LOCUS       NM_006769               4993 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens LIM domain only 4 (LMO4), transcript variant 1, mRNA.
ACCESSION   NM_006769
VERSION     NM_006769.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4993)
  AUTHORS   Tu,Z., Wei,W., Zeng,F., Wang,W., Zhang,Y., Zhang,Y., Zhou,F.,
            Cai,C., Zhang,S. and Zhou,H.
  TITLE     IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4 in
            Psoriatic Keratinocytes through Activation of the MEK/ERK/NF-kappaB
            Pathway
  JOURNAL   Am J Pathol 194 (5), 708-720 (2024)
   PUBMED   38320628
  REMARK    GeneRIF: IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4
            in Psoriatic Keratinocytes through Activation of the
            MEK/ERK/NF-kappaB Pathway.
REFERENCE   2  (bases 1 to 4993)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4993)
  AUTHORS   Jiang,Y.M., Liu,W., Jiang,L. and Chang,H.
  TITLE     CircLDLR Promotes Papillary Thyroid Carcinoma Tumorigenicity by
            Regulating miR-637/LMO4 Axis
  JOURNAL   Dis Markers 2021, 3977189 (2021)
   PUBMED   34925640
  REMARK    GeneRIF: CircLDLR Promotes Papillary Thyroid Carcinoma
            Tumorigenicity by Regulating miR-637/LMO4 Axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4993)
  AUTHORS   Shao,K., Chen,G., Xia,L., Chen,C. and Huang,S.
  TITLE     MicroRNA-139-5p Alleviates High Glucose-Triggered Human Retinal
            Pigment Epithelial Cell Injury by Targeting LIM-Only Factor 4
  JOURNAL   Mediators Inflamm 2021, 1629783 (2021)
   PUBMED   34725544
  REMARK    GeneRIF: MicroRNA-139-5p Alleviates High Glucose-Triggered Human
            Retinal Pigment Epithelial Cell Injury by Targeting LIM-Only Factor
            4.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4993)
  AUTHORS   Xue,W., Zheng,X., Hu,X. and Zhang,Y.
  TITLE     Research and Clinical Significance of the Differentially Expressed
            Genes TP63 and LMO4 in Human Immunodeficiency Virus-Related Penile
            Squamous Cell Carcinoma
  JOURNAL   Am J Mens Health 15 (2), 15579883211011380 (2021)
   PUBMED   33906487
  REMARK    GeneRIF: Research and Clinical Significance of the Differentially
            Expressed Genes TP63 and LMO4 in Human Immunodeficiency
            Virus-Related Penile Squamous Cell Carcinoma.
REFERENCE   6  (bases 1 to 4993)
  AUTHORS   Deane,J.E., Visvader,J.E., Mackay,J.P. and Matthew,J.M.
  TITLE     1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1
            complex
  JOURNAL   J Biomol NMR 23 (2), 165-166 (2002)
   PUBMED   12153047
  REMARK    GeneRIF: 1H, 15N and 13C assignments of FLIN4, an intramolecular
            LMO4:ldb1 complex
REFERENCE   7  (bases 1 to 4993)
  AUTHORS   Sum,E.Y., Peng,B., Yu,X., Chen,J., Byrne,J., Lindeman,G.J. and
            Visvader,J.E.
  TITLE     The LIM domain protein LMO4 interacts with the cofactor CtIP and
            the tumor suppressor BRCA1 and inhibits BRCA1 activity
  JOURNAL   J Biol Chem 277 (10), 7849-7856 (2002)
   PUBMED   11751867
  REMARK    GeneRIF: These findings reveal a novel complex between BRCA1, LMO4,
            and CtIP and indicate a role for LMO4 as a repressor of BRCA1
            activity in breast tissue.
REFERENCE   8  (bases 1 to 4993)
  AUTHORS   Tse,E., Grutz,G., Garner,A.A., Ramsey,Y., Carter,N.P., Copeland,N.,
            Gilbert,D.J., Jenkins,N.A., Agulnick,A., Forster,A. and
            Rabbitts,T.H.
  TITLE     Characterization of the Lmo4 gene encoding a LIM-only protein:
            genomic organization and comparative chromosomal mapping
  JOURNAL   Mamm Genome 10 (11), 1089-1094 (1999)
   PUBMED   10556429
REFERENCE   9  (bases 1 to 4993)
  AUTHORS   Racevskis,J., Dill,A., Sparano,J.A. and Ruan,H.
