LOCUS       NM_005574               2081 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens LIM domain only 2 (LMO2), transcript variant 1, mRNA.
ACCESSION   NM_005574
VERSION     NM_005574.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2081)
  AUTHORS   Ge,J., Yue,Y., Nie,H.Y., Liu,K.G., Li,H., Lin,H.G., Zhang,T.,
            Yan,H.F., Sun,H.W., Yang,J.W., Zhou,J.L. and Cui,Y.
  TITLE     Simulated microgravity altered the gene expression profiles and
            inhibited the proliferation of Kupffer cells in the early phase by
            downregulating LMO2 and EZH2
  JOURNAL   Life Sci Space Res (Amst) 40, 21-34 (2024)
   PUBMED   38245345
  REMARK    GeneRIF: Simulated microgravity altered the gene expression
            profiles and inhibited the proliferation of Kupffer cells in the
            early phase by downregulating LMO2 and EZH2.
REFERENCE   2  (bases 1 to 2081)
  AUTHORS   Berker,N., Yegen,G., Ozluk,Y. and Dogan,O.
  TITLE     Value of GCET1, HGAL (GCET2), and LMO2 in the Determination of
            Germinal Center Phenotype in Diffuse Large B-cell Lymphoma
  JOURNAL   Turk J Haematol 40 (3), 162-173 (2023)
   PUBMED   37519110
  REMARK    GeneRIF: Value of GCET1, HGAL (GCET2), and LMO2 in the
            Determination of Germinal Center Phenotype in Diffuse Large B-cell
            Lymphoma.
REFERENCE   3  (bases 1 to 2081)
  AUTHORS   Lu,L., Wang,J., Fang,F., Guo,A., Jiang,S., Tao,Y., Zhang,Y., Li,Y.,
            Zhang,K., Zhang,Z., Zhuo,R., Chu,X., Li,X., Tian,Y., Ma,L.,
            Sang,X., Chen,Y., Yu,J., Yang,Y., Cao,H., Gao,J., Lu,J., Hu,S.,
            Pan,J. and He,H.
  TITLE     LMO2 promotes the development of AML through interaction with
            transcription co-regulator LDB1
  JOURNAL   Cell Death Dis 14 (8), 518 (2023)
   PUBMED   37573405
  REMARK    GeneRIF: LMO2 promotes the development of AML through interaction
            with transcription co-regulator LDB1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2081)
  AUTHORS   Wang,H., Wang,J., Li,R. and Zhu,Z.
  TITLE     Potential link of single nucleotide polymorphisms within LMO2 to
            the risk of cervical squamous-cell carcinoma in Chinese populations
  JOURNAL   Asian J Surg 46 (2), 1139-1141 (2023)
   PUBMED   35999096
  REMARK    GeneRIF: Potential link of single nucleotide polymorphisms within
            LMO2 to the risk of cervical squamous-cell carcinoma in Chinese
            populations.
REFERENCE   5  (bases 1 to 2081)
  AUTHORS   Pan,X., Liu,D., Ying,M., Zheng,G., Fan,C., Pan,F. and Ke,Q.
  TITLE     PAK5 is a potential target in myelodysplastic syndrome through
            interacting with LMO2 and GATA1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (9), 77-85 (2022)
   PUBMED   36905268
  REMARK    GeneRIF: PAK5 is a potential target in myelodysplastic syndrome
            through interacting with LMO2 and GATA1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2081)
  AUTHORS   Dong,W.F., Xu,Y., Hu,Q.L., Munroe,D., Minowada,J., Housman,D.E. and
            Minden,M.D.
  TITLE     Molecular characterization of a chromosome translocation breakpoint
            t(11;14)(p13;q11) from the cell line KOPT-K1
  JOURNAL   Leukemia 9 (11), 1812-1817 (1995)
   PUBMED   7475267
REFERENCE   7  (bases 1 to 2081)
  AUTHORS   Osada,H., Grutz,G., Axelson,H., Forster,A. and Rabbitts,T.H.
  TITLE     Association of erythroid transcription factors: complexes involving
            the LIM protein RBTN2 and the zinc-finger protein GATA1
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9585-9589 (1995)
   PUBMED   7568177
REFERENCE   8  (bases 1 to 2081)
  AUTHORS   Royer-Pokora,B., Loos,U. and Ludwig,W.D.
