LOCUS       NM_001306080            7147 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens LIM domain 7 (LMO7), transcript variant 3, mRNA.
ACCESSION   NM_001306080
VERSION     NM_001306080.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7147)
  AUTHORS   Luo,A., Liu,H., Huang,C. and Wei,S.
  TITLE     Exosome-transmitted circular RNA circ-LMO7 facilitates the
            progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis
  JOURNAL   Cancer Biol Ther 25 (1), 2343450 (2024)
   PUBMED   38742566
  REMARK    GeneRIF: Exosome-transmitted circular RNA circ-LMO7 facilitates the
            progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis.
REFERENCE   2  (bases 1 to 7147)
  AUTHORS   Zeng,Q., Jiang,T. and Wang,J.
  TITLE     Role of LMO7 in cancer (Review)
  JOURNAL   Oncol Rep 52 (3) (2024)
   PUBMED   38994754
  REMARK    GeneRIF: Role of LMO7 in cancer (Review).
            Review article
REFERENCE   3  (bases 1 to 7147)
  AUTHORS   Israelsson,P., Oda,H., Ofverman,C., Stefansson,K. and Lindquist,D.
  TITLE     Immunoreactivity of LMO7 and other molecular markers as potential
            prognostic factors in oropharyngeal squamous cell carcinoma
  JOURNAL   BMC Oral Health 24 (1), 729 (2024)
   PUBMED   38918827
  REMARK    GeneRIF: Immunoreactivity of LMO7 and other molecular markers as
            potential prognostic factors in oropharyngeal squamous cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7147)
  AUTHORS   Zhang,Y., Wang,W., Duan,C., Li,M. and Gao,L.
  TITLE     Novel Long Non-Coding RNA (lncRNA) Transcript AL137782.1 Promotes
            the Migration of Normal Lung Epithelial Cells through Positively
            Regulating LMO7
  JOURNAL   Int J Mol Sci 24 (18), 13904 (2023)
   PUBMED   37762205
  REMARK    GeneRIF: Novel Long Non-Coding RNA (lncRNA) Transcript AL137782.1
            Promotes the Migration of Normal Lung Epithelial Cells through
            Positively Regulating LMO7.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7147)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 7147)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 7147)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   8  (bases 1 to 7147)
  AUTHORS   Rozenblum,E., Vahteristo,P., Sandberg,T., Bergthorsson,J.T.,
            Syrjakoski,K., Weaver,D., Haraldsson,K., Johannsdottir,H.K.,
            Vehmanen,P., Nigam,S., Golberger,N., Robbins,C., Pak,E., Dutra,A.,
            Gillander,E., Stephan,D.A., Bailey-Wilson,J., Juo,S.H., Kainu,T.,
            Arason,A., Barkardottir,R.B., Nevanlinna,H., Borg,A. and
            Kallioniemi,O.P.
  TITLE     A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer
            development: identification and characterization of candidate genes
  JOURNAL   Hum Genet 110 (2), 111-121 (2002)
   PUBMED   11935316
REFERENCE   9  (bases 1 to 7147)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
REFERENCE   10 (bases 1 to 7147)
  AUTHORS   Putilina,T., Jaworski,C., Gentleman,S., McDonald,B., Kadiri,M. and
            Wong,P.
  TITLE     Analysis of a human cDNA containing a tissue-specific alternatively
            spliced LIM domain
  JOURNAL   Biochem Biophys Res Commun 252 (2), 433-439 (1998)
   PUBMED   9826547
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA313248.1, FJ711162.1,
            AL137782.9, AF330045.1 and AF144237.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001306080.1.
