LOCUS       NM_001136049            7137 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens leishmanolysin like peptidase (LMLN), transcript
            variant 1, mRNA.
ACCESSION   NM_001136049
VERSION     NM_001136049.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7137)
  AUTHORS   Xiang,P., Yeung,Y.T., Wang,J., Wu,Q., Du,R., Huang,C., Jia,X.,
            Gao,Y., Zhi,Y., Guo,F., Wei,H., Zhang,D., Liu,Y., Liu,L., Liang,L.,
            Wang,J., Song,Y., Liu,K. and Fang,B.
  TITLE     miR-17-3p promotes the proliferation of multiple myeloma cells by
            downregulating P21 expression through LMLN inhibition
  JOURNAL   Int J Cancer 148 (12), 3071-3085 (2021)
   PUBMED   33609405
  REMARK    GeneRIF: miR-17-3p promotes the proliferation of multiple myeloma
            cells by downregulating P21 expression through LMLN inhibition.
REFERENCE   2  (bases 1 to 7137)
  AUTHORS   Cobbe,N., Marshall,K.M., Gururaja Rao,S., Chang,C.W., Di Cara,F.,
            Duca,E., Vass,S., Kassan,A. and Heck,M.M.
  TITLE     The conserved metalloprotease invadolysin localizes to the surface
            of lipid droplets
  JOURNAL   J Cell Sci 122 (Pt 18), 3414-3423 (2009)
   PUBMED   19706689
  REMARK    GeneRIF: Immunofluorescent detection of human invadolysin in
            cultured cells reveals the protein to be associated with the
            surface of lipid droplets.
REFERENCE   3  (bases 1 to 7137)
  AUTHORS   McHugh,B., Krause,S.A., Yu,B., Deans,A.M., Heasman,S.,
            McLaughlin,P. and Heck,M.M.
  TITLE     Invadolysin: a novel, conserved metalloprotease links mitotic
            structural rearrangements with cell migration
  JOURNAL   J Cell Biol 167 (4), 673-686 (2004)
   PUBMED   15557119
  REMARK    GeneRIF: Functional characterization of a similar protein in
            Drosophila and comparative studies with the human protein.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ312399.1, AK299119.1 and
            AC135893.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 22, 2021 this sequence version replaced NM_001136049.2.
            
            Summary: This gene encodes a zinc-metallopeptidase. The encoded
            protein may play a role in cell migration and invasion. Studies of
            a similar protein in Drosophila indicate a potential role in
            mitotic progression. Alternatively spliced transcript variants have
            been described. [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.24797.1,
                                           SRR14038191.1504817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal (PMID:15557119)
            MANE Ensembl match               :: ENST00000420910.7/
                                                ENSP00000410926.3
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AJ312399.1         18-33
            17-2428             AK299119.1         1-2412
            2429-7137           AC135893.2         157199-161907
FEATURES             Location/Qualifiers
     source          1..7137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..7137
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /note="leishmanolysin like peptidase"
                     /db_xref="GeneID:89782"
                     /db_xref="HGNC:HGNC:15991"
                     /db_xref="MIM:609380"
     exon            1..224
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..2084
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /EC_number="3.4.24.36"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; invadolysin; leishmanolysin-2;
                     leishmanolysin-like (metallopeptidase M8 family)"
                     /codon_start=1
                     /product="leishmanolysin-like peptidase isoform 1
                     precursor"
                     /protein_id="NP_001129521.3"
                     /db_xref="CCDS:CCDS46988.2"
                     /db_xref="GeneID:89782"
