LOCUS       NM_005573               2890 bp    mRNA    linear   PRI 20-JAN-2025
DEFINITION  Homo sapiens lamin B1 (LMNB1), transcript variant 1, mRNA.
ACCESSION   NM_005573
VERSION     NM_005573.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2890)
  AUTHORS   Yoshioka,Y., Huang,Y., Jin,X., Ngo,K.X., Kumaki,T., Jin,M.,
            Toyoda,S., Takayama,S., Inotsume,M., Fujita,K., Homma,H., Ando,T.,
            Tanaka,H. and Okazawa,H.
  TITLE     PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal
            Lamin B1 degradation
  JOURNAL   EMBO J 43 (18), 3968-3999 (2024)
   PUBMED   39103492
  REMARK    GeneRIF: PQBP3 prevents senescence by suppressing PSME3-mediated
            proteasomal Lamin B1 degradation.
REFERENCE   2  (bases 1 to 2890)
  AUTHORS   Zhang,Y., Liu,G., Huang,L., He,X., Su,Y., Nie,X., Mao,Z. and
            Xing,X.
  TITLE     SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal
            GTPase Septin12 mediating the sperm head-and-tail junction
  JOURNAL   Mol Hum Reprod 30 (7) (2024)
   PUBMED   38870534
  REMARK    GeneRIF: SUN5 interacts with nuclear membrane LaminB1 and
            cytoskeletal GTPase Septin12 mediating the sperm head-and-tail
            junction.
REFERENCE   3  (bases 1 to 2890)
  AUTHORS   Huang,F., Wang,Y., Lv,X. and Huang,C.
  TITLE     WTAP-mediated N6-methyladenosine modification promotes the
            inflammation, mitochondrial damage and ferroptosis of kidney
            tubular epithelial cells in acute kidney injury by regulating LMNB1
            expression and activating NF-kappaB and JAK2/STAT3 pathways
  JOURNAL   J Bioenerg Biomembr 56 (3), 285-296 (2024)
   PUBMED   38517565
  REMARK    GeneRIF: WTAP-mediated N6-methyladenosine modification promotes the
            inflammation, mitochondrial damage and ferroptosis of kidney
            tubular epithelial cells in acute kidney injury by regulating LMNB1
            expression and activating NF-kappaB and JAK2/STAT3 pathways.
REFERENCE   4  (bases 1 to 2890)
  AUTHORS   Ma,X., Li,Y., Zhu,H., Lu,K., Huang,Y., Li,X., Han,S., Ding,H. and
            Sun,S.
  TITLE     ENPP1 inhibits the transcription activity of the hepatitis B virus
            pregenomic promoter by upregulating the acetylation of LMNB1
  JOURNAL   Arch Virol 169 (2), 36 (2024)
   PUBMED   38265511
  REMARK    GeneRIF: ENPP1 inhibits the transcription activity of the hepatitis
            B virus pregenomic promoter by upregulating the acetylation of
            LMNB1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2890)
  AUTHORS   Lin,F. and Worman,H.J.
  TITLE     Structural organization of the human gene (LMNB1) encoding nuclear
            lamin B1
  JOURNAL   Genomics 27 (2), 230-236 (1995)
   PUBMED   7557986
REFERENCE   6  (bases 1 to 2890)
  AUTHORS   Raininko,R., Gosky,M. and Padiath,Q.S.
  TITLE     LMNB1-Related Autosomal Dominant Leukodystrophy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   26749591
REFERENCE   7  (bases 1 to 2890)
  AUTHORS   Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der
            Knaap,M.S.
  TITLE     Leukodystrophy Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24501781
REFERENCE   8  (bases 1 to 2890)
  AUTHORS   Foisner,R., Traub,P. and Wiche,G.
  TITLE     Protein kinase A- and protein kinase C-regulated interaction of
            plectin with lamin B and vimentin
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3812-3816 (1991)
   PUBMED   2023931
REFERENCE   9  (bases 1 to 2890)
  AUTHORS   Djabali,K., Portier,M.M., Gros,F., Blobel,G. and Georgatos,S.D.