            
            Summary: This gene encodes a protein containing a calponin homology
            (CH) domain, a PDZ domain, and a LIM domain, and may be involved in
            protein-protein interactions. Several alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene, however, the full-length nature of some variants is not
            known. [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (3) is alternatively spliced at
            the 5' end, and contains two additional internal coding exons,
            compared to transcript variant 1. The encoded isoform (3) has a
            distinct N-terminus and is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ711162.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377534.8/ ENSP00000366757.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               DA313248.1         43-370
            329-1023            FJ711162.1         1-695
            1024-1024           AL137782.9         131213-131213
            1025-1736           FJ711162.1         697-1408
            1737-1737           AL137782.9         134582-134582
            1738-2008           FJ711162.1         1410-1680
            2009-2009           AL137782.9         134854-134854
            2010-5224           FJ711162.1         1682-4896
            5225-5958           AF330045.1         5310-6043
            5959-5965           AF144237.1         3505-3511
            5966-7147           AF330045.1         6051-7232
FEATURES             Location/Qualifiers
     source          1..7147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q22.2"
     gene            1..7147
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /note="LIM domain 7"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
     exon            1..397
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..5224
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /EC_number="3.4.19.12"
                     /note="isoform 3 is encoded by transcript variant 3;
                     zinc-finger domain-containing protein; F-box only protein
                     20; F-box protein Fbx20; LIM domain only protein 7; LMO-7;
                     LIM domain only 7 protein"
                     /codon_start=1
                     /product="LIM domain only protein 7 isoform 3"
                     /protein_id="NP_001293009.1"
                     /db_xref="CCDS:CCDS81773.1"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
                     /translation="MEGLEEAEANCSVAFAEAQRWVEAVTEKNFETKDFRASLENGVL
                     LCDLINKLKPGVIKKINRLSTPIAGLDNINVFLKACEQIGLKEAQLFHPGDLQDLSNR
                     VTVKQEETDRRVKNVLITLYWLGRKAQSNPYYNGPHLNLKAFENLLGQALTKALEDSS
                     FLKRSGRDSGYGDIWCPERGEFLAPPRHHKREDSFESLDSLGSRSLTSCSSDITLRGG
                     REGFESDTDSEFTFKMQDYNKDDMSYRRISAVEPKTALPFNRFLPNKSRQPSYVPAPL
                     RKKKPDKHEDNRRSWASPVYTEADGTFSSNQRRIWGTNVENWPTVQGTSKSSCYLEEE
                     KAKTRSIPNIVKDDLYVRKLSPVMPNPGNAFDQFLPKCWTPEDVNWKRIKRETYKPWY
                     KEFQGFSQFLLLQALQTYSDDILSSETHTKIDPTSGPRLITRRKNLSYAPGYRRDDLE
                     MAALDPDLENDDFFVRKTGAFHANPYVLRAFEDFRKFSEQDDSVERDIILQCREGELV
                     LPDLEKDDMIVRRIPAQKKEVPLSGAPDRYHPVPFPEPWTLPPEIQAKFLCVLERTCP
