LOCUS       NM_032737               4634 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens lamin B2 (LMNB2), mRNA.
ACCESSION   NM_032737
VERSION     NM_032737.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4634)
  AUTHORS   Li,Y., Zhu,J., Yu,Z., Li,H. and Jin,X.
  TITLE     The role of lamin B2 in human diseases
  JOURNAL   Gene 870, 147423 (2023)
   PUBMED   37044185
  REMARK    GeneRIF: The role of lamin B2 in human diseases.
            Review article
REFERENCE   2  (bases 1 to 4634)
  AUTHORS   Ji,J., Li,H., Chen,J. and Wang,W.
  TITLE     Lamin B2 contributes to the proliferation of bladder cancer cells
            via activating the expression of cell division cycle-associated
            protein 3
  JOURNAL   Int J Mol Med 50 (3) (2022)
   PUBMED   35775376
  REMARK    GeneRIF: Lamin B2 contributes to the proliferation of bladder
            cancer cells via activating the expression of cell division
            cycleassociated protein 3.
REFERENCE   3  (bases 1 to 4634)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4634)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4634)
  AUTHORS   Schumacher,J., Reichenzeller,M., Kempf,T., Schnolzer,M. and
            Herrmann,H.
  TITLE     Identification of a novel, highly variable amino-terminal amino
            acid sequence element in the nuclear intermediate filament protein
            lamin B(2) from higher vertebrates
  JOURNAL   FEBS Lett 580 (26), 6211-6216 (2006)
   PUBMED   17070523
  REMARK    GeneRIF: human lamin B(2) is indeed synthesized as a longer version
            than previously reported, because it contains these additional 20
            amino acids
REFERENCE   6  (bases 1 to 4634)
  AUTHORS   Biamonti,G., Giacca,M., Perini,G., Contreas,G., Zentilin,L.,
            Weighardt,F., Guerra,M., Della Valle,G., Saccone,S., Riva,S. et al.
  TITLE     The gene for a novel human lamin maps at a highly transcribed locus
            of chromosome 19 which replicates at the onset of S-phase
  JOURNAL   Mol Cell Biol 12 (8), 3499-3506 (1992)
   PUBMED   1630457
REFERENCE   7  (bases 1 to 4634)
  AUTHORS   Biamonti,G., Perini,G., Weighardt,F., Riva,S., Giacca,M., Norio,P.,
            Zentilin,L., Diviacco,S., Dimitrova,D. and Falaschi,A.
  TITLE     A human DNA replication origin: localization and transcriptional
            characterization
  JOURNAL   Chromosoma 102 (1 Suppl), S24-S31 (1992)
   PUBMED   1291239
REFERENCE   8  (bases 1 to 4634)
  AUTHORS   Kasahara,K., Chida,K., Tsunenaga,M., Kohno,Y., Ikuta,T. and
            Kuroki,T.
  TITLE     Identification of lamin B2 as a substrate of protein kinase C in
            BALB/MK-2 mouse keratinocytes
  JOURNAL   J Biol Chem 266 (30), 20018-20023 (1991)
   PUBMED   1939065
REFERENCE   9  (bases 1 to 4634)
  AUTHORS   Muller,W.E., Okamoto,T., Reuter,P., Ugarkovic,D. and Schroder,H.C.
  TITLE     Functional characterization of Tat protein from human
            immunodeficiency virus. Evidence that Tat links viral RNAs to
            nuclear matrix
  JOURNAL   J Biol Chem 265 (7), 3803-3808 (1990)
   PUBMED   2406262
REFERENCE   10 (bases 1 to 4634)
  AUTHORS   Bender,H.G., Werner,C., Greuel,H. and Timp,P.
  TITLE     [Vulvar neoplasms and preoperative lymphography]
  JOURNAL   Fortschr Med 95 (44), 2645-2652 (1977)
   PUBMED   924328
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL560944.3, BC006551.2 and
            AC011522.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032737.3.
            
            Summary: This gene encodes a B type nuclear lamin. The nuclear
            lamina consists of a two-dimensional matrix of proteins located
            next to the inner nuclear membrane. The lamin family of proteins
            make up the matrix and are highly conserved in evolution. During
            mitosis, the lamina matrix is reversibly disassembled as the lamin
            proteins are phosphorylated. Lamin proteins are thought to be
            involved in nuclear stability, chromatin structure and gene
            expression. Vertebrate lamins consist of two types, A and B.