  TITLE     Molecular cloning of LMO41, a new human LIM domain gene
  JOURNAL   Biochim Biophys Acta 1445 (1), 148-153 (1999)
   PUBMED   10209267
REFERENCE   10 (bases 1 to 4993)
  AUTHORS   Kenny,D.A., Jurata,L.W., Saga,Y. and Gill,G.N.
  TITLE     Identification and characterization of LMO4, an LMO gene with a
            novel pattern of expression during embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 95 (19), 11257-11262 (1998)
   PUBMED   9736723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI962216.1, BU580860.1,
            U24576.1, AC092392.2 and BU619915.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006769.3.
            
            Summary: This gene encodes a cysteine-rich protein that contains
            two LIM domains but lacks a DNA-binding homeodomain. The encoded
            protein may play a role as a transcriptional regulator or as an
            oncogene. [provided by RefSeq, Aug 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.92917.1, U24576.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370544.10/ ENSP00000359575.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AI962216.1         1-201               c
            202-624             BU580860.1         64-486
            625-1487            U24576.1           1037-1899
            1488-4353           AC092392.2         58771-61636
            4354-4993           BU619915.1         11-650              c
FEATURES             Location/Qualifiers
     source          1..4993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..4993
                     /gene="LMO4"
                     /note="LIM domain only 4"
                     /db_xref="GeneID:8543"
                     /db_xref="HGNC:HGNC:6644"
                     /db_xref="MIM:603129"
     exon            1..365
                     /gene="LMO4"
                     /inference="alignment:Splign:2.1.0"
     exon            366..604
                     /gene="LMO4"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..866
                     /gene="LMO4"
                     /note="LMO-4; breast tumor autoantigen; LIM domain only
                     protein 4; LIM-only 4 protein"
                     /codon_start=1
                     /product="LIM domain transcription factor LMO4"
                     /protein_id="NP_006760.1"
                     /db_xref="CCDS:CCDS713.1"
                     /db_xref="GeneID:8543"
                     /db_xref="HGNC:HGNC:6644"
                     /db_xref="MIM:603129"
                     /translation="MVNPGSSSQPPPVTAGSLSWKRCAGCGGKIADRFLLYAMDSYWH
                     SRCLKCSCCQAQLGDIGTSCYTKSGMILCRNDYIRLFGNSGACSACGQSIPASELVMR
                     AQGNVYHLKCFTCSTCRNRLVPGDRFHYINGSLFCEHDRPTALINGHLNSLQSNPLLP
                     DQKVC"
     exon            605..701
                     /gene="LMO4"
                     /inference="alignment:Splign:2.1.0"
     exon            702..857
                     /gene="LMO4"
                     /inference="alignment:Splign:2.1.0"
     exon            858..4993
                     /gene="LMO4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1627..1632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMO4"
                     /note="hexamer: AATAAA"
     polyA_site      1650
                     /gene="LMO4"
                     /note="major polyA site"