                     SKEKSNSCRILVPSYRQKKDDMLTRKIQSWKLGTTVPPISFTPGPCSEADLKRWEAIR
                     EASRLRHKKRLMVERLFQKIYGENGSKSMSDVSAEDVQNLRQLRYEEMQKIKSQLKEQ
                     DQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEKSKRSSKTFKEMLQDRESQN
                     QKSTVPSRRRMYSFDDVLEEGKRPPTMTVSEASYQSERVEEKGATYPSEIPKEDSTTF
                     AKREDRVTTEIQLPSQSPVEEQSPASLSSLRSRSTQMESTRVSASLPRSYRKTDTVRL
                     TSVVTPRPFGSQTRGISSLPRSYTMDDAWKYNGDVEDIKRTPNNVVSTPAPSPDASQL
                     ASSLSSQKEVAATEEDVTRLPSPTSPFSSLSQDQAATSKATLSSTSGLDLMSESGEGE
                     ISPQREVSRSQDQFSDMRISINQTPGKSLDFGFTIKWDIPGIFVASVEAGSPAEFSQL
                     QVDDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKAGSPETKWIDATSG
                     IYNSEKSSNLSVTTDFSESLQSSNIESKEINGIHDESNAFESKASESISLKNLKRRSQ
                     FFEQGSSDSVVPDLPVPTISAPSRWVWDQEEERKRQERWQKEQDRLLQEKYQREQEKL
                     REEWQRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLATWEATWSEGSKSSDREG
                     TRAGEEERRQPQEEVVHEDQGKKPQDQLVIERERKWEQQLQEEQEQKRLQAEAEEQKR
                     PAEEQKRQAEIERETSVRIYQYRRPVDSYDIPKTEEASSGFLPGDRNKSRSTTELDDY
                     STNKNGNNKYLDQIGNMTSSQRRSKKEQVPSGAELERQQILQEMRKRTPLHNDNSWIR
                     QRSASVNKEPVSLPGIMRRGESLDNLDSPRSNSWRQPPWLNQPTGFYASSSVQDFSRP
                     PPQLVSTSNRAYMRNPSSSVPPPSAGSVKTSTTGVATTQSPTPRSHSPSASQSGSQLR
                     NRSVSGKRICSYCNNILGKGAAMIIESLGLCYHLHCFKCVACECDLGGSSSGAEVRIR
                     NHQLYCNDCYLRFKSGRPTAM"
     exon            398..468
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            469..538
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            539..645
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            646..676
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            677..790
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            791..989
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1242
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1524
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..2244
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2274
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2392
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2535
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2968
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3277
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3392
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3554
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3661
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3722
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3779
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..3805
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3806..3910
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4003
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4359
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            4360..4425
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            4426..4478
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            4479..4692
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..4989
