LOCUS       NM_002315               1294 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens LIM domain only 1 (LMO1), transcript variant 1, mRNA.
ACCESSION   NM_002315
VERSION     NM_002315.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1294)
  AUTHORS   Yu,Y., Li,H., Wu,C. and Li,J.
  TITLE     Circ_0021087 acts as a miR-184 sponge and represses gastric cancer
            progression by adsorbing miR-184 and elevating FOSB expression
  JOURNAL   Eur J Clin Invest 51 (11), e13605 (2021)
   PUBMED   34076278
  REMARK    GeneRIF: Circ_0021087 acts as a miR-184 sponge and represses
            gastric cancer progression by adsorbing miR-184 and elevating FOSB
            expression.
REFERENCE   2  (bases 1 to 1294)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1294)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1294)
  AUTHORS   Hashemi,M., Sarabandi,S., Karami,S., Smieja,J., Moazeni-Roodi,A.,
            Ghavami,S. and Los,M.J.
  TITLE     LMO1 polymorphisms and the risk of neuroblastoma: Assessment of
            meta-analysis of case-control studies
  JOURNAL   J Cell Mol Med 24 (2), 1160-1168 (2020)
   PUBMED   31830377
  REMARK    GeneRIF: LMO1 polymorphisms and the risk of neuroblastoma:
            Assessment of meta-analysis of case-control studies.
            Review article
REFERENCE   5  (bases 1 to 1294)
  AUTHORS   Wang,L., Tan,T.K., Durbin,A.D., Zimmerman,M.W., Abraham,B.J.,
            Tan,S.H., Ngoc,P.C.T., Weichert-Leahey,N., Akahane,K., Lawton,L.N.,
            Rokita,J.L., Maris,J.M., Young,R.A., Look,A.T. and Sanda,T.
  TITLE     ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic
            neuroblastoma core regulatory circuitry
  JOURNAL   Nat Commun 10 (1), 5622 (2019)
   PUBMED   31819055
  REMARK    GeneRIF: ASCL1 and LMO1 directly regulate the expression of CRC
            genes, indicating that ASCL1 is a member and LMO1 is a coregulator
            of the ADRN neuroblastoma core regulatory circuitry.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1294)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   7  (bases 1 to 1294)
  AUTHORS   Boehm,T., Foroni,L., Kaneko,Y., Perutz,M.F. and Rabbitts,T.H.
  TITLE     The rhombotin family of cysteine-rich LIM-domain oncogenes:
            distinct members are involved in T-cell translocations to human
            chromosomes 11p15 and 11p13
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4367-4371 (1991)
   PUBMED   2034676
REFERENCE   8  (bases 1 to 1294)
  AUTHORS   Boehm,T., Spillantini,M.G., Sofroniew,M.V., Surani,M.A. and
            Rabbitts,T.H.
  TITLE     Developmentally regulated and tissue specific expression of mRNAs
            encoding the two alternative forms of the LIM domain oncogene
            rhombotin: evidence for thymus expression
  JOURNAL   Oncogene 6 (5), 695-703 (1991)
   PUBMED   2052354
REFERENCE   9  (bases 1 to 1294)
  AUTHORS   McGuire,E.A., Davis,A.R. and Korsmeyer,S.J.
  TITLE     T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein
            normally expressed in neural lineage cells
  JOURNAL   Blood 77 (3), 599-606 (1991)
   PUBMED   1703797
REFERENCE   10 (bases 1 to 1294)
  AUTHORS   Chen,Q., Cheng,J.T., Tasi,L.H., Schneider,N., Buchanan,G.,
            Carroll,A., Crist,W., Ozanne,B., Siciliano,M.J. and Baer,R.
  TITLE     The tal gene undergoes chromosome translocation in T cell leukemia
            and potentially encodes a helix-loop-helix protein
  JOURNAL   EMBO J 9 (2), 415-424 (1990)
   PUBMED   2303035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091013.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002315.2.