     regulatory      3155..3160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMO4"
                     /note="hexamer: ATTATA"
     polyA_site      3175
                     /gene="LMO4"
     regulatory      4970..4975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMO4"
                     /note="hexamer: AATAAA"
     polyA_site      4993
                     /gene="LMO4"
ORIGIN      
        1 gcagcagcga ttgcagcagt tgctgccgct gcgccgcgcc tgaagccgcg ccgcgcgggc
       61 cgagggctcc tgcagctgct cgcgcgcagt cggaggcgga gaaggacgaa gactgagact
      121 gacacttctg ctcccggccg cccggcactt acgcgggggc cccccaaccc gccccagagc
      181 aacgcgattt aaaaaaaaaa aaaaagccgc ccttagcccc ctcctcccct ttcctgcttc
      241 tgcgagaact ccctccctcc ctccagctcc gccagcccag gcgccccttc cctggaagcc
      301 gagcggcttc gctcgcattt caccgccgcc gcctctcgca atattgcaat ataggggaaa
      361 agcagaccat ggtgaatccg ggcagcagct cgcagccgcc cccggtgacg gccggctccc
      421 tctcctggaa gcggtgcgca ggctgcgggg gcaagattgc ggaccgcttt ctgctctatg
      481 ccatggacag ctattggcac agccggtgcc tcaagtgctc ctgctgccag gcgcagctgg
      541 gcgacatcgg cacgtcctgt tacaccaaaa gtggcatgat cctttgcaga aatgactaca
      601 ttaggttatt tggaaatagc ggtgcttgca gcgcttgcgg acagtcgatt cctgcgagtg
      661 aactcgtcat gagggcgcaa ggcaatgtgt atcatcttaa gtgttttaca tgctctacct
      721 gccggaatcg cctggtcccg ggagatcggt ttcactacat caatggcagt ttattttgtg
      781 aacatgatag acctacagct ctcatcaatg gccatttgaa ttcacttcag agcaatccac
      841 tactgccaga ccagaaggtc tgctaaaagg tcagagtaat gcagaatgcg tgccttcatc
      901 tcagatttgt tcatcacagg tggatcccat gtgtcttcag tagacaagtc acctttgtag
      961 ctagcaccag tgccagctcc atgccattgc accttcttta gtcttgattg cccttcccgc
     1021 atttattggt gtattaaaat gactgaatat gaacattaag gactccatga acctgggcta
     1081 atgggagact gtagagaaaa tgaaaaaaga tccaccagag gacatcttgg ggagggggag
     1141 ggagctgggg gggagggaaa tgactaatga agctaattaa aagaagcatt caaatctgct
     1201 ttctaccctc attaacaatt agcagggcac tggccagagt ttgtaccctg tgttttacct
     1261 taacaacatt ctatttgctc tttgtatatt taagtgttgt aaggaaacgt gtttcaatca
     1321 aaactgacca tgagataaag gaaagagatg tggcttttgt gatattctat cacaaacact
     1381 tattgtatct ctgtaaaata caatgtatgt atgcatgtaa gtgtttttgt cctaatgttg
     1441 ctactcccat ggcaaagaaa aaaaaaagaa tgaaaaaaag aaaaaaattt ggaaaaaaaa
     1501 atcaggctca tagcagctac tgtgtagaaa attcccccta cttctaattt gctgaatgaa
     1561 gaaaaaaaaa aatcttttat ttgtgatatt ttcagagaca tttgctctag tatggtgtat
     1621 ttaaataata aaaacttaaa agaaaaaata tttaatggtg tttgggttta aacactgctt
     1681 tttctcttct gtattttgaa gaaatttagt ttttattgtt gttgaataac aagctcactt
     1741 taaatttgaa ggagttgagg gaggtggagt gtatatttat ttagctctgg gccagtaagg
     1801 tattcttcaa attacttaac cacgccatta ttggcagggg tacaaagtag tttctaacag
     1861 ggtcctttct ataagtcaag aatattctgt taacagcatt tcgttacact tctatatcac
     1921 agtaagtctt ttgtgtttat aaatacttga gtgtccacta ttttgtttat tctttttctc
     1981 aatagcaaac aaagccttgg gtattgatga aaagtatgta taaaaaaaaa tacggcacaa
     2041 ccatcctgtt ctcttattga gtttatagct tttgaaggaa gtcacaattt ctaagtcata
     2101 cctgtacata ttttgaagct cacttagttg tagggaccca gagctctttt tttatggtga
     2161 tctttgattg gtgaagtagc catttcctgg tgacccttag gctcgtgtgg ttggctgtaa
     2221 ggtgtttatt ttgttttgct cctacacttc tttactgact gcgtttccgt atgtattttg
     2281 ggggaagatt ctgacttcat ttagtcttag tcttgagata ctgagttgct ggttgcaggc