                     /db_xref="HGNC:HGNC:15991"
                     /db_xref="MIM:609380"
                     /translation="MAAEWGGGVGYSGSGPGRSRWRWSGSVWVRSVLLLLGGLRASAT
                     STPVSLGSSPPCRHHVPSDTEVINKVHLKANHVVKRDVDEHLRIKTVYDKSVEELLPE
                     KKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQCATNQYLRKENDPHRYCTGECAA
                     HTKCGPVIVPEEHLQQCRVYRGGKWPHGAVGVPDQEGISDADFVLYVGALATERCSHE
                     NIISYAAYCQQEANMDRPIAGYANLCPNMISTQPQEFVGMLSTVKHEVIHALGFSAGL
                     FAFYHDKDGNPLTSRFADGLPPFNYSLGLYQWSDKVVRKVERLWDVRDNKIVRHTVYL
                     LVTPRVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNRVLS
                     RITLALMEDTGWYKANYSMAEKLDWGRGMGCDFVRKSCKFWIDQQRQKRQMLSPYCDT
                     LRSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELSGIPAEDLPYYGGSVEIAD
                     YCPFSQEFSWHLSGEYQRSSDCRILENQPEIFKNYGAEKYGPHSVCLIQKSAFVMEKC
                     ERKLSYPDWGSGCYQVSCSPQGLKVWVQDTSYLCSRAGQVLPVSIQMNGWIHDGNLLC
                     PSCWDFCELCPPETDPPATNLTRALPLDLCSCSSSLVVTLWLLLGNLFPLLAGFLLCI
                     WH"
     exon            225..322
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            323..353
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            354..436
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            437..554
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            555..733
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            734..839
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            840..934
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1052
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1160
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1237
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1348
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1481
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1641
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1772
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1983
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..7137
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5475..5480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /note="hexamer: GATAAA"
     regulatory      5486..5491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /note="hexamer: GATAAA"
     polyA_site      5509
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
     polyA_site      5512
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
     regulatory      7120..7125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /note="hexamer: AATAAA"
     polyA_site      7137
                     /gene="LMLN"
                     /gene_synonym="GP63; INV; IX14; LMNL1; MSP"
                     /note="major polyA site"
ORIGIN      
        1 actccatggt aacgacgctc ggcccgaaga tggcggccga atggggcgga ggagtgggtt
       61 actcgggctc aggcccgggc cggagccggt ggcgctggag cgggtctgtg tgggtccgaa
      121 gcgttttact cctgttgggc gggctccggg ccagcgccac atctactccc gtctccttgg
      181 gcagttcccc tccctgccgg caccacgtcc cctctgacac tgaggtcata aataaagttc
      241 atcttaaggc aaatcatgtg gtcaagagag atgttgatga gcatttaaga atcaagactg
      301 tctatgataa aagtgttgaa gagttgctcc ctgagaaaaa gaatcttgta aagaacaagc
      361 ttttcccaca agcgatttct tatttagaga agacttttca ggtccgtcga cctgcgggca
      421 ctatcttact tagcagacaa tgtgcaacaa accaatacct ccggaaggaa aacgatcctc
      481 acaggtactg caccggggag tgtgccgcac acacaaagtg cggccccgtt attgttcctg
      541 aggaacatct ccagcaatgc cgggtctacc gtgggggtaa gtggcctcat ggagcagtgg
      601 gtgtgccaga ccaagaaggc atctcagatg cagactttgt tctttacgtt ggtgctctgg
      661 ccaccgagag atgcagccat gaaaacatca tctcttatgc agcctattgt cagcaggaag
      721 caaacatgga caggccaata gcaggatatg ctaacctgtg tccaaatatg atctctaccc
      781 agcctcagga gtttgttggg atgctgtcca cagtgaaaca tgaggttatt catgccctgg
      841 gtttctctgc tgggctgttt gcattctacc atgataaaga tggaaatcct ctcacttcaa