            
            Summary: This locus encodes a transcriptional regulator that
            contains two cysteine-rich LIM domains but lacks a DNA-binding
            domain. LIM domains may play a role in protein interactions; thus
            the encoded protein may regulate transcription by competitively
            binding to specific DNA-binding transcription factors. Alterations
            at this locus have been associated with acute lymphoblastic T-cell
            leukemia. Chromosomal rearrangements have been observed between
            this locus and at least two loci, the delta subunit of the T-cell
            antigen receptor gene and the LIM domain binding 1 gene.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M26682.1, BC069793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335790.8/ ENSP00000338207.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-541               AC091013.7         126374-126914
            542-755             AC091013.7         159748-159961
            756-881             AC091013.7         163152-163277
            882-1294            AC091013.7         165531-165943
FEATURES             Location/Qualifiers
     source          1..1294
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1294
                     /gene="LMO1"
                     /gene_synonym="RBTN1; RHOM1; TTG1"
                     /note="LIM domain only 1"
                     /db_xref="GeneID:4004"
                     /db_xref="HGNC:HGNC:6641"
                     /db_xref="MIM:186921"
     exon            1..541
                     /gene="LMO1"
                     /gene_synonym="RBTN1; RHOM1; TTG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..987
                     /gene="LMO1"
                     /gene_synonym="RBTN1; RHOM1; TTG1"
                     /note="isoform a is encoded by transcript variant 1;
                     rhombotin-1; LMO-1; LIM domain only protein 1;
                     cysteine-rich protein TTG-1; T-cell translocation protein
                     1; T-cell translocation gene 1; LIM domain only 1
                     (rhombotin 1)"
                     /codon_start=1
                     /product="rhombotin-1 isoform a"
                     /protein_id="NP_002306.1"
                     /db_xref="CCDS:CCDS44534.1"
                     /db_xref="GeneID:4004"
                     /db_xref="HGNC:HGNC:6641"
                     /db_xref="MIM:186921"
                     /translation="MMVLDKEDGVPMLSVQPKGKQKGCAGCNRKIKDRYLLKALDKYW
                     HEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGTTGNCAACSKLIPAFEMVM
                     RARDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQMDYEEGQLNGTFESQVQ"
     exon            542..755
                     /gene="LMO1"
                     /gene_synonym="RBTN1; RHOM1; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..881
                     /gene="LMO1"
                     /gene_synonym="RBTN1; RHOM1; TTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1294
                     /gene="LMO1"
                     /gene_synonym="RBTN1; RHOM1; TTG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1270..1275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMO1"
                     /gene_synonym="RBTN1; RHOM1; TTG1"
                     /note="hexamer: ATTAAA"
     polyA_site      1294
                     /gene="LMO1"
                     /gene_synonym="RBTN1; RHOM1; TTG1"
                     /note="major polyA site"
ORIGIN      
        1 atacattgag ggagaaaggc agcgggagac ggccacgaga ttcccccatc tctttgaata
       61 taattttaga ttgagattca gattaaatcc gaggggaaaa cactttatga ggctgaaagc
      121 tgtgtcgttg ccagagacag ggttatgagc tatcaaatgc aattacatta agacagatta
      181 tactgggcaa attgagccat ttagaaggtg agaatcaaag aaacggctct gatcctcttt
      241 tcccccttct ctctccctct ccctctctct ctaaattgca gttcgtagtt ccttccaatt
      301 ctgaggcaca aaagtaggtg agactgcttt tgtatctgcg aagtgcttca ctcctgaatg
      361 taattctagc tgagtgcaat ctaggttaag agccggacaa gcgggtaatt agagcccgct
      421 agctgcccga agaccggccg cccctccaaa gcgcgccccg agtcggcgcc cttctcccgg
      481 ccgagcctag ctgcggctgg acacggagcg cccgagatga tggtgctgga caaggaggac
      541 ggcgtgccga tgctctccgt ccagcccaaa gggaagcaga agggctgtgc gggctgtaac
      601 cgcaagatca aggaccgcta tctgctgaag gcattggaca agtactggca cgaagactgc
      661 ctcaagtgtg cctgctgtga ctgccgcctg ggcgaggtgg gctccaccct ctacaccaag
      721 gccaacctca tcctgtgccg acgcgactac ctgaggctct ttggcaccac agggaactgt
      781 gctgcttgca gcaagctgat cccagccttc gagatggtga tgcgggcccg ggacaacgtg
      841 tatcacctcg actgcttcgc ctgccagctc tgcaaccaga gattttgtgt gggagacaaa
      901 ttcttcctga agaacaacat gatcttgtgt cagatggact atgaggaagg gcagctcaat
      961 ggcacctttg aatcccaagt tcagtaacgc ccggcgcctg gcctccaggc ccgtctgtcc
     1021 atctgcccgc ctgcccacct gcctggccgg ccagccagcc actctaccag tgcaggctgg
     1081 ccagccgctc tcctgccaca ttagaacttc tccgtcctcg atgggaggga tggcccttcc
     1141 tcctccacca ccgcccgtct gtgtgtgacc cctcctgggg ccaggccggg cctgtacagt
     1201 ctgtcttctg tatataaatg ggaacattta ttttatgaga aatgtaatgc gattttatta
     1261 ctggcgtgga ttaaacttat gaatgtttcc ggga
//