     2341 agcagagtgt ccaccacagt gcctgcactg cccgcagagc tgccctccgg aaagcatgca
     2401 gtataacagc tagtgctgga aggaggaaaa ccaaataggc ctggaggctg aggttgtact
     2461 gccagcttcc ttagatgtga gcaaatttca actacaactt ccatcacagg ctaataaaac
     2521 caggtgtgtg aacgctacta ttttaaattt tcttttttaa gatggcattt tattttgttc
     2581 cagaaaagcg cctgatgtag accctccctc tgagaatagc cgtggagcca tgtagagagg
     2641 tgtagctcag cacatctcaa ctaccagtca gcttcccttt gagaacttct gtgctcactt
     2701 cctgttttca gagattccag ggcaggggaa aaaaaaaatc agttgaactt caaacctcct
     2761 agaggagatt gtaaaggcat agagttgagg tgaatagttt tgttagaacc ttataaaaat
     2821 aaaatgcaag aaaataatat gaagaaatca catatatatg tttgaattag atgtctgttt
     2881 gaattagatc cttggggaat ttcttcaaac tagttctggt tcttatattt gttttttttc
     2941 ctttaaggaa ctttctgaag gaagttagac tgcgatggta aagggggaaa tgggttaatg
     3001 agattgcagg cattttctat attctttttg gcataagcac ttatgtccct gatatgtaca
     3061 aattcaaagg aggtggttaa taactttagt aaataatata ttgtcgcatt taatgatgtg
     3121 gagggctaag gtcattacgg actttaaata aactattata tggctggttc ctcaagcact
     3181 gctgcgtatt taataatgag cttctaaaag catttcttaa gttgcagacc tataagatta
     3241 caaatgtcac tcatgttagt ataatccaca tgcaagtgat gaagccttct ctttgatgtg
     3301 ctaaattgga gaaggactaa tggagctatg aatatacaat agaacatatt taagtagtag
     3361 tcttgcttta ggtaaaacac tttcttgaaa ccagaggcat ttcaaacaat aaaacccggc
     3421 tctaatgggg atgctctgtg tggatagaaa gctactaaaa acactcaggt ttattctgat
     3481 gtgagcagcg attgtgtgca gttcctcccc caatctcaac attgcttagg aaaaaaaaaa
     3541 atctatgagt ttattccacc tttcatccat tgcatttgtg atgttattag ttagcaagat
     3601 ggacactgtt ctttagaaag gacttattta atattaacca cgtcatagag caagatggcc
     3661 cccagtccct acaagcaagt gcaattaaaa ataaaagcaa atgttactga gccctgctga
     3721 actcctgata aaaaaaatta tgtttatggt acatataaat gtctcaatca tgcaaattgt
     3781 cactcttgtt aatgaaacaa ttttgtaaaa agatagtcct ctaaaagggt ttaatgtttt
     3841 ttacctatct aactgtctaa ttagatttac acatcccgca aggcagggga gcctgaagct
     3901 tttccaaacc aaatcgtttg ccactagaaa ctattttcag ctcttcatga tttattagga
     3961 aatagtttaa cccggactgt agtgtcttat aaaatacaaa acgagaaaac tgacacacca
     4021 aaatgaagtc tgtgaaattg tcatcctctt aatattacct gtatttaaat tctttctttt
     4081 gcccttatta acactgatat ttgaaacaac taatcatcta aaaggaagct cttaaagggc
     4141 tttaaatgtc aatatagtaa gattctaatg tgcactacta tttatataaa atatttctta
     4201 gggcccataa atcatataat aaacagtgaa cccaagagct acatatggag tctagtgaag
     4261 agttcccatg tagcctaact aattgtattt aaattgagga gatccaaaaa ccccatcacc
     4321 cttcacccca aagacccctt cacccttcac cagggaattc tatcctgggt gctgtcccac
     4381 ctatgacccc ttcaagaggc cattggaaaa aggccattta caagttaatg ttacttatag
     4441 ctttgttact aagactcacc tattgttagt gcagccaagt cacagaagtg cttattgcag
     4501 ttaaatagca atttgtttcc atgaaactgc aattaaagta ttactgagca gccattttag
     4561 attggcagtg ctctgaacgc atgttaaaca gccagctact cccacttgca gagtctgaga
     4621 tctgactagc agcaaagtgt agcacattcg ccgatgctgg gtacctagtt aaagaggcat
     4681 ttgtagccct ctgctcccat cgtgaacatg ctgagagcaa tgacaagtca gggctgattt
     4741 ttggaaggtg aacttgcaac ttacctcaag tgaatactgt tttcagttgt gcaagaagtg
     4801 ctttatgcta gtagatatgt gcatgtttcc tagagggaat gttttcaagt tcagattgat
     4861 tctgctgaga atggacggca actcggaggc ctcaagccaa taatgtacta caggccctga
     4921 catgttacag ctgtgtaaac agggccattc tatttcctaa atcacaacta ataaagcaga
     4981 ggatgaaaat caa
//