            Mutations in this gene are associated with acquired partial
            lipodystrophy. [provided by RefSeq, May 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006551.2, SRR1163655.19160.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325327.4/ ENSP00000327054.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL560944.3         10-35
            27-1952             BC006551.2         1-1926
            1953-4634           AC011522.8         19414-22095         c
FEATURES             Location/Qualifiers
     source          1..4634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4634
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /note="lamin B2"
                     /db_xref="GeneID:84823"
                     /db_xref="HGNC:HGNC:6638"
                     /db_xref="MIM:150341"
     exon            1..290
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1889
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /note="lamin B3; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="lamin-B2"
                     /protein_id="NP_116126.3"
                     /db_xref="CCDS:CCDS12090.2"
                     /db_xref="GeneID:84823"
                     /db_xref="HGNC:HGNC:6638"
                     /db_xref="MIM:150341"
                     /translation="MSPPSPGRRREQRRPRAAATMATPLPGRAGGPATPLSPTRLSRL
                     QEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELAD
                     ARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSE
                     VELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEE
                     LDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKL
                     ELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDR
                     IRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYR
                     KLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPS
                     VLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVL
                     EGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVN
                     ADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM"
     exon            291..427
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     exon            428..584
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     exon            585..710
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     exon            711..881
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1007
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1228
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1508
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1616
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1736
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1847
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..4634
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4616..4621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /note="hexamer: AATAAA"
     polyA_site      4634
                     /gene="LMNB2"
                     /gene_synonym="EPM9; LAMB2; LMN2; MCPH27"
                     /note="major polyA site"
ORIGIN      
        1 atcttgcagc cggcggcgcg gattgaatga gcccgccgag cccgggccgc cgtcgggagc
       61 agcgcaggcc gcgagccgcc gccaccatgg ccacgccgct gcccggccgc gcgggcgggc
      121 ccgccacgcc gctgtcgccc acgcgcctgt cgcggctgca ggagaaggag gagctgcgcg
      181 agctcaacga ccgcctggcg cactacatcg accgcgtccg cgcgctggag ctggagaacg
      241 accggctcct gctcaagatc tcagagaagg aggaggtgac cacgcgcgag gtgagtggca
      301 tcaaggcgct gtacgagtcg gagctggccg atgcccggag agtcctggat gagacggctc
      361 gagagcgtgc ccggctgcag atagagattg ggaagctgag ggcagagttg gacgaggtca
      421 acaagagcgc caagaagagg gagggcgagc ttacggtggc ccagggccgt gtgaaggacc
      481 tggagtccct gttccaccgg agcgaggtgg agctggcagc tgccctcagc gacaagcgcg
      541 gcctggagag tgacgtggct gagctgcggg cccagctggc caaggccgag gacggtcatg
      601 cagtggccaa aaagcagctg gagaaggaga cgctgatgcg tgtggacctg gagaaccgct
      661 gccagagcct gcaggaggag ctggacttcc ggaagagtgt gttcgaggag gaggtgcggg
      721 agacgcggcg gcggcacgag cggcgcctgg tggaggtgga cagcagccgg cagcaggagt
      781 acgacttcaa gatggcacag gcgctggagg agctgcggag ccagcacgac gagcaagtgc
      841 ggctctacaa gctggagctg gagcagacct accaggccaa gctggacagc gccaagctga
      901 gctctgacca gaacgacaag gcggccagtg cggctcgcga ggagctgaag gaggcccgca
      961 tgcgcctgga gtccctcagc taccagctct ccggcctcca gaagcaggcc agtgccgctg
     1021 aagatcgcat tcgggagctg gaggaggcca tggccgggga gcgggacaag ttccggaaga