  TITLE     TTG-2, a new gene encoding a cysteine-rich protein with the LIM
            motif, is overexpressed in acute T-cell leukaemia with the
            t(11;14)(p13;q11)
  JOURNAL   Oncogene 6 (10), 1887-1893 (1991)
   PUBMED   1923511
REFERENCE   9  (bases 1 to 2081)
  AUTHORS   Boehm,T., Foroni,L., Kaneko,Y., Perutz,M.F. and Rabbitts,T.H.
  TITLE     The rhombotin family of cysteine-rich LIM-domain oncogenes:
            distinct members are involved in T-cell translocations to human
            chromosomes 11p15 and 11p13
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4367-4371 (1991)
   PUBMED   2034676
REFERENCE   10 (bases 1 to 2081)
  AUTHORS   Boehm,T., Spillantini,M.G., Sofroniew,M.V., Surani,M.A. and
            Rabbitts,T.H.
  TITLE     Developmentally regulated and tissue specific expression of mRNAs
            encoding the two alternative forms of the LIM domain oncogene
            rhombotin: evidence for thymus expression
  JOURNAL   Oncogene 6 (5), 695-703 (1991)
   PUBMED   2052354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X61118.1, CN355348.1,
            AC132216.7 and AC113192.3.
            
            On Nov 23, 2018 this sequence version replaced NM_005574.3.
            
            Summary: LMO2 encodes a cysteine-rich, two LIM-domain protein that
            is required for yolk sac erythropoiesis. The LMO2 protein has a
            central and crucial role in hematopoietic development and is highly
            conserved. The LMO2 transcription start site is located
            approximately 25 kb downstream from the 11p13 T-cell translocation
            cluster (11p13 ttc), where a number T-cell acute lymphoblastic
            leukemia-specific translocations occur. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms.[provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X61118.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257818.3/ ENSP00000257818.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               X61118.1           214-576
            364-509             CN355348.1         207-352
            510-624             AC132216.7         36713-36827         c
            625-865             AC132216.7         36349-36589         c
            866-1081            AC132216.7         31605-31820         c
            1082-2062           AC113192.3         3765-4745
            2063-2081           X61118.1           2277-2295
FEATURES             Location/Qualifiers
     source          1..2081
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..2081
                     /gene="LMO2"
                     /gene_synonym="LMO-2; RBTN2; RBTNL1; RHOM2; TTG2"
                     /note="LIM domain only 2"
                     /db_xref="GeneID:4005"
                     /db_xref="HGNC:HGNC:6642"
                     /db_xref="MIM:180385"
     exon            1..282
                     /gene="LMO2"
                     /gene_synonym="LMO-2; RBTN2; RBTNL1; RHOM2; TTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            283..346
                     /gene="LMO2"
                     /gene_synonym="LMO-2; RBTN2; RBTNL1; RHOM2; TTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            347..624
                     /gene="LMO2"
                     /gene_synonym="LMO-2; RBTN2; RBTNL1; RHOM2; TTG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             618..1301
                     /gene="LMO2"
                     /gene_synonym="LMO-2; RBTN2; RBTNL1; RHOM2; TTG2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-cell translocation gene 2; rhombotin-like 1;
                     rhombotin-2; LIM domain only protein 2; cysteine-rich
                     protein TTG-2; T-cell translocation protein 2"
                     /codon_start=1
                     /product="rhombotin-2 isoform 1"
                     /protein_id="NP_005565.2"
                     /db_xref="CCDS:CCDS7888.2"