  TITLE     Network antibodies identify nuclear lamin B as a physiological
            attachment site for peripherin intermediate filaments
  JOURNAL   Cell 64 (1), 109-121 (1991)
   PUBMED   1986862
REFERENCE   10 (bases 1 to 2890)
  AUTHORS   Pollard,K.M., Chan,E.K., Grant,B.J., Sullivan,K.F., Tan,E.M. and
            Glass,C.A.
  TITLE     In vitro posttranslational modification of lamin B cloned from a
            human T-cell line
  JOURNAL   Mol Cell Biol 10 (5), 2164-2175 (1990)
   PUBMED   2325650
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC103723.1, AC137794.2 and
            AW512433.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005573.3.
            
            Summary: This gene encodes one of the two B-type lamin proteins and
            is a component of the nuclear lamina. A duplication of this gene is
            associated with autosomal dominant adult-onset leukodystrophy
            (ADLD). Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.375233.1, M34458.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261366.10/ ENSP00000261366.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2178              BC103723.1         9-2186
            2179-2849           AC137794.2         32281-32951         c
            2850-2890           AW512433.1         18-58               c
FEATURES             Location/Qualifiers
     source          1..2890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..2890
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /note="lamin B1"
                     /db_xref="GeneID:4001"
                     /db_xref="HGNC:HGNC:6637"
                     /db_xref="MIM:150340"
     exon            1..732
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..2134
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="lamin-B1 isoform 1"
                     /protein_id="NP_005564.1"
                     /db_xref="CCDS:CCDS4140.1"
                     /db_xref="GeneID:4001"
                     /db_xref="HGNC:HGNC:6637"
                     /db_xref="MIM:150340"
                     /translation="MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLA
                     VYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAK
                     LQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLE
                     GDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKSMYEEEINE
                     TRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHAKLENAR
                     LSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDLLAKEKDN
                     SRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLKLSP
                     SPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEEIDVD
                     GKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQTVTIWAANAGVTAS
                     PPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTIPEEEEEEEEAAGVVVE
                     EELFHQQGTPRASNRSCAIM"
     exon            733..889
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1015
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1186
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1312
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1533
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1759
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1864
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1984
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2092
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2890
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2866..2871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /note="hexamer: AATAAA"
     polyA_site      2890
                     /gene="LMNB1"
                     /gene_synonym="ADLD; ADLDAT; LMN; LMN2; LMNB; MCPH26"
