LOCUS       NM_033200               2593 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens lipase maturation factor 2 (LMF2), transcript variant
            1, mRNA.
ACCESSION   NM_033200
VERSION     NM_033200.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2593)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2593)
  AUTHORS   Kobayashi,N., Shinagawa,S., Nagata,T., Shimada,K., Shibata,N.,
            Ohnuma,T., Kasanuki,K., Arai,H., Yamada,H., Nakayama,K. and
            Kondo,K.
  TITLE     Development of Biomarkers Based on DNA Methylation in the
            NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease
            and Amnesic Mild Cognitive Impairment
  JOURNAL   PLoS One 11 (1), e0146449 (2016)
   PUBMED   26742120
  REMARK    GeneRIF: DNA methylation in the NCAPH2/LMF2 promoter region is
            significantly decreased in Alzheimer disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2593)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2593)
  AUTHORS   Peterfy,M., Ben-Zeev,O., Mao,H.Z., Weissglas-Volkov,D.,
            Aouizerat,B.E., Pullinger,C.R., Frost,P.H., Kane,J.P., Malloy,M.J.,
            Reue,K., Pajukanta,P. and Doolittle,M.H.
  TITLE     Mutations in LMF1 cause combined lipase deficiency and severe
            hypertriglyceridemia
  JOURNAL   Nat Genet 39 (12), 1483-1487 (2007)
   PUBMED   17994020
REFERENCE   5  (bases 1 to 2593)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI917400.1, BC002942.2, U62317.2, BX412067.2 and BU628394.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033200.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021143.1, SRR3476690.795388.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000474879.7/ ENSP00000424381.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BI917400.1         5-26
            23-882              BC002942.2         1-860
            883-883             U62317.2           134720-134720
            884-1985            BC002942.2         862-1963
            1986-2589           BX412067.2         1-604               c
            2590-2593           BU628394.1         21-24               c
FEATURES             Location/Qualifiers
     source          1..2593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..2593
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /note="lipase maturation factor 2"
                     /db_xref="GeneID:91289"
                     /db_xref="HGNC:HGNC:25096"
     exon            1..121
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2151
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 153; transmembrane protein 112B"
                     /codon_start=1
                     /product="lipase maturation factor 2 isoform 1"
                     /protein_id="NP_149977.2"
                     /db_xref="CCDS:CCDS14093.2"
                     /db_xref="GeneID:91289"
                     /db_xref="HGNC:HGNC:25096"
                     /translation="MAGSRLPRQLFLQGVAAVFMFAFASLYTQIPGLYGPEGILPARR
                     TLRPQGKGRWQQLWETPTLLWEAPRLGLDTAQGLELLSLLGALVALGALLLSPLRHPV
                     IYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRKEAPQGRQAGA
                     LPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPAWWGLTALTYHYETQCLPTPAAWFAH
                     HLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFFNL
                     MTLVLTTALLDDQHLAAEPGHGSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHY
                     FGLEVDWQQRTIHSRTTFTFHQFSQWLKTLTLPTVWLGVASLVWELLSALWRWTQVRG
                     WLRKLSAVVQLSLVGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGAVEHLQLAN
                     SYGLFRRMTGLGGRPEVVLEGSYDGHHWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQM
                     WFAALGPHTHSPWFTSLVLRLLQGKEPVIRLVQSQVARYPFHKQPPTYVRAQRYKYWF
                     SQPGEQGQWWRRQWVEEFFPSVSLGDPTLETLLRQFGLQEKSPPRTRSANSTLAQALH
                     WTRSQLSPLEAPALLWGLLMAVGAVRFVQALLAPCSLRSSPLAPVSGEKRRPASQKDS
                     GAASEQATAAPNPCSSSSRTTRRKK"
     exon            122..375
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            376..404
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            405..622