                     /db_xref="GeneID:4005"
                     /db_xref="HGNC:HGNC:6642"
                     /db_xref="MIM:180385"
                     /translation="MEGSAVTVLERGGASSPAERRSKRRRRSGGDGGGGGGARAPEGV
                     RAPAAGQPRATKGAPPPPGTPPPSPMSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGC
                     QQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQD
                     GLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIY
                     EWTKINGMI"
     exon            625..865
                     /gene="LMO2"
                     /gene_synonym="LMO-2; RBTN2; RBTNL1; RHOM2; TTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1081
                     /gene="LMO2"
                     /gene_synonym="LMO-2; RBTN2; RBTNL1; RHOM2; TTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..2081
                     /gene="LMO2"
                     /gene_synonym="LMO-2; RBTN2; RBTNL1; RHOM2; TTG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMO2"
                     /gene_synonym="LMO-2; RBTN2; RBTNL1; RHOM2; TTG2"
                     /note="hexamer: AATAAA"
     polyA_site      2081
                     /gene="LMO2"
                     /gene_synonym="LMO-2; RBTN2; RBTNL1; RHOM2; TTG2"
                     /note="major polyA site"
ORIGIN      
        1 aaaccctgga tttgcaacat cctcaaagaa cagcaacggg ccttgagcag aattgagaag
       61 gaaatacccc cacctgccct cagccgttaa gtgggctttg ctattcacaa gggcctctgg
      121 gtgtcctggc agagagggga gatggcacag gcaccaggtg ctagggtgcc agggcctccc
      181 gagaaggaac aggtgcaaag caggcaatta gcccagaagg tatccgtggg gcaggcagcc
      241 tagatctgat gggggaagcc accaggatta catcatctgc tgtaacaact gctctgaaaa
      301 gaagatattt ttcaacctga acttgcagta gctagtggag aggcaggaaa aaggaaatga
      361 aaccagagac agagggaagc tgagcgaaaa tagaccttcc cgagagagga ggaagcccgg
      421 agagagacgc acggtcccct ccccgcccct aggccgccgc cccctctctg ccctcggcgg
      481 cgagcagcgc gccgcgaccc gggccgaagg tgcgaggggc tccgggcggc cgggcgggcg
      541 cacaccatcc ccgcgggcgg cgcggagccg gcgacagcgc gcgagaggga ccgggcggtg
      601 gcggcggcgg gaccgggatg gaagggagcg cggtgactgt ccttgagcgc ggaggggcga
      661 gctcgccggc ggagcgccgg agcaagcgga ggcgcaggag cggcggcgac ggcggcggcg
      721 gcggcggcgc ccgagcaccc gagggggtcc gagccccggc agccggccag ccccgcgcca
      781 caaagggagc gcccccgccg cccggcaccc cgcctccctc cccaatgtcc tcggccatcg
      841 aaaggaagag cctggaccct tcagaggaac cagtggatga ggtgctgcag atccccccat
      901 ccctgctgac atgcggcggc tgccagcaga acattgggga ccgctacttc ctgaaggcca
      961 tcgaccagta ctggcacgag gactgcctga gctgcgacct ctgtggctgc cggctgggtg
     1021 aggtggggcg gcgcctctac tacaaactgg gccggaagct ctgccggaga gactatctca
     1081 ggctttttgg gcaagacggt ctctgcgcat cctgtgacaa gcggattcgt gcctatgaga
     1141 tgacaatgcg ggtgaaagac aaagtgtatc acctggaatg tttcaaatgc gccgcctgtc
     1201 agaagcattt ctgtgtaggt gacagatacc tcctcatcaa ctctgacata gtgtgcgaac
     1261 aggacatcta cgagtggact aagatcaatg ggatgatata ggcccgagtc cccgggcatc
     1321 tttggggagg tgttcactga agacgccgtc tccatggcat cttcgtcttc actcttaggc
     1381 actttggggg tttgagggtg gggtaaggga tttcttaggg gatggtagac ctttattggg
     1441 tatcaagaca tagcatccaa gtggcataat tcaggggctg acacttcaag gtgacagaag
     1501 gaccagccct tgagggagaa cttatggcca cagcccatcc atagtaactg acatgattag
     1561 cagaagaaag gaacatttag gggcaagcag gcgctgtgct atcatgatgg aatttcatat
     1621 ctacagatag agagttgttg tgtacagact tgttgtgact ttgacgcttg cgaactagag
     1681 atgtgcaatt gatttctttt cttcctggct ttttaactcc cctgtttcaa tcactgtcct
     1741 ccacacaagg gaaggacaga aaggagagtg gccattcttt ttttcttggc ccccttccca
     1801 aggccttaag ctttggaccc aaggaaaact gcatggagac gcatttcggt tgagaatgga
     1861 aaccacaact tttaaccaaa caattattta aagcaatgct gatgaatcac tgtttttaga
     1921 caccttcatt ttgaggggag gagttccaca gattgtttct atacaaatat aaatcttaaa
     1981 aagttgttca actattttat tatcctagat tatatcaaag tatttgtcgt gtgtagaaaa
     2041 aaaaacagct ctgcaggctt aataaaaatg acagactgaa a
//
