcaga tggacccggc ccatccctgg ggacgtgctg gcgtggcagg
     5821 tccagagagc tgcaccctgc acggggcacc gcaccgcttc cctccgcgca gctcttctgc
     5881 ctggttttcg gaggccaggc tgctgggaag cttccgtgtt cctgtcagtc cttccttcaa
     5941 gaagccgggg aactcaggca gactcatctc cgcagagcat accagccgtg ggggaccgtt
     6001 cgacttgatg atgtgtgcac acttcaggtg gtggggactt gagctttaaa aaaacctcca
     6061 cagccgaatc ttctcctccg agccactcca cgtcacgtcc agctgggcct ggccagtctg
     6121 tggttatcca tgtgggatga gataacacca catcctgcag ctgtgaaggg ggatggacaa
     6181 gggacgacgg ccgacggcag agcatcagca gccgacacat agttcgggtc ggggccttgg
     6241 gtggtcctgc atggcccggg actcatctca cggaccctcc gttctgcatt aagccccagg
     6301 ttctcttctg gctttgaaag ggcccgagtg ctcccagtgt agcttcgtca catcgtcacg
     6361 agcccctgtg gtcatgggcg acctcacacc tccctccctg agttctgctc tgacataagg
     6421 aagtcctcgg tggctggtgc agcgcggctg tgctgtgctg gggaggcagc cgttccttcg
     6481 ggggtccttg ggcctgcagt cccctcatac tcacccttca cccaacatat tttccggtgc
     6541 tgatatgttt ccagactcca gcgcaacctg gggtgctctc cagacccgtg caggggccgc
     6601 ctggggtaca cggaaggaag ttgagtccta gtgcaaaatg caggcggacg ttgccagaga
     6661 gtgcgcagca aatgaccttc attgccagtt ccaccctact cctctcattt tttatactaa
     6721 gcaataactt tccaaagcaa gaagttcagg atggagagag tcccctcctg tgtaggcatg
     6781 gggtggatgc ggtgcccacc tgggctatgt ggggagcacc actgtctcgg gatgcgcgaa
     6841 tttttttttt ttttttaatt aacagggcat tagaagatga ttttgccaaa attgtcatga
     6901 ctctgaattc ttgctgtggg gacttcctga gttttctcag tttttacatc taagattagt
     6961 cttggctgaa gagaaatgag acgtgattat actacttttt caattgcagg tttaaggagt
     7021 tcagatttaa tgaccaaagt catacagatc atggaatctg tcgtcgtctt atacagtgtc
     7081 agcctcgagt acatttatta accttttggg gctgtcagtt ttccactagg attaagattt
     7141 tggccgggcg cggtggctca cgcctgcaat cccaacacat tggggggtcg aggcggacgg
     7201 atcactttga gcccaggagt tcaagaccag cctgggcaac atggcgaaac ctcgtctcta
     7261 ctaaaaatac aaaatatata tatatatata tatactagct ggggcacata gtggtgtgca
     7321 cctgtagtcc cagctgcttg ggaggctgag gtgggaggat ggctagagcc caggagatgg
     7381 gtgttgcagt gagctgagac catgccactg tactctagcc tgggtaacag ccagaccctg
     7441 tctcaaaaaa aaaaacaatt tttttcataa cataattccc atttttattt attttgagtc
     7501 actcataatt aattgccaaa aaagcatttt atacattgag ttggggggta gtggatctta
     7561 gtgtggtgtt gcatggaggg gcgagatttt atatttataa tcaacacgtg ggttaacatg
     7621 tttttttgaa atccaagcaa tacacaggaa atttaagtag aataaaaatt gcagcccatt
     7681 tttgaaatgt cagcatgtgc tgtgttcagt tcaggttttt gttgtttgtt ttgttatttt
     7741 ttaactaata agttggttat cagtggtggg ttttcaaaat gtacttgttc taataagttg
     7801 tacaatgaac taaatcagtg gcattctcta gataatgtgg gggaaggtta gaatattttc
     7861 tggccttcta tggggtagca acccagaatc aatctgaatt agtcctgttt tggtggagtt
     7921 tgtacatttt aaatcctata acaaaaataa tctagttttc atttccttac tagctagatg
     7981 cgaatttgtc tttttgaatg accctgtcaa taagccagaa agggcaaccc agaaaaagtg
     8041 ctccccacat ccttctgaga cttggcctgt gtgtgtggac gagaagccat tcaccgtaag
     8101 ggtgcagaaa gctcgaccaa gccgaattgc aaacaacgtt cgttctattt ttaaatgtac
     8161 aggttcgatc gtttctatag aaatgggttt atctaagaaa agtcttggtt tgtcttgctg
     8221 ctgtaaaagg cctttccaaa cccctccttt tattcctgtt tcccgaaata aggtatttgt
     8281 agagttaagg acctactgca tgcctgtccc cagggccccg gtggaaggaa ggcagcgcct
     8341 gctcttcctt aactcagccc atcatctgaa aattcagaag tgaaccaagg gttagacgcc
     8401 agaggttggg cttctgttag agtggcttca aaacatgagc cttatgggaa gtagccttaa
     8461 aaaaagaatg ggtatacgca gtgacttccg atggaaatct ccaaaacaat attcctaagt
     8521 agcaatgggg ttggctcaag tctttattaa caaagaacat tctctttcat ctataaagaa
     8581 attcttaaag atgcattgac agtgttgaat taccaacagc ctgtgaagat cagtttgacc
     8641 ggtgtggaca cgtgctggtt aagcactcag gcctacgtgg gccgagcggg atcttgatca
     8701 tggggctggt gtatggatcc accgtcggat tccgtctgca gaggaggacg tagggggccg
     8761 tcacacccac caggcctccc tgctgtgctt taacacaggc agaagaggtt catggcaata
     8821 taatagtcaa tgaactttca gtttaaattg tgtacatttt taaattgtaa gatttttact
     8881 gtatattgat gcatagtgtg attcaataaa ttgcttgtaa tttaaaaact atttaatatt
     8941 caaaataaat atagttatat atttataaac tctg
//
