LOCUS       NM_018640               3393 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens LIM domain only 3 (LMO3), transcript variant 1, mRNA.
ACCESSION   NM_018640
VERSION     NM_018640.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3393)
  AUTHORS   Ohara,Y., Craig,A.J., Liu,H., Yang,S., Moreno,P., Dorsey,T.H.,
            Cawley,H., Azizian,A., Gaedcke,J., Ghadimi,M., Hanna,N., Ambs,S.
            and Hussain,S.P.
  TITLE     LMO3 is a suppressor of the basal-like/squamous subtype and reduces
            disease aggressiveness of pancreatic cancer through glycerol
            3-phosphate metabolism
  JOURNAL   Carcinogenesis 45 (7), 475-486 (2024)
   PUBMED   38366633
  REMARK    GeneRIF: LMO3 is a suppressor of the basal-like/squamous subtype
            and reduces disease aggressiveness of pancreatic cancer through
            glycerol 3-phosphate metabolism.
REFERENCE   2  (bases 1 to 3393)
  AUTHORS   Wei,M., Yin,R., Qu,L. and Tang,J.
  TITLE     Circ_0007385 promotes the proliferation and inhibits the apoptosis
            of non-small cell lung cancer cells via miR-337-3p-dependent
            regulation of LMO3
  JOURNAL   Histol Histopathol 38 (7), 797-810 (2023)
   PUBMED   36426731
  REMARK    GeneRIF: Circ_0007385 promotes the proliferation and inhibits the
            apoptosis of non-small cell lung cancer cells via
            miR-337-3p-dependent regulation of LMO3.
REFERENCE   3  (bases 1 to 3393)
  AUTHORS   Dominguez-Castro,M., Dominguez-Galicia,A., Perez-Perez,O.,
            Hernandez-Pineda,J., Mancilla-Herrera,I., Bazan-Tejeda,M.L.,
            Rodriguez-Cruz,L., Gonzalez-Torres,M.C., Montoya-Estrada,A.,
            Reyes-Munoz,E. and Romo-Yanez,J.
  TITLE     Hyperglycemia affects neuronal differentiation and Nestin, FOXO1,
            and LMO3 mRNA expression of human Wharton's jelly mesenchymal stem
            cells of children from diabetic mothers
  JOURNAL   Biochem Biophys Res Commun 637, 300-307 (2022)
   PUBMED   36413852
  REMARK    GeneRIF: Hyperglycemia affects neuronal differentiation and Nestin,
            FOXO1, and LMO3 mRNA expression of human Wharton's jelly
            mesenchymal stem cells of children from diabetic mothers.
REFERENCE   4  (bases 1 to 3393)
  AUTHORS   Kang,Y. and Pei,W.
  TITLE     Transcriptomic analysis and biological evaluation reveals that LMO3
            regulates the osteogenic differentiation of human adipose derived
            stem cells via PI3K/Akt signaling pathway
  JOURNAL   J Mol Histol 53 (2), 379-394 (2022)
   PUBMED   35165791
  REMARK    GeneRIF: Transcriptomic analysis and biological evaluation reveals
            that LMO3 regulates the osteogenic differentiation of human adipose
            derived stem cells via PI3K/Akt signaling pathway.
REFERENCE   5  (bases 1 to 3393)
  AUTHORS   Wagner,G., Fenzl,A., Lindroos-Christensen,J., Einwallner,E.,
            Husa,J., Witzeneder,N., Rauscher,S., Groger,M., Derdak,S., Mohr,T.,
            Sutterluty,H., Klinglmuller,F., Wolkerstorfer,S., Fondi,M.,
            Hoermann,G., Cao,L., Wagner,O., Kiefer,F.W., Esterbauer,H. and
            Bilban,M.
  TITLE     LMO3 reprograms visceral adipocyte metabolism during obesity
  JOURNAL   J Mol Med (Berl) 99 (8), 1151-1171 (2021)
   PUBMED   34018016
  REMARK    GeneRIF: LMO3 reprograms visceral adipocyte metabolism during
            obesity.
REFERENCE   6  (bases 1 to 3393)
  AUTHORS   Larsen,S., Yokochi,T., Isogai,E., Nakamura,Y., Ozaki,T. and
            Nakagawara,A.
  TITLE     LMO3 interacts with p53 and inhibits its transcriptional activity
  JOURNAL   Biochem Biophys Res Commun 392 (3), 252-257 (2010)
   PUBMED   19995558
  REMARK    GeneRIF: LMO3 acts as a co-repressor of p53, suppressing
            p53-dependent transcriptional regulation without inhibition of its
            DNA-binding activity.
REFERENCE   7  (bases 1 to 3393)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 3393)
  AUTHORS   Aoyama,M., Ozaki,T., Inuzuka,H., Tomotsune,D., Hirato,J.,
            Okamoto,Y., Tokita,H., Ohira,M. and Nakagawara,A.
  TITLE     LMO3 interacts with neuronal transcription factor, HEN2, and acts
            as an oncogene in neuroblastoma
  JOURNAL   Cancer Res 65 (11), 4587-4597 (2005)
   PUBMED   15930276
  REMARK    GeneRIF: The deregulated expression of neuronal-specific LMO3 and
            HEN2 contributes to the genesis and progression of human
            neuroblastoma in a lineage-specific manner.