      901 gatttgcaga tggcctccca ccttttaatt atagtctggg attatatcaa tggagtgata
      961 aagtagttcg aaaagtggag agattatggg atgttcgaga taataagata gttcgtcaca
     1021 ctgtgtatct cctggtaacg cctcgtgttg ttgaggaagc acgaaaacat tttgattgtc
     1081 cagttctaga gggaatggaa cttgaaaatc aaggtggtgt gggcactgag ctcaaccatt
     1141 gggaaaaaag gttattagag aatgaagcga tgactggttc tcacactcag aatcgagtac
     1201 tctctcgaat cactctggca ttaatggagg acactggctg gtataaagca aattacagca
     1261 tggctgagaa gttagactgg ggccgaggaa tgggctgtga ctttgtcagg aagagctgta
     1321 aattctggat tgatcagcag agacaaaaga gacagatgct gagcccttac tgtgacacgc
     1381 tcagaagtaa cccactgcag ctaacttgca gacaggacca gagagcagtt gccgtgtgta
     1441 atttgcagaa gttccctaag cctttaccac aggaatacca gtactttgat gaactcagtg
     1501 gaatacctgc agaagatttg ccttattatg gtggctccgt ggaaattgct gactactgcc
     1561 ctttcagtca ggaattcagt tggcatttaa gtggtgaata tcagcgcagc tcagattgta
     1621 gaatattgga aaatcaacca gaaattttta agaactatgg cgctgaaaag tatggacctc
     1681 attccgtttg tctaattcag aaatcagcat tcgttatgga gaagtgtgag aggaagctga
     1741 gttacccaga ctggggaagc ggatgctatc aggtttcttg ttctcctcaa ggtctgaaag
     1801 tttgggtcca agatacttca tatttgtgta gtcgggctgg gcaggtcctc cctgtcagta
     1861 tccagatgaa tggctggatt cacgatggaa acctgctctg cccatcatgt tgggacttct
     1921 gtgagctctg tcctccagaa acagatcctc cagccactaa cctgacccga gctctgccac
     1981 ttgatctttg ttcctgttcc tcgagcctgg tggtcaccct ctggcttctg ctaggcaatc
     2041 tgtttcctct gctggctgga tttcttctgt gtatatggca ctaggaatgg aaaagtggat
     2101 cttcaagata ttcttttatg ttatgttctt gtgaacaaag cacaaagttt gagtgagtgc
     2161 caacctatgc agatggtaga agtggcattc ctggctttgg cttggaagaa ttgacgacca
     2221 tcagaccttg aagcagaact tcacagcagc ctgtcctcat cagcaaccca accaccttca
     2281 tcagcaaccc aaccaccttc atcagcaacc caaccacctc gtcagcaacc caaccacctc
     2341 gtcagcaacc caaccacctc gtcagcaacc cagccacctt catcagcaac ccaaccacct
     2401 catcagcaac ccagccacct tcatcagcaa cccaaccacc tcatcagcaa accaaccact
     2461 ttcatctgca acccaaccac tttcatcagc aactcaacac cttcatctgc aacccaacca
     2521 ccttcatcag caaaccaacc accttcttca gcaacccaac cacctcatct tggagaagga
     2581 gaaggaactg caagccacca agtcttcatt tttcagggtt tgtaatcttc ccaaagtttt
     2641 cctttgaaaa taggataatg ggtggaattt tcagagtgat tacatacctc aacattttta
     2701 ttaacataca acaatgggaa agttcatcat ccatatactg cagtcactta aacaacagcc
     2761 aattattgca agattagaat tggagatctt gtcctcaaaa gtataaattg tcctttgagt
     2821 tatagaaaat aatggaattg ggatttctac atatcattat tatacctatt ttaaatttaa
     2881 tggcagccag gcatggttcc agctacttgg gaggctgagg caggaggatc gcttgagccc
     2941 aggagttcaa ggctgcagtg agctatgatt gcaccactgt attccagcct gcacgataga
     3001 gttagaccct gtatcttaaa aaaaaaaaaa ttaatggctg gtatatagta aacttaattc
     3061 actgttccca ttgttctaaa gaattttttt aaataatgtt tcattaaatc ttatgattta
     3121 accgtgcttg ccctttttgc cagctatgtg gcagtttacg gcagaactgc tgtcagtgtg
     3181 ctggtagccc tctattcatc cctcctcaga gcccagcttc cagaactgct atcactgtgc
     3241 tggtagccct ctgtattcat ccctcttcag agctcagctt ctggttgtat tctccatgag
     3301 tttaataatg acatgaaaaa atgtggaagc cgagagagta aaatactctg ccctgtaaaa
     3361 acatggaaga catgcaaaca gaaaaaaaat aattgtattg ttttagataa tacttaagac
     3421 aactgtgaaa caacaaaaac acaactattc ctttgtgacc gatgaagata aaaagaaatt
     3481 ctggtaaaga cgggtatgca gttttttaaa atgggttaag aaattgttgc agaagaattt
     3541 ctaacatctg aaaatggttt tatgtttaag aaggatggtc tgaattgtgt actaatagca
     3601 aggtataagt ttggtgtaga gcctatccag tagcgtccac tgtaccactt ttaagtaaga
     3661 ctcagtccac agaagctgga agattgcctt cgctttaaat atcctttacc ttctgcattt
     3721 gacactcctc ctgttactac atagattccg gtccccagaa gcaattttac actggtacta
     3781 gagcttacca gccccattta gtaattttta atggctagat gaggtttaac aagaatatga
     3841 aaagaaaaaa gaaaaaatat attcatgaat gataggcgat gcccattctt tctctcaagc
     3901 taatgaagtc ctatggcatt ctaaccacaa ccctcggaca gactcctcct attcctccat
     3961 ggcattgtaa ccacaaccct cggacagact cctcctattc ctccatggca ttgtaaccac