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            4990..5098
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            5099..5201
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     exon            5202..7147
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5936..5941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /note="hexamer: AATAAA"
     polyA_site      5958
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /note="major polyA site"
     regulatory      7124..7129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /note="hexamer: AATAAA"
     polyA_site      7147
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
ORIGIN      
        1 aaactgtcgt cggggctggt gccgcgcgct gccgctgggc acccgcttcg cttcccgcgt
       61 cctgcctgac tgcccgggtc cccgcgggcc ttgggtcgct ttcaggagtt tagagaaagc
      121 caggtcttca cgttcgtgta ggttcgagac cttaacgaac tgcagagcgc aacaaaggga
      181 actagagccc cggcgccttc gcagccggag cggaagccgg agttgtggga ggcccgcgtg
      241 ccctccccgc ccgtggggcc cagacgcgcg gggacaaccc ctcccctcca cgcatcccga
      301 gtctctctct ccctcccttg tcctagccat ggaagggctg gaggaggcag aggccaactg
      361 ctccgtggcg ttcgctgagg ctcagagatg ggtggaggca gtaacagaga agaattttga
      421 aacaaaagat tttcgagcct ctctagaaaa tggtgttctg ctgtgtgatt tgattaataa
      481 gcttaaacct ggcgtcatta agaagatcaa tagactgtct acaccaatag caggattgga
      541 taatataaac gttttcttga aagcttgtga acagattgga ttgaaagaag cccagctttt
      601 ccatcctgga gatctacagg atttatcaaa tcgagtcact gtcaagcaag aagagactga
      661 caggagagtg aaaaatgttt tgataacatt gtactggctg ggaagaaaag cacaaagcaa
      721 cccgtactat aatggtcccc atcttaattt gaaagcgttt gagaatcttt taggacaagc
      781 actgacgaag gcactcgaag actccagctt cctgaaaaga agtggcaggg acagtggcta
      841 cggtgacatc tggtgtcctg aacgtggaga atttcttgct cctccaaggc accataagag
      901 agaagattcc tttgaaagct tggactcttt gggctcgagg tcattgacaa gctgctcctc
      961 tgatatcacg ttgagagggg ggcgtgaagg ttttgaaagt gacacagatt cggaatttac
     1021 atttaagatg caggattata ataaagatga tatgtcgtat cgaaggattt cggctgttga
     1081 gccaaagact gcgttaccct tcaatcgttt tttacccaac aaaagtagac agccatccta
     1141 tgtaccagca cctctgagaa agaaaaagcc agacaaacat gaggataaca gaagaagttg
     1201 ggcaagcccg gtttatacag aagcagatgg aacattttca agtaatcaga ggaggatttg
     1261 gggcaccaat gtggagaact ggccaactgt acaaggaact tcaaagtcct cttgttattt
     1321 ggaagaggaa aaagcaaaga caagaagcat acccaacatt gtaaaggatg atctttatgt
     1381 gcgcaagctc agtccagtca tgccaaaccc agggaatgct tttgatcagt ttcttcccaa
     1441 atgttggacc ccagaagatg tgaactggaa aagaataaaa agggaaactt ataagccatg
     1501 gtataaagaa tttcagggat tcagtcagtt tttactgctt caggccctcc aaacatactc
     1561 tgatgacatc ttgtcttctg aaacacatac caaaattgat cccacttctg gcccaaggct
     1621 cataacccgc aggaagaatc tctcttatgc accaggctat agaagagatg acctcgagat
     1681 ggcagccctg gatcctgact tagagaatga tgatttcttt gtcagaaaga ctggggcttt
     1741 ccatgcaaat ccatatgttc tccgagcttt tgaagacttt agaaagttct ctgagcaaga
     1801 tgattctgta gagcgagata taattttaca gtgtagagaa ggtgaacttg tacttccgga
     1861 tttggaaaaa gatgatatga ttgttcgccg aattccagca cagaagaaag aagtgccgct
     1921 gtctggggcc ccagatagat accacccagt cccttttccc gaaccctgga ctcttcctcc
     1981 agaaattcaa gcaaaatttc tctgtgtact tgaaaggaca tgcccatcca aagaaaaaag