REFERENCE   9  (bases 1 to 3393)
  AUTHORS   Shi,J., Cai,W., Chen,X., Ying,K., Zhang,K. and Xie,Y.
  TITLE     Identification of dopamine responsive mRNAs in glial cells by
            suppression subtractive hybridization
  JOURNAL   Brain Res 910 (1-2), 29-37 (2001)
   PUBMED   11489251
REFERENCE   10 (bases 1 to 3393)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC026311.1, AL050152.1 and
            BQ029059.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018640.4.
            
            Summary: The protein encoded by this gene belongs to the rhombotin
            family of cysteine-rich LIM domain oncogenes. This gene is
            predominantly expressed in the brain. Related family members, LMO1
            and LMO2 on chromosome 11, have been reported to be involved in
            chromosomal translocations in T-cell leukemia. Many alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (1). Variants 1-4 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.14880.1,
                                           SRR1660809.184020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537304.6/ ENSP00000440099.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1043              BC026311.1         337-1379
            1044-3345           AL050152.1         521-2822
            3346-3393           BQ029059.1         18-65               c
FEATURES             Location/Qualifiers
     source          1..3393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..3393
                     /gene="LMO3"
                     /gene_synonym="RBTN3; RBTNL2; Rhom-3; RHOM3"
                     /note="LIM domain only 3"
                     /db_xref="GeneID:55885"
                     /db_xref="HGNC:HGNC:6643"
                     /db_xref="MIM:180386"
     exon            1..97
                     /gene="LMO3"
                     /gene_synonym="RBTN3; RBTNL2; Rhom-3; RHOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            98..311
                     /gene="LMO3"
                     /gene_synonym="RBTN3; RBTNL2; Rhom-3; RHOM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..543
                     /gene="LMO3"
                     /gene_synonym="RBTN3; RBTNL2; Rhom-3; RHOM3"
                     /note="isoform 1 is encoded by transcript variant 1; LIM
                     domain only protein 3; rhombotin-3; neuronal-specific
                     transcription factor DAT1; LIM domain only 3
                     (rhombotin-like 2); dopamine associated transcription
                     factor-1"
                     /codon_start=1
                     /product="LIM domain only protein 3 isoform 1"
                     /protein_id="NP_061110.2"
                     /db_xref="CCDS:CCDS8678.1"
                     /db_xref="GeneID:55885"
                     /db_xref="HGNC:HGNC:6643"
                     /db_xref="MIM:180386"
                     /translation="MLSVQPDTKPKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCD
                     CRLGEVGSTLYTKANLILCRRDYLRLFGVTGNCAACSKLIPAFEMVMRAKDNVYHLDC
                     FACQLCNQRFCVGDKFFLKNNMILCQTDYEEGLMKEGYAPQVR"
     exon            312..437
                     /gene="LMO3"
                     /gene_synonym="RBTN3; RBTNL2; Rhom-3; RHOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..3393
                     /gene="LMO3"
                     /gene_synonym="RBTN3; RBTNL2; Rhom-3; RHOM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3317..3322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMO3"
                     /gene_synonym="RBTN3; RBTNL2; Rhom-3; RHOM3"
                     /note="hexamer: AATAAA"
     polyA_site      3341
                     /gene="LMO3"
                     /gene_synonym="RBTN3; RBTNL2; Rhom-3; RHOM3"
                     /note="major polyA site"
     regulatory      3373..3378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMO3"
                     /gene_synonym="RBTN3; RBTNL2; Rhom-3; RHOM3"
                     /note="hexamer: AATAAA"
     polyA_site      3393
                     /gene="LMO3"
                     /gene_synonym="RBTN3; RBTNL2; Rhom-3; RHOM3"
ORIGIN      
        1 aaacaatgct tctttttgac ctttcccaag gagaagcgct acaaagcagc cactgtgctt