     4021 aaccctcgga cagactcctc ctactcctcc atggcattgt aaccacaacc ctcggacaga
     4081 ctcctcctac tcctccatgg cattgtaacc acaaccctcg gacagactcc tcctactcct
     4141 ccatggcatt gtaaccacaa ccctcggaca gactcctcct attcctccat ggcattgtaa
     4201 ccacaaccct cggacagact cctcctattc ctccatggca ttgtaaccac aaccctcgga
     4261 cagactcctc ctattcctcc atggcattgt aaccacaacc ctcggacaga ctcctattcc
     4321 tccatggcat tgtaaccaca accctcggac agactcctcc tattcctcca tggcattgta
     4381 accacaaccc tcggacagac tccttctgtt cctcctttcc tcgtccttcc ctgcttttcg
     4441 tccattcagc atatagctat tcagtactcc attgaagaaa ttatgctaag tgagcaaagc
     4501 aacataatta ctaagaatta attctgatta tttggcacta gagccaacag caaccccagc
     4561 acagaggaaa gtcgcttttt tttcaaatgc ataaatttaa agtatgtatt tgcatgcagt
     4621 tttaaatggg aggtatttgt cattgtgaaa agctgggaat ctcaaacata gtcaacttaa
     4681 ctaaaaagaa gctaatacag gttgagcatt cctaatccaa aaatccagaa tccaaattgc
     4741 tccaaaatct gaaactttct gaatgctgac ctgatactac aagtagaaaa ttccacatac
     4801 aagtacttaa cacaaacttt gtttcatgca caaactacta aaaatattgt ataaaattac
     4861 cttcaggcag tgtgtgtagt tatatatgaa acatgaattt catgtttaga cttgggtcca
     4921 tgcccaagat acctcattag gtatctgtaa atatccgaaa tccaaaaaaa agtctgaaat
     4981 ctgaaacact tctggtccca agcatttcag taagtgatgc tcaacctgcg taatggtctg
     5041 cgggccagtg ctcattttct gcctatgttg tacatacttt aaattgtgta aattaaaagt
     5101 caaagcaaag agtctatttt taaagaaact tacaataatc taaacatata cttcttatga
     5161 ttatgaatca tcctgcaaag ctgaatgaag aattttacca aaaatacaat gaattaatca
     5221 tatatttgag agtcacagtg ataggttcga ctatattttg actgttgtgt agtggcaccg
     5281 tttaggtagt attgtttctg agcatggtgc tttttatact tgaaatatat ttttgcttta
     5341 ttttttattg atataattat atttgcacta atggctttct gaagaaaata ttatagatga
     5401 cattttttgt atatatattt attaagcttg ggaacctggt cgcccagtgt tttctctgga
     5461 caaatgtgaa actggataaa gtatggataa agtcttgagt tcctcagggt aactgtgttg
     5521 atgtctcccg tcctcttcag taaggcttga atatgatttt actcatcatt gattctgcat
     5581 agtgtaccca gcaagactta gaaggacact gaacctgtca gagattttaa gaggcacatt
     5641 ttagtcactt tgaatatggt agtggtgggc gcggtgactg aagcctgtaa tctcagcact
     5701 tcgggaggcc aaggcaagca gatcacgaga tcaggagttt gaggttacag tgagctgatc
     5761 gcaccactgc actgcagcct ggatgacaga gtgagacttt cttgggaaaa aaaaaaatga
     5821 cagtgaagca gacttttaga atccgagatg tcattgcaga attattggta taaaattcag
     5881 ctgcaaagtg aagaaattga aatggcccac acgttgatat cctgtggcag gttataccct
     5941 tcatgttagc aaagacgaag ccacgtcgct gtgttaagag ggacaggctg ggccggctgc
     6001 agctgtagtg gaagtgaggg acacagggaa ggaatgggga gcagcaattt ggggacagta
     6061 gactggagtc actttctgac tcaaaaaggg tcaagtactt attaaaaact atcttggttt
     6121 tctgttcaga cttaggctca ttttgatcat tttaaggtcc cagttgtcaa aaatatcaag
     6181 tgaatttgtc tcaggttttc agaaacaaaa tttacaggaa ggaagcaaaa gccatgtcag
     6241 tagccttgag ctgacagctt taaagaaact ggcaaacagg taggttgtcc tcatatagat
     6301 ccttccagta ttctgaaaaa catcctttta tttcttaaaa ccagtaaccc ttacattttt
     6361 cctataggat agttattttt gttgagatca aatagacatt ctataaatgt tataaattat
     6421 gcttgcagtt actcagccta tctaggctta aggtttatca atatttgaag ttgaaacatc
     6481 atcttatgag gtttagtttt aggaagataa ataaatatat caaagtattt cataaagttg
     6541 tatcaatgtt ccttctaaca ttagaagact tactgactga ggccatctgt gaacgactag
     6601 gtgatctcag aatccttcca gctctaatac cctctgacta acactcaccc agaattgctg
     6661 tctgtgctgg ctgtgatctg cctccaggag catacgccat cctgcgtgct gtgtccatca
     6721 cagtgtctgt gctcggtgcc ttaccactgt ccgtgtcctt ggacgctgac tggacagaga
     6781 ggagcctgtc tctcagggca catgagtcgt cgtggcagga ggagacgggc ctcagtcaca
     6841 gtgtcacaga cccttgtcac agtggacact agtcattcct gccatgtcct tgcagcccag
     6901 gaggactaaa aagattttaa tgaagtctgt gttactcatt ctgaagaaaa gaacttacct
     6961 gagaggagta atattttttt aatatatatt gggtcaggga cagggatgga gtggttgttt
     7021 tatgtttaca tttttaataa gtaaaataga agatttaaga actaatattt atggtattga
     7081 actttaagtg tgatatattc cttagaaaaa cacaacttta ataaaaatgg aaactaa
//