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            623..801
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            802..943
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1078
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1184
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1281
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1464
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1633
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1745
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1842
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2593
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2569..2574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /note="hexamer: AATAAA"
     polyA_site      2593
                     /gene="LMF2"
                     /gene_synonym="TMEM112B; TMEM153"
                     /note="major polyA site"
ORIGIN      
        1 cctgctctag cgggccgcgt agcggacatg gcgggctccc ggctcccgcg gcagctcttc
       61 ctccagggcg tggcggccgt cttcatgttt gctttcgctt ccctctacac gcaaatccca
      121 ggcctgtatg gccccgaggg catcctacct gcaaggagga cgctgcggcc tcagggcaag
      181 gggcgctggc agcagctgtg ggagaccccg acgctgctgt gggaagcgcc gagactgggg
      241 ctggacacgg cccagggcct ggagctgctg agcctgctgg gtgcactagt ggccctggga
      301 gccctgctgc tgagcccact gcgccaccct gtcatctact tgctgctttg ggccgcctac
      361 ctgtcagcct gccaggtggg ccaggtgttc ctttatttcc agtgggactc cctgctgcta
      421 gagactggct tcctggccgt gctggtggcc ccgctgaggc cagcctccca ccgcaaggag
      481 gccccccagg gcaggcaggc aggggccctg ccccacgaag acctcccctt ctggctggtg
      541 cgatggctgc tgttccgcct catgttcgcc tcaggcgtgg tcaagctgac cagccgctgc
      601 cctgcgtggt gggggctcac tgccctcacc taccactacg agacccagtg cctgcccacg
      661 cccgccgcct ggttcgcaca ccacctgccg gtctggctgc acaagctcag cgtggtggcc
      721 accttcctaa ttgagatcgc tgtgccgccc ctgttcttcg cccccattcg acgcctgcgc
      781 ttggctgctt tctactcgca ggtgctgctg caggtcctga ttatcatcac cggcaactac
      841 aacttcttca acctgatgac gctggtgctt accactgcgc tgctggacga ccagcacctg
      901 gctgctgagc ctggccacgg cagccgcaag aagacggcca cctcctggcc caaggccctg
      961 ctggccaccc tgtcgctgct gctggaacta gccgtctacg ggcttctggc ctatggcact
     1021 gtgcactact ttggcctgga ggttgactgg cagcagcgca ccatccactc cagaaccact
     1081 ttcaccttcc accagttttc tcagtggctg aagacactga cgctgcccac tgtgtggctg
     1141 ggtgtggcct ccctggtctg ggagctgctg agtgccctgt ggaggtggac ccaggtgcgg
     1201 ggctggctac ggaagctcag tgctgtagtc caactgtccc ttgtgggcac tgcgaccgtg
     1261 gccttgttcc tgattagcct ggtgccgtac tcctacgtgg agcccgggac ccacgggcgc
     1321 ctctggaccg gggcccaccg cctgtttggt gccgtggagc acctacagct ggccaactcc
     1381 tacggcctct tccgccgcat gactgggctt ggtggacggc ctgaggtggt gctggagggc
     1441 agttacgacg gccaccactg gacggagatc gagttcatgt acaagcctgg gaacctgagc
     1501 cggccgcccc cggttgtggt gccccaccag ccacgcctgg actggcagat gtggtttgca
     1561 gccctgggcc cacacacgca cagcccgtgg ttcacaagcc tggtcttgcg cctgctgcag
     1621 ggcaaggagc cagtgatccg ccttgtccag agccaagtgg ccaggtatcc cttccacaag
     1681 cagccgccca cctacgtccg agcccagcgc tacaagtact ggttctccca gcctggggag
     1741 cagggccagt ggtggcggcg ccagtgggtg gaggagttct tcccatccgt gtccctgggg
     1801 gaccccacgc tggagacgct gctcaggcag tttggactac aggagaaaag cccacctcgc
     1861 acccgcagcg ccaacagcac cctggcccag gccctccact ggactcgctc tcagctgtct
     1921 cccctggagg cccccgccct gctctggggg ctcctcatgg ccgtgggggc tgtcagattt
     1981 gtgcaagccc tgctagcacc ctgttctctc cggtcctccc cgctggcacc agtcagcggg
     2041 gagaagcgca ggccagcctc ccagaaagac tccggagctg cctccgaaca ggccaccgca
     2101 gcccccaacc cctgctccag tagttcgagg accacccggc gaaagaagta gctgtgttct
     2161 cccagctgca cgtcctgaga gggccaggtc gccgggagtg ctctggcctc cggcaggaca
     2221 ggacccagcc actgtgcctt agctgaccct gcagggccag gcacaggttg gggggctgcc
     2281 cctggggttt gcagggtgct gcattgaggg ctccaggccc cacccccacg ccagccatgc
     2341 ccctccccag gactcccact attgcctctg tgattggccc aggaggaaaa cacgaccaag
     2401 ctcaagaccc ttcccctgcc ctgggctgtg ggggtctgag tctagagccc ccaaccctag
     2461 gccccgtgcc agaggggaag aggctgactc ccaggggaag aggggaagca ctgtcatctt
     2521 ccacgtcatc ttcacaccag cccatcctgc cctttagatc tgggcaccaa taaaggcgtc
     2581 ttttgtgctt ggc
//