       61 actgaacggc ctccccctgt atcgcttaat tgagaaggta tacaaatgct ctcagtccag
      121 ccagacacca agccgaaagg ttgtgctggc tgcaaccgaa agatcaagga ccggtatctt
      181 ctaaaggcac tggacaaata ctggcatgaa gactgcctga agtgtgcctg ctgtgactgt
      241 cgcttgggag aggtgggctc caccctgtac actaaagcta atcttatcct ttgtcgcaga
      301 gactatctga ggctctttgg tgtaacggga aactgcgctg cctgtagtaa gctcatccct
      361 gcctttgaga tggtgatgcg tgccaaggac aatgtttacc acctggactg ctttgcatgt
      421 cagctttgta atcagagatt ttgtgttgga gacaaatttt tcctaaagaa taacatgatc
      481 ctttgccaga cggactacga ggaaggttta atgaaagaag gttatgcacc ccaggttcgc
      541 tgatctatca acatcacccc attaagaata caaagcacta cattctttta tcttttttgc
      601 tccacatgta cataagaatt gacacaggaa cctactgaat agcgtagata taggaaggca
      661 ggatggttat atggaataaa aggcggactg catctgtatg tagtgaaatt gccccagttc
      721 agagttgaat gtttattatt aaagaaaaaa gtaatgtaca tatggctgga tttttttgct
      781 tgctattcgt ttttgtgtca cttggcatga gatgtttatt ttggactatt gtatataatg
      841 tattgtaata tttgaagcac aaatgtaata cagttttatt gtgttaccat ttgtgttcca
      901 tttgcttctt tgtattgttg catttagtac aatcagtgtt taaacttact gtatatttat
      961 gctttctgta tttaccagct attttaaatg agctgtaact ttctagtaaa gaattgaaaa
     1021 gcaaatctca ctaatgatac acagatagat aaagcaagtc tatcaacatt aaaaatacta
     1081 aaaaataaag acacacacag agcattttag tgacatccac tacttattgc cgctatgagt
     1141 tagagtctat cagtgttctt gttataaccc cctattttca gggggttaaa aatcagcttt
     1201 aaaaaaatac ataaaaattt catcttaaag cactttcatt ttataccaac gtgaaaagtg
     1261 ccatttttag aataacttta aagcttaaca ggtttccttt taatatcctt tttttgtgtg
     1321 ctctttactt acacaatggc tttgttttgc tttttcagcc acacccctta tgtgaactag
     1381 tgcctttggg tatcacgtaa aattttttcc aaagggttac tttaaaaatc tgttaccaca
     1441 attatgagat gatttttaag tgataaatta aacttcttct tgtataaatt ctgcccagat
     1501 ctctccacaa gagctgaggg tttcataact ttatggctta ataaatgtat gacactgaaa
     1561 agatttgagt gtgaatctac tgaaatcact ataatgcaca ttgaagctat gatggtattt
     1621 gagtagtgag gttacttttg atcggagcaa cataatgctc atagaatctt ctagaagaag
     1681 agaaacaaag ggattgataa aatgctgaga actagtgatt atatattttt ctgtatttac
     1741 ctgacattta ttttaatgtt caaaaagtaa acactttaag tttgatgtgt tttactctct
     1801 cattgtttta agtaattgcc aactcagaat acatcattct taggctgaaa tttgtctttc
     1861 cattttttaa ggtgaaatag tactacctta cgtgatagca tacaaagaag aaagctctag
     1921 aaagagaaat tatggagaat gattatttaa attacaatta aggaaatgag aatatgatcc
     1981 cctcttccga gttgcccaca aacttgcttc tttgcttttg ctccctgtaa tagaactact
     2041 tttcaacaaa tctaattttg cacggcaccg ttaaccatat tttcactaca gcaaacttag
     2101 tgctatgggt tttctttttc tttgtttttt tcttgatcac ttgtatagga aacaatattt
     2161 tccagtgtta tttgcatata tattttgtcc ttccaatata tgcattacag atgaaaatta
     2221 aatgttatac ctgaattctt gggttggggc caaaatatta agctgaaaat aatgctggtg
     2281 tggatttgtt ttaaaacaaa gctttattat gaacatgcat gtgaatctgg atattgcctc
     2341 ttatttttaa gaaaatggtt ctgtgaaaag tgaatgatat gtatttttcc aaatgcttca
     2401 tggttaggag tcttcaagtt ccatgttccc cagatttgag atatactaaa gaaagaaatt
     2461 caaaagtagc tatttggggc ccacaaaaat aactattatt ttagccttag agccttacac
     2521 ttgtttcatg aagagaaagg acttgcataa ccaaaataaa caaagcaaga caaattaaaa
     2581 atatgtgggg gagagatcag tgaaaagtgg ttttcttaat gcagccctgc tggtccccat
     2641 taacaattgc ttgaaattca catggatgta aaattataat tgtcaggatc ttattcagat
     2701 gatcttttaa ggtttaactg gttttgcttt tgtttatcta tatgtcaaaa tacttgtaaa
     2761 ttgggaacaa acttctctca gcttcttgaa gttgttcaac tatccttgcc actggaagac
     2821 caaacaaggt tttcactgct ttttctttta cataatatgc tgagaattat ttcttatgct
     2881 ttttactaca aacaaaatta ctcacctgga ttaaagatta aggccttaat ctgtttagat
     2941 tatctttaat ctccatgaaa tcgtgaaata agacaagaat agtgtttcag ctgtaggcca
     3001 ttttacagct aattgcccat aaattgtagc atttattgac ctgaagtact aagctaattg
     3061 tcttgactac tcaaagcccc tgaattgttg tcaactttcc cctttgtgtt gtgtagccct
     3121 aacgtcattt agcttgttgt ctgatgcctc cagtaggaca cctccgatgg agctttgatt
     3181 tctgagcagc gaaagctccc ttcctaagat gcatctcgca taggctgcct atgatgaagg
     3241 accgtgcacc tccactccaa cagagtgctg agtttaaaag ttgacctgtg tttgtaattt
     3301 cactttcatc ttgcttaata aatatctgct ggattctttc attcactttt ttacatttgg
     3361 atttatgttt ttaataaaag gggtgttaca cta
//