     2041 taatagctgt agaatattag ttccttcata tcggcagaag aaagatgaca tgctgacacg
     2101 taagattcag tcctggaaac tgggaactac cgtgcctccc atcagtttca cccctggccc
     2161 ctgcagtgag gctgacttga agagatggga ggccatccgg gaggccagca gacttaggca
     2221 caagaaaagg ctgatggtgg agagactctt tcaaaagatt tatggtgaga atgggagtaa
     2281 gtccatgagt gatgtcagcg cagaagatgt tcaaaacttg cgtcagctgc gttacgagga
     2341 gatgcagaaa ataaaatcac aattaaaaga acaagatcag aaatggcagg atgaccttgc
     2401 aaaatggaaa gatcgtcgaa aaagttacac ttcagatctg cagaagaaaa aagaagagag
     2461 agaagaaatt gaaaagcagg cacttgagaa gtctaagaga agctctaaga cgtttaagga
     2521 aatgctgcag gacagggaat cccaaaatca aaagtctaca gttccgtcaa gaaggagaat
     2581 gtattctttt gatgatgtgc tggaggaagg aaagcgaccc cctacaatga ctgtgtcaga
     2641 agcaagttac cagagtgaga gagtagaaga gaagggagca acttatcctt cagaaattcc
     2701 caaagaagat tctaccactt ttgcaaaaag agaggaccgt gtaacaactg aaattcagct
     2761 tccttctcaa agtcctgtgg aagaacaaag cccagcctct ttgtcttctc tgcgttcacg
     2821 gagcacacaa atggaatcaa ctcgtgtttc agcttctctc cccagaagtt accggaaaac
     2881 tgatacagtc aggttaacat ctgtggtcac accaagaccc tttggctctc agacaagggg
     2941 aatctcatca ctccccagat cttacacgat ggatgatgct tggaagtata atggagatgt
     3001 tgaagacatt aagagaactc caaacaatgt ggtcagcacc cctgcaccaa gcccggacgc
     3061 aagccaactg gcttcaagct tatctagcca gaaagaggta gcagcaacag aagaagatgt
     3121 gacaaggctg ccctctccta catccccctt ctcatctctt tcccaagacc aggctgccac
     3181 ttctaaagcc acattgtctt ccacatctgg tcttgattta atgtctgaat ctggagaagg
     3241 ggaaatctcc ccacaaagag aagtctcaag atcccaggat cagttcagtg atatgagaat
     3301 cagcataaac cagacgcctg ggaagagtct tgactttggg tttacaataa aatgggatat
     3361 tcctgggatc ttcgtagcat cagttgaagc aggtagccca gcagaatttt ctcagctaca
     3421 agtagatgat gaaattattg ctattaacaa caccaagttt tcatataacg attcaaaaga
     3481 gtgggaggaa gccatggcta aggctcaaga aactggacac ctagtgatgg atgtgaggcg
     3541 ctatggaaag gctggttcac ctgaaacaaa gtggattgat gcaacttctg gaatttacaa
     3601 ctcagaaaaa tcttcaaatc tatctgtaac aactgatttc tccgaaagcc ttcagagttc
     3661 taatattgaa tccaaagaaa tcaatggaat tcatgatgaa agcaatgctt ttgaatcaaa
     3721 agcatctgaa tccatttctt tgaaaaactt aaaaaggcga tcacaatttt ttgaacaagg
     3781 aagctctgat tcggtggttc ctgatcttcc agttccaacc atcagtgccc cgagtcgctg
     3841 ggtgtgggat caagaggagg agcggaagcg gcaggagagg tggcagaagg agcaggaccg
     3901 cctactgcag gaaaaatatc aacgtgagca ggagaaactg agggaagagt ggcaaagggc
     3961 caaacaggag gcagagagag agaattccaa gtacttggat gaggaactga tggtcctaag
     4021 ctcaaacagc atgtctctga ccacacggga gccctctctt gccacctggg aagctacctg
     4081 gagtgaaggg tccaagtctt cagacagaga aggaacccga gcaggagaag aggagaggag
     4141 acagccacaa gaggaagttg ttcatgagga ccaaggaaag aagccgcagg atcagcttgt
     4201 tattgagaga gagaggaaat gggagcaaca gcttcaggaa gagcaagagc aaaagcggct
     4261 tcaggctgag gctgaggagc agaagcgtcc tgcggaggag cagaagcgcc aggcagagat
     4321 agagcgggaa acatcagtca gaatatacca gtacaggagg cctgttgatt cctatgatat
     4381 accaaagaca gaagaagcat cttcaggttt tcttcctggt gacaggaata aatccagatc
     4441 tactactgaa ctggatgatt actccacaaa taaaaatgga aacaataaat atttagacca
     4501 aattgggaac atgacctctt cacagaggag atccaagaaa gaacaagtac catcaggagc
     4561 agaattggag aggcaacaaa tccttcagga aatgaggaag agaacacccc ttcacaatga