                     /note="major polyA site"
ORIGIN      
        1 gctccgtgca gcctgagagg aaacaaagtg ctgcgagcag gagacggcgg cggcgcgaac
       61 cctgctgggc ctccagtcac cctcgtcttg cattttcccg cgtgcgtgtg tgagtgggtg
      121 tgtgtgtttt cttacaaagg gtatttcgcg atcgatcgat tgattcgtag ttcccccccg
      181 cgcgcctttg ccctttgtgc tgtaatcgag ctcccgccat cccaggtgct tctccgttcc
      241 tctaaacgcc agcgtctgga cgtgagcgca ggtcgccggt ttgtgccttc ggtccccgct
      301 tcgccccctg ccgtcccctc cttatcacgg tcccgctcgc ggcctcgccg ccccgctgtc
      361 tccgccgccc gccatggcga ctgcgacccc cgtgccgccg cggatgggca gccgcgctgg
      421 cggccccacc acgccgctga gccccacgcg cctgtcgcgg ctccaggaga aggaggagct
      481 gcgcgagctc aatgaccggc tggcggtgta catcgacaag gtgcgcagcc tggagacgga
      541 gaacagcgcg ctgcagctgc aggtgacgga gcgcgaggag gtgcgcggcc gtgagctcac
      601 cggcctcaag gcgctctacg agaccgagct ggccgacgcg cgacgcgcgc tcgacgacac
      661 ggcccgcgag cgcgccaagc tgcagatcga gctgggcaag tgcaaggcgg aacacgacca
      721 gctgctcctc aactatgcta agaaggaatc tgatcttaat ggcgcccaga tcaagcttcg
      781 agaatatgaa gcagcactga attcgaaaga tgcagctctt gctactgcac ttggtgacaa
      841 aaaaagttta gagggagatt tggaggatct gaaggatcag attgcccagt tggaagcctc
      901 cttagctgca gccaaaaaac agttagcaga tgaaacttta cttaaagtag atttggagaa
      961 tcgttgtcag agccttactg aggacttgga gtttcgcaaa agcatgtatg aagaggagat
     1021 taacgagacc agaaggaagc atgaaacgcg cttggtagag gtggattctg ggcgtcaaat
     1081 tgagtatgag tacaagctgg cgcaagccct tcatgagatg agagagcaac atgatgccca
     1141 agtgaggctg tataaggagg agctggagca gacttaccat gccaaacttg agaatgccag
     1201 actgtcatca gagatgaata cttctactgt caacagtgcc agggaagaac tgatggaaag
     1261 ccgcatgaga attgagagcc tttcatccca gctttctaat ctacagaaag agtctagagc
     1321 atgtttggaa aggattcaag aattagagga cttgcttgct aaagaaaaag acaactctcg
     1381 tcgcatgctg acagacaaag agagagagat ggcggaaata agggatcaaa tgcagcaaca
     1441 gctgaatgac tatgaacagc ttcttgatgt aaagttagcc ctggacatgg aaatcagtgc
     1501 ttacaggaaa ctcttagaag gcgaagaaga gaggttgaag ctgtctccaa gcccttcttc
     1561 ccgtgtgaca gtatcccgag catcctcaag tcgtagtgta cgtacaacta gaggaaagcg
     1621 gaagagggtt gatgtggaag aatcagaggc gagtagtagt gttagcatct ctcattccgc
     1681 ctcagccact ggaaatgttt gcatcgaaga aattgatgtt gatgggaaat ttatccgctt
     1741 gaagaacact tctgaacagg atcaaccaat gggaggctgg gagatgatca gaaaaattgg
     1801 agacacatca gtcagttata aatatacctc aagatatgtg ctgaaggcag gccagactgt
     1861 tacaatttgg gctgcaaacg ctggtgtcac agccagcccc ccaactgacc tcatctggaa
     1921 gaaccagaac tcgtggggca ctggcgaaga tgtgaaggtt atattgaaaa attctcaggg
     1981 agaggaggtt gctcaaagaa gtacagtctt taaaacaacc atacctgaag aagaggagga
     2041 ggaggaagaa gcagctggag tggttgttga ggaagaactt ttccaccagc agggaacccc
     2101 aagagcatcc aatagaagct gtgcaattat gtaaaatttt caactgtctt cctcaaaata
     2161 aagaagtatg gtaatcttta cctgtataca gtgcagagcc ttctcagaag cacagaatat
     2221 ttttatattt cctttatgtg aatttttaag ctgcaaatct gatggcctta atttcctttt
     2281 tgacactgaa agttttgtaa aagaaatcat gtccatacac tttgttgcaa gatgtgaatt
     2341 attgacactg aacttaataa ctgtgtactg ttcggaaggg gttcctcaaa ttttttgact
     2401 ttttttgtat gtgtgttttt tctttttttt taagttctta tgaggagggg agggtaaata
     2461 aaccactgtg cgtcttggtg taatttgaag attgccccat ctagactagc aatctcttca
     2521 ttattctctg ctatatataa aacggtgctg tgagggaggg gaaaagcatt tttcaatata
     2581 ttgaactttt gtactgaatt tttttgtaat aagcaatcaa ggttataatt ttttttaaaa
     2641 tagaaatttt gtaagaaggc aatattaacc taatcaccat gtaagcactc tggatgatgg
     2701 attccacaaa acttggtttt atggttactt cttctcttag attcttaatt catgaggagg
     2761 gtgggggagg gaggtggagg gagggaaggg tttctctatt aaaatgcatt cgttgtgttt
     2821 tttaagatag tgtaacttgc ttaaatttct tatgtgacat taacaaataa aaaagctctt
     2881 ttaatattga
//