     1081 tgctggacgc caaggagcag gagatgacgg agatgcggga cgtgatgcag cagcagctgg
     1141 ccgagtacca ggagctgctg gacgtgaagc tggccctgga catggagatc aacgcctacc
     1201 ggaagctcct ggagggcgag gaggagaggc tgaagctgtc ccccagccca tcctcgcgcg
     1261 tcaccgtctc acgagccacc tcgagcagca gcggcagctt gtccgccacc gggcgcctgg
     1321 gccgcagtaa gcggaagcgg ctggaggtgg aggagccctt gggcagcggc ccaagcgtcc
     1381 tgggcacggg cacgggtggc agcggtggct tccacctggc ccagcaggcc tcggcctcgg
     1441 gtagcgtcag catcgaggag atcgacctgg agggcaagtt tgtgcagctc aagaacaact
     1501 cggacaagga tcagtctctg gggaactgga gaatcaagag gcaggtcttg gagggggagg
     1561 agatcgccta caagttcacg cccaagtaca tcctgcgcgc cggccagatg gtcacggtgt
     1621 gggcagctgg tgcgggggtg gcccacagcc ccccctcgac gctggtgtgg aagggccaga
     1681 gcagctgggg cacgggcgag agcttccgca ccgtcctggt taacgcggat ggcgaggaag
     1741 tggccatgag gactgtgaag aagtcctcgg tgatgcgtga gaatgagaat ggggaggaag
     1801 aggaggagga agccgagttt ggcgaggagg atcttttcca ccaacagggg gacccgagga
     1861 ccacctcaag aggctgctac gtgatgtgaa cccacactcc tcatccacac acctttcttt
     1921 acccagagcc actgaaaact atttttatat cattggcttt ctttagttct tgatacattt
     1981 ctagagaatt tctaagcgaa ctgccagaac gtgtgggtgg gtctccccca gccctccctc
     2041 ctggcgggtc tcctccagcc tcacttcgct gccacttcgc cgctgccccg gagacttttc
     2101 aatcccaccc cactcctcat ctcaccattt ggtcaaattg gaagcccagg gccaggaccc
     2161 ggaggtttag aagatgcttg ggcttggagg gaggagggcc ggcgaggcta gcgaggggac
     2221 aggagacggc cctgctgcgg acggagcgcg gaaactgcgt aggaattcag tggtggtggg
     2281 tttttttaag gctttctaca aaaccaaatt cagaatccag gcgtcgacct ggtggggccc
     2341 ggggccaagc ctgcattctg gctgcccagc ttcggacagc gggaactcct caggcagcca
     2401 cgcagcgggt gtgggccagc atggggatgg cgtggccccc agggcgggtt ttcactccgc
     2461 tgcctgggct tccagattcc cgttctggca gcgcaccggc cgggtttctc ggaccgttga
     2521 ctttatttgg gggagttttc ccgcagttca gttcctgact gtgcaaggcc aacagggcag
     2581 gggaggggaa gacctgggga aggaagaatg aggacagtcc cgtcgtaaga cctgtcacaa
     2641 caataagcag ggaggggaga tgtggagggg acacatctgg ttgccttgga ggcagaagct
     2701 gtgagtttca gaacagctgt ctgcagggaa cgccaccatg ttgaccctct ggaggagagc
     2761 gctgtggagc ccctcccgtg ttccagctcc gtctgccctg tgcctatata tacacatgcg
     2821 tctatccata ctgtgctttt atctgtgatt ttctcgctga aaccatgttt ctcagacagg
     2881 ccaaggccac ctgactccta tcacgacgca cccaagcccc tcagtccagc ttcccaatgc
     2941 ctggcacccc ccttcggcaa tagctcaccg tttacaccct ccctcataga tacacagaag
     3001 ttattttttt aatggatatt tattttttta cattggtcag tacacaggtc aggagctcac
     3061 gccagggcct tgaggacagg ctgaccctcc tccccggggt ggcgtggggc tggggcaccc
     3121 tccgacggca gagcctcctt cagaaagtgc agctcaagtc ttaaagacac caaaactgag
     3181 ccatgggcac gcgccgtctc cgggccatgg cgttcactgc agggcggggg cggcaccgct
     3241 cccctgtgac tgcatcccgc ctccctgggg acctgcctgt ggcaggaagg aatggggggc
     3301 cccagcccca ggccgggaag gagccagcgg ccgacaaagc agaaacaccc gctgctccac
     3361 gtagcccctg ctcgctgtcc ttgctctcag aagtcccggt cccatgtaga tagagggggg
     3421 cgcatcttac caaagcattt cctcctggag gctacgccgc tgtgctccca gtcaggcggc
     3481 tggtagggag ctttgcctgc cccggggata ccctctgcca gccgctggaa gtgggaatgc
     3541 tggcgacaga ctgtgtcctc tttcccacct tcatagcagg aatcacccgg acccgactgg
     3601 ctgggcttcg tgctagcgag ggttctgggg gtgggtcttg gtgatcttgt cctatgggga
     3661 gtctgcagtg gtctcagcca catcctatgt attttggctc tggaggagca aagctgtatc
     3721 ctggagttgg tctgtgattt gccgacagcc ttgcaggctg ggctcaggga caaagtcccc
     3781 cccaaaaccc gcaggtcctc atgtccagac gctgcccagt cctgtcctga aaacagcacg
     3841 ccccaggccc acagaacccc ccaccctaca tttgccttgg gtggagctgg gggtggtcct
     3901 aggactgcgg gtgcccttag ctgaaggggg tggggagaag cgtggactgg gcagcctgtg
     3961 ggtaattgga ggttcattga gaattgagtc tttggaaaca ctaagaaaat caaattttta
     4021 aaagttattt atggcctggg aaacaatttg catttgtccc caaatacgct tagctgtgtg
     4081 ccgcttagaa cgatgcgaaa ccatccctct gtgtaagccc gtgccgtgtg actcgaagcc
     4141 tagcgccctc cctgcgaagc atcagacgcc acccagccct ggggggaggc ccacgcctgc
     4201 tggaccaacg cgggttctgg ggtgcacagc gccaggttaa cgctgaagcc tgccccgctg
     4261 agcccaggag ccgggaggcc tgcgggctga cccagaatcc gatcatgcac ctgtcctcat
     4321 gccagcggct ttggctgggg ttggtctgaa gcctgcacgc ggcagttctt tgttaaagat
     4381 ctgagggact cctcagtcct ggggcgtcgc cgcctgcagc ctcttccaag ccctgcgtcc
     4441 agcgagcgtc acagcacaac ctgcaaaaac ggagctgggc tgcagctggg gctggcatgg
     4501 actttcattt cagagattcg gtttttaaga agatgcatgc ctaatgtgtt cttttttttt
     4561 tccaatgatt tgtaatatac attttatgac tggaaacttt tttgtacaac actccaataa
     4621 acattttgat ttta
//