     4621 caacagctgg atccgacagc gcagtgccag tgtcaacaaa gagcctgtta gtcttcctgg
     4681 gatcatgaga agaggcgaat ctttagataa cctggactcc ccccgatcca attcttggag
     4741 acagcctcct tggctcaatc agcccacagg attctatgct tcttcctctg tgcaagactt
     4801 tagtcgccca ccacctcagc tggtgtccac atcaaaccgt gcctacatgc ggaacccctc
     4861 ctccagcgtg cccccacctt cagctggctc cgtgaagacc tccaccacag gtgtggccac
     4921 cacacagtcc cccaccccga gaagccattc cccttcagct tcacagtcag gctctcagct
     4981 gcgtaacagg tcagtcagtg ggaagcgcat atgctcctac tgcaataaca ttctgggcaa
     5041 aggagccgcc atgatcatcg agtccctggg tctttgttat catttgcatt gttttaagtg
     5101 tgttgcctgt gagtgtgacc tcggaggctc ttcctcagga gctgaagtca ggatcagaaa
     5161 ccaccaactg tactgcaacg actgctatct cagattcaaa tctggacggc caaccgccat
     5221 gtgatgtaag cctccatacg aaagcactgt tgcagataga agaagaggtg gttgctgctc
     5281 atgtagatct ataaatatgt gttgtatgtc ttttttgctt tttttttaaa aaaaagaata
     5341 actttttttg cctctttaga ttacatagaa gcattgtagt cttggtagaa ccagtatttt
     5401 tgttgtttat ttataaggta attgtgtgtg gggaaaagtg cagtatttac ctgttgaatt
     5461 cagcatcttg agagcacaag ggaaaaaata agaacctacg aatatttttg aggcagataa
     5521 tgatctagtt tgactttcta gttagtggtg ttttgaagag ggtattttat tgttttttaa
     5581 aaaaaggttc ttaaacatta tttgaaatag ttaatataaa tacataattg catttgctct
     5641 gtttattgta atgtattcta aattaatgca gaaccatatg gaaaatttca ttaaaatcta
     5701 tccccaaatg tgctttctgt atccttcctt ctacctatta ttctgatttt taaaaatgca
     5761 gttaatgtac catttatttg cttgatgaag ggagctctat tttctttacc agaaatgttg
     5821 ctaagtaatt cccaatagaa agctgcttat tttcattaat gaaaaataac catggtttgt
     5881 atactagaag tcttcttcag aaactggtga gcctttctgt tcaattgcat ttgtaaataa
     5941 acttgctgat gcatttaacg agtgggtcgt ctttttctta ggtgtatgtg tctgacctca
     6001 ggccttttag ccatatttca gtatgtggcc ttttttgatg ttatgtttta tccagtagct
     6061 ttactaaggt ataattgatg taataaactg catatattta aagtgtatac tttgacaaat
     6121 tttgacatgg tgtatacctt cgaaactatg ccacagtctg gatgtgttta ctgaaacatt
     6181 ttaataagga agtttatttt tgataaagtt atgtttttgg atacaatata tttgtatggt
     6241 gagagtgatg aattgttgga tcatttgaat aaaatctttt actaacccca tgataaaagg
     6301 agaagacaac agtgagctta gaatatctat aaagcaaaaa atgtagtctc ttgtttaaaa
     6361 aatctggagc gggaatgcaa ggatacaaaa ctttagcatg ctttgagcaa aaatttaaac
     6421 ttactggaat cttttataat aatgtaagtg gaatggagga ttctaggaac tgagaactgt
     6481 attggaatag gttcaaaata tgtaagaaat gctaatgtgg gagataaaaa ttttatttag
     6541 tacttattct gattattatt aaagtaataa tgtgttcctt gaggataact tgtcaaatgc
     6601 cccaaagcat aaagaatata attctgaatc ccaaattcca aagacaagaa ctctgtgttt
     6661 gaattcattc tgcatataat tatttataag tatagattgt gaatttttcc atgttcttaa
     6721 aattattttt atcttttttc atggttgcat agtgctccat tgtttggcct tggtaatatt
     6781 tagttgataa ttccattact gtgtattttt cacttgtttc taagatcaaa cattttaata
     6841 tgtgcatgtt atatataaat atgtaaattc tgtgatactc tatgatcatc tctttcttta
     6901 tattattttc atagacatga aatagttgct cagagattat gcattttaag acactcatag
     6961 tatatattgc caaagtggtt tccagaaagg cactgctggc ttcgactcct ataagcagca
     7021 cgtgggcttg ttcatctcac tgcatgttta tgaagataca gttcttttgc cttgttctct
     7081 gcctgatgtg tatgcagagg cagccctcaa tatgcagtgg ttgaataaat gaatgaagaa
     7141 accacta
//
